-
1
-
-
38949203861
-
Contributions of microorganisms to industrial biology
-
Demain A.L., and Adrio J.L. Contributions of microorganisms to industrial biology. Mol Biotechnol 38 (2008) 41-55
-
(2008)
Mol Biotechnol
, vol.38
, pp. 41-55
-
-
Demain, A.L.1
Adrio, J.L.2
-
2
-
-
0025895183
-
Toward a science of metabolic engineering
-
Bailey J.E. Toward a science of metabolic engineering. Science 252 (1991) 1668-1675
-
(1991)
Science
, vol.252
, pp. 1668-1675
-
-
Bailey, J.E.1
-
3
-
-
0035209901
-
Metabolic engineering for microbial production of aromatic amino acids and derived compounds
-
Bongaerts J., Kramer M., Muller U., Raeven L., and Wubbolts M. Metabolic engineering for microbial production of aromatic amino acids and derived compounds. Metab Eng 3 (2001) 289-300
-
(2001)
Metab Eng
, vol.3
, pp. 289-300
-
-
Bongaerts, J.1
Kramer, M.2
Muller, U.3
Raeven, L.4
Wubbolts, M.5
-
4
-
-
45149111660
-
The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli
-
An excellent review of strategies and methods currently used in the development for genome-scale redesign and engineering of metabolic networks with E. coli as the model.
-
Feist A.M., and Palsson B.O. The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli. Nat Biotechnol 26 (2008) 659-667. An excellent review of strategies and methods currently used in the development for genome-scale redesign and engineering of metabolic networks with E. coli as the model.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 659-667
-
-
Feist, A.M.1
Palsson, B.O.2
-
5
-
-
28544451327
-
Foundations for engineering biology
-
Endy D. Foundations for engineering biology. Nature 438 (2005) 449-453
-
(2005)
Nature
, vol.438
, pp. 449-453
-
-
Endy, D.1
-
6
-
-
56749102636
-
Regulatory activity revealed by dynamic correlations in gene expression noise
-
Dunlop M.J., Cox R.S., Levine J.H., Murray R.M., and Elowitz M.B. Regulatory activity revealed by dynamic correlations in gene expression noise. Nat Genet 40 (2008) 1493-1498
-
(2008)
Nat Genet
, vol.40
, pp. 1493-1498
-
-
Dunlop, M.J.1
Cox, R.S.2
Levine, J.H.3
Murray, R.M.4
Elowitz, M.B.5
-
7
-
-
28544440364
-
Reconstruction of genetic circuits
-
Sprinzak D., and Elowitz M.B. Reconstruction of genetic circuits. Nature 438 (2005) 443-448
-
(2005)
Nature
, vol.438
, pp. 443-448
-
-
Sprinzak, D.1
Elowitz, M.B.2
-
9
-
-
17844374314
-
A synthetic multicellular system for programmed pattern formation
-
Basu S., Gerchman Y., Collins C.H., Arnold F.H., and Weiss R. A synthetic multicellular system for programmed pattern formation. Nature 434 (2005) 1130-1134
-
(2005)
Nature
, vol.434
, pp. 1130-1134
-
-
Basu, S.1
Gerchman, Y.2
Collins, C.H.3
Arnold, F.H.4
Weiss, R.5
-
10
-
-
36849005857
-
Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium
-
Brenner K., Karig D.K., Weiss R., and Arnold F.H. Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium. Proc Natl Acad Sci U S A 104 (2007) 17300-17304
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 17300-17304
-
-
Brenner, K.1
Karig, D.K.2
Weiss, R.3
Arnold, F.H.4
-
11
-
-
66249088017
-
The second wave of synthetic biology: from modules to systems
-
A comprehensive review about the goals and approaches of synthetic biology as well as a crucial discussion and reflection on questions, challenges, and future quests of synthetic biology.
