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Volumn 229, Issue 1, 2013, Pages 1-9

A systematic review to evaluate the effectiveness of carnitine supplementation in improving walking performance among individuals with intermittent claudication

Author keywords

Carnitine; Peripheral arterial disease; Walking performance

Indexed keywords

ACETYLCARNITINE; CARNITINE; PLACEBO; PROPIONYLCARNITINE;

EID: 84879409393     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.03.004     Document Type: Review
Times cited : (24)

References (33)
  • 2
    • 0035204120 scopus 로고    scopus 로고
    • Management of peripheral arterial disease and intermittent claudication
    • Schainfeld R.M. Management of peripheral arterial disease and intermittent claudication. JAm Board Fam Prac 2001, 14:443-450.
    • (2001) JAm Board Fam Prac , vol.14 , pp. 443-450
    • Schainfeld, R.M.1
  • 3
    • 33645810153 scopus 로고    scopus 로고
    • ACC/AHA 2005 practice guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic)
    • Hirsch A.T., Haskal Z.J., Hertzer N.R., et al. ACC/AHA 2005 practice guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic). Circulation 2006, 113(11):e463-e465.
    • (2006) Circulation , vol.113 , Issue.11
    • Hirsch, A.T.1    Haskal, Z.J.2    Hertzer, N.R.3
  • 4
    • 55049093707 scopus 로고    scopus 로고
    • Exercise for intermittent claudication
    • Art. No.: CD000990
    • Watson L., Ellis B., Leng G.C. Exercise for intermittent claudication. Cochrane Database Syst Rev 2008, (4). Art. No.: CD000990. 10.1002/14651858.CD000990.pub2.
    • (2008) Cochrane Database Syst Rev , Issue.4
    • Watson, L.1    Ellis, B.2    Leng, G.C.3
  • 5
  • 7
    • 0026009064 scopus 로고
    • Muscle carnitine deficiency in patients with severe peripheral vascular disease
    • Brevetti G., Angelini C., Rosa M., et al. Muscle carnitine deficiency in patients with severe peripheral vascular disease. Circulation 1991, 84:1490-1495.
    • (1991) Circulation , vol.84 , pp. 1490-1495
    • Brevetti, G.1    Angelini, C.2    Rosa, M.3
  • 8
    • 10644245703 scopus 로고    scopus 로고
    • Carnitine and peripheral arterial disease
    • Hiatt W.R. Carnitine and peripheral arterial disease. Ann N Y Acad Sci 2004, 1033:92-98.
    • (2004) Ann N Y Acad Sci , vol.1033 , pp. 92-98
    • Hiatt, W.R.1
  • 9
    • 0026683401 scopus 로고
    • Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease
    • Hiatt W.R., Wolfel E.E., Regensteiner J.G., Brass E.P. Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease. JAppl Physiol 1992, 73(1):346-353.
    • (1992) JAppl Physiol , vol.73 , Issue.1 , pp. 346-353
    • Hiatt, W.R.1    Wolfel, E.E.2    Regensteiner, J.G.3    Brass, E.P.4
  • 10
    • 0028849885 scopus 로고
    • Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study
    • Brevetti G., Perna S., Sabba C., Martone V.D., Condorelli M. Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study. JAm Coll Cardiol 1995, 26(6):1411-1416.
    • (1995) JAm Coll Cardiol , vol.26 , Issue.6 , pp. 1411-1416
    • Brevetti, G.1    Perna, S.2    Sabba, C.3    Martone, V.D.4    Condorelli, M.5
  • 11
    • 77952752103 scopus 로고    scopus 로고
    • Does endothelial dysfunction contribute to the clinical status of patients with peripheral arterial disease?
    • Vita J.A., Hamburg N.M. Does endothelial dysfunction contribute to the clinical status of patients with peripheral arterial disease?. Can J Cardiol 2010, 26(Suppl. A):45A-50A.
    • (2010) Can J Cardiol , vol.26 , Issue.SUPPL. A
    • Vita, J.A.1    Hamburg, N.M.2
  • 12
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: is blinding necessary?
    • Jadad A.R., Moore R.A., Carroll D., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Contr Clin Trial 1996, 17(1):1-12.
    • (1996) Contr Clin Trial , vol.17 , Issue.1 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 13
    • 0030444753 scopus 로고    scopus 로고
    • Changes in energy metabolism of calf muscle in patients with intermittent claudication assessed by 31P magnetic resonance spectroscopy: a phase II open study
    • Taylor D.J., Amato A., Hands L.J., et al. Changes in energy metabolism of calf muscle in patients with intermittent claudication assessed by 31P magnetic resonance spectroscopy: a phase II open study. Vasc Med 1996, 1(4):241-245.
