Matrix assisted autologous chondrocyte transplantation for cartilage treatment: A systematic review

Bone and Joint Research

Volumn 2, Issue 2, 2013, Pages 18-25

  Kon, E ^a   Filardo, G ^a   Di Matteo, B ^a   Perdisa, F ^a   Marcacci, M ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Bioengineering; Cartilage regeneration; Matrix assisted autologous chondrocyte transplantation; Scaffold; Tissue engineering

Indexed keywords

EID: 84879538753     PISSN: None     EISSN: 20463758     Source Type: Journal    
DOI: 10.1302/2046-3758.22.2000092     Document Type: Review

References (76)

1. Buckwalter JA, Mankin HJ. Articular cartilage. Part I: tissue design and chondrocyte-matrix interactions. J Bone Joint Surg [Am] 1997;79-A:600-611.
2. Buckwalter JA, Mankin HJ. Articular cartilage. Part II: degeneration and osteoarthrosis, repair, regeneration, and tranplantation. J Bone Joint Surg [Am] 1997;79-A:612-632.
3. Changoor A, Nelea M, Méthot S, et al. Structural characteristics of the collagen network in human normal, degraded and repair articular cartilages observed in polarized light and scanning electron microscopies. Osteoarthritis Cartilage 2011;19:1458-1468.
4. Nehrer S, Spector M, Minas T. Hystologic analysis of tissue after failed cartilage repair procedures. Clin Orthop Relat Res 1999;365:149-162.
5. Kon E, Gobbi A, Filardo G, et al. Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective nonrandomized study at 5 years. Am J Sports Med 2009;37:33-41.
6. Marcacci M, Kon E, Delcogliano M, et al. Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up. Am J Sports Med 2007;35:2014-2021.
7. Bugbee W, Cavallo M, Giannini S. Osteochondral allograft transplantation in the knee. J Knee Surg 2012;25:109-116.
8. Demange M, Gomoll AH. The use of osteochondral allografts in the management of cartilage defects. Curr Rev Musculoskelet Med 2012;53:229-235.
9. Gross AE, Shasha N, Aubin P. Long-term followup of the use of fresh osteochondral allografts for posttraumatic knee defects. Clin Orthop Relat Res 2005;435:79-87.
10. Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-895.
11. Vasiliadis HS, Danielson B, Ljungberg M, et al. Autologous chondrocyte implantation in cartilage lesions of the knee: long-term evaluation with magnetic resonance imaging and delayed gadolinium-enhanced magnetic resonance imaging technique. Am J Sports Med 2010;38:943-949.
12. Peterson L, Vasiliadis HS, Brittberg M, Lindahl A. Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med 2010;38:1117-1124.
13. Kon E, Verdonk P, Condello V, et al. Matrix-assisted autologous chondrocyte transplantation for the repair of cartilage defects of the knee: systematic clinical data review and study quality analysis. Am J Sports Med 2009;37(Suppl):156S-166S.
14. Kon E, Delcogliano M, Filardo G, Montaperto C, Marcacci M. Second generation issues in cartilage repair. Sports Med Arthrosc 2008;16:221-229.
15. Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (MATC/MACI): 5-year follow-up. Knee 2006;13:194-202.
16. Ronga M, Grassi FA, Manelli A, Bulgheroni P. Tissue engineering techniques for the treatment of a complex knee injury. Arthroscopy 2006;22:576-571.
17. Salzmann GM, Paul J, Bauer JS, et al. T2 assessment and clinical outcome following autologous matrix-assisted chondrocyte and osteochondral autograft transplantation. Osteoarthritis Cartilage 2009;17:1576-1582.
18. Gigante A, Enea D, Greco F, et al. Distal realignment and patellar autologous chondrocyte implantation: mid-term results in a selected population. Knee Surg Sports Traumatol Arthrosc 2009;17:2-10.
19. Basad E, Ishaque B, Bachmann G, Stürz H, Steinmeyer J. Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study. Knee Surg Sports Traumatol Arthrosc 2010;18:519-527.
