Brain structure in preclinical huntington's disease: A multi-method approach

Neurodegenerative Diseases

Volumn 12, Issue 1, 2013, Pages 13-22

  Wolf, Robert Christian ^a,b   Thomann, Philipp Arthur ^a   Thomann, Anne Kerstin ^a   Vasic, Nenad ^b   Wolf, Nadine Donata ^c   Landwehrmeyer, G Bernhard ^b   Orth, Michael ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Cortex; Huntington's disease; Magnetic resonance imaging; Neuropsychology; Striatum; Voxel based morphometry

Indexed keywords

ADULT; ARTICLE; BRAIN CORTEX; BRAIN REGION; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE COURSE; EXECUTIVE FUNCTION; FEMALE; HUMAN; HUNTINGTON CHOREA; MALE; MOTOR DYSFUNCTION; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; VOXEL BASED MORPHOMETRY; AUTOSOMAL DOMINANT INHERITANCE; BRAIN; CAG REPEAT; DEGENERATIVE DISEASE; EARLY DIAGNOSIS; GENE MUTATION; METHODOLOGY; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE SCANNER; UNIFIED HUNTINGTON DISEASE RATING SCALE; WISCONSIN CARD SORTING TEST;

ADULT; ASYMPTOMATIC DISEASES; BRAIN; COGNITION; CORPUS STRIATUM; DATA INTERPRETATION, STATISTICAL; DISEASE PROGRESSION; FEMALE; HUMANS; HUNTINGTON DISEASE; MAGNETIC RESONANCE IMAGING; MALE; THALAMUS;

EID: 84879415816     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000338635     Document Type: Article

References (63)

