Influenza, but not HIV-specific CTL epitopes, elicits delayed-type hypersensitivity (DTH) reactions in HIV-infected patients

European Journal of Immunology

Volumn 43, Issue 6, 2013, Pages 1545-1554

  Ruiz Riol, Marta ^a   Mothe, Beatriz ^a,b   Gandhi, Rajesh T ^c   Bhardwaj, Nina ^d   Scadden, David T ^c   Sanchez Merino, Victor ^e   Brander, Christian ^a,f  

^a AIDS Research Institute IrsiCaixa HIVACAT   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HOSPITAL CLÍNIC   (Spain)

^f INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Delayed type hypersensitivity; Epitope specific CTL; HIV infection; Homing markers

Indexed keywords

CD103 ANTIGEN; CUTANEOUS LYMPHOCYTE ASSOCIATED ANTIGEN; EPITOPE; GAG PROTEIN; GL9 PROTEIN; MATRIX PROTEIN; SL9 PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIGEN EXPRESSION; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREACTIVITY; INFLUENZA VIRUS; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; VIRUS LOAD;

CELLS, CULTURED; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; EPITOPES, T-LYMPHOCYTE; HIV; HIV INFECTIONS; HLA-A2 ANTIGEN; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNIZATION; INFLUENZA, HUMAN; ORTHOMYXOVIRIDAE; PEPTIDE FRAGMENTS; PROTEIN BINDING; SKIN; T-LYMPHOCYTES, CYTOTOXIC; VIRAL MATRIX PROTEINS;

EID: 84879507199     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242732     Document Type: Article

References (41)

