A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Rothe, Camilla ^a   Sloan, Derek J ^a,b,d   Goodson, Patrick ^d   Chikafa, Jean ^a   Mukaka, Mavuto ^a,c   Denis, Brigitte ^a   Harrison, Tom ^e   van Oosterhout, Joep J ^a   Heyderman, Robert S ^a,c   Lalloo, David G ^c   Allain, Theresa ^a   Feasey, Nicholas A ^a,b  

^a UNIVERSITY OF MALAWI   (Malawi)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d QUEEN ELIZABETH CENTRAL HOSPITAL   (Malawi)

^e ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIRETROVIRUS AGENT; FLUCONAZOLE;

ADOLESCENT; ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONFUSION; CONSCIOUSNESS; CONTROLLED STUDY; CRANIAL NERVE PARALYSIS; CRYPTOCOCCAL MENINGITIS; DISEASE DURATION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FEVER; GLASGOW COMA SCALE; HEADACHE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; MALAWI; MALE; MONOTHERAPY; MORTALITY; OUTCOME ASSESSMENT; RANKIN SCALE; RISK ASSESSMENT; RISK FACTOR; SURVIVAL; TREATMENT FAILURE; WEAKNESS;

ADOLESCENT; ADULT; ANTIFUNGAL AGENTS; FEMALE; FLUCONAZOLE; HIV INFECTIONS; HUMANS; INDUCTION CHEMOTHERAPY; KAPLAN-MEIER ESTIMATE; LONGITUDINAL STUDIES; MALAWI; MALE; MENINGITIS, CRYPTOCOCCAL; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; TREATMENT FAILURE; YOUNG ADULT;

EID: 84879515411     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067311     Document Type: Article

References (32)