    • (1996) Vasc Med , vol.1 , Issue.4 , pp. 241-245
    • Taylor, D.J.1    Amato, A.2    Hands, L.J.3
  • 14
    • 0034840105 scopus 로고    scopus 로고
    • Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease
    • Barker G.A., Green S., Askew C.D., Green A.A., Walker P.J. Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease. Med Sci Sports Exerc 2001, 33(9):1415-1422.
    • (2001) Med Sci Sports Exerc , vol.33 , Issue.9 , pp. 1415-1422
    • Barker, G.A.1    Green, S.2    Askew, C.D.3    Green, A.A.4    Walker, P.J.5
  • 15
    • 4143079204 scopus 로고    scopus 로고
    • Effects of propionyl-carnitine in patients with type 2 diabetes and peripheral vascular disease: results of a pilot trial
    • Ragozzino G., Mattera E., Madrid E., et al. Effects of propionyl-carnitine in patients with type 2 diabetes and peripheral vascular disease: results of a pilot trial. Drugs Res Develop 2004, 5(4):185-190.
    • (2004) Drugs Res Develop , vol.5 , Issue.4 , pp. 185-190
    • Ragozzino, G.1    Mattera, E.2    Madrid, E.3
  • 16
    • 47249155341 scopus 로고    scopus 로고
    • Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriche stage II
    • Riccioni C., Sarcinella R., Palermo G., et al. Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriche stage II. Int Angiol 2008, 27(3):253-259.
    • (2008) Int Angiol , vol.27 , Issue.3 , pp. 253-259
    • Riccioni, C.1    Sarcinella, R.2    Palermo, G.3
  • 17
    • 46649113319 scopus 로고    scopus 로고
    • Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease
    • Allegra C., Antignani P.L., Schachter I., Koverech A., Messano M., Vermani A. Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease. Ann Vasc Surg 2008, 22(4):552-558.
    • (2008) Ann Vasc Surg , vol.22 , Issue.4 , pp. 552-558
    • Allegra, C.1    Antignani, P.L.2    Schachter, I.3    Koverech, A.4    Messano, M.5    Vermani, A.6
  • 18
    • 0026532404 scopus 로고
    • Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentre controlled study vs. placebo
    • Coto V., D'Alessandro L., Grattarola G., et al. Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentre controlled study vs. placebo. Drugs Exp Clin Res 1992, 18(1):29-36.
    • (1992) Drugs Exp Clin Res , vol.18 , Issue.1 , pp. 29-36
    • Coto, V.1    D'Alessandro, L.2    Grattarola, G.3
  • 19
    • 0033230534 scopus 로고    scopus 로고
    • European multicenter study on propionyl-L-carnitine in intermittent claudication
    • Brevetti G., Diehm C., Lambert D. European multicenter study on propionyl-L-carnitine in intermittent claudication. JAm Coll Cardiol 1999, 34(5):1618-1624.
    • (1999) JAm Coll Cardiol , vol.34 , Issue.5 , pp. 1618-1624
    • Brevetti, G.1    Diehm, C.2    Lambert, D.3
  • 20
    • 0032931592 scopus 로고    scopus 로고
    • Effects of propionyl-L-carnitine on peripheral arterial obliterative disease of the lower limbs: a double-blind clinical trial
    • Dal Lago A., De Martini D., Flore R., et al. Effects of propionyl-L-carnitine on peripheral arterial obliterative disease of the lower limbs: a double-blind clinical trial. Drugs Exp Clin Res 1999, 25(1):29-36.
    • (1999) Drugs Exp Clin Res , vol.25 , Issue.1 , pp. 29-36
    • Dal Lago, A.1    De Martini, D.2    Flore, R.3
  • 21
    • 0035369894 scopus 로고    scopus 로고
    • Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication
    • Hiatt W.R., Regensteiner J.G., Creager M.A., et al. Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. Am J Med 2001, 110(8):616-622.
    • (2001) Am J Med , vol.110 , Issue.8 , pp. 616-622
    • Hiatt, W.R.1    Regensteiner, J.G.2    Creager, M.A.3
  • 22
    • 39149128229 scopus 로고    scopus 로고
    • Levo-propionyl-carnitine improves the effectiveness of supervised physical training on the absolute claudication distance in patients with intermittent claudication
    • Andreozzi G.M., Leone A., Laudani R., Martin R., Deinit G., Cataldi V. Levo-propionyl-carnitine improves the effectiveness of supervised physical training on the absolute claudication distance in patients with intermittent claudication. Angiol 2008, 59(1):84-89.
    • (2008) Angiol , vol.59 , Issue.1 , pp. 84-89
    • Andreozzi, G.M.1    Leone, A.2    Laudani, R.3    Martin, R.4    Deinit, G.5    Cataldi, V.6
