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Volumn 33, Issue 8, 2013, Pages 746-755

Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines

Author keywords

Arsenite; Epigenetics; Gene expression; Histone H3; Phosphorylation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ARSENIC TRIOXIDE; EARLY GROWTH RESPONSE FACTOR 1; HEAT SHOCK PROTEIN; HEME OXYGENASE 1; HISTONE H3; INTERLEUKIN 8; MESSENGER RNA; PROTEIN FOS; SERINE;

EID: 84879504082     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2724     Document Type: Article
Times cited : (11)

References (41)
  • 1
    • 1342332350 scopus 로고    scopus 로고
    • Antisense to the early growth response-1 gene (Egr-1) inhibits prostate tumor development in TRAMP mice
    • Baron V, Duss S, Rhim J, Mercola D. 2003. Antisense to the early growth response-1 gene (Egr-1) inhibits prostate tumor development in TRAMP mice. Ann. NY Acad. Sci. 1002: 197-216.
    • (2003) Ann. NY Acad. Sci. , vol.1002 , pp. 197-216
    • Baron, V.1    Duss, S.2    Rhim, J.3    Mercola, D.4
  • 2
    • 21344450516 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation
    • doi: 10.1158/0008-5472.CAN-05-0197
    • Choi HS, Choi BY, Cho YY, Mizuno H, Kang BS, Bode AM, Dong Z. 2005. Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation. Cancer Res. 65: 5818-5827; doi: 10.1158/0008-5472.CAN-05-0197
    • (2005) Cancer Res. , vol.65 , pp. 5818-5827
    • Choi, H.S.1    Choi, B.Y.2    Cho, Y.Y.3    Mizuno, H.4    Kang, B.S.5    Bode, A.M.6    Dong, Z.7
  • 3
    • 77955918808 scopus 로고    scopus 로고
    • Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression
    • doi: 10.1016/j.toxlet.2010.07.006
    • Chowdhury R, Chatterjee R, Giri AK, Mandal C, Chaudhuri K. 2010. Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression. Toxicol. Lett. 198: 263-271; doi: 10.1016/j.toxlet.2010.07.006
    • (2010) Toxicol. Lett. , vol.198 , pp. 263-271
    • Chowdhury, R.1    Chatterjee, R.2    Giri, A.K.3    Mandal, C.4    Chaudhuri, K.5
  • 4
    • 0036804280 scopus 로고    scopus 로고
    • The molecular mechanisms of arsenic-induced cell transformation and apoptosis
    • Dong Z 2002. The molecular mechanisms of arsenic-induced cell transformation and apoptosis. Environ. Health Perspect. 110(suppl. 5): 757-759.
    • (2002) Environ. Health Perspect. , vol.110 , Issue.SUPPL. 5 , pp. 757-759
    • Dong, Z.1
  • 7
    • 33750806047 scopus 로고    scopus 로고
    • Induction of cyclin D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes
    • doi: 10.1016/j.taap.2006.08.006
    • Hwang BJ, Utti C, Steinberg M. 2006. Induction of cyclin D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes. Toxicol. Appl. Pharmacol. 217: 161-167; doi: 10.1016/j.taap.2006.08.006
    • (2006) Toxicol. Appl. Pharmacol. , vol.217 , pp. 161-167
    • Hwang, B.J.1    Utti, C.2    Steinberg, M.3
  • 8
    • 13744250596 scopus 로고    scopus 로고
    • IARC. IARC Monographs on the Evaluation of Carc ogenic Risks to Humans, IARC: Lyon.
    • IARC. 2004. Some Drinking-water Disinfectants and Contaminants, Including Arsenic. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 84. IARC: Lyon.
    • (2004) Some Drinking-water Disinfectants and Contaminants, Including Arsenic , vol.84
  • 9
    • 0003445540 scopus 로고    scopus 로고
    • IPCS, 2nd edn. Environmental Health Criteria, World Health Organization: Geneva.
    • IPCS. 2001. Arsenic and Arsenic Compounds, 2nd edn. Environmental Health Criteria, Vol. 224. World Health Organization: Geneva.
