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Volumn 4, Issue 4, 2012, Pages 302-309

In silico investigation and structural characterization of virulent factor and a metallo peptidase present in Helicobacter pylori strain J99

Author keywords

drug target; gastric cancer; genomics and proteomics; Helicobacter. pylori J99; metallo peptidase; subtractive study; VacA

Indexed keywords

HELICOBACTER; HELICOBACTER PYLORI;

EID: 84879350365     PISSN: 19132751     EISSN: 18671462     Source Type: Journal    
DOI: 10.1007/s12539-012-0145-6     Document Type: Article
Times cited : (2)

References (46)
  • 1
    • 0029059733 scopus 로고
    • Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration
    • Atherton, J. C., Cao, P., Peek, R. M., Tummuru, M. K., Blaser, M. J., Cover, T. L. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270, 17771-17777.
    • (1995) J Biol Chem , vol.270 , pp. 17771-17777
    • Atherton, J.C.1    Cao, P.2    Peek, R.M.3    Tummuru, M.K.4    Blaser, M.J.5    Cover, T.L.6
  • 2
    • 84883263582 scopus 로고    scopus 로고
    • In silico identification of potential therapeutic targets in Clostridium botulinum
    • Bhasin, M., Garg, A., G. P. S. 2005. In silico identification of potential therapeutic targets in Clostridium botulinum. Int J Bioinform Res 2, 2010-2015.
    • (2005) Int J Bioinform Res , vol.2 , pp. 2010-2015
    • Bhasin, M.1    Garg, A.2    Garg, G.P.S.3
  • 3
    • 0027749278 scopus 로고
    • Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens
    • Borén, T., Falk, P., Roth, K. A., Larson, G., Normark, S. 1993. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 262, 1892-1895.
    • (1993) Science , vol.262 , pp. 1892-1895
    • Borén, T.1    Falk, P.2    Roth, K.A.3    Larson, G.4    Normark, S.5
  • 8
    • 15944418287 scopus 로고    scopus 로고
    • Helicobacter pylori VacA, a paradigm for toxin multifuntionality
    • Cover, T. L., Blanke, S. R. 2005. Helicobacter pylori VacA, a paradigm for toxin multifuntionality. Nat Rev Microbiol 3, 320-332.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 320-332
    • Cover, T.L.1    Blanke, S.R.2
  • 9
    • 0028308711 scopus 로고
    • Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
    • Cover, T. L., Tummuru, M. K., Cao, P., Thompson, S. A., Blaser, M. J. 1994. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 269, 10566-10573.
    • (1994) J Biol Chem , vol.269 , pp. 10566-10573
    • Cover, T.L.1    Tummuru, M.K.2    Cao, P.3    Thompson, S.A.4    Blaser, M.J.5
  • 10
    • 0033515072 scopus 로고    scopus 로고
    • The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH
    • Czajkowsky, D. M., Iwamoto, H., Cover, T. L., Shao, Z. F. 1999. The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH. Proc Natl Acad Sci USA 96, 2001-2006.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2001-2006
    • Czajkowsky, D.M.1    Iwamoto, H.2    Cover, T.L.3    Shao, Z.F.4
  • 12
    • 33745202607 scopus 로고    scopus 로고
    • In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori
    • Dutta, A., Singh, S. K., Ghosh, P., Mukherjee, R., Mitter, S., Bandyopadhyay, D. 2006. In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori. In silico Biology 6, 0005.
    • (2006) In Silico Biology , vol.6 , pp. 0005
    • Dutta, A.1    Singh, S.K.2    Ghosh, P.3    Mukherjee, R.4    Mitter, S.5    Bandyopadhyay, D.6
  • 13
    • 0033807944 scopus 로고    scopus 로고
    • Recent developments in the epidemiology of Helicobacter pylori
    • Everhart, J. E. 2000. Recent developments in the epidemiology of Helicobacter pylori. Gastroenterol Clin North Am 29, 559-578.
    • (2000) Gastroenterol Clin North Am , vol.29 , pp. 559-578
    • Everhart, J.E.1
  • 15
    • 0032728399 scopus 로고    scopus 로고
    • Searching for drug targets in microbial genomes
    • Galperin, M. Y., Koonin, E. V. 1999. Searching for drug targets in microbial genomes. Curr Opin Biotechnol 10, 571-578.
    • (1999) Curr Opin Biotechnol , vol.10 , pp. 571-578
    • Galperin, M.Y.1    Koonin, E.V.2
  • 17
    • 0031473847 scopus 로고    scopus 로고
    • SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling
    • Guex, N., Peitsch, M. C. 1997. SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling. Electrophoresis 18, 2714-2723.
    • (1997) Electrophoresis , vol.18 , pp. 2714-2723
    • Guex, N.1    Peitsch, M.C.2
  • 18
    • 70449096096 scopus 로고    scopus 로고