  • 23
    • 79952438900 scopus 로고    scopus 로고
    • Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease
    • Hiatt W.R., Creager M.A., Amato A., Brass E.P. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. JCardiopulm Rehabil Prev 2011, 31(2):125-132.
    • (2011) JCardiopulm Rehabil Prev , vol.31 , Issue.2 , pp. 125-132
    • Hiatt, W.R.1    Creager, M.A.2    Amato, A.3    Brass, E.P.4
  • 24
    • 84861815980 scopus 로고    scopus 로고
    • L-Carnitine plus cilostazol versus cilostazol alone for the treatment of claudication in patients with peripheral artery disease: a multicenter, randomized, double-blind, placebo-controlled trial
    • Golderberg N.A., Krantz M.J., Hiatt W.R. L-Carnitine plus cilostazol versus cilostazol alone for the treatment of claudication in patients with peripheral artery disease: a multicenter, randomized, double-blind, placebo-controlled trial. Vasc Med 2012, 17(3):145-154.
    • (2012) Vasc Med , vol.17 , Issue.3 , pp. 145-154
    • Golderberg, N.A.1    Krantz, M.J.2    Hiatt, W.R.3
  • 25
    • 0023905696 scopus 로고
    • Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study
    • Brevetti G., Chiarello M., Ferulano G., et al. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Circulation 1988, 77(4):767-773.
    • (1988) Circulation , vol.77 , Issue.4 , pp. 767-773
    • Brevetti, G.1    Chiarello, M.2    Ferulano, G.3
  • 26
    • 0026516893 scopus 로고
    • Superiority of L-propionylcarnitine vs. L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study
    • Brevetti G., Perna S., Sabba C., et al. Superiority of L-propionylcarnitine vs. L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. Eur Heart J 1992, 13(2):251-255.
    • (1992) Eur Heart J , vol.13 , Issue.2 , pp. 251-255
    • Brevetti, G.1    Perna, S.2    Sabba, C.3
  • 27
    • 33747885680 scopus 로고    scopus 로고
    • Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment
    • Loffredo L., Pignatelli P., Cangemi R., et al. Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment. JVasc Surg 2006, 44(3):525-530.
    • (2006) JVasc Surg , vol.44 , Issue.3 , pp. 525-530
    • Loffredo, L.1    Pignatelli, P.2    Cangemi, R.3
  • 28
    • 0031443202 scopus 로고    scopus 로고
    • Carnitine and its derivatives in cardiovascular disease
    • Arsenian M.A. Carnitine and its derivatives in cardiovascular disease. Prog Cardiovasc Dis 1997, 40(3):265-286.
    • (1997) Prog Cardiovasc Dis , vol.40 , Issue.3 , pp. 265-286
    • Arsenian, M.A.1
  • 29
    • 10644229056 scopus 로고    scopus 로고
    • Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism
    • Rebouche C.J. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Ann N Y Acad Sci 2004, 1033:30-41.
    • (2004) Ann N Y Acad Sci , vol.1033 , pp. 30-41
    • Rebouche, C.J.1
  • 30
    • 0029035063 scopus 로고
    • Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients
    • Brass E.P. Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients. Clin Ther 1995, 17(2):176-185.
    • (1995) Clin Ther , vol.17 , Issue.2 , pp. 176-185
    • Brass, E.P.1
  • 31
    • 0012738864 scopus 로고    scopus 로고
    • Pharmacokinetics of L-carnitine
    • Evans A.M., Fornasini G. Pharmacokinetics of L-carnitine. Clin Pharm 2003, 42(11):941-967.
    • (2003) Clin Pharm , vol.42 , Issue.11 , pp. 941-967
    • Evans, A.M.1    Fornasini, G.2
  • 32
    • 10644296223 scopus 로고    scopus 로고
    • Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review
    • Ferrari R., Merli E., Cicchitelli G., Mele D., Fucili A., Ceconi C. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Ann N Y Acad Sci 2004, 1033:79-91.
    • (2004) Ann N Y Acad Sci , vol.1033 , pp. 79-91
    • Ferrari, R.1    Merli, E.2    Cicchitelli, G.3    Mele, D.4    Fucili, A.5    Ceconi, C.6
  • 33
    • 0033729907 scopus 로고    scopus 로고
    • Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsoprtion
    • Pace S., Longo A., Toon S., Rolan P., Evans A.M. Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsoprtion. Br J Clin Pharmacol 2000, 50(5):441-448.
    • (2000) Br J Clin Pharmacol , vol.50 , Issue.5 , pp. 441-448
    • Pace, S.1    Longo, A.2    Toon, S.3    Rolan, P.4    Evans, A.M.5


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