L1cam promotes tumor progression and metastasis and is an independent unfavorable prognostic factor in gastric cancer

Journal of Hematology and Oncology

Volumn 6, Issue 1, 2013, Pages

  Chen, Dong Liang ^a   Zeng, Zhao Lei ^a   Yang, Jing ^a   Ren, Chao ^a   Wang, De Shen ^a   Wu, Wen Jing ^a   Xu, Rui Hua ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Gastric cancer; L1cam; Metastasis; PI3K Akt; Prognosis

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; L1CAM PROTEIN; PROTEIN; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER PROGNOSIS; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; DISTANT METASTASIS; ENZYME PHOSPHORYLATION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PHENOTYPE; STOMACH CANCER; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM METASTASIS; NEURAL CELL ADHESION MOLECULE L1; PHOSPHATIDYLINOSITOL 3-KINASES; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; STOMACH NEOPLASMS; TRANSFECTION;

EID: 84879458817     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-6-43     Document Type: Article

References (55)

1. Cancer statistics, 2010. Jemal A, Siegel R, Xu J, Ward E, CA Cancer J Clin 2010 60 277 300 10.3322/caac.20073 20610543
2. Some problems in the surgical treatment of gastric cancer. Wang XN, Liang H, Chin J Cancer 2010 29 369 373 10.5732/cjc.009.10629 20346210
3. Metastasis suppressors alter the signal transduction of cancer cells. Steeg PS, Nat Rev Cancer 2003 3 55 63 10.1038/nrc967 12509767
4. Hohenberger P, Gretschel S, Gastric cancer. Lancet 2003 362 305 315
5. L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum. Lindner J, Rathjen FG, Schachner M, Nature 1983 305 427 430 10.1038/305427a0 6621692
6. Axonal glycoproteins with immunoglobulin- and fibronectin type III-related domains in vertebrates: structural features, binding activities, and signal transduction. Brummendorf T, Rathjen FG, J Neurochem 1993 61 1207 1219 10.1111/j.1471-4159.1993.tb13611.x 8376980
7. The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Hortsch M, Neuron 1996 17 587 593 10.1016/S0896-6273(00)80192-0 8893017
8. Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Moos M, Tacke R, Scherer H, Teplow D, Fruh K, Schachner M, Nature 1988 334 701 703 10.1038/334701a0 3412448
9. Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion. Rathjen FG, Schachner M, EMBO J 1984 3 1 10 6368220
10. Disruption of the mouse L1 gene leads to malformations of the nervous system. Dahme M, Bartsch U, Martini R, Anliker B, Schachner M, Mantei N, Nat Genet 1997 17 346 349 10.1038/ng1197-346 9354804
11. The cell adhesion molecule L1 is developmentally regulated in the renal epithelium and is involved in kidney branching morphogenesis. Debiec H, Christensen EI, Ronco PM, J Cell Biol 1998 143 2067 2079 10.1083/jcb.143.7.2067 9864376
12. Characterization of the cell adhesion molecules L1, N-CAM and J1 in the mouse intestine. Thor G, Probstmeier R, Schachner M, EMBO J 1987 6 2581 2586 3315649
13. L1 adhesion molecule on human lymphocytes and monocytes: expression and involvement in binding to alpha v beta 3 integrin. Ebeling O, Duczmal A, Aigner S, Geiger C, Schollhammer S, Kemshead JT, Moller P, Schwartz-Albiez R, Altevogt P, Eur J Immunol 1996 26 2508 2516 10.1002/eji.1830261035 8898967
14. Expression of l1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer. Kajiwara Y, Ueno H, Hashiguchi Y, Shinto E, Shimazaki H, Mochizuki H, Hase K, Am J Clin Pathol 2011 136 138 144 10.1309/AJCP63NRBNGCTXVF 21685041
15. The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma. Doberstein K, Pfeilschifter J, Gutwein P, Carcinogenesis 2011 32 1713 1723 10.1093/carcin/bgr195 21880579
16. Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-kappaB activation. Bondong S, Kiefel H, Hielscher T, Zeimet AG, Zeillinger R, Pils D, Schuster E, Castillo-Tong DC, Cadron I, Vergote I, et al. Ann Oncol 2012 23 1795 1802 10.1093/annonc/mdr568 22228447
17. Aberrant l1 cell adhesion molecule affects tumor behavior and chemosensitivity in anaplastic thyroid carcinoma. Kim KS, Min JK, Liang ZL, Lee K, Lee JU, Bae KH, Lee MH, Lee SE, Ryu MJ, Kim SJ, et al. Clin Cancer Res 2012 18 3071 3078 10.1158/1078-0432.CCR-11-2757 22472175
