P38 MAP kinase activation does not stimulate serotonin transport in rat brain: Implications for sickness behaviour mechanisms

Life Sciences

Volumn 93, Issue 1, 2013, Pages 30-37

  Andreetta, Filippo ^a,b,c   Barnes, Nicholas M ^b   Wren, Paul B ^a,d   Carboni, Lucia ^a,e  

^a GSK   (Italy)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c Aptuit Inc   (United States)

^d GLAXOSMITHKLINE   (China)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Anisomycin; Interleukin 1 ; Major depressive disorder p38 MAPK; Serotonin transporter; Sickness behaviour

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; BACTERIUM LIPOPOLYSACCHARIDE; FLUOXETINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; SEROTONIN; SEROTONIN TRANSPORTER; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; COGNITION; CONTROLLED STUDY; CYTOKINE RELEASE; DEPRESSION; DISEASE ASSOCIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; ILLNESS BEHAVIOR; MALE; MEDIATOR RELEASE; MICHAELIS MENTEN KINETICS; NERVE CELL; NEUROCHEMISTRY; NEUROENDOCRINOLOGY; NEUROMODULATION; NONHUMAN; PROTEIN PHOSPHORYLATION; PSYCHOPHARMACOLOGY; RAT; SEROTONIN UPTAKE;

ANALYSIS OF VARIANCE; ANIMALS; ANISOMYCIN; BIOLOGICAL TRANSPORT; BRAIN; CYTOKINES; DEPRESSION; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HELA CELLS; HUMANS; ILLNESS BEHAVIOR; INTERLEUKIN-1BETA; LEAST-SQUARES ANALYSIS; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SYNAPTOSOMES;

BACTERIA (MICROORGANISMS); MUS; RATTUS;

EID: 84879504857     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.05.014     Document Type: Article

References (49)

