Reward system dysfunction in autism spectrum disorders

Social Cognitive and Affective Neuroscience

Volumn 8, Issue 5, 2013, Pages 565-572

  Kohls, Gregor ^a,b,c   Schulte Rüther, Martin ^b,c   Nehrkorn, Barbara ^b   Müller, Kristin ^b,c   Fink, Gereon R ^c,d   Kamp Becker, Inge ^e   Herpertz Dahlmann, Beate ^b,f   Schultz, Robert T ^a   Konrad, Kerstin ^b,c,f  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

^f JARA TRANSLATIONAL BRAIN MEDICINE   (Germany)

Author keywords

Autism spectrum disorders; Functional magnetic resonance imaging; Limbic system; Nucleus accumbens; Reward

Indexed keywords

OXYGEN;

ADOLESCENT; ANALYSIS OF VARIANCE; ARTICLE; ASSOCIATION; AUTISM; AUTISM SPECTRUM DISORDERS; BLOOD; BRAIN; CASE CONTROL STUDY; CHILD; DECISION MAKING; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; IMAGE PROCESSING; LEARNING DISORDER; LIMBIC SYSTEM; MALE; MOTIVATION; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS ACCUMBENS; PATHOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; QUESTIONNAIRE; REACTION TIME; REWARD; SEVERITY OF ILLNESS INDEX; VASCULARIZATION; COMPLICATION; LEARNING DISORDERS;

AUTISM SPECTRUM DISORDERS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; LIMBIC SYSTEM; NUCLEUS ACCUMBENS; REWARD;

ADOLESCENT; ANALYSIS OF VARIANCE; BRAIN; CASE-CONTROL STUDIES; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CUES; DECISION MAKING; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LEARNING DISORDERS; MAGNETIC RESONANCE IMAGING; MALE; MOTIVATION; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PHOTIC STIMULATION; QUESTIONNAIRES; REACTION TIME; REWARD; SEVERITY OF ILLNESS INDEX;

EID: 84879542573     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nss033     Document Type: Article

References (42)