-
Purnick P.E.M., and Weiss R. The second wave of synthetic biology: from modules to systems. Nat Rev Mol Cell Biol 10 (2009) 410-422. A comprehensive review about the goals and approaches of synthetic biology as well as a crucial discussion and reflection on questions, challenges, and future quests of synthetic biology.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 410-422
-
-
Purnick, P.E.M.1
Weiss, R.2
-
12
-
-
34250304606
-
Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli
-
Katsuyama Y., Funa N., Miyahisa I., and Horinouchi S. Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli. Chem Biol 14 (2007) 613-621
-
(2007)
Chem Biol
, vol.14
, pp. 613-621
-
-
Katsuyama, Y.1
Funa, N.2
Miyahisa, I.3
Horinouchi, S.4
-
13
-
-
33645779318
-
Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli
-
Watts K.T., Lee P.C., and Schmidt-Dannert C. Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli. BMC Biotechnol 6 (2006) 12
-
(2006)
BMC Biotechnol
, vol.6
, pp. 12
-
-
Watts, K.T.1
Lee, P.C.2
Schmidt-Dannert, C.3
-
14
-
-
0142200413
-
Biosynthesis of novel thermoplastic polythioesters by engineered Escherichia coli
-
Lutke-Eversloh T., Fischer A., Remminghorst U., Kawada J., Marchessault R.H., Bogershausen A., Kalwei M., Eckert H., Reichelt R., Liu S.-J., et al. Biosynthesis of novel thermoplastic polythioesters by engineered Escherichia coli. Nat Mater 1 (2002) 236-240
-
(2002)
Nat Mater
, vol.1
, pp. 236-240
-
-
Lutke-Eversloh, T.1
Fischer, A.2
Remminghorst, U.3
Kawada, J.4
Marchessault, R.H.5
Bogershausen, A.6
Kalwei, M.7
Eckert, H.8
Reichelt, R.9
Liu, S.-J.10
-
15
-
-
49949088247
-
Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae
-
Hawkins K.M., and Smolke C.D. Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat Chem Biol 4 (2008) 564-573
-
(2008)
Nat Chem Biol
, vol.4
, pp. 564-573
-
-
Hawkins, K.M.1
Smolke, C.D.2
-
16
-
-
38049001166
-
Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
-
86-U13
-
Atsumi S., Hanai T., and Liao J.C. Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Nature 451 (2008) 86-U13
-
(2008)
Nature
, vol.451
-
-
Atsumi, S.1
Hanai, T.2
Liao, J.C.3
-
17
-
-
58549111802
-
Expanding metabolism for biosynthesis of nonnatural alcohols
-
A complex metabolic engineering approach, including engineering of enzyme activities, was used to reroute and augment the metabolic network of E. coli for the de novo production of unnatural alcohols as biofuels.
-
Zhang K.C., Sawaya M.R., Eisenberg D.S., and Liao J.C. Expanding metabolism for biosynthesis of nonnatural alcohols. Proc Natl Acad Sci U S A 105 (2008) 20653-20658. A complex metabolic engineering approach, including engineering of enzyme activities, was used to reroute and augment the metabolic network of E. coli for the de novo production of unnatural alcohols as biofuels.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 20653-20658
-
-
Zhang, K.C.1
Sawaya, M.R.2
Eisenberg, D.S.3
Liao, J.C.4
-
20
-
-
34247182988
-
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s
-
Chang M.C.Y., Eachus R.A., Trieu W., Ro D.K., and Keasling J.D. Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol 3 (2007) 274-277
-
(2007)
Nat Chem Biol
, vol.3
, pp. 274-277
-
-
Chang, M.C.Y.1
Eachus, R.A.2
Trieu, W.3
Ro, D.K.4
Keasling, J.D.5
-
21
-
-
0038391517
-
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
-
Martin V.J.J., Pitera D.J., Withers S.T., Newman J.D., and Keasling J.D. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol 21 (2003) 796-802
-
(2003)
Nat Biotechnol
, vol.21
, pp. 796-802
-
-
Martin, V.J.J.1
Pitera, D.J.2
Withers, S.T.3
Newman, J.D.4
Keasling, J.D.5
-
22
-
-
44249111668
-
Application of functional genomics to pathway optimization for increased isoprenoid production
-
Kizer L., Pitera D.J., Pfleger B.F., and Keasling J.D. Application of functional genomics to pathway optimization for increased isoprenoid production. Appl Environ Microbiol 74 (2008) 3229-3241
-
(2008)
Appl Environ Microbiol
, vol.74
, pp. 3229-3241
-
-
Kizer, L.1
Pitera, D.J.2
Pfleger, B.F.3
Keasling, J.D.4
-
23
-
-
33847309176
-
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli
-
Pitera D.J., Paddon C.J., Newman J.D., and Keasling J.D. Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab Eng 9 (2007) 193-207
-
(2007)
Metab Eng
, vol.9
, pp. 193-207
-
-
Pitera, D.J.1
Paddon, C.J.2
Newman, J.D.3
Keasling, J.D.4
-
24
-
-
44949201614
-
Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways
-
Yoshikuni Y., Dietrich J.A., Nowroozi F.F., Babbitt P.C., and Keasling J.D. Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways. Chem Biol 15 (2008) 607-618
-
(2008)
Chem Biol
, vol.15
, pp. 607-618
-
-
Yoshikuni, Y.1
Dietrich, J.A.2
Nowroozi, F.F.3
Babbitt, P.C.4
Keasling, J.D.5
-
25
-
-
68449088806
-
Synthetic protein scaffolds provide modular control over metabolic flux
-
This paper describes the first example of a designed protein scaffold for the creation of recombinant, metabolic multi-enzyme complexes. Results show that effective substrate channeling can have a dramatic impact on the flux of a metabolic pathway.