    • (2001) Arsenic and Arsenic Compounds , vol.224
  • 10
    • 0027965988 scopus 로고
    • Nerve growth factor induces transcription of transforming growth factor-beta 1 through a specific promoter element in PC12 cells
    • Kim SJ, Park K, Rudkin BB, Dey BR, Sporn MB, Roberts AB. 1994. Nerve growth factor induces transcription of transforming growth factor-beta 1 through a specific promoter element in PC12 cells. J. Biol. Chem. 269: 3739-3744.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3739-3744
    • Kim, S.J.1    Park, K.2    Rudkin, B.B.3    Dey, B.R.4    Sporn, M.B.5    Roberts, A.B.6
  • 11
    • 39549101455 scopus 로고    scopus 로고
    • The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity
    • doi: 10.1016/j.j orgbio.2007.10.021
    • Kitchin KT, Wallace K. 2008. The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J. Inorg. Biochem. 102: 532-539; doi: 10.1016/j.jinorgbio.2007.10.021
    • (2008) J. Inorg. Biochem. , vol.102 , pp. 532-539
    • Kitchin, K.T.1    Wallace, K.2
  • 12
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • doi: 10.1016/j.cell.2007.02.005
    • Kouzarides T. 2007. Chromatin modifications and their function. Cell 128: 693-705; doi: 10.1016/j.cell.2007.02.005
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 13
    • 1642545632 scopus 로고    scopus 로고
    • Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells
    • doi: 10.1093/carc /bgg179
    • Lau AT, Li M, Xie R, He QY, Chiu JF. 2004. Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells. Carcinogenesis 25: 21-28; doi: 10.1093/carcin/bgg179
    • (2004) Carcinogenesis , vol.25 , pp. 21-28
    • Lau, A.T.1    Li, M.2    Xie, R.3    He, Q.Y.4    Chiu, J.F.5
  • 14
    • 0037147333 scopus 로고    scopus 로고
    • Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells
    • doi: 10.1074/jbc.M207836200
    • Li J, Chen P, Sinogeeva N, Gorospe M, Wersto RP, Chrest FJ, Barnes J, Liu Y. 2002. Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J. Biol. Chem. 277: 49504-49510; doi: 10.1074/jbc.M207836200
    • (2002) J. Biol. Chem. , vol.277 , pp. 49504-49510
    • Li, J.1    Chen, P.2    Sinogeeva, N.3    Gorospe, M.4    Wersto, R.P.5    Chrest, F.J.6    Barnes, J.7    Liu, Y.8
  • 15
    • 0038376022 scopus 로고    scopus 로고
    • Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts
    • doi: 10.1074/jbc.M300269200
    • Li J, Gorospe M, Barnes J, Liu Y. 2003. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. J. Biol. Chem. 278: 13183-13191; doi: 10.1074/jbc.M300269200
    • (2003) J. Biol. Chem. , vol.278 , pp. 13183-13191
    • Li, J.1    Gorospe, M.2    Barnes, J.3    Liu, Y.4
  • 16
    • 0034980906 scopus 로고    scopus 로고
    • Stress-related gene expression in mice treated with inorganic arsenicals
    • Liu J, Kadiiska MB, Liu Y, Lu T, Qu W, Waalkes MP. 2001a. Stress-related gene expression in mice treated with inorganic arsenicals. Toxicol. Sci. 61: 314-320.