1. Achenbach, T.M. (1991). Manual for the Child Behavior Checklist/4-18 and 1991 Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
2. Bartz, J.A., Zaki, J., Bolger, N., Ochsner, K.N. (2011). Social effects of oxytocin in humans: context and person matter. Trends in Cognitive Sciences, 15, 301-9.
3. Berridge, K.C., Robinson, T.E., Aldridge, J.W. (2009). Dissecting components of reward: "liking", "wanting", and learning. Current Opinion in Pharmacology, 9(1), 65-73.
4. Bjork, J.M., Hommer, D.W. (2007). Anticipating instrumentally obtained and passively-received rewards: a factorial fMRI investigation. Behavioural Brain Research, 177(1), 165-70.
5. Blatter, K., Schultz, W. (2006). Rewarding properties of visual stimuli. Experimental Brain Research, 168, 541-6.
6. Botvinick, M.M., Huffstetler, S., McGuire, J.T. (2009). Effort discounting in human nucleus accumbens. Cognitive, Affective, and Behavioral Neuroscience, 9, 16-27.
7. Chevallier, C., Kohls, G., Troiani, V., Brodkin, E.S., Schultz, R.T. (2012). The social motivation theory of autism. Trends in Cognitive Sciences [March 17 Epub ahead of print; doi:10.1016/j.tics.2012.02.007].
8. Constantino, J.N., Gruber, C.P. (2002). Social Responsiveness Scale (SRS) Manual. Los Angeles: Western Psychological Services.
9. Dawson, G., Webb, S.J., McPartland, J. (2005). Understanding the nature of face processing impairment in autism: insights from behavioral and electrophysiological studies. Developmental Neuropsychology, 27, 403-24.
10. Dichter, G.S., Felder, J.N., Green, S.R., Rittenberg, A.M., Sasson, N.J., Bodfish, J.W. (2012a). Reward circuitry function in autism spectrum disorders. Social Cognitive and Affective Neuroscience, 7, 160-72.
11. Dichter, G.S., Richey, J.A., Rittenberg, A.M., Sabatino, A., Bodfish, J.W. (2012b). Reward circuitry function in autism during face anticipation and outcomes. Journal of Autism and Developmental Disorders, 42, 147-160.
12. Estle, S.J., Green, L., Myerson, J., Holt, D.D. (2007). Discounting of monetary and directly consumable rewards. Psychological Sciences, 18, 58-63.
13. Geschwind, D.H., Levitt, P. (2007). Autism spectrum disorders: developmental disconnection syndromes. Current Opinion in Neurobiology, 17, 103-11.
14. Gleissner, U., von Ondarza, G., Freitag, H., Karlmeier, A. (2003). Auswahl einer HAWIK-III-Kurzform für Kinder und Jugendliche mit Epilepsie. Zeitschrift für Neuropsychologie, 14, 3-11.
15. Gotham, K., Pickles, A., Lord, C. (2009). Standardizing ADOS scores for a measure of severity in autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(5), 693-705.
16. Haber, S.N., Knutson, B. (2010). The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology, 35(1), 4-26.
17. Hill, E.L. (2004). Evaluating the theory of executive dysfunction in autism. Developmental Review, 24, 189-233.
18. Kalivas, P.W., Volkow, N.D. (2005). The neural basis of addiction: a pathology of motivation and choice. The American Journal of Psychiatry, 162(8), 1403-13.
19. Kaufman, J., Birmaher, B., Brent, D., et al. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy for Child and Adolescent Psychiatry, 36, 980-8.
20. Kohls, G., Peltzer, J., Herpertz-Dahlmann, B., Konrad, K. (2009a). Differential effects of social and non-social reward on response inhibition in children and adolescents. Developmental Science, 12, 614-25.
21. Kohls, G., Herpertz-Dahlmann, B., Konrad, K. (2009b). Hyperresponsiveness to social rewards in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Behavioral and Brain Functions, 5, 20.
22. Kohls, G., Peltzer, J., Schulte-Rüther, M., et al. (2011). Atypical brain responses to reward cues in autism as revealed by event-related potentials. Journal of Autism and Developmental Disorders, 41, 1523-33.
23. Levy, S.E., Mandell, D.S., Schultz, R.T. (2009). Autism. The Lancet, 374, 1627-38.
24. Lord, C., Rutter, M., Le Couteur, A. (1994). Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorder, 24, 659-85.
25. Lord, G., Risi, S., Lambrecht, L., et al. (2000). The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorder, 30, 205-23.
26. Marsgall, H.R., Magruder, L. (1960). Relations between parent money education practices and children's knowledge and use of money. Child Development, 31, 253-284.
27. Neuhaus, E., Beauchaine, T.P., Bernier, R. (2010). Neurobiological correlates of social functioning in autism. Clinical Psychology Review, 30(6), 733-48.
28. Pennington, B.F., Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry, 37, 51-87.
29. Rinehart, N.J., Bellgrove, M.A., Tonge, B.J., Brereton, A.V., Howells-Rankin, D., Bradshaw, J.L. (2006). An examination of movement kinematics in young people with high-functioning autism and Asperger's disorder: further evidence for a motor planning deficit. Journal of Autism and Developmental Disorder, 36, 757-767.
30. Rubia, K., Halari, R., Cubillo, A., Mohammad, A.-M., Brammer, M., Taylor, E. (2009). Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task. Neuropharmacology, 57(7-8), 640-52.
31. Rutter, M., Bailey, A., Lord, C. (2003). Social Communication Questionnaire. Manual for the SCQ. Los Angeles, CA: Western Psychological Services.
32. Schmitz, N., Rubia, K., van Amelsvoort, T., Daly, E., Smith, A., Murphy, D.G.M. (2008). Neural correlates of reward in autism. The British Journal of Psychiatry, 192, 19-24.
33. Schultz, R.T. (2005). Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area. International Journal of Developmental Neuroscience, 23, 125-41.
34. Schultz, W., Apicella, P., Scarnati, E., Ljungberg, T. (1992). Neuronal activity in monkey ventral striatum related to the expectation of reward. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 12(12), 4595-610.
35. Scott-Van Zeeland, A.A., Dapretto, M., Ghahremani, D.G., Poldrack, R.A., Bookheimer, S. (2010a). Reward processing in autism. Autism Research, 3, 53-67.
36. Scott-Van Zeeland, A.A., Abrahams, B.S., Alvarez-Retuerto, A.I., et al. (2010b). Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Science Translational Medicine, 2(56), 56ra80.
37. Sesack, S.R., Grace, A.A. (2010). Cortico-basal ganglia reward network: microcircuitry. Neuropsychopharmacology, 35(1), 27-47.
38. South, M., Dana, J., White, S.E., Crowley, M.J. (2011). Failure is not an option: risk-taking is moderated by anxiety and also by cognitive ability in children and adolescents diagnosed with an autism spectrum disorder. Journal of Autism and Developmental Disorders, 41(1), 55-65.
39. Turner-Brown, L.M., Lam, K.S.L., Holtzclaw, T.N., Dichter, G.S., Bodfish, J.W. (2011). Phenomenology and measurement of circumscribed interests in autism spectrum disorders. Autism, 15, 437-56.
40. Vismara, L.A., Rogers, S.J. (2010). Behavioral treatments in autism spectrum disorder: what do we know? Annual Review of Clinical Psychology, 6, 447-468.
41. Worsley, K.J. (2001). Statistical analysis of activation images. In: Jezzard, P., Matthews, P.M., Smith, S.M., editors. Functional MRI: An Introduction to Methods. New York: Oxford University Press.
42. Zink, C.F., Stein, J.L., Kempf, L., Hakimi, S., Meyer-Lindenberg, A. (2010). Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans. The Journal of Neuroscience, 30(20), 7017-22.