18. Gene expression of neural cell adhesion molecule L1 in malignant gliomas and biological significance of L1 in glioma invasion. Izumoto S, Ohnishi T, Arita N, Hiraga S, Taki T, Hayakawa T, Cancer Res 1996 56 1440 1444 8640837
19. A comparison of targeting of neuroblastoma with mIBG and anti L1-CAM antibody mAb chCE7: therapeutic efficacy in a neuroblastoma xenograft model and imaging of neuroblastoma patients. Hoefnagel CA, Rutgers M, Buitenhuis CK, Smets LA, de Kraker J, Meli M, Carrel F, Amstutz H, Schubiger PA, Novak-Hofer I, Eur J Nucl Med 2001 28 359 368 10.1007/s002590000454 11315605
20. Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. Thies A, Schachner M, Moll I, Berger J, Schulze HJ, Brunner G, Schumacher U, Eur J Cancer 2002 38 1708 1716 10.1016/S0959-8049(02)00105-3 12175686
21. The L1CAM extracellular region: a multi-domain protein with modular and cooperative binding modes. Haspel J, Grumet M, Front Biosci 2003 8 1210 s1225 10.2741/1108 12957823
22. Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells. Voura EB, Ramjeesingh RA, Montgomery AM, Siu CH, Mol Biol Cell 2001 12 2699 2710 10.1091/mbc.12.9.2699 11553709
23. The L1 adhesion molecule supports alpha v beta 3-mediated migration of human tumor cells and activated T lymphocytes. Duczmal A, Schollhammer S, Katich S, Ebeling O, Schwartz-Albiez R, Altevogt P, Biochem Biophys Res Commun 1997 232 236 239 10.1006/bbrc.1997.6265 9125139
24. L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers. Gavert N, Vivanti A, Hazin J, Brabletz T, Ben-Ze'ev A, Mol Cancer Res 2011 9 14 24 10.1158/1541-7786.MCR-10-0406 21123622
25. L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma. Min JK, Kim JM, Li S, Lee JW, Yoon H, Ryu CJ, Jeon SH, Lee JH, Kim JY, Yoon HK, et al. Clin Cancer Res 2010 16 3571 3580 10.1158/1078-0432.CCR-09-3075 20501614
26. The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo. Jung J, Son YS, Park H, Jeon SK, Lee JW, Choi SY, Kim JM, Kwon YG, Hong HJ, Min JK, Oncol Rep 2011 25 945 952 21318226
27. Expression of L1 cell adhesion molecule is a significant prognostic factor in pT3-stage gastric cancer. Kodera Y, Nakanishi H, Ito S, Misawa K, Ito Y, Nakayama G, Koike M, Fujiwara M, Yamamura Y, Nakao A, Anticancer Res 2009 29 4033 4039 19846947
28. Cellular survival: a play in three Akts. Datta SR, Brunet A, Greenberg ME, Genes Dev 1999 13 2905 2927 10.1101/gad.13.22.2905 10579998
29. PKB/AKT: functional insights from genetic models. Scheid MP, Woodgett JR, Nat Rev Mol Cell Biol 2001 2 760 768 10.1038/35096067 11584303
30. AKT/PKB signaling: navigating downstream. Manning BD, Cantley LC, Cell 2007 129 1261 1274 10.1016/j.cell.2007.06.009 17604717
31. L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Fogel M, Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Smirnov A, Edler L, Ben-Arie A, Huszar M, Altevogt P, Lancet 2003 362 869 875 10.1016/S0140-6736(03)14342-5 13678974
32. L1 adhesion molecule (CD 171) in development and progression of human malignant melanoma. Fogel M, Mechtersheimer S, Huszar M, Smirnov A, Abu-Dahi A, Tilgen W, Reichrath J, Georg T, Altevogt P, Gutwein P, Cancer Lett 2003 189 237 247 10.1016/S0304-3835(02)00513-X 12490317
33. A novel model of glioma cell invasion using organotypic brain slice culture. Ohnishi T, Matsumura H, Izumoto S, Hiraga S, Hayakawa T, Cancer Res 1998 58 2935 2940 9679949
34. L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer. Boo YJ, Park JM, Kim J, Chae YS, Min BW, Um JW, Moon HY, Ann Surg Oncol 2007 14 1703 1711 10.1245/s10434-006-9281-8 17211730
35. L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. Kaifi JT, Reichelt U, Quaas A, Schurr PG, Wachowiak R, Yekebas EF, Strate T, Schneider C, Pantel K, Schachner M, et al. Mod Pathol 2007 20 1183 1190 10.1038/modpathol.3800955 17873897
36. L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. Gavert N, Conacci-Sorrell M, Gast D, Schneider A, Altevogt P, Brabletz T, Ben-Ze'ev A, J Cell Biol 2005 168 633 642 10.1083/jcb.200408051 15716380