    • (2001) Toxicol. Sci. , vol.61 , pp. 314-320
    • Liu, J.1    Kadiiska, M.B.2    Liu, Y.3    Lu, T.4    Qu, W.5    Waalkes, M.P.6
  • 17
    • 0035852735 scopus 로고    scopus 로고
    • Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity
    • doi: 10.1073/pnas.031482998
    • Liu SX, Athar M, Lippai I, Waldren C, Hei TK. 2001b. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc. Natl Acad. Sci. U S A 98: 1643-1648; doi: 10.1073/pnas.031482998
    • (2001) Proc. Natl Acad. Sci. U S A , vol.98 , pp. 1643-1648
    • Liu, S.X.1    Athar, M.2    Lippai, I.3    Waldren, C.4    Hei, T.K.5
  • 18
    • 71749111154 scopus 로고    scopus 로고
    • Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy
    • doi: 10.1074/jbc.M109.016246
    • Ma J, Ren Z, Ma Y, Xu L, Zhao Y, Zheng C, Fang Y, Xue T, Sun B, Xiao W. 2009. Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. J. Biol. Chem. 284: 34600-34606; doi: 10.1074/jbc.M109.016246
    • (2009) J. Biol. Chem. , vol.284 , pp. 34600-34606
    • Ma, J.1    Ren, Z.2    Ma, Y.3    Xu, L.4    Zhao, Y.5    Zheng, C.6    Fang, Y.7    Xue, T.8    Sun, B.9    Xiao, W.10
  • 19
    • 0027968552 scopus 로고
    • The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the G0-to-G1 transition of the cell cycle
    • Molnar G, Crozat A, Pardee AB. 1994. The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the G0-to-G1 transition of the cell cycle. Mol. Cell. Biol. 14: 5242-5248.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5242-5248
    • Molnar, G.1    Crozat, A.2    Pardee, A.B.3
  • 20
    • 20344392179 scopus 로고    scopus 로고
    • Nonapical and cytoplasmic expression of interleukin-8, CXCR1, CXCR2 correlates with cell proliferation and microvessel density in prostate cancer
    • doi: 10.1158/1078-0432.CCR-04-1518
    • Murphy C, McGurk M, Pettigrew J, Santinelli A, Mazzucchelli R, Johnston PG, Montironi R, Waugh DJ. 2005. Nonapical and cytoplasmic expression of interleukin-8, CXCR1, CXCR2 correlates with cell proliferation and microvessel density in prostate cancer. Clin. Cancer Res. 11: 4117-4127; doi: 10.1158/1078-0432.CCR-04-1518
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4117-4127
    • Murphy, C.1    McGurk, M.2    Pettigrew, J.3    Santinelli, A.4    Mazzucchelli, R.5    Johnston, P.G.6    Montironi, R.7    Waugh, D.J.8
  • 21
    • 1642326716 scopus 로고    scopus 로고
    • Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation
    • Nowak SJ, Corces VG. 2004. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet. 20: 214-220.
    • (2004) Trends Genet. , vol.20 , pp. 214-220
    • Nowak, S.J.1    Corces, V.G.2
  • 22
    • 4444354222 scopus 로고    scopus 로고
    • A trivalent dimethylarsenic compound, dimethylarsine iodide, induces cellular transformation, aneuploidy, centrosome abnormality and multipolar spindle formation in Syrian hamster embryo cells
    • Ochi T, Suzuki T, Barrett JC, Tsutsui T. 2004a. A trivalent dimethylarsenic compound, dimethylarsine iodide, induces cellular transformation, aneuploidy, centrosome abnormality and multipolar spindle formation in Syrian hamster embryo cells. Toxicology 203: 155-163.
    • (2004) Toxicology , vol.203 , pp. 155-163
    • Ochi, T.1    Suzuki, T.2    Barrett, J.C.3    Tsutsui, T.4
  • 23
    • 4644285573 scopus 로고    scopus 로고
    • In vitro cytotoxic and genotoxic effects of diphenylarsinic acid, a degradation product of chemical warfare agents
    • Ochi T, Suzuki T, Isono H, Kaise T. 2004b. In vitro cytotoxic and genotoxic effects of diphenylarsinic acid, a degradation product of chemical warfare agents. Toxicol. Appl. Pharmacol. 200: 64-72.
    • (2004) Toxicol. Appl. Pharmacol. , vol.200 , pp. 64-72
    • Ochi, T.1    Suzuki, T.2    Isono, H.3    Kaise, T.4
  • 24
    • 40849085135 scopus 로고    scopus 로고
    • Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione
    • Ochi T, Kita K, Suzuki T, Rumpler A, Goessler W, Francesconi KA. 2008. Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione. Toxicol. Appl. Pharmacol. 228: 59-67.