-
Dueber J.E., Wu G.C., Malmirchegini G.R., Moon T.S., Petzold C.J., Ullal A.V., Prather K.L.J., and Keasling J.D. Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol 27 (2009) 753-759. This paper describes the first example of a designed protein scaffold for the creation of recombinant, metabolic multi-enzyme complexes. Results show that effective substrate channeling can have a dramatic impact on the flux of a metabolic pathway.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 753-759
-
-
Dueber, J.E.1
Wu, G.C.2
Malmirchegini, G.R.3
Moon, T.S.4
Petzold, C.J.5
Ullal, A.V.6
Prather, K.L.J.7
Keasling, J.D.8
-
26
-
-
22844452835
-
Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets
-
Alper H., Miyaoku K., and Stephanopoulos G. Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets. Nat Biotechnol 23 (2005) 612-616
-
(2005)
Nat Biotechnol
, vol.23
, pp. 612-616
-
-
Alper, H.1
Miyaoku, K.2
Stephanopoulos, G.3
-
27
-
-
34547109364
-
Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli
-
Jin Y.S., and Stephanopoulos G. Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metab Eng (2007)
-
(2007)
Metab Eng
-
-
Jin, Y.S.1
Stephanopoulos, G.2
-
28
-
-
68949161807
-
Programming cells by multiplex genome engineering and accelerated evolution
-
894-U133
-
Wang H.H., Isaacs F.J., Carr P.A., Sun Z.Z., Xu G., Forest C.R., and Church G.M. Programming cells by multiplex genome engineering and accelerated evolution. Nature 460 (2009) 894-U133
-
(2009)
Nature
, vol.460
-
-
Wang, H.H.1
Isaacs, F.J.2
Carr, P.A.3
Sun, Z.Z.4
Xu, G.5
Forest, C.R.6
Church, G.M.7
-
29
-
-
70349324305
-
Creating bacterial strains from genomes that have been cloned and engineered in yeast
-
This work represents the extension of previous work on the assembly of a bacterial genome in yeast. Here the authors designed the synthetic bacterial genomes such that they can be replicated, maintained, and manipulated in a yeast cell before transformation into recipient bacterial cells.
-
Lartigue C., Vashee S., Algire M.A., Chuang R.Y., Benders G.A., Ma L., Noskov V.N., Denisova E.A., Gibson D.G., Assad-Garcia N., et al. Creating bacterial strains from genomes that have been cloned and engineered in yeast. Science 325 (2009) 1693-1696. This work represents the extension of previous work on the assembly of a bacterial genome in yeast. Here the authors designed the synthetic bacterial genomes such that they can be replicated, maintained, and manipulated in a yeast cell before transformation into recipient bacterial cells.
-
(2009)
Science
, vol.325
, pp. 1693-1696
-
-
Lartigue, C.1
Vashee, S.2
Algire, M.A.3
Chuang, R.Y.4
Benders, G.A.5
Ma, L.6
Noskov, V.N.7
Denisova, E.A.8
Gibson, D.G.9
Assad-Garcia, N.10
-
30
-
-
39449112551
-
Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome
-
Gibson D.G., Benders G.A., Andrews-Pfannkoch C., Denisova E.A., Baden-Tillson H., Zaveri J., Stockwell T.B., Brownley A., Thomas D.W., Algire M.A., et al. Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome. Science 319 (2008) 1215-1220
-
(2008)
Science
, vol.319
, pp. 1215-1220
-
-
Gibson, D.G.1
Benders, G.A.2
Andrews-Pfannkoch, C.3
Denisova, E.A.4
Baden-Tillson, H.5
Zaveri, J.6
Stockwell, T.B.7
Brownley, A.8
Thomas, D.W.9
Algire, M.A.10
-
31
-
-
67650685038
-
Biosynthesis and biotechnological production of flavanones: current state and perspectives
-
Fowler Z.L., and Koffas M.A.G. Biosynthesis and biotechnological production of flavanones: current state and perspectives. Appl Microbiol Biotechnol 83 (2009) 799-808
-
(2009)
Appl Microbiol Biotechnol
, vol.83
, pp. 799-808
-
-
Fowler, Z.L.1
Koffas, M.A.G.2
-
32
-
-
0029310653
-
Combinatorial biosynthesis of unnatural natural-products-the polyketide example
