Low Blood Long Chain Omega-3 Fatty Acids in UK Children Are Associated with Poor Cognitive Performance and Behavior: A Cross-Sectional Analysis from the DOLAB Study

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Montgomery, Paul ^a   Burton, Jennifer R ^a   Sewell, Richard P ^a   Spreckelsen, Thees F ^a   Richardson, Alexandra J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; STEARIDONIC ACID;

ARTICLE; CHILD; CHILD BEHAVIOR; CHILD NUTRITION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EMOTIONALITY; FATTY ACID BLOOD LEVEL; FEMALE; FISH; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL PERFORMANCE; NORMAL HUMAN; PRESCHOOL CHILD; PSYCHOLOGICAL RATING SCALE; READING; SCHOOL CHILD; SOCIAL STATUS; UNITED KINGDOM; WORKING MEMORY;

CHILD; COGNITION DISORDERS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FATTY ACIDS, OMEGA-3; FEMALE; GREAT BRITAIN; HUMANS; MALE;

EID: 84879471386     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066697     Document Type: Article

References (30)

1. Ryan AS, Astwood JD, Gautier S, Kuratko CN, Nelson EB, et al. (2010) Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids 82: 305-314.
2. Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A, (2010) Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur J Pediatr 169: 149-164.
3. Blasbalg TL, Hibbeln JR, Ramsden CE, Majchrzak SF, Rawlings RR, (2011) Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr 93: 950-962.
4. Riediger ND, Othman RA, Suh M, Moghadasian MH, (2009) A systemic review of the roles of n-3 fatty acids in health and disease. Journal of the American Dietetic Association 109: 668-679.
5. Ramakrishnan U, Imhoff-Kunsch B, DiGirolamo AM, (2009) Role of docosahexaenoic acid in maternal and child mental health. American Journal of Clinical Nutrition 89: 958-962.
6. Richardson AJ, (2006) Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry 18: 155-172.
7. Stevens LJ, Zentall SS, Deck JL, Abate ML, Watkins BA, et al. (1995) Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 62: 761-768.
8. Chen JR, Hsu SF, Hsu CD, Hwang LH, Yang SC, (2004) Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J Nutr Biochem 15: 467-472.
9. Sinn N, Bryan J, Wilson C, (2008) Cognitive effects of polyunsaturated fatty acids in children with attention deficit hyperactivity disorder symptoms: a randomised controlled trial. Prostaglandins Leukot Essent Fatty Acids 78: 311-326.
10. Bloch MH, Qawasmi A, (2011) Omega-3 Fatty Acid Supplementation for the Treatment of Children With Attention-Deficit/Hyperactivity Disorder Symptomatology: Systematic Review and Meta-Analysis. Journal of the American Academy of Child and Adolescent Psychiatry 50: 991-1000.
11. Richardson AJ, Montgomery P, (2005) The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115: 1360-1366.
12. Burgess JR, Stevens LJ (2003) Essential fatty acids in relation to attention deficit hyperactivity disorder. In: Glen I, Horrobin DF, editors. Phospholipid spectrum disorders in psychiatry and neurology Carnforth: Marius Press. 511-519.
13. Cyhlarova E, Bell JG, Dick JR, Mackinlay EE, Stein JF, et al. (2007) Membrane fatty acids, reading and spelling in dyslexic and non-dyslexic adults. Eur Neuropsychopharmacol 17: 116-121.
14. Kirby A, Woodward A, Jackson S, Wang Y, Crawford MA, (2010) A double-blind, placebo-controlled study investigating the effects of omega-3 supplementation in children aged 8-10 years from a mainstream school population. Res Dev Disabil 31: 718-730.
15. Bailey-Hall E, Nelson EB, Ryan AS, (2008) Validation of a rapid measure of blood PUFA levels in humans. Lipids 43: 181-186.
16. Marangoni F, Colombo C, Galli C, (2004) A method for the direct evaluation of the fatty acid status in a drop of blood from a fingertip in humans: applicability to nutritional and epidemiological studies. Anal Biochem 326: 267-272.
17. Richardson AJ, Burton JR, Sewell RP, Spreckelsen TF, Montgomery P, (2012) Docosahexaenoic Acid for Reading, Cognition and Behavior in Children Aged 7-9 Years: A Randomized, Controlled Trial (The DOLAB Study). PLoS one 7: e43909 doi:43910.41371/journal.pone.0043909.
18. Department of Education (2001) Special Educational Needs Code of Practice- DfES/581/2001. Available online: https://www.education.gov.uk/publications/eOrderingDownload/DfES%200581%20200MIG2228.pdf. Accessed: 2013 Mar 20.
19. Standards and Testing Agency (2012) National Curriculum assessments- Assessment and reporting arrangements Key Stage 1. Available online: http://www.education.gov.uk/schools/teachingandlearning/assessment/a00197251/assessment-and-reporting-arrangements. Accessed: 2012 May 15.
20. Hobbs G, Vignoles A, (2010) Is children's free school meal 'eligibility' a good proxy for family income? British Educational Research Journal 36: 673-690.
21. Morrison WR, Smith LM, (1964) Preparation of Fatty Acid Methyl Esters+Dimethylacetals from Lipids with Boron Fluoride-Methanol. Journal of Lipid Research 5: 600-608.
22. Harris WS, von Schacky C, (2004) The Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive Medicine 39: 212-220.
23. Harris WS, Klurfeld DM, (2011) Twentieth-century trends in essential fatty acid intakes and the predicted omega-3 index: evidence versus estimates. Am J Clin Nutr 93: 907-908.
24. Elliott CD, Smith P, McCulloch K (1997) British Ability Scales II: Technical Manual; Wales NFfERiEa, editor. London: NferNelson.
25. Conners KC (1997) Conners' Rating Scales-Revised - Instruments for use with Children and Adolescents: Technical Manual. New York: Multi-Health Systems.
26. Galli C, Risé C, Ghezzi S, Colombo C, Ahrens W, et al. (2010) Blood levels of n-3 long chain polyunsaturated fatty acids differ significantly in children from 8 European countries: the IDEFICS study. Poster 9th Conference of the International Society for the Study of Fatty Acids and Lipids (ISSFAL): Maastricht, 2010 May 31.
27. Glaser C, Demmelmair H, Sausenthaler S, Herbarth O, Heinrich J, et al. (2010) Fatty acid composition of serum glycerophospholipids in children. J Pediatr 157: 826-831 e821.
28. Food Standards Agency (2010) Eat Well- Your guide to healthy eating (2010 amended edition). Available online: http://www.food.gov.uk/multimedia/pdfs/publication/eatwell0708.pdf. Accessed: 2013 March 20.
29. Mathias RA, Sergeant S, Ruczinski I, Torgerson DG, Hugenschmidt CE, et al. (2011) The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. Bmc Genetics 12: doi:-10.1186/1471-2156-1112-1150.
30. Decsi T, Kennedy K, (2011) Sex-specific differences in essential fatty acid metabolism. American Journal of Clinical Nutrition 94: 1914-1919.