    • (2008) Toxicol. Appl. Pharmacol. , vol.228 , pp. 59-67
    • Ochi, T.1    Kita, K.2    Suzuki, T.3    Rumpler, A.4    Goessler, W.5    Francesconi, K.A.6
  • 25
    • 0037105758 scopus 로고    scopus 로고
    • Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability
    • Ota T, Suto S, Katayama H, Han ZB, Suzuki F, Maeda M, Tanino M, Terada Y, Tatsuka M. 2002. Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. Cancer Res. 62: 5168-5177.
    • (2002) Cancer Res. , vol.62 , pp. 5168-5177
    • Ota, T.1    Suto, S.2    Katayama, H.3    Han, Z.B.4    Suzuki, F.5    Maeda, M.6    Tanino, M.7    Terada, Y.8    Tatsuka, M.9
  • 26
    • 40949115930 scopus 로고    scopus 로고
    • PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation
    • doi: 10.1289/ehp.10403
    • Ouyang W, Luo W, Zhang D, Jian J, Ma Q, Li J, Shi X, Chen J, Gao J, Huang C. 2008. PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. Environ. Health Perspect. 116: 1-6; doi: 10.1289/ehp.10403
    • (2008) Environ. Health Perspect. , vol.116 , pp. 1-6
    • Ouyang, W.1    Luo, W.2    Zhang, D.3    Jian, J.4    Ma, Q.5    Li, J.6    Shi, X.7    Chen, J.8    Gao, J.9    Huang, C.10
  • 27
    • 0141613756 scopus 로고    scopus 로고
    • Phosphorylation of serine 10 in histone H3, what for?
    • Prigent C, Dimitrov S. 2003. Phosphorylation of serine 10 in histone H3, what for? J. Cell Sci. 116: 3677-3685.
    • (2003) J. Cell Sci. , vol.116 , pp. 3677-3685
    • Prigent, C.1    Dimitrov, S.2
  • 28
    • 78751495821 scopus 로고    scopus 로고
    • An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    • doi: 10.1289/ehp.1002114
    • Ren X, McHale CM, Skibola CF, Smith AH, Smith MT, Zhang L. 2011. An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ. Health Perspect. 119: 11-19; doi: 10.1289/ehp.1002114
    • (2011) Environ. Health Perspect. , vol.119 , pp. 11-19
    • Ren, X.1    McHale, C.M.2    Skibola, C.F.3    Smith, A.H.4    Smith, M.T.5    Zhang, L.6
  • 29
    • 38949195955 scopus 로고    scopus 로고
    • Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
    • doi: 10.1021/tx700198a
    • Salnikow K, Zhitkovich A. 2008. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem. Res. Toxicol. 21: 28-44; doi: 10.1021/tx700198a
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 28-44
    • Salnikow, K.1    Zhitkovich, A.2
  • 30
    • 0036098552 scopus 로고    scopus 로고
    • AP-1 as a regulator of cell life and death
    • doi: 10.1038/ncb0502-e131
    • Shaulian E, Karin M. 2002. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4: E131-136; doi: 10.1038/ncb0502-e131
    • (2002) Nat. Cell Biol. , vol.4
    • Shaulian, E.1    Karin, M.2
  • 32
    • 70350599526 scopus 로고    scopus 로고
    • Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells
    • doi: 10.1016/j.taap.2009.08.017
    • Suzuki T, Miyazaki K, Kita K, Ochi T. 2009. Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells. Toxicol. Appl. Pharmacol. 241: 275-282; doi: 10.1016/j.taap.2009.08.017
    • (2009) Toxicol. Appl. Pharmacol. , vol.241 , pp. 275-282
    • Suzuki, T.1    Miyazaki, K.2    Kita, K.3    Ochi, T.4
  • 33
    • 0026030544 scopus 로고
    • Promoter region of the human platelet-derived growth factor A-chain gene
    • Takimoto Y, Wang ZY, Kobler K, Deuel TF. 1991. Promoter region of the human platelet-derived growth factor A-chain gene. Proc. Natl Acad. Sci. U S A 88: 1686-1690.