-
Tsoi C.J., and Khosla C. Combinatorial biosynthesis of unnatural natural-products-the polyketide example. Chem Biol 2 (1995) 355-362
-
(1995)
Chem Biol
, vol.2
, pp. 355-362
-
-
Tsoi, C.J.1
Khosla, C.2
-
33
-
-
33845709126
-
Molecular engineering approaches to peptide, polyketide and other antibiotics
-
Baltz R.H. Molecular engineering approaches to peptide, polyketide and other antibiotics. Nat Biotechnol 24 (2006) 1533-1540
-
(2006)
Nat Biotechnol
, vol.24
, pp. 1533-1540
-
-
Baltz, R.H.1
-
34
-
-
65349098181
-
Revisiting the modularity of modular polyketide synthases
-
Khosla C., Kapur S., and Cane D.E. Revisiting the modularity of modular polyketide synthases. Curr Opin Chem Biol 13 (2009) 135-143
-
(2009)
Curr Opin Chem Biol
, vol.13
, pp. 135-143
-
-
Khosla, C.1
Kapur, S.2
Cane, D.E.3
-
35
-
-
44049083124
-
Protein-protein interactions in multienzyme megasynthetases
-
Weissman K.J., and Muller R. Protein-protein interactions in multienzyme megasynthetases. ChemBioChem 9 (2008) 826-848
-
(2008)
ChemBioChem
, vol.9
, pp. 826-848
-
-
Weissman, K.J.1
Muller, R.2
-
36
-
-
65649123015
-
A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3)
-
Dietrich J.A., Yoshikuni Y., Fisher K.J., Woolard F.X., Ockey D., McPhee D.J., Renninger N.S., Chang M.C.Y., Baker D., and Keasling J.D. A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3). ACS Chem Biol 4 (2009) 261-267
-
(2009)
ACS Chem Biol
, vol.4
, pp. 261-267
-
-
Dietrich, J.A.1
Yoshikuni, Y.2
Fisher, K.J.3
Woolard, F.X.4
Ockey, D.5
McPhee, D.J.6
Renninger, N.S.7
Chang, M.C.Y.8
Baker, D.9
Keasling, J.D.10
-
37
-
-
0037562074
-
Biosynthesis of structurally novel carotenoids in Escherichia coli
-
Lee P.C., Momen A.Z.R., Mijts B.N., and Schmidt-Dannert C. Biosynthesis of structurally novel carotenoids in Escherichia coli. Chem Biol 10 (2003) 453-462
-
(2003)
Chem Biol
, vol.10
, pp. 453-462
-
-
Lee, P.C.1
Momen, A.Z.R.2
Mijts, B.N.3
Schmidt-Dannert, C.4
-
38
-
-
17844400062
-
Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution
-
Mijts B.N., Lee P.C., and Schmidt-Dannert C. Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution. Chem Biol 12 (2005) 453-460
-
(2005)
Chem Biol
, vol.12
, pp. 453-460
-
-
Mijts, B.N.1
Lee, P.C.2
Schmidt-Dannert, C.3
-
39
-
-
0033941389
-
Molecular breeding of carotenoid biosynthetic pathways
-
Schmidt-Dannert C., Umeno D., and Arnold F.H. Molecular breeding of carotenoid biosynthetic pathways. Nat Biotechnol 18 (2000) 750-753
-
(2000)
Nat Biotechnol
, vol.18
, pp. 750-753
-
-
Schmidt-Dannert, C.1
Umeno, D.2
Arnold, F.H.3
-
40
-
-
33645975530
-
Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways
-
Tobias A.V., and Arnold F.H. Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways. Biochim Biophys Acta Mol Cell Biol Lipids 1761 (2006) 235-246
-
(2006)
Biochim Biophys Acta Mol Cell Biol Lipids
, vol.1761
, pp. 235-246
-
-
Tobias, A.V.1
Arnold, F.H.2
-
41
-
-
41949101106
-
Optimizing glycosyltransferase specificity via "Hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization
-
Williams G.J., Goff R.D., Zhang C.S., and Thorson J.S. Optimizing glycosyltransferase specificity via "Hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization. Chem Biol 15 (2008) 393-401
-
(2008)
Chem Biol
, vol.15
, pp. 393-401
-
-
Williams, G.J.1
Goff, R.D.2
Zhang, C.S.3
Thorson, J.S.4
-
42
-
-
34548685673
-
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution
-
Williams G.J., Zhang C., and Thorson J.S. Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution. Nat Chem Biol 3 (2007) 657-662
-
(2007)
Nat Chem Biol
, vol.3
, pp. 657-662
-
-
Williams, G.J.1
Zhang, C.2
Thorson, J.S.3
-
43
-
-
34249019887