1. Jarvis JN, Harrison TS, (2007) HIV-associated cryptococcal meningitis. AIDS 21: 2119-2129.
2. Kisenge PR, Hawkins AT, Maro VP, McHele JP, Swai NS, et al. (2007) Low CD4 count plus coma predicts cryptococcal meningitis in Tanzania. BMC Infect Dis 7: 39.
3. Gordon SB, Walsh AL, Chaponda M, Gordon MA, Soko D, et al. (2000) Bacterial meningitis in Malawian adults: pneumococcal disease is common, severe, and seasonal. Clin Infect Dis 31: 53-57.
4. Hakim JG, Gangaidzo IT, Heyderman RS, Mielke J, Mushangi E, et al. (2000) Impact of HIV infection on meningitis in Harare, Zimbabwe: a prospective study of 406 predominantly adult patients. AIDS 14: 1401-1407.
5. Bekondi C, Bernede C, Passone N, Minssart P, Kamalo C, et al. (2006) Primary and opportunistic pathogens associated with meningitis in adults in Bangui, Central African Republic, in relation to human immunodeficiency virus serostatus. Int J Infect Dis 10: 387-395.
6. Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, et al. (2009) Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23: 525-530.
7. Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, et al. (2010) Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clin Infect Dis 50: 291-322.
8. Mayanja-Kizza H, Oishi K, Mitarai S, Yamashita H, Nalongo K, et al. (1998) Combination therapy with fluconazole and flucytosine for cryptococcal meningitis in Ugandan patients with AIDS. Clin Infect Dis 26: 1362-1366.
9. Mwaba P, Mwansa J, Chintu C, Pobee J, Scarborough M, et al. (2001) Clinical presentation, natural history, and cumulative death rates of 230 adults with primary cryptococcal meningitis in Zambian AIDS patients treated under local conditions. Postgrad Med J 77: 769-773.
10. Schaars CF, Meintjes GA, Morroni C, Post FA, Maartens G, (2006) Outcome of AIDS-associated cryptococcal meningitis initially treated with 200 mg/day or 400 mg/day of fluconazole. BMC Infect Dis 6: 118.
11. Longley N, Muzoora C, Taseera K, Mwesigye J, Rwebembera J, et al. (2008) Dose response effect of high-dose fluconazole for HIV-associated cryptococcal meningitis in southwestern Uganda. Clin Infect Dis 47: 1556-1561.
12. Milefchik E, Leal MA, Haubrich R, Bozzette SA, Tilles JG, et al. (2008) Fluconazole alone or combined with flucytosine for the treatment of AIDS-associated cryptococcal meningitis. Med Mycol 46: 393-395.
13. Ministry of Health (2008) Management of HIV-related diseases. Lilongwe, Malawi Ministry of Health.
14. McCarthy K, Meintjes G, Arthington-Skaggs B, Bicanic T, Cotton, et al, (2007) Guidelines for the prevention, diagnosis and management of cryptococcal meningitis and disseminated cryptococcosis in HIV-infected patients. South African Journal of HIV Medicine 28: 25-35.
15. Makadzange AT, Ndhlovu CE, Takarinda K, Reid M, Kurangwa M, et al. (2010) Early versus delayed initiation of antiretroviral therapy for concurrent HIV infection and cryptococcal meningitis in sub-saharan Africa. Clin Infect Dis 50: 1532-1538.
16. Muzoora CK, Kabanda T, Ortu G, Ssentamu J, Hearn P, et al. (2012) Short course amphotericin B with high dose fluconazole for HIV-associated cryptococcal meningitis. J Infect 64: 76-81.
17. Bicanic T, Wood R, Meintjes G, Rebe K, Brouwer A, et al. (2008) High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial. Clin Infect Dis 47: 123-130.
18. Pappas PG, Chetchotisakd P, Larsen RA, Manosuthi W, Morris MI, et al. (2009) A phase II randomized trial of amphotericin B alone or combined with fluconazole in the treatment of HIV-associated cryptococcal meningitis. Clin Infect Dis 48: 1775-1783.
19. Bicanic T, Meintjes G, Wood R, Hayes M, Rebe K, et al. (2007) Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with amphotericin B or fluconazole. Clin Infect Dis 45: 76-80.
20. Loyse A, Wilson D, Meintjes G, Jarvis JN, Bicanic T, et al. (2012) Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis. Clin Infect Dis 54: 121-128.
21. Lewis DK, Callaghan M, Phiri K, Chipwete J, Kublin JG, et al. (2003) Prevalence and indicators of HIV and AIDS among adults admitted to medical and surgical wards in Blantyre, Malawi. Trans R Soc Trop Med Hyg 97: 91-96.
22. Heikinheimo T, Chimbayo D, Kumwenda JJ, Kampondeni S, Allain TJ, (2012) Stroke outcomes in Malawi, a country with high prevalence of HIV: a prospective follow-up study. PLoS ONE 7: e33765.
23. Hodkinson HM, (1972) Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing 1: 233-238.
24. Allain TJ, Wilson AO, Gomo ZA, Adamchak DJ, Matenga JA, (1996) Abbreviated Mental Test (AMT) in the elderly: shortcoming of an adapted AMT in Zimbabwe. Cent Afr J Med 42: 98-101.
25. Evaluation and Standards Laboratory, (2012) Centre for Infections (2012) UK BSOP 27 Investigation of Cerebrospinal Fluid Standards Unit. Bacteriology B27 5 (1): 1-27.
26. Bicanic T, Jarvis J, Loyse A, Jackson A, Muzoora C, et al. (2011) Determinants of Acute Outcome and long-term survival in HIV-associated cryptococcal meningitis: Results from a combined cohort of 523 patients. 18th Conference on Retroviruses and Opportunistic Infections. Boston, USA.
27. Heyderman RS, Gangaidzo IT, Hakim JG, Mielke J, Taziwa A, et al. (1998) Cryptococcal meningitis in human immunodeficiency virus-infected patients in Harare, Zimbabwe. Clin Infect Dis 26: 284-289.
28. Johansson KA, Robberstad B, Norheim OF, (2010) Further benefits by early start of HIV treatment in low income countries: survival estimates of early versus deferred antiretroviral therapy. AIDS Res Ther 7: 3.
29. Nussbaum JC, Jackson A, Namarika D, Phulusa J, Kenala J, et al. (2010) Combination flucytosine and high-dose fluconazole compared with fluconazole monotherapy for the treatment of cryptococcal meningitis: a randomized trial in Malawi. Clin Infect Dis 50: 338-344.
30. Day JN, Chau TT, Wolbers M, Mai PP, Dung NT, et al. (2013) Combination antifungal therapy for cryptococcal meningitis. N Engl J Med 368: 1291-1302.
31. Jarvis JN, Percival A, Bauman S, Pelfrey J, Meintjes G, et al. (2011) Evaluation of a novel point-of-care cryptococcal antigen test on serum, plasma, and urine from patients with HIV-associated cryptococcal meningitis. Clin Infect Dis 53: 1019-1023.
32. World Health Organisation (2011) Rapid Advice: diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children. Geneva, Switzerland. Available: http://whqlibdoc.who.int/publications/2011/9789241502979_eng.pdf.