Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats

European Journal of Nutrition

Volumn 52, Issue 3, 2013, Pages 1191-1199

  Giriwono, Puspo E ^a   Shirakawa, Hitoshi ^a   Ohsaki, Yusuke ^a   Hata, Shuichi ^b   Kuriyama, Hiroki ^b   Sato, Shoko ^a   Goto, Tomoko ^a   Komai, Michio ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Tama Biochemical Co Ltd   (Japan)

Author keywords

Geranylgeraniol; Irak1; Liver inflammation; NF B inhibition; Traf6

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOKINE; GERANYLGERANIOL; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE MARKER; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; GENE EXPRESSION; GENE TARGETING; HEPATITIS; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TREATMENT DURATION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOKINES; DIETARY SUPPLEMENTS; DITERPENES; DOWN-REGULATION; HEPATIC INSUFFICIENCY; HEPATITIS; I-KAPPA B KINASE; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPOLYSACCHARIDES; LIVER; MALE; NF-KAPPA B; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6;

RATTUS;

EID: 84879550418     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0429-y     Document Type: Article

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