1. Prado, J. G., Carrillo, J., Blanco-Heredia, J. and Brander, C., Immune correlates of HIV control. Curr. Med. Chem. 2011. 18: 3963-3970.
2. Koup, R. A., Roederer, M., Lamoreaux, L., Fischer, J., Novik, L., Nason, M. C., Larkin, B. D. et al., Priming immunization with DNA augments immunogenicity of recombinant adenoviral vectors for both HIV-1 specific antibody and T-cell responses. PLoS One 2010. 5: e9015.
3. Yang, O. O., Will we be able to 'spot' an effective HIV-1 vaccine?. Trends Immunol. 2003. 24: 67-72.
4. Birx, D. L., Brundage, J., Larson, K., Engler, R., Smith, L., Squire, E., Carpenter, G. et al., The prognostic utility of delayed-type hypersensitivity skin testing in the evaluation of HIV-infected patients. Military Medical Consortium for Applied Retroviral Research. J. Acquir. Immune. Defic. Syndr. 1993. 6: 1248-1257.
5. Palmer, D. L. and Reed, W. P., Delayed hypersensitivity skin testing. II. Clinical correlates and anergy. J. Infect. Dis. 1974. 130: 138-143.
6. Palmer, D. L. and Reed, W. P., Delayed hypersensitivity skin testing. I. Response rates in a hospitalized population. J. Infect. Dis. 1974. 130: 132-137.
7. Hladik, F., Bender, S., Akridge, R. E., Hu, Y. X., Galloway, C., Francis, D. and McElrath, M. J., Recombinant HIV-1 glycoprotein 120 induces distinct types of delayed hypersensitivity in persons with or without pre-existing immunologic memory. J. Immunol. 2001. 166: 3580-3588.
8. Kundig, T. M., Althage, A., Hengartner, H. and Zinkernagel, R. M., Skin test to assess virus-specific cytotoxic T-cell activity. Proc. Natl. Acad. Sci. U. S. A. 1992. 89: 7757-7761.
9. Chen, Q., Jackson, H., Shackleton, M., Parente, P., Hopkins, W., Sturrock, S., MacGregor, D. et al., Characterization of antigen-specific CD8+ T lymphocyte responses in skin and peripheral blood following intradermal peptide vaccination. Cancer Immun. 2005. 5: 5-12.
10. Brander, C., Mauri-Hellweg, D., Bettens, F., Rolli, H., Goldman, M. and Pichler, W. J., Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals. J. Immunol. 1995. 155: 2670-2678.
11. Babon, J. A., Cruz, J., Orphin, L., Pazoles, P., Co, M. D., Ennis, F. A. and Terajima, M., Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4(+) T-cell responses to internal proteins, hemagglutinins, and neuraminidases. Hum. Immunol. 2009. 70: 711-721.
12. Brander, C., Wyss-Coray, T., Mauri, D., Bettens, F. and Pichler, W. J., Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide. Eur. J. Immunol. 1993. 23: 3217-3223.
13. Brander, C., Hartman, K. E., Trocha, A. K., Jones, N. G., Johnson, R. P., Korber, B., Wentworth, P. et al., Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection. J. Clin. Invest. 1998. 101: 2559-2566.
14. Appay, V., van Lier, R. A., Sallusto, F. and Roederer, M., Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 2008. 73: 975-983.
15. Appay, V., Dunbar, P. R., Callan, M., Klenerman, P., Gillespie, G. M., Papagno, L., Ogg, G. S. et al., Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002. 8: 379-385.
16. Picker, L. J., Michie, S. A., Rott, L. S. and Butcher, E. C., A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am. J. Pathol. 1990. 136: 1053-1068.
17. Picker, L. J., Terstappen, L. W., Rott, L. S., Streeter, P. R., Stein, H. and Butcher, E. C., Differential expression of homing-associated adhesion molecules by T cell subsets in man. J. Immunol. 1990. 145: 3247-3255.
18. Woodberry, T., Suscovich, T. J., Henry, L. M., August, M., Waring, M. T., Kaur, A., Hess, C. et al., Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population. J. Immunol. 2005. 175: 4355-4362.
19. Francis, J. N., Jacobson, M. R., Lloyd, C. M., Sabroe, I., Durham, S. R. and Till, S. J., CXCR1+CD4 +T cells in human allergic disease. J. Immunol. 2004. 172: 268-273.
20. Ohnishi, H., Miyahara, N. and Gelfand, E. W., The role of leukotriene B(4) in allergic diseases. Allergol. Int. 2008. 57: 291-298.
21. Seneviratne, S. L., Black, A. P., Jones, L., Bailey, A. S. and Ogg, G. S., The role of skin-homing T cells in extrinsic atopic dermatitis. QJM. 2007. 100: 19-27.
22. Stemmler, S., Arinir, U., Klein, W., Rohde, G., Hoffjan, S., Wirkus, N., Reinitz-Rademacher, K. et al., Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma. Genes. Immun. 2005. 6: 225-230.
