High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis

Helicobacter

Volumn 18, Issue 4, 2013, Pages 290-298

  Han, Song Hee ^a   Joo, Mee ^a   Kim, Kyoung Mee ^b  

^a Inje University College of Medicine   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Apoptosis; Cytotoxic molecules; Helicobacter pylori; Intraepithelial lymphocytes; Lymphocytic gastritis

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; DNA NUCLEOTIDYLEXOTRANSFERASE; GRANZYME B;

APOPTOSIS; ARTICLE; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; EPITHELIUM CELL; FEMALE; GASTRITIS; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; LYMPHOCYTIC GASTRITIS; MALE; NICK END LABELING; PHENOTYPE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CHILD; EPITHELIAL CELLS; FEMALE; GASTRIC MUCOSA; GASTRITIS; GRANZYMES; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IN SITU NICK-END LABELING; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; YOUNG ADULT;

HELICOBACTER PYLORI;

EID: 84879458995     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/hel.12042     Document Type: Article

References (29)

1. Dixon MF, Wyatt JI, Burke DA, Rathbone BJ. Lymphocytic gastritis-relationship to Campylobacter pylori infection. J Pathol 1988;154:125-32.
2. Haot J, Hamichi L, Wallez L, Mainguet P. Lymphocytic gastritis: a newly described entity: a retrospective endoscopic and histological study. Gut 1988;29:1258-64.
3. Wu TT, Hamilton SR. Lymphocytic gastritis: association with etiology and topology. Am J Surg Pathol 1999;23:153-8.
4. Mäkinen JM, Niemelä S, Kerola T, Lehtola J, Karttunen TJ. Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: effect of H. pylori treatment. World J Gastroenterol 2003;9:2706-10.
5. Trejdosiewicz LK. What is the role of human intestinal intraepithelial lymphocytes? Clin Exp Immunol 1993;94:395-7.
6. Hayday A, Theodoridis E, Ramsburg E, Shires J. Intraepithelial lymphocytes: exploring the Third Way in immunology. Nat Immunol 2001;2:997-1003.
7. Oberhuber G, Bodingbauer M, Mosberger I, Stolte M, Vogelsang H. High proportion of granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis. Am J Surg Pathol 1998;22:450-8.
8. Oberhuber G, Vogelsang H, Stolte M, Muthenthaler S, Kummer JA, Radaszkiewicz T. Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis. Am J Pathol 1996;148:1351-7.
9. Inagaki-Ohara K, Nishimura H, Sakai T, Lynch DH, Yoshikai Y. Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine. Lab Invest 1997;77:421-9.
10. Kagi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata S, Hengartner H, Golstein P. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994;265:528-30.
11. Anderson P. TIA-1: structural and functional studies on a new class of cytolytic effector molecule. Curr Top Microbiol Immunol 1995;198:131-43.
12. Anderson P, Nagler-Anderson C, O'Brien C, Levine H, Watkins S, Slayter HS, Blue ML, Schlossman SF. A monoclonal antibody reactive with a 15-kDa cytoplasmic granule-associated protein defines a subpopulation of CD8+ T lymphocytes. J Immunol 1990;144:574-82.
13. Griffiths GM, Mueller C. Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells. Immunol Today 1991;12:415-9.
14. Mitomi H, Ohkura Y, Yokoyama K, Sada M, Kobayashi K, Tanabe S, Fukui N, Kanazawa H, Kishimoto I, Saigenji K. Contribution of TIA-1+ and granzyme B+ cytotoxic T lymphocytes to cryptal apoptosis and ulceration in active inflammatory bowel disease. Pathol Res Pract 2007;203:717-23.
15. Rubio CA, Sjodahl K, Lagergren J. Lymphocytic esophagitis: a histologic subset of chronic esophagitis. Am J Clin Pathol 2006;125:432-7.
16. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161-81.
17. Jarry A, Cerf-Bensussan N, Brousse N, Selz F, Guy-Grand D. Subsets of CD3+ (T cell receptor alpha/beta or gamma/delta) and CD3- lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol 1990;20:1097-103.
18. Hatz RA, Meimarakis G, Bayerdorffer E, Stolte M, Kirchner T, Enders G. Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis. Scand J Gastroenterol 1996;31:222-8.
19. Suzuki T, Ito M, Hayasaki N, Ishihara A, Ando T, Ina K, Kusugami K. Cytotoxic molecules expressed by intraepithelial lymphocytes may be involved in the pathogenesis of acute gastric mucosal lesions. J Gastroenterol 2003;38:216-21.
20. Carmack SW, Lash RH, Gulizia JM, Genta RM. Lymphocytic disorders of the gastrointestinal tract: a review for the practicing pathologist. Adv Anat Pathol 2009;16:290-306.
21. Jones NL, Day AS, Jennings HA, Sherman PM. Helicobacter pylori induces gastric epithelial cell apoptosis in association with increased Fas receptor expression. Infect Immun 1999;67:4237-42.
22. Wagner S, Beil W, Westermann J, Logan RP, Bock CT, Trautwein C, Bleck JS, Manns MP. Regulation of gastric epithelial cell growth by Helicobacter pylori: Evidence for a major role of apoptosis. Gastroenterology 1997;113:1836-47.
23. Rudi J, Kuck D, Strand D, von Herbay A, Mariani SM, Krammer PH, Galle PR, Stremmel W. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 1998;102:1506-14.
24. Wang J, Fan X, Lindholm C, Bennett M, O'Connoll J, Shanahan F, Brooks EG, Reyes VE, Ernst PB. Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions. Infect Immun 2000;68:4303-11.
25. Ohara T, Morishita T, Suzuki H, Masaoka T, Ishii H. Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation. Hepatogastroenterology 2003;50:1774-9.
26. Souza HS, Neves MS, Elia CC, Tortori CJ, Dines I, Martinusso CA, Madi K, Andrade L, Castelo-Branco MT. Distinct patterns of mucosal apoptosis in H. pylori-associated gastric ulcer are associated with altered FasL and perforin cytotoxic pathways. World J Gastroenterol 2006;12:6133-41.
27. Leers MP, Kölgen W, Björklund V, et al. Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J Pathol 1999;187:567-72.
28. Suarez G, Reyes VE, Beswick EJ. Immune response to H. pylori. World J Gastroenterol 2006;12:5593-8.
29. Wilson KT, Crabtree JE. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 2007;133:288-308.