A rapid alternative to X-ray crystallography for chiral determination: Case studies of vibrational circular dichroism (VCD) to advance drug discovery projects

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4019-4025

  Wesolowski, Steven S ^a   Pivonka, Don E ^b  

^a ASTRAZENECA   (United Kingdom)

^b Drug Metabolism Pharmacokinetics Clinical Pharmacology   (United States)

Author keywords

Candidate drugs; Chirality; Stereochemistry; Vibrational circular dichroism

Indexed keywords

AZD 2624; AZD 6765; HISTAMINE H3 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; NEUROKININ 3 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANTIDEPRESSANT ACTIVITY; CHIRALITY; CIRCULAR DICHROISM; DRUG DETERMINATION; HIGH THROUGHPUT SCREENING; QUANTUM MECHANICS; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINOQUINOLINES; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; N-METHYLASPARTATE; PHARMACEUTICAL PREPARATIONS; RECEPTORS, HISTAMINE H3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84879409277     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.005     Document Type: Review

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