-
Cofactor regeneration for sustainable enzymatic biosynthesis
-
Liu W., and Wang P. Cofactor regeneration for sustainable enzymatic biosynthesis. Biotechnol Adv 25 (2007) 369-384
-
(2007)
Biotechnol Adv
, vol.25
, pp. 369-384
-
-
Liu, W.1
Wang, P.2
-
44
-
-
0034016755
-
In vitro ATP regeneration from polyphosphate and AMP by polyphosphate:AMP phosphotransferase and adenylate kinase from Acinetobacter johnsonii 210A
-
Resnick S.M., and Zehnder A.J.B. In vitro ATP regeneration from polyphosphate and AMP by polyphosphate:AMP phosphotransferase and adenylate kinase from Acinetobacter johnsonii 210A. Appl Environ Microbiol 66 (2000) 2045-2051
-
(2000)
Appl Environ Microbiol
, vol.66
, pp. 2045-2051
-
-
Resnick, S.M.1
Zehnder, A.J.B.2
-
45
-
-
0034927661
-
A novel ATP regeneration system using polyphosphate-AMP phosphotransferase and polyphosphate kinase
-
Kameda A., Shiba T., Kawazoe Y., Satoh Y., Ihara Y., Munekata M., Ishige K., and Noguchi T. A novel ATP regeneration system using polyphosphate-AMP phosphotransferase and polyphosphate kinase. J Biosci Bioeng 91 (2001) 557-563
-
(2001)
J Biosci Bioeng
, vol.91
, pp. 557-563
-
-
Kameda, A.1
Shiba, T.2
Kawazoe, Y.3
Satoh, Y.4
Ihara, Y.5
Munekata, M.6
Ishige, K.7
Noguchi, T.8
-
46
-
-
34547215445
-
An enzyme module system for in situ regeneration of deoxythymidine 5'-diphosphate (dTDP)-activated deoxy sugars
-
Rupprath C., Kopp M., Hirtz D., Mueller R., and Elling L. An enzyme module system for in situ regeneration of deoxythymidine 5'-diphosphate (dTDP)-activated deoxy sugars. Adv Synth Catal 349 (2007) 1489-1496
-
(2007)
Adv Synth Catal
, vol.349
, pp. 1489-1496
-
-
Rupprath, C.1
Kopp, M.2
Hirtz, D.3
Mueller, R.4
Elling, L.5
-
47
-
-
33747591649
-
Coimmobilization of a redox enzyme and a cofactor regeneration system
-
Betancor L., Berne C., Luckarift H.R., and Spain J.C. Coimmobilization of a redox enzyme and a cofactor regeneration system. Chem Commun (2006) 3640-3642
-
(2006)
Chem Commun
, pp. 3640-3642
-
-
Betancor, L.1
Berne, C.2
Luckarift, H.R.3
Spain, J.C.4
-
48
-
-
67549134374
-
A new regeneration system for oxidized nicotinamide cofactors
-
Aksu S., Arends I.W.C.E., and Hollmann F. A new regeneration system for oxidized nicotinamide cofactors. Adv Synth Catal 351 (2009) 1211-1216
-
(2009)
Adv Synth Catal
, vol.351
, pp. 1211-1216
-
-
Aksu, S.1
Arends, I.W.C.E.2
Hollmann, F.3
-
49
-
-
55049133052
-
Novel chemo-enzymatic mimic of hydrogen peroxide-forming NAD(P)H oxidase for efficient regeneration of NAD(+) and NADP(+)
-
Pival S.L., Klimacek M., and Nidetzky B. Novel chemo-enzymatic mimic of hydrogen peroxide-forming NAD(P)H oxidase for efficient regeneration of NAD(+) and NADP(+). Adv Synth Catal 350 (2008) 2305-2312
-
(2008)
Adv Synth Catal
, vol.350
, pp. 2305-2312
-
-
Pival, S.L.1
Klimacek, M.2
Nidetzky, B.3
-
50
-
-
0242607605
-
Cofactor regeneration of both NAD(+) from NADH and NADP(+) from NADPH: NADH oxidase from Lactobacillus sanfranciscensis
-
Riebel B.R., Gibbs P.R., Wellborn W.B., and Bommarius A.S. Cofactor regeneration of both NAD(+) from NADH and NADP(+) from NADPH: NADH oxidase from Lactobacillus sanfranciscensis. Adv Synth Catal 345 (2003) 707-712
-
(2003)
Adv Synth Catal
, vol.345
, pp. 707-712
-
-
Riebel, B.R.1
Gibbs, P.R.2
Wellborn, W.B.3
Bommarius, A.S.4
-
51
-
-
54249116802
-
Orchestration of concurrent oxidation and reduction cycles for stereoinversion and deracemisation of sec-alcohols
-
This is the first report of a concurrent enzymatic oxidation/reduction process involving opposite co-factor recycling systems. The authors are able to orchestrate four highly specific oxidoreductases to achieve deracemization and steroinversion of sec-alcohols.