20. Ebert JR, Robertson WB, Woodhouse J, et al. Clinical and magnetic resonance imaging-based outcomes to 5 years after matrix-induced autologous chondrocyte implantation to address articular cartilage defects in the knee. Am J Sports Med 2011;39:753-763.
21. Macmull S, Jaiswal PK, Bentley G, et al. The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae. Int Orthop 2012:Epub.
22. Bauer S, Khan RJ, Ebert JR, et al. Knee joint preservation with combined neutralising High Tibial Osteotomy (HTO) and Matrix-induced Autologous Chondrocyte Implantation (MACI) in younger patients with medial knee osteoarthritis: a case series with prospective clinical and MRI follow-up over 5years. Knee 2011:Epub.
23. Ventura A, Memeo A, Borgo E, et al. Repair of osteochondral lesions in the knee by chondrocyte implantation using the MACI technique. Knee Surg Sports Traumatol Arthrosc 2012;20:121-126.
24. Marcacci M, Berruto M, Brocchetta D, et al. Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res 2005;435:96-105.
25. Nehrer S, Domayer S, Dorotka R, et al. Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol 2006;57:3-8.
26. Gobbi A, Kon E, Berruto M, et al. Patellofemoral full-thickness chondral defects treated with Hyalograft-C: a clinical, arthroscopic, and histologic review. Am J Sports Med 2006;34:1763-1773.
27. Gobbi A, Kon E, Berruto M, et al. Patellofemoral full-thickness chondral defects treated with second-generation autologous chondrocyte implantation: results at 5 years' follow-up. Am J Sports Med 2009;37:1083-1092.
28. Marcacci M, Kon E, Zaffagnini S, et al. Arthroscopic second generation autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc 2007;15:610-619.
29. Nehrer S, Dorotka R, Domayer S, Stelzeneder D, Kotz R. Treatment of full-thickness chondral defects with hyalograft C in the knee: a prospective clinical case series with 2 to 7 years' follow-up. Am J Sports Med 2009;37(Suppl 1):81S-87S.
30. Ferruzzi A, Buda R, Faldini C, et al. Autologous chondrocyte implantation in the knee joint: open compared with arthroscopic technique: comparison at a minimum follow-up of five years. J Bone Joint Surg [Am] 2008;90-A(Suppl 4):90-101.
31. Kon E, Di Martino A, Filardo G, et al. Second-generation autologous chondrocyte transplantation: MRI findings and clinical correlations at a minimum 5-year follow-up. Eur J Radiol 2011;79:382-388.
32. Kon E, Filardo G, Berruto M, et al. Articular cartilage treatment in high-level male soccer players: a prospective comparative study of arthroscopic second-generation autologous chondrocyte implantation versus microfracture. Am J Sports Med 2011;39:2549-2557.
33. Della Villa S, Kon E, Filardo G, et al. Does intensive rehabilitation permit early return to sport without compromising the clinical outcome after arthroscopic autologous chondrocyte implantation in highly competitive athletes? Am J Sports Med 2010;38:68-77.
34. Clar H, Pascher A, Kastner N, et al. Matrix-assisted autologous chondrocyte implantation into a 14cm(2) cartilage defect, caused by steroid-induced osteonecrosis. Knee 2010;17:255-257.
35. Filardo G, Kon E, Berruto M, et al. Arthroscopic second generation autologous chondrocytes implantation associated with bone grafting for the treatment of knee osteochondritis dissecans: results at 6 years. Knee 2011:Epub.
36. Filardo G, Kon E, Di Martino A, et al. Second-generation arthroscopic autologous chondrocyte implantation for the treatment of degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 2011:Epub.
37. Filardo G, Kon E, Di Martino A, Iacono F, Marcacci M. Arthroscopic second-generation autologous chondrocyte implantation: a prospective 7-year follow-up study. Am J Sports Med 2011;39:2153-2160.
