TGF-β1 conjugated to gold nanoparticles results in protein conformational changes and attenuates the biological function

Small

Volumn 9, Issue 12, 2013, Pages 2119-2128

  Tsai, Yuh Shyan ^a   Chen, Yu Hung ^a   Cheng, Pai Chiao ^a   Tsai, Hsin Tzu ^a   Shiau, Ai Li ^a   Tzai, Tzong Shin ^a   Wu, Chao Liang ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

cancer therapy; conformational changes; gold nanoparticles; transforming growth factor 1

Indexed keywords

CANCER THERAPY; CONFORMATIONAL CHANGE; EPITHELIAL-MESENCHYMAL TRANSITION; GOLD NANOPARTICLES; IMMUNOSUPPRESSIVE AGENT; PROTEIN CONFORMATIONAL CHANGES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTORS;

AMINO ACIDS; BIOCOMPATIBILITY; BODY FLUIDS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GOLD; MAMMALS; METAL NANOPARTICLES; PHOTOELECTRONS; T-CELLS; TUMORS; X RAY PHOTOELECTRON SPECTROSCOPY;

PROTEINS;

MURINAE; MUS;

GOLD; INTERLEUKIN 10; METAL NANOPARTICLE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; ELECTROPHORESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; IMMUNOHISTOCHEMISTRY; INFRARED SPECTROSCOPY; METABOLISM; MOUSE; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; WESTERN BLOTTING; X RAY PHOTOELECTRON SPECTROSCOPY; DRUG EFFECTS;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; ELECTROPHORESIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GOLD; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; METAL NANOPARTICLES; MICE; PHOTOELECTRON SPECTROSCOPY; PROTEIN CONFORMATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84879374668     PISSN: 16136810     EISSN: 16136829     Source Type: Journal    
DOI: 10.1002/smll.201202755     Document Type: Article

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