23. Costa, N. M., Albuquerque, M., Lins, J. B., Alvares-Junior, J. T. and Stefani, M. M., Delayed-type hypersensitivity skin test responses to PPD and other antigens among BCG-vaccinated HIV-1-infected and healthy children and adolescents. Rev. Soc. Bras. Med. Trop. 2011. 44: 542-545.
24. Johnson, M. P., Coberly, J. S., Clermont, H. C., Chaisson, R. E., Davis, H. L., Losikoff, P., Ruff, A. J. et al., Tuberculin skin test reactivity among adults infected with human immunodeficiency virus. J. Infect. Dis. 1992. 166: 194-198.
25. Berger, C. T., Frahm, N., Price, D. A., Mothe, B., Ghebremichael, M., Hartman, K. L., Henry, L. M. et al., High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control. J. Virol. 2011. 85: 9334-9345.
26. Mothe, B., Llano, A., Ibarrondo, J., Zamarreno, J., Schiaulini, M., Miranda, C., Ruiz-Riol, M. et al., CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control. PLoS One 2012. 7: e29717.
27. Borowitz, M. J., Weidner, A., Olsen, E. A. and Picker, L. J., Abnormalities of circulating T-cell subpopulations in patients with cutaneous T-cell lymphoma: cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease. Leukemia 1993. 7: 859-863.
28. Dworzak, M. N., Froschl, G., Printz, D., Fleischer, C., Potschger, U., Fritsch, G., Gadner, H. et al., Skin-associated lymphocytes in the peripheral blood of patients with atopic dermatitis: signs of subset expansion and stimulation. J. Allergy. Clin. Immunol. 1999. 103: 901-906.
29. Ogg, G. S., Rod Dunbar, P., Romero, P., Chen, J. L. and Cerundolo, V., High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo. J. Exp. Med. 1998. 188: 1203-1208.
30. Antelo, D. P., Filgueira, A. L. and Cunha, J. M., Reduction of skin-homing cytotoxic T cells (CD8+ -CLA+) in patients with vitiligo. Photodermatol. Photoimmunol. Photomed. 2011. 27: 40-44.
31. Sigmundsdottir, H., Gudjonsson, J. E., Jonsdottir, I., Ludviksson, B. R. and Valdimarsson, H., The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease. Clin. Exp. Immunol. 2001. 126: 365-369.
32. Koelle, D. M., Huang, J., Hensel, M. T. and McClurkan, C. L., Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4 +lymphocytes. J. Virol. 2006. 80: 2863-2872.
33. Koelle, D. M., Liu, Z., McClurkan, C. M., Topp, M. S., Riddell, S. R., Pamer, E. G., Johnson, A. S. et. al., Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus. J. Clin. Invest. 2002. 110: 537-548.
34. Seneviratne, S. L., Jones, L., Bailey, A. S., Samuel, R. V., Black, A. P. and Ogg, G. S., Interleukin-4 induced down-regulation of skin homing receptor expression by human viral-specific CD8 T cells may contribute to atopic risk of cutaneous infection. Clin. Exp. Immunol. 2005. 141: 107-115.
35. Bihl, F., Narayan, M., Chisholm, J. V., 3rd, Henry, L. M., Suscovich, T. J., Brown, E. E., Welzel, T. M. et al., Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. J. Virol. 2007. 81: 4904-4908.
36. Sigmundsdottir, H., Johnston, A., Gudjonsson, J. E. and Valdimarsson, H., Differential effects of interleukin 12 and interleukin 10 on superantigen-induced expression of cutaneous lymphocyte-associated antigen (CLA) and alphaEbeta7 integrin (CD103) by CD8+ T cells. Clin. Immunol. 2004. 111: 119-125.
37. Gebhardt, T., Whitney, P. G., Zaid, A., Mackay, L. K., Brooks, A. G., Heath, W. R., Carbone, F. R. et al., Different patterns of peripheral migration by memory CD4 +and CD8+ T cells. Nature 2011. 477: 216-219.
38. Goodarzi, K., Goodarzi, M., Tager, A. M., Luster, A. D. and von Andrian, U. H., Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat. Immunol. 2003. 4: 965-973.
39. Takata, H., Tomiyama, H., Fujiwara, M., Kobayashi, N. and Takiguchi, M., Cutting edge: expression of chemokine receptor CXCR1 on human effector CD8+ T cells. J. Immunol. 2004. 173: 2231-2235.
40. Hess, C., Means, T. K., Autissier, P., Woodberry, T., Altfeld, M., Addo, M. M., Frahm, N. et al., IL-8 responsiveness defines a subset of CD8 T cells poised to kill. Blood 2004. 104: 3463-3471.
41. Magnani, Z. I., Confetti, C., Besozzi, G., Codecasa, L. R., Panina-Bordignon, P., Lang, R., Rossi, G. A. et al., Circulating, Mycobacterium tuberculosis-specific lymphocytes from PPD skin test-negative patients with tuberculosis do not secrete interferon-gamma (IFN-gamma) and lack the cutaneous lymphocyte antigen skin-selective homing receptor. Clin. Exp. Immunol. 2000. 119: 99-106.