β-Carotene Attenuates Angiotensin II-Induced Aortic Aneurysm by Alleviating Macrophage Recruitment in Apoe-/- Mice

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Gopal, Kaliappan ^a,d   Nagarajan, Perumal ^b   Jedy, Jose ^a   Raj, Avinash T ^a   Gnanaselvi, S Kalai ^a   Jahan, Parveen ^c   Sharma, Yogendra ^a   Shankar, Esaki M ^d   Kumar, Jerald M ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^c OSMANIA UNIVERSITY   (India)

^d UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANGIOTENSIN II; APOLIPOPROTEIN E; BETA CAROTENE; CHOLESTEROL; COLONY STIMULATING FACTOR 1; GELATINASE A; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN; MACROPHAGE ELASTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1; ANTIOXIDANT; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ABDOMINAL AORTA ANEURYSM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL TRANSPORT; CONTROLLED STUDY; DIET SUPPLEMENTATION; GENE EXPRESSION; INFLAMMATORY CELL; INTIMA; MACROPHAGE MIGRATION; MALE; MOUSE; NONHUMAN; RECEPTOR DOWN REGULATION; UPREGULATION; ABDOMINAL AORTA; ABDOMINAL AORTIC ANEURYSM; ANIMAL; DEFICIENCY; DIET THERAPY; DIETARY SUPPLEMENT; DISEASE MODEL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE; MACROPHAGE; METABOLISM; ORGAN SIZE; PATHOLOGY;

ANIMALIA; MUS;

ALPHA-TOCOPHEROL; ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; APOLIPOPROTEINS E; BETA CAROTENE; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; LYMPHOCYTES; MACROPHAGES; MALE; MICE, KNOCKOUT; ORGAN SIZE; PLAQUE, ATHEROSCLEROTIC;

EID: 84879541748     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067098     Document Type: Article

References (33)