1. Huntington Study Group: Unified Huntington's Disease Rating Scale: reliability and consistency. Mov Disord 1996; 11: 136-142
2. Aylward EH: Change in MRI striatal volumes as a biomarker in preclinical Huntington's disease. Brain Res Bull 2007; 72: 152- 158
3. Paulsen JS, Nopoulos PC, Aylward E, Ross CA, Johnson H, Magnotta VA, Juhl A, Pierson RK, Mills J, Langbehn D, Nance M: Striatal and white matter predictors of estimated diagnosis for Huntington disease. Brain Res Bull 2010; 82: 201-207
4. Paulsen JS, Magnotta VA, Mikos AE, Paulson HL, Penziner E, Andreasen NC, Nopoulos PC: Brain structure in preclinical Huntington's disease. Biol Psychiatry 2006; 59: 57-63
5. Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC: Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol 2009; 8: 791-801
6. Stoffers D, Sheldon S, Kuperman JM, Goldstein J, Corey-Bloom J, Aron AR: Contrasting gray and white matter changes in preclinical Huntington disease: an MRI study. Neurology 2010; 74: 1208-1216
7. Wolf RC, Vasic N, Schonfeldt-Lecuona C, Landwehrmeyer GB, Ecker D: Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI. Brain 2007; 130: 2845- 2857
8. Henley SM, Wild EJ, Hobbs NZ, Scahill RI, Ridgway GR, Macmanus DG, Barker RA, Fox NC, Tabrizi SJ: Relationship between CAG repeat length and brain volume in premanifest and early Huntington's disease. J Neurol 2009; 256: 203-212
9. Nopoulos PC, Aylward EH, Ross CA, Johnson HJ, Magnotta VA, Juhl AR, Pierson RK, Mills J, Langbehn DR, Paulsen JS: Cerebral cortex structure in prodromal Huntington disease. Neurobiol Dis 2010; 40: 544-554
10. Zimbelman JL, Paulsen JS, Mikos AE, Reynolds NC, Hoffman RG, Rao SM: fMRI detection of early neural dysfunction in preclinical Huntington's disease. J Int Neuropsychol Soc 2007; 13: 758-769
11. Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC: Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol 2011; 10: 31-42
12. Aylward EH, Sparks BF, Field KM, Yallapragada V, Shpritz BD, Rosenblatt A, Brandt J, Gourley LM, Liang K, Zhou H, Margolis RL, Ross CA: Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology 2004; 63: 66-72
13. Henley SM, Ridgway GR, Scahill RI, Kloppel S, Tabrizi SJ, Fox NC, Kassubek J: Pitfalls in the use of voxel-based morphometry as a biomarker: examples from Huntington disease. AJNR Am J Neuroradiol 2010; 31: 711-719
14. Hobbs NZ, Henley SM, Ridgway GR, Wild EJ, Barker RA, Scahill RI, Barnes J, Fox NC, Tabrizi SJ: The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study. J Neurol Neurosurg Psychiatry 2010; 81: 756-763
15. Rosas HD, Hevelone ND, Zaleta AK, Greve DN, Salat DH, Fischl B: Regional cortical thinning in preclinical Huntington disease and its relationship to cognition. Neurology 2005; 65: 745-747
16. Wolf RC, Sambataro F, Vasic N, Schonfeldt-Lecuona C, Ecker D, Landwehrmeyer B: Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington's disease. Exp Neurol 2008; 213: 137-144
17. Wolf RC, Sambataro F, Vasic N, Schonfeldt- Lecuona C, Ecker D, Landwehrmeyer B: Altered frontostriatal coupling in pre-manifest Huntington's disease: effects of increasing cognitive load. Eur J Neurol 2008; 15: 1180- 1190
18. Rupp J, Blekher T, Jackson J, Beristain X, Marshall J, Hui S, Wojcieszek J, Foroud T: Progression in prediagnostic Huntington disease. J Neurol Neurosurg Psychiatry 2009; 81: 379-384
19. Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR, Group IHsDC: A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clin Genet 2004; 65: 267-277
20. Zimmermann P, Fimm B: Tests of Attentional Performance. Herzogenrath, Psytest, 1994
21. Milner B: Effects of different brain lesions on card sorting. Arch Neurol 1963; 9: 90
22. Perlstein WM, Carter CS, Barch DM, Baird JW: The Stroop task and attention deficits in schizophrenia: a critical evaluation of card and single-trial Stroop methodologies. Neuropsychology 1998; 12: 414-425
23. Spitzer M, Franke B, Walter H, Buechler J, Wunderlich AP, Schwab M, Kovar K, Hermle L, Gron G: Enantio-selective cognitive and brain activation effects of N-ethyl-3,4-methylenedioxyamphetamine in humans. Neuropharmacology 2001; 41: 263-271
24. Dale AM, Fischl B, Sereno MI: Cortical surface- based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999; 9: 179-194
25. Fischl B, Sereno MI, Dale AM: Cortical surface- based analysis. II. Inflation, flattening, and a surface-based coordinate system. Neuroimage 1999; 9: 195-207
26. Fischl B, Sereno MI, Tootell RB, Dale AM: High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp 1999; 8: 272-284
27. Segonne F, Dale AM, Busa E, Glessner M, Salat D, Hahn HK, Fischl B: A hybrid approach to the skull stripping problem in MRI. Neuroimage 2004; 22: 1060-1075
28. Sled JG, Zijdenbos AP, Evans AC: A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 1998; 17: 87-97
29. Fischl B, Liu A, Dale AM: Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging 2001; 20: 70-80
30. Segonne F, Pacheco J, Fischl B: Geometrically accurate topology-correction of cortical surfaces using nonseparating loops. IEEE Trans Med Imaging 2007; 26: 518-529
31. Fischl B, Dale AM: Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA 2000; 97: 11050-11055
32. Genovese CR, Lazar NA, Nichols T: Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 2002; 15: 870-878
33. Brandt J, Inscore AB, Ward J, Shpritz B, Rosenblatt A, Margolis RL, Ross CA: Neuropsychological deficits in Huntington's disease gene carriers and correlates of early 'conversion'. J Neuropsychiatry Clin Neurosci 2008; 20: 466-472
34. Verny C, Allain P, Prudean A, Malinge MC, Gohier B, Scherer C, Bonneau D, Dubas F, Le Gall D: Cognitive changes in asymptomatic carriers of the Huntington disease mutation gene. Eur J Neurol 2007; 14: 1344-1350
