Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 25, 2013, Pages 10282-10287

  Ramadoss, Nitya S ^a   Alumasa, John N ^a   Cheng, Lin ^a   Wang, Yu ^b   Li, Sharon ^a   Chambers, Benjamin S ^a   Chang, Hoon ^a   Chatterjee, Arnab K ^b   Brinker, Achim ^b   Engels, Ingo H ^b,c   Keiler, Kenneth C ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c Appalachian College of Pharmacy   (United States)

Author keywords

Antibiotic target; Non stop translation; Tmrna

Indexed keywords

ANTIBIOTIC AGENT; KKL 10; KKL 22; KKL 35; KKL 52; KKL 55; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG TARGETING; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA TRANSLATION;

ANTIBIOTIC TARGET; NON-STOP TRANSLATION; TMRNA;

ANTI-BACTERIAL AGENTS; BIOLOGICAL ASSAY; CODON, TERMINATOR; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENE LIBRARY; HUMANS; LUCIFERASES; NUCLEIC ACID CONFORMATION; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, BACTERIAL; SMALL MOLECULE LIBRARIES;

ANIMALIA;

EID: 84879298824     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1302816110     Document Type: Article

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