38. Ossendorf C, Kaps C, Kreuz PC, et al. Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther 2007;9:R41.
39. Kreuz PC, Müller S, Ossendorf C, Kaps C, Erggelet C. Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four year clinical results. Arthritis Res Ther 2009;11:R33.
40. Kreuz PC, Müller S, Freymann U, et al. Repair of focal cartilage defects with scaffold-assisted autologous chondrocyte grafts: clinical and biomechanical results 48 months after transplantation. Am J Sports Med 2011;39:1697-1705.
41. Erggelet C, Kreuz PC, Mrosek EH, et al. Autologous chondrocyte implantation versus ACI using 3D-bioresorbable graft for the treatment of large full-thickness cartilage lesions of the knee. Arch Orthop Trauma Surg 2010;130:957-964.
42. Zeifang F, Oberle D, Nierhoff C, et al. Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation: a randomized clinical trial. Am J Sports Med 2010;38:924-933.
43. Crawford DC, Heveran CM, Cannon WD Jr, Foo LF, Potter HG. An autologous cartilage tissue implant NeoCart for treatment of grade III chondral injury to the distal femur: prospective clinical safety trial at 2 years. Am J Sports Med 2009;37:1334-1343.
44. Panagopoulos A, van Niekerk L, Triantafillopoulos I. Autologous chondrocyte implantation for knee cartilage injuries: moderate functional outcome and performance in patients with high-impact activities. Orthopedics 2012;35:6-14.
45. Welsch GH, Mamisch TC, Zak L, et al. Evaluation of cartilage repair tissue after matrix-associated autologous chondrocyte transplantation using a hyaluronic-based or a collagen-based scaffold with morphological MOCART scoring and biochemical T2 mapping: preliminary results. Am J Sports Med 2010;38:934-942.
46. Wondrasch B, Zak L, Welsch GH, Marlovits S. Effect of accelerated weightbearing after matrix-associated autologous chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after 2 years: a prospective, randomized controlled pilot study. Am J Sports Med 2009;37(Suppl 1):88S-96S.
47. Schneider U, Rackwitz L, Andereya S, et al. A prospective multicenter study on the outcome of type I collagen hydrogel-based autologous chondrocyte implantation (CaReS) for the repair of articular cartilage defects in the knee. Am J Sports Med 2011;39:2558-2565.
48. Selmi TA, Verdonk P, Chambat P, et al. Autologous chondrocyte implantation in a novel alginate-agarose hydrogel: outcome at two years. J Bone Joint Surg [Br] 2008;90-B:597-604.
49. Choi NY, Kim BW, Yeo WJ, et al. Gel-type autologous chondrocyte (Chondron) implantation for treatment of articular cartilage defects of the knee. BMC Musculoskelet Disord 2010;11:103.
50. Kim MK, Choi SW, Kim SR, Oh IS, Won MH. Autologous chondrocyte implantation in the knee using fibrin. Knee Surg Sports Traumatol Arthrosc 2010;18:528-534.
51. Adachi N, Ochi M, Deie M, Ishikawa M, Ito Y. Osteonecrosis of the knee treated with a tissue-engineered cartilage and bone implant: a case report. J Bone Joint Surg [Am] 2007;89-A:2752-2757.
52. Tohyama H, Yasuda K, Minami A, et al. Atelocollagen-associated autologous chondrocyte implantation for the repair of chondral defects of the knee: a prospective multicenter clinical trial in Japan. J Orthop Sci 2009;14:579-588.
53. Kon E, Delcogliano M, Filardo G, et al. Novel nano-composite multilayered biomaterial for osteochondral regeneration: a pilot clinical trial. Am J Sports Med 2011;39:1180-1190.
54. Marcacci M, Kon E, Zaffagnini S, et al. New cell-based technologies in bone and cartilage tissue engineering. II. Cartilage regeneration. Chir Organi Mov 2003;88:42-47.
55. Cherubino P, Grassi FA, Bulgheroni P, Ronga M. Autologous chondrocyte implantation using a bilayer collagen membrane: a preliminary report. J Orthop Surg (Hong Kong) 2003;11:10-15.