-
Voss C.V., Gruber C.C., Faber K., Knaus T., Macheroux P., and Kroutil W. Orchestration of concurrent oxidation and reduction cycles for stereoinversion and deracemisation of sec-alcohols. J Am Chem Soc 130 (2008) 13969-13972. This is the first report of a concurrent enzymatic oxidation/reduction process involving opposite co-factor recycling systems. The authors are able to orchestrate four highly specific oxidoreductases to achieve deracemization and steroinversion of sec-alcohols.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 13969-13972
-
-
Voss, C.V.1
Gruber, C.C.2
Faber, K.3
Knaus, T.4
Macheroux, P.5
Kroutil, W.6
-
52
-
-
67549130333
-
One-pot multienzymatic synthesis of 12-ketoursodeoxycholic acid: subtle cofactor specificities rule the reaction equilibria of five biocatalysts working in a row
-
Monti D., Ferrandi E.E., Zanellato I., Hua L., Polentini F., Carrea G., and Riva S. One-pot multienzymatic synthesis of 12-ketoursodeoxycholic acid: subtle cofactor specificities rule the reaction equilibria of five biocatalysts working in a row. Adv Synth Catal 351 (2009) 1303-1311
-
(2009)
Adv Synth Catal
, vol.351
, pp. 1303-1311
-
-
Monti, D.1
Ferrandi, E.E.2
Zanellato, I.3
Hua, L.4
Polentini, F.5
Carrea, G.6
Riva, S.7
-
53
-
-
20544439844
-
The substrate spectrum of mandelate racemase: minimum structural requirements for substrates and substrate model
-
Felfer U., Goriup M., Koegl M.F., Wagner U., Larissegger-Schnell B., Faber K., and Kroutil W. The substrate spectrum of mandelate racemase: minimum structural requirements for substrates and substrate model. Adv Synth Catal 347 (2005) 951-961
-
(2005)
Adv Synth Catal
, vol.347
, pp. 951-961
-
-
Felfer, U.1
Goriup, M.2
Koegl, M.F.3
Wagner, U.4
Larissegger-Schnell, B.5
Faber, K.6
Kroutil, W.7
-
54
-
-
56749102605
-
Asymmetric synthesis of optically pure pharmacologically relevant amines employing omega-transaminases
-
Koszelewski D., Lavandera I., Clay D., Rozzel l, and Kroutil W. Asymmetric synthesis of optically pure pharmacologically relevant amines employing omega-transaminases. Adv Synth Catal 350 (2008) 2761-2766
-
(2008)
Adv Synth Catal
, vol.350
, pp. 2761-2766
-
-
Koszelewski, D.1
Lavandera, I.2
Clay, D.3
Rozzel l4
Kroutil, W.5
-
55
-
-
34547224693
-
Stereo-complementary two-step cascades using a two-enzyme system leading to enantiopure epoxides
-
Seisser B., Lavandera I., Faber K., Lutje Spelberg J.H., and Kroutil W. Stereo-complementary two-step cascades using a two-enzyme system leading to enantiopure epoxides. Adv Synth Catal 349 (2007) 1399-1404
-
(2007)
Adv Synth Catal
, vol.349
, pp. 1399-1404
-
-
Seisser, B.1
Lavandera, I.2
Faber, K.3
Lutje Spelberg, J.H.4
Kroutil, W.5
-
56
-
-
48249137414
-
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
-
Sattely E.S., Fischbach M.A., and Walsh C.T. Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Nat Prod Rep 25 (2008) 757-793
-
(2008)
Nat Prod Rep
, vol.25
, pp. 757-793
-
-
Sattely, E.S.1
Fischbach, M.A.2
Walsh, C.T.3
-
57
-
-
42049099494
-
Deconstruction of iterative multidomain polyketide synthase function
-
Crawford J.M., Thomas P.M., Scheerer J.R., Vagstad A.L., Kelleher N.L., and Townsend C.A. Deconstruction of iterative multidomain polyketide synthase function. Science 320 (2008) 243-246
-
(2008)
Science
, vol.320
, pp. 243-246
-
-
Crawford, J.M.1
Thomas, P.M.2
Scheerer, J.R.3
Vagstad, A.L.4
Kelleher, N.L.5
Townsend, C.A.6
-
58
-
-
0028521189
-
Genetically engineered synthesis of precorrin-6x and the complete corrinoid, hydrogenobyrinic acid, an advanced precursor of vitamin B12
-