37. L1 cell adhesion molecules as regulators of tumor cell invasiveness. Siesser PF, Maness PF, Cell Adh Migr 2009 3 275 277 10.4161/cam.3.3.8689 19483471
38. Endocytosis of beta1 integrins is an early event in migration promoted by the cell adhesion molecule L1. Panicker AK, Buhusi M, Erickson A, Maness PF, Exp Cell Res 2006 312 299 307 16330023
39. L1 stimulation of human glioma cell motility correlates with FAK activation. Yang M, Li Y, Chilukuri K, Brady OA, Boulos MI, Kappes JC, Galileo DS, J Neurooncol 2011 105 27 44 10.1007/s11060-011-0557-x 21373966
40. EMT-associated up-regulation of L1CAM provides insights into L1CAM-mediated integrin signalling and NF-kappaB activation. Kiefel H, Bondong S, Pfeifer M, Schirmer U, Erbe-Hoffmann N, Schafer H, Sebens S, Altevogt P, Carcinogenesis 2012 33 1919 1929 10.1093/carcin/bgs220 22764136
41. L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression. Kiefel H, Bondong S, Erbe-Hoffmann N, Hazin J, Riedle S, Wolf J, Pfeifer M, Arlt A, Schafer H, Muerkoster SS, Altevogt P, Oncogene 2010 29 4766 4778 10.1038/onc.2010.230 20543863
42. Targeting cancer stem cells through L1CAM suppresses glioma growth. Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon RE, Hjelmeland AB, Rich JN, Cancer Res 2008 68 6043 6048 10.1158/0008-5472.CAN-08-1079 18676824
43. The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies. Gast D, Riedle S, Issa Y, Pfeifer M, Beckhove P, Sanderson MP, Arlt M, Moldenhauer G, Fogel M, Kruger A, Altevogt P, Oncogene 2008 27 1281 1289 10.1038/sj.onc.1210747 17952127
44. Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. Arlt MJ, Novak-Hofer I, Gast D, Gschwend V, Moldenhauer G, Grunberg J, Honer M, Schubiger PA, Altevogt P, Kruger A, Cancer Res 2006 66 936 943 10.1158/0008-5472.CAN-05-1818 16424028
45. Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis. Knogler K, Grunberg J, Zimmermann K, Cohrs S, Honer M, Ametamey S, Altevogt P, Fogel M, Schubiger PA, Novak-Hofer I, Clin Cancer Res 2007 13 603 611 10.1158/1078-0432.CCR-06-1486 17255283
46. Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells. Sebens Muerkoster S, Werbing V, Sipos B, Debus MA, Witt M, Grossmann M, Leisner D, Kotteritzsch J, Kappes H, Kloppel G, et al. Oncogene 2007 26 2759 2768 10.1038/sj.onc.1210076 17086212
47. Combined treatment of L1CAM antibodies and cytostatic drugs improve the therapeutic response of pancreatic and ovarian carcinoma. Schafer H, Dieckmann C, Korniienko O, Moldenhauer G, Kiefel H, Salnikov A, Kruger A, Altevogt P, Sebens S, Cancer Lett 2012 319 66 82 10.1016/j.canlet.2011.12.035 22210381
48. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery AM, J Biol Chem 2004 279 28880 28888 10.1074/jbc.M404075200 15128735
49. L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Stoeck A, Gast D, Sanderson MP, Issa Y, Gutwein P, Altevogt P, Gynecol Oncol 2007 104 461 469 10.1016/j.ygyno.2006.08. 038 17030349
50. L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells. Yoon H, Min JK, Lee DG, Kim DG, Koh SS, Hong HJ, Cancer Lett 2012 316 70 76 10.1016/j.canlet.2011.10.024 22088438
51. Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma. Zeng ZL, Wu WJ, Yang J, Tang ZJ, Chen DL, Qiu MZ, Luo HY, Wang ZQ, Jin Y, Wang DS, Xu RH, J Transl Med 2012 10 181 10.1186/1479-5876-10-181 22935435
52. Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells. Zou J, Li P, Lu F, Liu N, Dai J, Ye J, Qu X, Sun X, Ma D, Park J, Ji C, J Hematol Oncol 2013 6 3 10.1186/1756-8722-6-3 23289374
53. High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma. Wu ZL, Song YQ, Shi YF, Zhu J, J Hematol Oncol 2011 4 31 10.1186/1756-8722-4-31 21806788
54. ADAM10 is upregulated in melanoma metastasis compared with primary melanoma. Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, et al. J Invest Dermatol 2010 130 763 773 10.1038/jid.2009.335 19865098
55. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. Huang S, Jean D, Luca M, Tainsky MA, Bar-Eli M, EMBO J 1998 17 4358 4369 10.1093/emboj/17.15.4358 9687504