Natural isoprenoids inhibit LPS-induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes

International Immunopharmacology

Volumn 10, Issue 6, 2010, Pages 639-642

  Marcuzzi, Annalisa ^a   Tommasini, Alberto ^a,b   Crovella, Sergio ^b,c   Pontillo, Alessandra ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Inflammation; Isoprenoid; MKD; Periodic fever

Indexed keywords

ALENDRONIC ACID; FARNESOL; GERANIOL; GERANYLGERANIOL; GERANYLGERANYL PYROPHOSPHATE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MENTHOL; NITRIC OXIDE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CHILD; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MEVALONATE KINASE DEFICIENCY; MONOCYTE; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ANIMALS; CELL LINE; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CYTOKINES; DIPHOSPHONATES; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MEVALONATE KINASE DEFICIENCY; MICE; MONOCYTES; NITRIC OXIDE; TERPENES;

EID: 77951838958     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.03.008     Document Type: Article

References (13)

1. Reszka A.A., and Rodan G.A. Mechanism of action of bisphosphonates. Curr Osteoporos Rep 1 (2003) 45-52
2. Russell R.G., Watts N.B., Ebetino F.H., and Rogers M.J. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int 19 (2008) 733-759
3. Kuijk L.M., Beekman J.M., Koster J., Waterham H.R., Frenkel J., and Coffer P.J. HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood 112 (2008) 3563-3573
4. Kuijk L.M., Mandey S.H., Schellens I., Waterham H.R., Rijkers G.T., Coffer P.J., and Frenkel J. Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1. Mol Immunol 45 (2008) 2158-2165
5. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 (1983) 55-63
6. Polo M.P., and de Bravo M.G. Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. Biochem Cell Biol 84 (2006) 102-111
7. He L., Mo H., Hadisusilo S., Qureshi A.A., and Elson C.E. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 127 (1997) 668-674
8. Houten S.M., Schneiders M.S., Wanders R.J., and Waterham H.R. Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients. J Biol Chem 278 (2003) 5736-5743
9. Park E.J., Kim S.H., Kim B.J., Kim S.Y., So I., and Jeon J.H. Menthol enhances an antiproliferative activity of 1alpha, 25-dihydroxyvitamin D(3) in LNCaP cells. J Clin Biochem Nutr 44 (2009) 125-130
10. Marcuzzi A., Pontillo A., De Leo L., Tommasini A., Decorti G., Not T., and Ventura A. Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. Pediatr Res 64 (2008) 177-182
11. Chang F.Y., and Lu C.L. Treatment of irritable bowel syndrome using complementary and alternative medicine. J Chin Med Assoc 72 (2009) 294-300
12. Merat S., Khalili S., Mostajabi P., Ghorbani A., Ansari R., and Malekzadeh R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig Dis Sci (2009) 10.1007/s10620-009-0854-9
13. Houten S.M., Wanders R.J., and Waterham H.R. Biochemical and genetic aspects of mevalonate kinase and its deficiency. Biochim Biophys Acta 1529 (2000) 19-32