Roessner C.A., Spencer J.B., Stolowich N.J., Wang J., Nayar G.P., Santander P.J., Pichon C., Min C., Holderman M.T., and Scott A.I. Genetically engineered synthesis of precorrin-6x and the complete corrinoid, hydrogenobyrinic acid, an advanced precursor of vitamin B12. Chem Biol 1 (1994) 119-124
-
(1994)
Chem Biol
, vol.1
, pp. 119-124
-
-
Roessner, C.A.1
Spencer, J.B.2
Stolowich, N.J.3
Wang, J.4
Nayar, G.P.5
Santander, P.J.6
Pichon, C.7
Min, C.8
Holderman, M.T.9
Scott, A.I.10
-
59
-
-
0242385433
-
Enzymatic synthesis of antithrombin III-binding heparan sulfate pentasaccharide
-
Kuberan B., Lech M.Z., Beeler D.L., Wu Z.L.L., and Rosenberg R.D. Enzymatic synthesis of antithrombin III-binding heparan sulfate pentasaccharide. Nat Biotechnol 21 (2003) 1343-1346
-
(2003)
Nat Biotechnol
, vol.21
, pp. 1343-1346
-
-
Kuberan, B.1
Lech, M.Z.2
Beeler, D.L.3
Wu, Z.L.L.4
Rosenberg, R.D.5
-
60
-
-
53149118243
-
Pathway engineered enzymatic de novo purine nucleotide synthesis
-
A one-pot in vitro enzymatic synthesis was demonstrated that involves three dozen different isolated enzymes carrying out a complex biosynthetic scheme. In total five different co-factor regeneration schemes were incorporated that drive the in vitro biosynthetic process.
-
Schultheisz H.L., Szymczyna B.R., Scott L.G., and Williamson J.R. Pathway engineered enzymatic de novo purine nucleotide synthesis. ACS Chem Biol 3 (2008) 499-511. A one-pot in vitro enzymatic synthesis was demonstrated that involves three dozen different isolated enzymes carrying out a complex biosynthetic scheme. In total five different co-factor regeneration schemes were incorporated that drive the in vitro biosynthetic process.
-
(2008)
ACS Chem Biol
, vol.3
, pp. 499-511
-
-
Schultheisz, H.L.1
Szymczyna, B.R.2
Scott, L.G.3
Williamson, J.R.4
-
61
-
-
0020725573
-
Site-to-site directed immobilization of enzymes with bis-NAD analogues
-
Mansson M.O., Siegbahn N., and Mosbach K. Site-to-site directed immobilization of enzymes with bis-NAD analogues. Proc Natl Acad Sci U S A 80 (1983) 1487-1491
-
(1983)
Proc Natl Acad Sci U S A
, vol.80
, pp. 1487-1491
-
-
Mansson, M.O.1
Siegbahn, N.2
Mosbach, K.3
-
62
-
-
0025768057
-
Multienzyme systems obtained by gene fusion
-
Bulow L., and Mosbach K. Multienzyme systems obtained by gene fusion. Trends Biotechnol 9 (1991) 226-231
-
(1991)
Trends Biotechnol
, vol.9
, pp. 226-231
-
-
Bulow, L.1
Mosbach, K.2
-
63
-
-
34547209337
-
Enzyme immobilization: the quest for optimum performance
-
Sheldon R.A. Enzyme immobilization: the quest for optimum performance. Adv Synth Catal 349 (2007) 1289-1307
-
(2007)
Adv Synth Catal
, vol.349
, pp. 1289-1307
-
-
Sheldon, R.A.1
-
65
-
-
38849169990
-
Evaluation of different glutaryl hydolysis of acylase mutants to improve the cephalosporin C in the absence of hydrogen peroxide
-
Lopez-Gallego F., Betancor L., Sio C.F., Reis C.R., Jimenez P.N., Guisan J.M., Quax W.J., and Fernandez-Lafuente R. Evaluation of different glutaryl hydolysis of acylase mutants to improve the cephalosporin C in the absence of hydrogen peroxide. Adv Synth Catal 350 (2008) 343-348
-
(2008)
Adv Synth Catal
, vol.350
, pp. 343-348
-
-
Lopez-Gallego, F.1
Betancor, L.2
Sio, C.F.3
Reis, C.R.4
Jimenez, P.N.5
Guisan, J.M.6
Quax, W.J.7
Fernandez-Lafuente, R.8
-
66
-
-
33644680778
-
Synthesis of enantiomerically pure (S)-mandelic acid using an oxynitrilase-nitrilase bienzymatic cascade: a nitrilase surprisingly shows nitrile hydratase activity
-
Mateo C., Chmura A., Rustler S., van Rantwijk F., Stolz A., and Sheldon R.A. Synthesis of enantiomerically pure (S)-mandelic acid using an oxynitrilase-nitrilase bienzymatic cascade: a nitrilase surprisingly shows nitrile hydratase activity. Tetrahedron: Asymmetry 17 (2006) 320-323