    • Helicobacter pylori and gastric adenocarcinoma
    • Herrera, V., Parsonnet, J. 2009. Helicobacter pylori and gastric adenocarcinoma. Clin Microbiol Infect 15, 971-976.
    • (2009) Clin Microbiol Infect , vol.15 , pp. 971-976
    • Herrera, V.1    Parsonnet, J.2
  • 19
    • 77953152285 scopus 로고    scopus 로고
    • Epidemiology of gastrointestinal and liver tumors
    • Herszényi, L., Tulassay, Z. 2010. Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci 14, 249-258.
    • (2010) Eur Rev Med Pharmacol Sci , vol.14 , pp. 249-258
    • Herszényi, L.1    Tulassay, Z.2
  • 21
    • 67849118788 scopus 로고    scopus 로고
    • Web server to infer homology between proteins using sequence and structural similarity
    • Kim, B.-H., Cheng, H., Grishin, N. V., Hor, A. 2009. Web server to infer homology between proteins using sequence and structural similarity. Nucleic Acids Res 37, 532-538.
    • (2009) Nucleic Acids Res , vol.37 , pp. 532-538
    • Kim, B.-H.1    Cheng, H.2    Grishin, N.V.3    Hor, A.4
  • 22
    • 0000243829 scopus 로고
    • PROCHECK: A program to check the stereo chemical quality of protein structures
    • Laskowski, R. A., MacArthur, M. W., Moss, D. S., Thornton, J. M. 1993. PROCHECK: A program to check the stereo chemical quality of protein structures. J Appl Cryst 26, 283-291.
    • (1993) J Appl Cryst , vol.26 , pp. 283-291
    • Laskowski, R.A.1    MacArthur, M.W.2    Moss, D.S.3    Thornton, J.M.4
  • 23
    • 48449105393 scopus 로고    scopus 로고
    • The Rosetta Dock server for local protein protein docking
    • Lyskov, S., Gray, J. J. 2008. The Rosetta Dock server for local protein protein docking. Nucleic Acids Res 36, 233-238.
    • (2008) Nucleic Acids Res , vol.36 , pp. 233-238
    • Lyskov, S.1    Gray, J.J.2
  • 24
    • 0035374653 scopus 로고    scopus 로고
    • Living dangerously how Helicobacter pylori survives in the human stomach
    • Montecucco, C., Rappuoli, R. 2001. Living dangerously how Helicobacter pylori survives in the human stomach. Nat Rev Mol Cell Biol 2, 457-466.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 457-466
    • Montecucco, C.1    Rappuoli, R.2
  • 25
    • 0035158890 scopus 로고    scopus 로고
    • Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin
    • Nguyen, V. Q., Caprioli, R. M., Cover, T. L. 2001. Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin. Infect Immun 69, 543-546.
    • (2001) Infect Immun , vol.69 , pp. 543-546
    • Nguyen, V.Q.1    Caprioli, R.M.2    Cover, T.L.3
  • 26
    • 17344379177 scopus 로고    scopus 로고
    • Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion
    • Odenbreit, S., Puls, J., Sedlmaier, B., Gerland, E., Fischer, W., Hass, R. 2000. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287, 1497-1500.
    • (2000) Science , vol.287 , pp. 1497-1500
    • Odenbreit, S.1    Puls, J.2    Sedlmaier, B.3    Gerland, E.4    Fischer, W.5    Hass, R.6
  • 29
    • 0036370334 scopus 로고    scopus 로고
    • Helicobacter pylori and gastrointestinal tract adenocarcinomas
    • Peek, R. M. Jr., Blaser, M. J. 2002. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2, 28-37.
    • (2002) Nat Rev Cancer , vol.2 , pp. 28-37
    • Peek Jr., R.M.1    Blaser, M.J.2
  • 30
    • 0028280638 scopus 로고
    • Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori
    • Phadnis, S. H., Ilver, D., Janzon, L., Normark, S., Westblom, T. U. 1994. Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect Immun 62, 1557-1565.
    • (1994) Infect Immun , vol.62 , pp. 1557-1565
    • Phadnis, S.H.1    Ilver, D.2    Janzon, L.3    Normark, S.4    Westblom, T.U.5
  • 31
    • 39749152810 scopus 로고    scopus 로고
    • Preservation of protein clefts in comparative models
    • Piedra, D., Lois, S., De La Cruz, X. 2008. Preservation of protein clefts in comparative models. BMC Struct Biol 8, 2.
    • (2008) BMC Struct Biol , vol.8 , pp. 2
    • Piedra, D.1    Lois, S.2    De La Cruz, X.3
  • 32
    • 0035266309 scopus 로고    scopus 로고
    • Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation
    • Prinz, C., Schoniger, M., Rad, R., Becker, I., Keiditsch, E., Wagenpfeil, S., Classen, M., Rosch, T., Schepp, W., Gerhard, M. 2001. Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation. Cancer Res 61, 1903-1909.
    • (2001) Cancer Res , vol.61 , pp. 1903-1909
