Effects of propionyl-L-carnitine on peripheral arterial obliterative disease of the lower limbs: A double-blind clinical trial

Drugs under Experimental and Clinical Research

Volumn 25, Issue 1, 1999, Pages 29-36

  Dal Lago, A ^a   De Martini, D ^a   Flore, R ^a   Gaetani, E ^a   Gasbarrini, A ^a   Gerardino, L ^a   Pola, R ^a   Santoliquido, A ^a   Serricchio, M ^a   Tondi, P ^a   Nolfe, G ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE DERIVATIVE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROPIONYLCARNITINE; REAGENT; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BLOOD FILTRATION; BLOOD FLOW VELOCITY; BLOOD VISCOSITY; CLAUDICATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPPLER FLOWMETRY; DOUBLE BLIND PROCEDURE; ERYTHROCYTE DEFORMABILITY; FEMALE; HEMATOCRIT; HUMAN; LEG DISEASE; MALE; ORAL DRUG ADMINISTRATION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHYSICAL EXAMINATION; RANDOMIZED CONTROLLED TRIAL; SPECTROMETER; TREADMILL; VISCOMETER;

ADULT; AGED; ARTERIAL OCCLUSIVE DISEASES; CARDIOTONIC AGENTS; CARNITINE; DOUBLE-BLIND METHOD; EXERCISE TEST; FEMALE; HUMANS; INTERMITTENT CLAUDICATION; LEG; MALE; MIDDLE AGED; PLACEBOS;

EID: 0032931592     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Brenner J. Carnitine - metabolism and function. Physiol. Rev., 63, 1420, 1983.
2. Fritz I.B., Arrigoni-Martelli E. Sites of action of carnitine and its derivatives on the cardiovascular system. T.I.P.S., 14, 355, 1993.
3. De Jong J.W., Ferrari R. (Eds.). "The Carnitine System: A New Therapeutical Approach To Cardiovascular Diseases". Kluwer Academic Publishers, The Netherlands, 1995.
4. Cevese A., Schena F., Poltronieri R., Cerutti G. Short-term effects of intra-arterial propionyl-l-carnitine on isolated canine hindlimbs. Cardioscience, 6, 59, 1995.
5. Bertelli A., Giovannini L., Galmozzi G., Bertelli A.A.E. Protective role of propionyl-carnitine in vascular disorders experimentally induced by endothelin (ET-1) and K-carrageenin. Drugs Exptl. Clin. Res., XIX(1), 7, 1993.
6. Bertelli A., Bertelli A.A.E., Galmozzi G., Giovannini L., Mian M. Thrombosis induced by endothelin (ET-1) and carrageenin in rats treated with endomethacin and propionyl-carnitine. Drugs Exptl. Clin. Res., XIX (2), 75, 1993.
7. Corsico N., Nardone A., Lucreziotti M.R., et al. Effect of propionyl-l-carnitine in a rat model of peripheral arteriopathy: a functional histologic and NMR spectroscopy study. Cardiovasc. Drugs Ther., 7, 241, 1993.
8. Pola P., Flore R., Tondi P. Rheological activity of propionyl-l-carnitine. Drugs Exptl. Clin. Res., XVII (3), 191, 1991.
9. Pola P., Flore R., Serricchio M., Tondi P. New carnitine derivatives for the therapy of cutaneous ulcers in vasculopathics. Drugs Exptl. Clin. Res., XVII (5), 275, 1991.
10. Pola P., De Martini D., Gerardino L., De Rossi S., Tondi P. The action of propionyl-l-carnitine on the vasal endothelium: increased tPA synthesis and decrease in the activity of PAI-1. A preliminary study. Drugs Exptl. Clin. Res., XVIII, 343, 1992.
11. Brevetti G., Perna S., Sabbà C., et al. Superiority of L-propionyl-carnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. Eur. Heart J., 13, 251, 1992.
12. Corsi C., Pollastri M., Marrapodi E., Leanza D., Giordano S., D'lddio S. L-propionyl-carnitine effect on post-exercise and post-ischemic hyperemia in patients affected by peripheral vascular disease. Angiology, 8, 705, 1995.
13. Bolognesi M., Amodio P., Merkel C., Godi L, Gatta A. Effect of 8-day therapy with propionyl-l-carnitine on muscular and subcutaneous blood flow of the lower limbs in patients with peripheral arterial disease. Clin, Phys., 15, 417, 1995.
14. Coto V., D'Alessandro L., Grattarola G., et al. Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentric controlled study vs placebo. Drugs Exptl. Clin. Res., XVIII(1), 9, 1992.
15. 99mTc-Mibi leg scintigraphy during propionyl-l-carnitine administration in patients with peripheral arterial obstructive disease. J. Nucl. Biol. Med., 38 (2), 186, 1994.
16. Pocock S.J. (Ed.). "Clinical Trials: A Practical Approach". J. Wiley & Sons, New York, 1985.
17. Reid H.L., Barnes A.J., Lock P.J., Dormandy J.A., Dormandy A.G. A simple method for measuring erythrocyte deformability. J. Clin. Pathol., 29, 855, 1976.