-
(2006)
Tetrahedron: Asymmetry
, vol.17
, pp. 320-323
-
-
Mateo, C.1
Chmura, A.2
Rustler, S.3
van Rantwijk, F.4
Stolz, A.5
Sheldon, R.A.6
-
67
-
-
0037007176
-
Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads
-
Liu Z.Y., Zhang J.B., Chen X., and Wang P.G. Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads. ChemBioChem 3 (2002) 348-355
-
(2002)
ChemBioChem
, vol.3
, pp. 348-355
-
-
Liu, Z.Y.1
Zhang, J.B.2
Chen, X.3
Wang, P.G.4
-
68
-
-
62349135778
-
Substrate channelling in an engineered bifunctional aldolase/kinase enzyme confers catalytic advantage for C-C bond formation
-
Here, the authors describe a bifunctional fusion protein (aldolase and kinase) for the synthesis of aldol aducts using dehydroxyacetone as initial donor. Fusion of the two enzymes increases reaction rates as the result of substrate channeling.
-
Iturrate L., Sanchez-Moreno I., Doyaguez E.G., and Garcia-Junceda E. Substrate channelling in an engineered bifunctional aldolase/kinase enzyme confers catalytic advantage for C-C bond formation. Chem Commun (Camb) (2009) 1721-1723. Here, the authors describe a bifunctional fusion protein (aldolase and kinase) for the synthesis of aldol aducts using dehydroxyacetone as initial donor. Fusion of the two enzymes increases reaction rates as the result of substrate channeling.
-
(2009)
Chem Commun (Camb)
, pp. 1721-1723
-
-
Iturrate, L.1
Sanchez-Moreno, I.2
Doyaguez, E.G.3
Garcia-Junceda, E.4
-
69
-
-
34250878420
-
Incorporation of fungal cellulases in bacterial minicellulosomes yields viable, synergistically acting cellulolytic complexes
-
Mingardon F., Chanal A., Lopez-Contreras A.M., Dray C., Bayer E.A., and Fierobe H.P. Incorporation of fungal cellulases in bacterial minicellulosomes yields viable, synergistically acting cellulolytic complexes. Appl Environ Microbiol 73 (2007) 3822-3832
-
(2007)
Appl Environ Microbiol
, vol.73
, pp. 3822-3832
-
-
Mingardon, F.1
Chanal, A.2
Lopez-Contreras, A.M.3
Dray, C.4
Bayer, E.A.5
Fierobe, H.P.6
-
70
-
-
61449164761
-
Molecular engineering of the cellulosome complex for affinity and bioenergy applications
-
Nordon R.E., Craig S.J., and Foong F.C. Molecular engineering of the cellulosome complex for affinity and bioenergy applications. Biotechnol Lett 31 (2009) 465-476
-
(2009)
Biotechnol Lett
, vol.31
, pp. 465-476
-
-
Nordon, R.E.1
Craig, S.J.2
Foong, F.C.3
-
71
-
-
64449084122
-
Enzyme cascades activated on topologically programmed DNA scaffolds
-
This is an excellent example for the application of enzyme-technology and nano-technology for the design of an innovative in vitro multi-enzymatic system. Self-organizing DNA structures are attached to a solid surface where they function as scaffolds for the controlled co-localization of enzymes. The spatial proximities achieved between the biocatalysts facilitate efficient catalysis.
-
Wilner O.I., Weizmann Y., Gill R., Lioubashevski O., Freeman R., and Willner I. Enzyme cascades activated on topologically programmed DNA scaffolds. Nat Nanotechnol 4 (2009) 249-254. This is an excellent example for the application of enzyme-technology and nano-technology for the design of an innovative in vitro multi-enzymatic system. Self-organizing DNA structures are attached to a solid surface where they function as scaffolds for the controlled co-localization of enzymes. The spatial proximities achieved between the biocatalysts facilitate efficient catalysis.
-
(2009)
Nat Nanotechnol
, vol.4
, pp. 249-254
-
-
Wilner, O.I.1
Weizmann, Y.2
Gill, R.3
Lioubashevski, O.4
Freeman, R.5
Willner, I.6
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