Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cells

Journal of Neuro-Oncology

Volumn 111, Issue 2, 2013, Pages 113-121

  Whiteway, Susan L ^a   Harris, Peter S ^a   Venkataraman, Sujatha ^a   Alimova, Irina ^a   Birks, Diane K ^b   Donson, Andrew M ^a   Foreman, Nicholas K ^a   Vibhakar, Rajeev ^a  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

CDK6; Medulloblastoma; PD0332991

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE 6; MESSENGER RNA; PALBOCICLIB; RETINOBLASTOMA PROTEIN; SHORT HAIRPIN RNA; 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-(5-PIPERAZIN-1-YLPYRIDIN-2-YLAMINO)-8H-PYRIDO(2,3-D)PYRIMIDIN-7-ONE; 6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 (5 PIPERAZIN 1 YLPYRIDIN 2 YLAMINO) 8H PYRIDO(2,3 D)PYRIMIDIN 7 ONE; BETA III TUBULIN PROTEIN, HUMAN; BETA III-TUBULIN PROTEIN, HUMAN; CDK6 PROTEIN, HUMAN; ENZYME INHIBITOR; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; TUBULIN;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CEREBELLUM; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IONIZING RADIATION; MEDULLOBLASTOMA; NEURAL STEM CELL; NONHUMAN; PRESCHOOL CHILD; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RNA INTERFERENCE; ANIMAL; CELL CYCLE; CEREBELLUM TUMOR; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; MALE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; TUMOR CELL LINE;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CEREBELLAR NEOPLASMS; CHILD, PRESCHOOL; CYCLIN-DEPENDENT KINASE 6; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MEDULLOBLASTOMA; MICE; NEURAL STEM CELLS; PIPERAZINES; PYRIDINES; RADIATION TOLERANCE; RADIATION, IONIZING; RNA INTERFERENCE; TUBULIN;

MLCS; MLOWN;

EID: 84879300977     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-012-1000-7     Document Type: Article

References (27)

1. Pizer BL, Clifford SC (2009) The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials. Br J Neurosurg 23(4):364-375
2. Packer RJ, Cogen P, Vezina G et al (1999) Medulloblastoma: clinical and biologic aspects. Neuro Oncol 1:232-250
3. Packer RJ (2005) Progress and challenges in childhood brain tumors. J Neurooncol 75:239-242
4. Dhall G (2009) Medulloblastoma. J Child Neurol 24:1418-1430
5. Taylor MD, Northcott PA, Korshunov A et al (2012) Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 123:465-472
6. Meyers-Needham M, Lewis JA, Gencer S et al (2012) Off-target function of the sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase2/ceramide induction. Mol Cancer Ther 11(5):1092-1102
7. Lee MJ, Hatton BA, Villavicencio EH et al (2012) Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in mouse medulloblastoma model. Proc Natl Acad Sci USA 109(20):7859-7864
8. Northcott PA, Korshunov A, Pfister S et al (2012) The clinical implications of medulloblastoma subgroups. Nat Rev Neurol 8(6):340-351
9. Musgrove EA, Caldon CE, Barraclough J et al (2011) Cyclin D as a therapeutic target in cancer. Nat Rev Cancer 11(8):558-572
10. Ericson KK, Krull D, Slomiany P et al (2003) Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured astrocytes. Mol Cancer Res 1(9):654-664
11. Grossel MJ, Hinds PW (2006) Beyond the cell cycle: a new role for CDK6 in differentiation. J Cell Biochem 97(3):485-493
12. Malumbres M, Barbacid M (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9(3):153-166
13. Mendryk F, Radlwimmer B, Joos S et al (2005) Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma. J Clin Oncol 23(34):8853-8862
14. Wu J, Qian J, Li C et al (2010) miR-129 regulates cell proliferation by downregulating CDK6 expression. Cell Cycle 9(9):1809-1818
15. Pierson J, Hostager B, Fan R et al (2008) Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma. J Neurooncol 90:1-7
16. Leonard JP, LaCasce AS, Smith MR et al (2012) Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Blood 119(20):4597-4607
17. Schwartz GK, LoRusso PM, Dickson MA et al (2011) Phase I study of PD0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1). Br J Cancer 104:1862-1868
18. Venkataraman S, Alimova I, Fan R et al (2010) MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. PLoS One 5(6):e10748
19. Barton VN, Donson AM, Kleinschmidt-DeMasters BK et al (2010) Unique molecular characteristics of pediatric myxopapillary ependymoma. Brain Pathol 20(3):560-570
20. Xing JZ, Zhu L, Jackson JA et al (2005) Dynamic monitoring of cytotoxicity on microelectronic sensors. Chem Res Toxicol 18:154-161
21. Su X, Gopalakrishnan V, Stearns D et al (2006) Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol 26(5):1666-1678
22. Northcott PA, Korshunov A, Witt H et al (2011) Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 29(11):1408-1414
23. Lapenna S, Giordano A (2009) Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov 8(7):547-566
24. Toogood P, Harvey PJ, Repine JT et al (2005) Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. J Med Chem 48(7):2388-2406
25. 1 length controls adult neurogenesis. Stem Cells 29:713-724
26. Michaud K, Solomon DA, Oermann E et al (2010) Pharmacologic inhibition of CDK4/6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res 70(8):3228-3238
27. Menu E, Garcia J, Huang X et al (2008) A novel therapeutic combination using PD 0332991 and Bortezomib: study in the 5T33MM myeloma model. Cancer Res 68(14):5519-5523 Stroke