1. Gavrila D, Li WG, McCormick ML, Thomas M, Daugherty A, et al. (2005) Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25: 1671-1677.
2. Nakahashi TK, Hoshina K, Tsao PS, Sho E, Sho M, et al. (2002) Flow loading induces macrophage antioxidative gene expression in experimental aneurysms. Arterioscler Thromb Vasc Biol 22: 2017-2022.
3. Shimizu K, Mitchell RN, Libby P, (2006) Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 26: 987-994.
4. Jiang F, Jones GT, Dusting GJ, (2007) Failure of antioxidants to protect against angiotensin-II induced aortic rupture in aged apolipoprotein (E)-deficient mice. Br J Pharmacol 152: 880-890.
5. Koul A, Bhatia V, Bansal MP, (2001) Effect of alpha-tocopherol on pulmonary antioxidant defence system and lipid peroxidation in cigarette smoke inhaling mice. BMC Biochem 2: 14.
6. Browatzki M, Larsen D, Pfeiffer CA, Gehrke SG, Schmidt J, et al. (2005) Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-kappaB and activator protein 1 in a redox- sensitive manner. J Vasc Res 42: 415-423.
7. Ziegelstein RC, He C, Hu Q, (2004) Hypoxia/reoxygenation stimulates Ca2+-dependent ICAM-1 mRNA expression in human aortic endothelial cells. Biochem Biophys Res Comm 322: 68-73.
8. Leeper NJ, Tedesco MM, Kojima Y, Schultz GM, Kundu RK, et al. (2009) Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Am J Physiol Heart Circ Physiol 296: 1329-1335.
9. Baxter BT, Terrin MC, Dalman RL, (2008) Medical management of small abdominal aortic aneurysms. Circulation 117: 1883-1889.
10. Alija AJ, Bresgen N, Bojaxhi E, Vogl C, Siems W, et al. (2010) Eck cytotoxicity of β-carotene cleavage products and its prevention by antioxidants. Acta Biochimica Polonica 57: 1968.
11. Shaish A, George J, Gilburd B, Keren P, Levkovitz H, et al. (1999) Dietary β-carotene and α-tocopherol combination does not inhibit atherogenesis in an Apoe-deficient mouse model. Arterioscler Thromb Vasc Biol 19: 1470-1475.
12. Sun J, Giraud DW, Moxley RA, Driskell JA, (1997) Beta-carotene and alpha-tocopherol inhibit the development of atherosclerotic lesions in hypercholesterolemic rabbits. Int J Vitam Nutr Res 67: 155-163.
13. Shaish A, Daugherty A, O'Sullivan F, Schonfeld G, Heinecke J, (1995) Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits. J Clin Invest 96: 2075-2082.
14. Manning MW, Cassi LA, Huang J, Szilvassy SJ, Daugherty A, (2002) Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease. Vasc Med 7: 45-54.
15. Takada T, Suzuki H, (2010) Molecular mechanisms of membrane transport of vitamin E. Mol Nutr Food Res. 54: 616-622.
16. Carrell TW, Smith A, Burnand KG, (1999) Experimental techniques and models in the study of the development and treatment of abdominal aortic aneurysm. Br J Surg 86: 305-12.
17. Gopal K, Kumar K, Nandini R, Jahan P, Kumar MJ, (2010) High fat diet containing cholesterol induces aortic aneurysm through recruitment and proliferation of circulating agranulocytes in Apoe knockout mice model. J Thromb Thrombolysis 30: 154-163.
18. Daugherty A, Manning MW, Cassis LA, (2000) Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 105: 1605-1612.
19. Reaven PD, Khouw A, Beltz WF, Parthasarathy S, Witztum JL (1993) Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene. Arterioscler Thromb Vasc Biol 13;590-600.
20. Reed A, Cho YJ, Coombes JS, Fassett RG, (2009) Time course and dose response of alpha tocopherol on oxidative stress in haemodialysis patients. BMC Nephrol 10: 32.
21. Munday JS, Thompson KG, James KAC, Manktelow BW, (1998) Dietary antioxidants do not reduce fatty streak formation in the C57BL/6 mouse atherosclerosis model. Arterioscler Thromb Vasc Biol 18: 114-119.
22. Phonpanichrasamee C, Komaratat P, Wilairat P, (1990) Hypocholesterolemic effect of vitamin E on cholesterol-fed rabbit. Int J Vitam Nutr Res 60: 240-244.
23. Kaliappan G, Nagarajan P, Moorthy R, Kalai Gana Selvi S, Avinash Raj T, et al. (2012) Ang II induce kidney damage by recruiting inflammatory cells and up regulates PPAR gamma and Renin 1 gene: effect of β carotene on chronic renal damage. J Thromb Thrombolysis.
24. Xiong W, Mactaggart J, Knispel R, Worth J, Zhua Z, et al. (2009) Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model. Atherosclerosis 202: 128-134.
25. Meli DN, Christen S, Leib SL, (2003) Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway. J Infect Dis 187: 1411-1415.
26. Sadek M, Hynecek RL, Goldenberg S, Kent KC, Marin ML, et al. (2008) Gene expression analysis of a porcine native abdominal aortic aneurysm model. Surgery 144: 252-258.
27. Pyo R, Lee JK, Shipley JM, Curci JA, Mao D, et al. (2000) Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aorticaneurysms. J Clin Invest 105: 1641-1649.
28. Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, et al. (2001) PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the abca1 pathway. Nature Med 7: 33-30.
29. Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, et al. (2007) PPARa deficiency in inflammatory cells suppresses tumor growth. PLoS ONE 2: 260.
30. Ziouzenkova O, Orasanu G, Sukhova G, Lau E, Berger JP, et al. (2007) Asymmetric cleavage of β-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator activated receptor responses. Mol Endocrinol 21: 77-88.
31. Grimaldi PA, (2007) Lipid sensing and lipid sensors: peroxisome proliferators activated receptors as sensors of fatty acids and derivatives. Cell Mol Life Sci 64: 2459-2464.
32. Shaw N, Elholm M, Noy N, (2003) Retinoic acid is a high affinity selective ligand for the peroxisomeproliferator activated receptor β/δ. J Biol Chem 278: 41589-41592.
33. Coll T, Calvo RR, Barroso E, Serrano L, Eyre E, et al. (2008) Peroxisome proliferators activated receptor (PPAR) β/δ: A new potencial therapeutic target for the tratment of metabolic syndrome. Curr Mol Pharmacol 2: 46-55.