Botulinum toxin modulates cortical maladaptation in post-stroke spasticity

Muscle and Nerve

Volumn 48, Issue 1, 2013, Pages 93-99

  Huynh, William ^a   Krishnan, Arun V ^b   Lin, Cindy S Y ^b   Vucic, Steve ^a   Katrak, Pesi ^b   Hornberger, Michael ^a,b   Kiernan, Matthew C ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Botulinum toxin; Cortical excitability; Nerve excitability; Spasticity; Stroke

Indexed keywords

BOTULINUM TOXIN;

ADULT; AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMISPHERE; HUMAN; MALE; MOTOR CORTEX; NERVE EXCITABILITY; PERIPHERAL NERVE; PRIORITY JOURNAL; SPASTICITY; TRANSCRANIAL MAGNETIC STIMULATION; UNAFFECTED HEMISPHERE;

ADAPTATION, PHYSIOLOGICAL; AGED; AGED, 80 AND OVER; BOTULINUM TOXINS, TYPE A; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MOTOR CORTEX; MUSCLE SPASTICITY; STROKE; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 84879551924     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.23719     Document Type: Article

References (54)

1. Lundstrom E, Terent A, Borg J. Prevalence of disabling spasticity 1 year after first-ever stroke. Eur J Neurol 2008;15:533-539.
2. Bhattacharya S, Saha SP, Basu A, Das SK. A 5 years prospective study of incidence, morbidity and mortality profile of stroke in a rural community of eastern India. J Indian Med Assoc 2005;103:655-659.
3. Pascual-Leone A, Amedi A, Fregni F, Merabet LB. The plastic human brain cortex. Annu Rev Neurosci 2005;28:377-401.
4. Liepert J, Storch P, Fritsch A, Weiller C. Motor cortex disinhibition in acute stroke. Clin Neurophysiol 2000;111:671-676.
5. Shimizu T, Hosaki A, Hino T, Sato M, Komori T, Hirai S, Rossini PM. Motor cortical disinhibition in the unaffected hemisphere after unilateral cortical stroke. Brain 2002;125:1896-1907.
6. Manganotti P, Acler M, Zanette GP, Smania N, Fiaschi A. Motor cortical disinhibition during early and late recovery after stroke. Neurorehabil Neural Repair 2008;22:396-403.
7. Huynh W, Vucic S, Krishnan AV, Lin CS, Hornberger M, Kiernan MC. Longitudinal plasticity across the neural axis in acute stroke. Neurorehabil Neural Repair 2013;27:219-229.
8. Murase N, Duque J, Mazzocchio R, Cohen LG. Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol 2004;55:400-409.
9. Swayne OB, Rothwell JC, Ward NS, Greenwood RJ. Stages of motor output reorganization after hemispheric stroke suggested by longitudinal studies of cortical physiology. Cereb Cortex 2008;18:1909-1922.
10. Ward NS. The neural substrates of motor recovery after focal damage to the central nervous system. Arch Phys Med Rehabil 2006;87(suppl 2):S30-35.
11. Ward AB. A literature review of the pathophysiology and onset of post-stroke spasticity. Eur J Neurol 2012;19:21-27.
12. Mally J, Dinya E. Recovery of motor disability and spasticity in post-stroke after repetitive transcranial magnetic stimulation (rTMS). Brain Res Bull 2008;76:388-395.
13. Currà A, Trompetto C, Abbruzzese G, Berardelli A. Central effects of botulinum toxin type A: evidence and supposition. Mov Disord 2004;19(suppl 8):S60-64.
14. Yerdelen D, Koc F, Sarica Y. Effects of botulinum toxin on strength-duration properties. Int J Neurosci 2007;117:1457-1464.
15. Byrnes ML, Thickbroom GW, Wilson SA, Sacco P, Shipman JM, Stell R, et al.. The corticomotor representation of upper limb muscles in writer's cramp and changes following botulinum toxin injection. Brain 1998;121:977-988.
16. Gilio F, Curra A, Lorenzano C, Modugno N, Manfredi M, Berardelli A. Effects of botulinum toxin type A on intracortical inhibition in patients with dystonia. Ann Neurol 2000;48:20-26.
17. Thickbroom GW, Byrnes ML, Stell R, Mastaglia FL. Reversible reorganisation of the motor cortical representation of the hand in cervical dystonia. Mov Disord 2003;18:395-402.
18. Pauri F, Boffa L, Cassetta E, Pasqualetti P, Rossini PM. Botulinum toxin type-A treatment in spastic paraparesis: a neurophysiological study. J Neurol Sci 2000;181:89-97.
19. Kojovic M, Caronni A, Bologna M, Rothwell JC, Bhatia KP, Edwards MJ. Botulinum toxin injections reduce associative plasticity in patients with primary dystonia. Mov Disord 2011;26:1282-1289.
20. Tomá ová Z, Hlu tik P, Král M, Otruba P, Herzig R, Krobot A, et al. Cortical activation changes in patients suffering from post-stroke arm spasticity and treated with botulinum toxin A. J Neuroimaging (in press).
21. Senkarova Z, Hlu tik P, Otruba P, Herzig R, Kanovsky P. Modulation of cortical activity in patients suffering from upper arm spasticity following stroke and treated with botulinum toxin A: an fMRI study. J Neuroimaging 2010;20:9-15.
22. Filippi GM, Errico P, Santarelli R, Bagolini B, Manni E. Botulinum A toxin effects on rat jaw muscle spindles. Acta Otolaryngol 1993;113:400-404.
23. Allam N, Fonte-Boa PM, Tomaz CA, Brasil-Neto JP. Lack of effect of botulinum toxin on cortical excitability in patients with cranial dystonia. Clin Neuropharmacol 2005;28:1-5.