    • (1991) Proc. Natl Acad. Sci. U S A , vol.88 , pp. 1686-1690
    • Takimoto, Y.1    Wang, Z.Y.2    Kobler, K.3    Deuel, T.F.4
  • 34
    • 19544384144 scopus 로고    scopus 로고
    • Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage
    • doi: 10.1002/pros.20223
    • Uehara H, Troncoso P, Johnston D, Bucana CD, Dinney C, Dong Z, Fidler IJ, Pettaway CA. 2005. Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage. Prostate 64: 40-49; doi: 10.1002/pros.20223
    • (2005) Prostate , vol.64 , pp. 40-49
    • Uehara, H.1    Troncoso, P.2    Johnston, D.3    Bucana, C.D.4    Dinney, C.5    Dong, Z.6    Fidler, I.J.7    Pettaway, C.A.8
  • 35
    • 58149232586 scopus 로고    scopus 로고
    • The interleukin-8 pathway in cancer
    • doi: 10.1158/1078-0432.CCR-07-4843
    • Waugh DJ, Wilson C. 2008. The interleukin-8 pathway in cancer. Clin. Cancer Res. 14: 6735-6741; doi: 10.1158/1078-0432.CCR-07-4843
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6735-6741
    • Waugh, D.J.1    Wilson, C.2
  • 36
    • 0033515426 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 is required for proper chromosome condensation and segregation
    • Wei Y, Yu L, Bowen J, Gorovsky MA, Allis CD. 1999. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 97: 99-109.
    • (1999) Cell , vol.97 , pp. 99-109
    • Wei, Y.1    Yu, L.2    Bowen, J.3    Gorovsky, M.A.4    Allis, C.D.5
  • 37
    • 27544467453 scopus 로고    scopus 로고
    • Bombesin regulates cyclin D1 expression through the early growth response protein Egr-1 in prostate cancer cells
    • doi: 10.1158/0008-5472.CAN-05-1830
    • Xiao D, Chinnappan D, Pestell R, Albanese C, Weber HC. 2005. Bombesin regulates cyclin D1 expression through the early growth response protein Egr-1 in prostate cancer cells. Cancer Res. 65: 9934-9942; doi: 10.1158/0008-5472.CAN-05-1830
    • (2005) Cancer Res. , vol.65 , pp. 9934-9942
    • Xiao, D.1    Chinnappan, D.2    Pestell, R.3    Albanese, C.4    Weber, H.C.5
  • 38
    • 0034849755 scopus 로고    scopus 로고
    • Interleukin-8 and human cancer biology
    • Xie K 2001. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev. 12: 375-391.
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 375-391
    • Xie, K.1
  • 39
    • 4444381916 scopus 로고    scopus 로고
    • Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice
    • Xie Y, Trouba KJ, Liu J, Waalkes MP, Germolec DR. 2004. Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice. Environ. Health Perspect. 112: 1255-1263.
    • (2004) Environ. Health Perspect. , vol.112 , pp. 1255-1263
    • Xie, Y.1    Trouba, K.J.2    Liu, J.3    Waalkes, M.P.4    Germolec, D.R.5
  • 40
    • 0036261878 scopus 로고    scopus 로고
    • Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment
    • Yih LH, Peck K, Lee TC. 2002. Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment. Carcinogenesis 23: 867-876.
    • (2002) Carcinogenesis , vol.23 , pp. 867-876
    • Yih, L.H.1    Peck, K.2    Lee, T.C.3
  • 41
    • 59149098529 scopus 로고    scopus 로고
    • c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells
    • doi: 10.1016/j.taap.2008.11.002
    • Zhang D, Li J, Gao J, Huang C. 2009. c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells. Toxicol. Appl. Pharmacol. 235: 18-24; doi: 10.1016/j.taap.2008.11.002
    • (2009) Toxicol. Appl. Pharmacol. , vol.235 , pp. 18-24
    • Zhang, D.1    Li, J.2    Gao, J.3    Huang, C.4


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