Vibrational Circular dichroism (VCD) chiral assignment of atropisomers: Application to γ-aminobutyric acid (GABA) modulators designed as potential anxiolytic drugs

Applied Spectroscopy

Volumn 67, Issue 4, 2013, Pages 365-370

  Pivonka, Don E ^a,b   Wesolowski, Steven S ^a  

^a ASTRAZENECA   (United Kingdom)

^b Drug Metabolism Pharmacokinetics Clinical Pharmacology   (United States)

Author keywords

Atropisomer; Computational chemistry; Infrared spectroscopy; Vibrational circular dichroism

Indexed keywords

AMINOBUTYRIC ACIDS; ATROPISOMERS; AXIAL CHIRALITY; INTERCONVERSIONS; MECHANICS SIMULATIONS; RESTRICTED ROTATIONS; VIBRATIONAL CIRCULAR DICHROISM; VIBRATIONAL CIRCULAR DICHROISM SPECTROSCOPY;

CHIRALITY; COMPUTATIONAL CHEMISTRY; DICHROISM; INFRARED SPECTROSCOPY; QUANTUM THEORY;

AMINO ACIDS;

4 AMINOBUTYRIC ACID; ANXIOLYTIC AGENT;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; CIRCULAR DICHROISM; COMPUTER SIMULATION; DRUG DEVELOPMENT; KINETICS; METHODOLOGY; QUANTUM THEORY; STEREOISOMERISM;

ANTI-ANXIETY AGENTS; CIRCULAR DICHROISM; COMPUTER SIMULATION; DRUG DISCOVERY; GAMMA-AMINOBUTYRIC ACID; KINETICS; MODELS, CHEMICAL; QUANTUM THEORY; STEREOISOMERISM;

EID: 84877004854     PISSN: 00037028     EISSN: 19433530     Source Type: Journal    
DOI: 10.1366/12-06934     Document Type: Article

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