    • Prinz, C.1    Schoniger, M.2    Rad, R.3    Becker, I.4    Keiditsch, E.5    Wagenpfeil, S.6    Classen, M.7    Rosch, T.8    Schepp, W.9    Gerhard, M.10
  • 34
    • 84883276103 scopus 로고    scopus 로고
    • Identification of potential targets and lead molecules for designing inhibitory drugs against Chlamydophila pneumonia
    • Reddy, E. H., Satpathy, G. R. 2009. Identification of potential targets and lead molecules for designing inhibitory drugs against Chlamydophila pneumonia. Online Journal of Bioinformatics 10, 14-28.
    • (2009) Online Journal of Bioinformatics , vol.10 , pp. 14-28
    • Reddy, E.H.1    Satpathy, G.R.2
  • 35
    • 10044239624 scopus 로고    scopus 로고
    • A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa
    • Sakharkar, K. R., Sakharkar, M. K., Chow, V. T. K. 2004. A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. In silico Biol 4, 0028.
    • (2004) In Silico Biol , vol.4 , pp. 0028
    • Sakharkar, K.R.1    Sakharkar, M.K.2    Chow, V.T.K.3
  • 36
    • 34547771792 scopus 로고    scopus 로고
    • Predictive oncology multidisciplinary, multi-scale in silico modeling linking phenotype, morphology and growth
    • Sanga, S., Frieboes, H. B., Zheng, X., Gatenby, R., Bearer, E. L., Cristini, V. 2007. Predictive oncology multidisciplinary, multi-scale in silico modeling linking phenotype, morphology and growth. Neuroimage 37, 120-134.
    • (2007) Neuroimage , vol.37 , pp. 120-134
    • Sanga, S.1    Frieboes, H.B.2    Zheng, X.3    Gatenby, R.4    Bearer, E.L.5    Cristini, V.6
  • 37
    • 79953848872 scopus 로고    scopus 로고
    • Subtractive genomics approach for in silico identification and characterization of novel drug targets in Neisseria Meningitides Serogroup B
    • Sarangi, A. N., Aggarwal, R., Rahman, Q., Trivedi, N. 2009. Subtractive genomics approach for in silico identification and characterization of novel drug targets in Neisseria Meningitides Serogroup B. J Comput Sci Syst Biol 2, 255-258.
    • (2009) J Comput Sci Syst Biol , vol.2 , pp. 255-258
    • Sarangi, A.N.1    Aggarwal, R.2    Rahman, Q.3    Trivedi, N.4
  • 38
    • 0028365481 scopus 로고
    • Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: Structural similarities with IgA protease type of exported protein
    • Schmitt, W., Haas, R. 1994. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: Structural similarities with IgA protease type of exported protein. Mol Microbiol 12, 307-319.
    • (1994) Mol Microbiol , vol.12 , pp. 307-319
    • Schmitt, W.1    Haas, R.2
  • 39
    • 0032563331 scopus 로고    scopus 로고
    • Vacuolation induced by cytotoxin from Helicobacter pylori is mediated by EGF receptor in HeLa cells
    • Seto, K., Hayashi-Kuwabara, Y., Yoneta, T., Suda, H., Tamaki, H. 1998. Vacuolation induced by cytotoxin from Helicobacter pylori is mediated by EGF receptor in HeLa cells. FEBS Lett 431, 347-350.
    • (1998) FEBS Lett , vol.431 , pp. 347-350
    • Seto, K.1    Hayashi-Kuwabara, Y.2    Yoneta, T.3    Suda, H.4    Tamaki, H.5
  • 41
    • 0027230726 scopus 로고
    • Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production
    • Tummuru, M. K., Cover, T. L., Blaser, M. J. 1993. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production. Infect Immun 61, 1799-1809.
    • (1993) Infect Immun , vol.61 , pp. 1799-1809
    • Tummuru, M.K.1    Cover, T.L.2    Blaser, M.J.3
  • 44
    • 0038583687 scopus 로고    scopus 로고
    • Protein-protein docking with a reduced protein model accounting for side-chain flexibility
    • Zachairias, M. 2003. Protein-protein docking with a reduced protein model accounting for side-chain flexibility. Protein Sci 12, 1271-1282.
    • (2003) Protein Sci , vol.12 , pp. 1271-1282
    • Zachairias, M.1
  • 45
    • 0033188147 scopus 로고    scopus 로고
    • Molecular response of gastric epithelial cells to Helicobacter pyloriinduced cell damage
    • Zarrilli, R., Ricci, V., Romano, M. 1999. Molecular response of gastric epithelial cells to Helicobacter pyloriinduced cell damage. Cell Microbiol 1, 93-99.
    • (1999) Cell Microbiol , vol.1 , pp. 93-99
    • Zarrilli, R.1    Ricci, V.2    Romano, M.3
  • 46
    • 0346494858 scopus 로고    scopus 로고
    • DEG: A database of essential genes
    • Zhang, R., Ou, H. Y., Zhang, C. T. 2004. DEG: A database of essential genes. Nucl Acid Res 32, D271-D272.
    • (2004) Nucl Acid Res , vol.32
    • Zhang, R.1    Ou, H.Y.2    Zhang, C.T.3


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