1. H. Anisman Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder J Psychiatry Neurosci 34 2009 4 20
2. H. Anisman, Z. Merali, M.O. Poulter, and S. Hayley Cytokines as a precipitant of depressive illness: animal and human studies Curr Pharm Des 11 2005 963 972
3. S. Bison, L. Carboni, R. Arban, S. Bate, P.A. Gerrard, and M. Razzoli Differential behavioral, physiological, and hormonal sensitivity to LPS challenge in rats Int J Interferon Cytokine Mediator Res 1 2009 1 13
4. S. Bison, M. Razzoli, R. Arban, F. Michielin, S. Bertani, and L. Carboni Effect of the p38 MAPK inhibitor SB-239063 on Lipopolysaccharide-induced psychomotor retardation and peripheral biomarker alterations in rats Eur J Pharmacol 661 2011 49 56
5. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
6. M.R. Bruchas, A.G. Schindler, H. Shankar, D.I. Messinger, M. Miyatake, and B.B. Land Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction Neuron 71 2011 498 511
7. L. Capuron, and A.H. Miller Immune system to brain signaling: neuropsychopharmacological implications Pharmacol Ther 130 2011 226 238
8. L. Capuron, A. Ravaud, P.J. Neveu, A.H. Miller, M. Maes, and R. Dantzer Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy Mol Psychiatry 7 2002 468 473
9. J.C. Chang, I.D. Tomlinson, M.R. Warnement, A. Ustione, A.M. Carneiro, and D.W. Piston Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation J Neurosci 32 2012 8919 8929
10. A. Cuenda, and S. Rousseau p38 MAP-kinases pathway regulation, function and role in human diseases Biochim Biophys Acta 1773 2007 1358 1375
11. R. Dantzer Cytokine, sickness behavior, and depression Neurol Clin 24 2006 441 460
12. R. Dantzer, J.C. O'Connor, G.G. Freund, R.W. Johnson, and K.W. Kelley From inflammation to sickness and depression: when the immune system subjugates the brain Nat Rev Neurosci 9 2008 46 56
13. R. Dantzer, J.C. O'Connor, M.A. Lawson, and K.W. Kelley Inflammation-associated depression: from serotonin to kynurenine Psychoneuroendocrinology 36 2011 426 436
14. A.J. Dunn, A.H. Swiergiel, and R. de Beaurepaire Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev 29 2005 891 909
15. K.F. Foley, C. Pantano, A. Ciolino, and G.M. Mawe IFN-gamma and TNF-alpha decrease serotonin transporter function and expression in Caco2 cells Am J Physiol Gastrointest Liver Physiol 292 2007 G779 G784
16. F. Frenois, M. Moreau, J. O'Connor, M. Lawson, C. Micon, and J. Lestage Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior Psychoneuroendocrinology 32 2007 516 531
17. C.A. Heidbreder, M. Bianchi, L.P. Lacroix, S. Faedo, E. Perdonà, and R. Remelli Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the noerpipephrine transporter in vitro and in vivo Synapse 50 2003 269 276
18. N.L. Johnston-Wilson, C.D. Sims, J.-P. Hofmann, L. Anderson, A.D. Shore, and E.F. Torrey Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder Mol Psychiatry 5 2000 142 149
19. K.M. Kulmatycki, and F. Jamali Drug disease interactions: role of inflammatory mediators in depression and variability in antidepressant drug response J Pharm Pharm Sci 9 2006 292 306
20. S. Lanquillon, J.C. Krieg, U. Bening-Abu-Shach, and H. Vedder Cytokine production and treatment response in major depressive disorder Neuropsychopharmacology 22 2000 370 379
21. B. Leonard, and M. Maes Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression Neurosci Biobehav Rev 36 2012 764 785
22. 7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells J Neurochem 93 2005 549 559
23. M. Maes Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression Prog Neuropsychopharmacol Biol Psychiatry 35 2011 664 675
24. J.J. Miguel-Hidalgo, C. Baucom, G. Dilley, J.C. Overholser, H.Y. Meltzer, and C.A. Stockmeier Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder Biol Psychiatry 48 2000 861 873
25. O. Morikawa, N. Sakai, H. Obara, and N. Saito Effects of interferon-alpha, interferon-gamma and cAMP on the transcriptional regulation of the serotonin transporter Eur J Pharmacol 349 1998 317 324
26. R. Mössner, A. Heils, G. Stöber, O. Okladnova, S. Daniel, and K.P. Lesch Enhancement of serotonin transporter function by tumor necrosis factor alpha but not by interleukin-6 Neurochem Int 33 1998 251 254
27. N. Muller, and M.J. Schwarz The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression Mol Psychiatry 12 2007 988 1000
28. Y. Nolan, E. Vereker, A.M. Lynch, and M.A. Lynch Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus Exp Neurol 184 2003 794 804
29. S.M. O'Brien, P. Scully, P. Fitzgerald, L.V. Scott, and T.G. Dinan Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy J Psychiatr Res 41 2007 326 331
30. J.C. O'Connor, M.A. Lawson, C. André, M. Moreau, J. Lestage, and N. Castanon Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice Mol Psychiatry 14 2009 511 522
31. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 4th ed. 1998 Academic Press
32. C.L. Raison, L. Capuron, and A.H. Miller Cytokines sing the blues: inflammation and the pathogenesis of depression Trends Immunol 27 2006 24 31
33. G. Rajkowska, and J.J. Miguel-Hidalgo Gliogenesis and glial pathology in depression CNS Neurol Disord Drug Targets 6 2007 219 233
34. S. Ramamoorthy, J.D. Ramamoorthy, P.D. Prasad, G.K. Bhat, V.B. Mahesh, and F.H. Leibach Regulation of the human serotonin transporter by interleukin-1 beta Biochem Biophys Res Commun 216 1995 560 567
35. M. Razzoli, L. Carboni, and R. Arban Alterations of behavioral and endocrinological reactivity induced by 3 brief social defeats in rats: relevance to human psychopathology Psychoneuroendocrinology 34 2009 1405 1416
36. D.J. Samuvel, L.D. Jayanthi, N.R. Bhat, and S. Ramamoorthy A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression J Neurosci 25 2005 29 41
37. T. Sato, E. Suzuki, M. Yokoyama, J. Semba, S. Watanabe, and H. Miyaoka Chronic intraperitoneal injection of interferon-alpha reduces serotonin levels in various regions of rat brain, but does not change levels of serotonin transporter mRNA, nitrite or nitrate Psychiatry Clin Neurosci 60 2006 499 506
38. R.S. Scheibel, A.D. Valentine, S. O'Brien, and C.A. Meyers Cognitive dysfunction and depression during treatment with interferon-alpha and chemotherapy J Neuropsychiatry Clin Neurosci 16 2004 185 191
39. O.J.G. Schiepers, M.C. Wichers, and M. Maes Cytokines and major depression Prog Neuropsychopharmacol Biol Psychiatry 29 2005 201 217
40. A.G. Schindler, D.I. Messinger, J.S. Smith, H. Shankar, R.M. Gustin, and S.S. Schattauer Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake J Neurosci 32 2012 17582 17596
41. J.S. Smith, A.G. Schindler, E. Martinelli, R.M. Gustin, M.R. Bruchas, and C. Chavkin Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference J Neurosci 32 2012 1488 1495
42. K. Sudom, N.P. Turrin, S. Hayley, and H. Anisman Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice Neuroimmunomodulation 11 2004 341 350
43. D.R. Thomas, D.R. Nelson, and A.M. Johnson Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor Psychopharmacology 93 1987 193 200
44. R. Yirmiya, D.L. Tio, and A.N. Taylor Effects of fetal alcohol exposure on fever, sickness behavior, and pituitary-adrenal activation induced by interleukin-1 beta in young adult rats Brain Behav Immun 10 1996 205 220
45. R. Yirmiya, Y. Pollak, O. Barak, R. Avitsur, H. Ovadia, and M. Bette Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents Neuropsychopharmacology 24 2001 531 544
46. C.B. Zhu, A.M. Carneiro, W.R. Dostmann, W.A. Hewlett, and R.D. Blakely p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process J Biol Chem 280 2005 15649 15658
47. C.B. Zhu, R.D. Blakely, and W.A. Hewlett The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters Neuropsychopharmacology 31 2006 2121 2131
48. C.B. Zhu, K.M. Lindler, A.W. Owens, L.C. Daws, R.D. Blakely, and W.A. Hewlett Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters Neuropsychopharmacology 35 2010 2510 2520
49. V. Zujovic, N. Schussler, D. Jourdain, D. Duverger, and V. Taupin In vivo neutralization of endogenous brain fractalkine increases hippocampal TNFalpha and 8-isoprostane production induced by intracerebroventricular injection of LPS J Neuroimmunol 115 2001 135 143