Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 26, 2013, Pages 10759-10764

  Xu, Pin ^a   Grueter, Brad A ^b   Britt, Jeremiah K ^c   McDaniel, Latisha ^c   Huntington, Paula J ^a   Hodge, Rachel ^a   Tran, Stephanie ^a   Mason, Brittany L ^a   Lee, Charlotte ^a   Vong, Linh ^d   Lowell, Bradford B ^d   Malenka, Robert C ^b   Lutter, Michael ^c   Pieper, Andrew A ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Anxiety disorders; Conditional knockout mice; Metabolism; Synaptic transmission

Indexed keywords

BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; MELANOCORTIN 4 RECEPTOR; MEMBRANE PROTEIN; SAPAP3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN ELECTROPHYSIOLOGY; COMPULSION; CONTINUOUS INFUSION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG INHIBITION; GENE DELETION; GENE EXPRESSION; GROOMING; MOUSE; NONHUMAN; OBESITY; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION;

ANXIETY DISORDERS; CONDITIONAL KNOCKOUT MICE; METABOLISM; SYNAPTIC TRANSMISSION;

ANIMALS; BODY WEIGHT; COMPULSIVE BEHAVIOR; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; FEMALE; GROOMING; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; OBESITY; PEPTIDES, CYCLIC; RECEPTOR, MELANOCORTIN, TYPE 4; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

MUS;

EID: 84879549441     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308195110     Document Type: Article

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