Synthesis and SAR of sulfoxide substituted carboxyquinolines as NK3 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1896-1899

  Xiong, Hui ^a   Kang, James ^a   Woods, James M ^a   McCauley Jr , John P ^a   Koether, Gerard M ^a   Albert, Jeffrey S ^a   Hinkley, Lindsay ^a   Li, Yan ^a   Gadient, Reto A ^a   Simpson, Thomas R ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Carboxyquinolines; Neurokinins; NK3 receptor antagonists; Sulfoxides

Indexed keywords

ALKYLSULFOXIDE; CARBOXYQUINOLINE DERIVATIVE; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR ANTAGONIST; OSANETANT; QUINOLINE DERIVATIVE; SULFOXIDE; TALENTANT; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GERBIL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; GERBILLINAE; MOTOR ACTIVITY; QUINOLINES; RECEPTORS, NEUROKININ-3; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOXIDES;

GERBILLINAE;

EID: 79952362368     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.003     Document Type: Article

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