35. Patenaude B: Bayesian Statistical Models of Shape and Appearance for Subcortical Brain Segmentation. Oxford, University of Oxford, 2007. 36
36. Ashburner J: A fast diffeomorphic image registration algorithm. Neuroimage 2007; 38: 95-113
37. Bergouignan L, Chupin M, Czechowska Y, Kinkingnehun S, Lemogne C, Le Bastard G, Lepage M, Garnero L, Colliot O, Fossati P: Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression? Neuroimage 2009; 45: 29-37
38. Yassa MA, Stark CE: A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe. Neuroimage 2009; 44: 319-327
39. Ashburner J, Friston KJ: Unified segmentation. Neuroimage 2005; 26: 839-851
40. Thieben MJ, Duggins AJ, Good CD, Gomes L, Mahant N, Richards F, McCusker E, Frackowiak RS: The distribution of structural neuropathology in pre-clinical Huntington's disease. Brain 2002; 125: 1815-1828
41. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS: A voxelbased morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14: 21-36
42. Kipps CM, Duggins AJ, Mahant N, Gomes L, Ashburner J, McCusker EA: Progression of structural neuropathology in preclinical Huntington's disease: a tensor based morphometry study. J Neurol Neurosurg Psychiatry 2005; 76: 650-655
43. Nopoulos P, Magnotta VA, Mikos A, Paulson H, Andreasen NC, Paulsen JS: Morphology of the cerebral cortex in preclinical Huntington's disease. Am J Psychiatry 2007; 164: 1428-1434
44. Kassubek J, Juengling FD, Ecker D, Landwehrmeyer GB: Thalamic atrophy in Huntington's disease co-varies with cognitive performance: a morphometric MRI analysis. Cereb Cortex 2005; 15: 846-853
45. Gomez-Anson B, Alegret M, Munoz E, Monte GC, Alayrach E, Sanchez A, Boada M, Tolosa E: Prefrontal cortex volume reduction on MRI in preclinical Huntington's disease relates to visuomotor performance and CAG number. Parkinsonism Relat Disord 2009; 15: 213-219
46. Winkler AM, Kochunov P, Blangero J, Almasy L, Zilles K, Fox PT, Duggirala R, Glahn DC: Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. Neuroimage 2009; 53: 1135-1146
47. Ruocco HH, Bonilha L, Li ML, Lopes- Cendes I, Cendes F: Longitudinal analysis of regional gray matter loss in Huntington disease: effects of the length of the expanded CAG repeat. J Neurol Neurosurg Psychiatry 2008; 79: 130-135
48. Tabrizi SJ, Reilmann R, Roos RA, Durr A, Leavitt B, Owen G, Jones R, Johnson H, Craufurd D, Hicks SL, Kennard C, Landwehrmeyer B, Stout JC, Borowsky B, Scahill RI, Frost C, Langbehn DR: Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACKHD study: analysis of 24 month observational data. Lancet Neurol 2012; 11: 42-53
49. Ferrante RJ, Gutekunst CA, Persichetti F, McNeil SM, Kowall NW, Gusella JF, Mac- Donald ME, Beal MF, Hersch SM: Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum. J Neurosci 1997; 17: 3052- 3063
50. Sapp E, Schwarz C, Chase K, Bhide PG, Young AB, Penney J, Vonsattel JP, Aronin N, DiFiglia M: Huntingtin localization in brains of normal and Huntington's disease patients. Ann Neurol 1997; 42: 604-612
51. Gutekunst CA, Li SH, Yi H, Mulroy JS, Kuemmerle S, Jones R, Rye D, Ferrante RJ, Hersch SM, Li XJ: Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology. J Neurosci 1999; 19: 2522-2534
52. Aylward EH, Nopoulos PC, Ross CA, Langbehn DR, Pierson RK, Mills JA, Johnson HJ, Magnotta VA, Juhl AR, Paulsen JS: Longitudinal change in regional brain volumes in prodromal Huntington disease. J Neurol Neurosurg Psychiatry 2011; 82: 405-410
53. Nopoulos PC, Aylward EH, Ross CA, Mills JA, Langbehn DR, Johnson HJ, Magnotta VA, Pierson RK, Beglinger LJ, Nance MA, Barker RA, Paulsen JS: Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment. Brain 2011; 134: 137-142
54. Orth M, Schippling S, Schneider SA, Bhatia KP, Talelli P, Tabrizi SJ, Rothwell JC: Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease. J Neurol Neurosurg Psychiatry 2010; 81: 267- 270
55. Schippling S, Schneider SA, Bhatia KP, Munchau A, Rothwell JC, Tabrizi SJ, Orth M: Abnormal motor cortex excitability in preclinical and very early Huntington's disease. Biol Psychiatry 2009; 65: 959-965
56. Campodonico JR, Codori AM, Brandt J: Neuropsychological stability over two years in asymptomatic carriers of the Huntington's disease mutation. J Neurol Neurosurg Psychiatry 1996; 61: 621-624
57. Brandt J, Shpritz B, Codori AM, Margolis R, Rosenblatt A: Neuropsychological manifestations of the genetic mutation for Huntington's disease in presymptomatic individuals. J Int Neuropsychol Soc 2002; 8: 918-924
58. Monchi O, Petrides M, Petre V, Worsley K, Dagher A: Wisconsin Card Sorting revisited: distinct neural circuits participating in different stages of the task identified by eventrelated functional magnetic resonance imaging. J Neurosci 2001; 21: 7733-7741
59. Snowden J, Craufurd D, Griffiths H, Thompson J, Neary D: Longitudinal evaluation of cognitive disorder in Huntington's disease. J Int Neuropsychol Soc 2001; 7: 33-44
60. Hasselbalch SG, Oberg G, Sorensen SA, Andersen AR, Waldemar G, Schmidt JF, Fenger K, Paulson OB: Reduced regional cerebral blood flow in Huntington's disease studied by SPECT. J Neurol Neurosurg Psychiatry 1992; 55: 1018-1023
61. Amos A: A computational model of information processing in the frontal cortex and basal ganglia. J Cogn Neurosci 2000; 12: 505- 519
62. Orth M, Schwenke C: Age-at-onset in Huntington disease. PLoS Currents: Huntington Disease, Version 65 2011, Jul 1 (revised 2011, Dec 21). http://knol.google.com/k/michaelorth/ age-at-onset-in-huntington-disease/ 3dua5u7tnja1b/3
63. Oldfield RC: The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971;9:97-113.