24. Wiegand H, Erdmann G, Wellhoner HH. 125I-labelled botulinum A neurotoxin: pharmacokinetics in cats after intramuscular injection. Naunyn Schmiedebergs Arch Pharmacol 1976;292:161-165.
25. Kiernan MC, Burke D, Andersen KV, Bostock H. Multiple measures of axonal excitability: a new approach in clinical testing. Muscle Nerve 2000;23:399-409.
26. Vucic S, Howells J, Trevillion L, Kiernan MC. Assessment of cortical excitability using threshold tracking techniques. Muscle Nerve 2006;33:477-486.
27. Bohannon RW, Smith MB. Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther 1987;67:206-207.
28. Haugh AB, Pandyan AD, Johnson GR. A systematic review of the Tardieu scale for the measurement of spasticity. Disabil Rehabil 2006;28:899-907.
29. Lance JW. Symposium synopsis. In: Feldman RG, Young RR, Koella WP, editors. Spasticity: disordered motor control. Miami, FL: Year Book Medical; 1980. p 485-494.
30. Fisher RJ, Nakamura Y, Bestmann S, Rothwell JC, Bostock H. Two phases of intracortical inhibition revealed by transcranial magnetic threshold tracking. Exp Brain Res 2002;143:240-248.
31. Vucic S, Kiernan MC. Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease. Brain 2006;129:2436-2446.
32. Vucic S, Burke T, Lenton K, Ramanathan S, Gomes L, Yannikas C, Kiernan MC. Cortical dysfunction underlies disability in multiple sclerosis. Mult Scler 2012;18:425-432.
33. Farrar MA, Vucic S, Johnston HM, Kiernan MC. Corticomotoneuronal integrity and adaptation in spinal muscular atrophy. Arch Neurol 2012;69:467-473.
34. Cantello R, Gianelli M, Civardi C, Mutani R. Magnetic brain stimulation: the silent period after the motor evoked potential. Neurology 1992;42:1951-1959.
35. Vucic S, Cheah BC, Krishnan AV, Burke D, Kiernan MC. The effects of alterations in conditioning stimulus intensity on short interval intracortical inhibition. Brain Res 2009;1273:39-47.
36. Krishnan AV, Lin CSY, Park SB, Kiernan MC. Axonal ion channels from bench to bedside: a translational neuroscience perspective. Prog Neurobiol 2009;89:288-313.
37. Jankelowitz SK, Burke D. Axonal excitability in the forearm: normal data and differences along the median nerve. Clin Neurophysiol 2009;120:167-173.
38. Weiss G. Sur la possibilité de rendre comparables entre eux les appareils servant l'excitation électrique. Arch Ital Biol 1901;35:413-446.
39. Burke D, Kiernan MC, Bostock H. Excitability of human axons. Clin Neurophysiol 2001;112:1575-1585.
40. Bostock H, Cikurel K, Burke D. Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 1998;21:137-158.
41. Escudero JV, Sancho J, Bautista D, Escudero M, Lopez-Trigo J. Prognostic value of motor evoked potential obtained by transcranial magnetic brain stimulation in motor function recovery in patients with acute ischemic stroke. Stroke 1998;29:1854-1859.
42. Palomar FJ, Mir P. Neurophysiological changes after intramuscular injection of botulinum toxin. Clin Neurophysiol 2012;123:54-60.
43. Marconi B, Filippi GM, Koch G, Giacobbe V, Pecchioli C, Versace V, et al.. Long-term effects on cortical excitability and motor recovery induced by repeated muscle vibration in chronic stroke patients. Neurorehabil Neural Repair 2011;25:48-60.
44. Kim DY, Oh BM, Paik NJ. Central effect of botulinum toxin type A in humans. Int J Neurosci 2006;116:667-680.
45. Welberg L. Techniques: Propriospinal neurons-old but not forgotten. Nat Rev Neurosci 2012;13:517.
46. Cote MP, Detloff MR, Wade RE Jr, Lemay MA, Houle JD. Plasticity in ascending long propriospinal and descending supraspinal pathways in chronic cervical spinal cord injured rats. Front Physiol 2012;3:330.
47. Jang SH. The role of the corticospinal tract in motor recovery in patients with a stroke: a review. NeuroRehabilitation 2009;24:285-290.
48. Davidoff RA. The pyramidal tract. Neurology 1990;40:332-339.
49. Hoyer EH, Celnik PA. Understanding and enhancing motor recovery after stroke using transcranial magnetic stimulation. Restor Neurol Neurosci 2011;29:395-409.
50. Yeo SS, Jang SH. Ipsilateral motor pathway without contralateral motor pathway in a stroke patient. NeuroRehabilitation 2012;30:303-306.
51. Jang SH. A review of motor recovery mechanisms in patients with stroke. NeuroRehabilitation 2007;22:253-259.
52. Misawa S, Kuwabara S, Matsuda S, Honma K, Ono J, Hattori T. The ipsilateral cortico-spinal tract is activated after hemiparetic stroke. Eur J Neurol 2008;15:706-711.
53. Nakanishi ST, Cope TC, Rich MM, Carrasco DI, Pinter MJ. Regulation of motoneuron excitability via motor endplate acetylcholine receptor activation. J Neurosci 2005;25:2226-2232.
54. Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A, et al.. Anti-spastic effect of low-frequency rTMS applied with occupational therapy in post-stroke patients with upper limb hemiparesis. Brain Injury 2011;25:496-502.