56. Pavesio A, Abatangelo G, Borrione A, et al. Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings. Novartis Found Symp 2003;249:203-217.
57. Ronga M, Grassi FA, Bulgheroni P. Arthroscopic autologous chondrocyte implantation for the treatment of a chondral defect in the tibial plateau of the knee. Arthroscopy 2004;20:79-84.
58. Marlovits S, Striessnig G, Kutscha-Lissberg F, et al. Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of fullthickness cartilage defects of the femoral condyle. Knee Surg Sports Traumatol Arthrosc 2005;13:451-457.
59. Bartlett W, Gooding CR, Carrington RW, et al. Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft: a preliminary report. J Bone Joint Surg [Br] 2005;87-B:330-332.
60. Bartlett W, Skinner JA, Gooding CR, et al. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg [Br] 2005;87-B:640-645.
61. Manfredini M, Zerbinati F, Gildone A, Faccini R. Autologous chondrocyte implantation: a comparison between an open periosteal-covered and an arthroscopic matrix-guided technique. Acta Orthop Belg 2007;73:207-218.
62. Ebert JR, Robertson WB, Lloyd DG, et al. Traditional vs accelerated approaches to post-operative rehabilitation following matrix-induced autologous chondrocyte implantation (MACI): comparison of clinical, biomechanical and radiographic outcomes. Osteoarthritis Cartilage 2008;16:1131-1140.
63. Vilchez F, Lara J, Alvarez-Lozano E, et al. Knee chondral lesions treated with autologous chondrocyte transplantation in a tridimensional matrix: clinical evaluation at 1-year follow-up. J Orthop Traumatol 2009;10:173-177.
64. Macmull S, Parratt MT, Bentley G, et al. Autologous chondrocyte implantation in the adolescent knee. Am J Sports Med 2011;39:1723-1730.
65. Enea D, Cecconi S, Busilacchi A, et al. Matrix-induced autologous chondrocyte implantation (MACI) in the knee. Knee Surg Sports Traumatol Arthrosc 2012;20:862-869.
66. Könst YE, Benink RJ, Veldstra R, et al. Treatment of severe osteochondral defects of the knee by combined autologous bone grafting and autologous chondrocyte implantation using fibrin gel. Knee Surg Sports Traumatol Arthrosc 2012;20:2263-2269.
67. Behrens P, Ehlers EM, Köchermann KU, et al. New therapy procedure for localized cartilage defects: encouraging results with autologous chondrocyte implantation. MMW Fortschr Med 1999;141:49-51 (in German).
68. Marcacci M, Zaffagnini S, Kon E, et al. Arthroscopic autologous chondrocyte transplantation: technical note. Knee Surg Sports Traumatol Arthrosc 2002;10:154-159.
69. Kon E, Filardo G, Condello V, et al. Second-generation autologous chondrocyte implantation: results in patients older than 40 years. Am J Sports Med 2011;39:1668-1675.
70. Grigolo B, Lisignoli G, Piacentini A, et al. Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAff 11): molecular, immunohistochemical and ultrastructural analysis. Biomaterials 2002;23:1187-1195.
71. Sharma B, Elisseeff JH. Engineering structurally organized cartilage and bone tissues. Ann Biomed Eng 2004;32:148-159.
72. Gille J, Schuseil E, Wimmer J, et al. Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee. Knee Surg Sports Traumatol Arthrosc 2010;18:1456-1464.
73. Carmont MR, Carey-Smith R, Saithna A, et al. Delayed incorporation of a TruFit plug: perseverance is recommended. Arthroscopy 2009;25:810-814.
74. Giannini S, Buda R, Vannini F, Cavallo M, Grigolo B. One-step bone marrowderived cell transplantation in talar osteochondral lesions. Clin Orthop Relat Res 2009;467:3307-3320.
75. Kon E, Delcogliano M, Filardo G, et al. A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: technique note and an early stability pilot clinical trial. Injury 2010;41:693-701.
76. Saris DB, Vanlauwe J, Victor J, et al. Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med 2009;37:10S-19S.