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Volumn 12, Issue , 2013, Pages 556-568

Ethanolic extract of Commiphora mukul gum resin attenuates streptozotocin-induced alterations in carbohydrate and lipid metabolism in rats

Author keywords

C. mukul; Diabetes; Gluconeogenesis; Glycolysis; Lipogenesis; Tissue lipids

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ALCOHOL; ANTIDIABETIC AGENT; CHOLESTEROL; COMMIPHORA MUKUL EXTRACT; FATTY ACID; FATTY ACID SYNTHASE; FRUCTOSE BISPHOSPHATASE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCOGEN; HEXOKINASE; LIPOPROTEIN LIPASE; MALATE DEHYDROGENASE (DECARBOXYLATING); PHOSPHOLIPID; PLANT EXTRACT; PYRUVATE KINASE; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84879288971     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (54)
  • 1
    • 84984423299 scopus 로고
    • The effect of sammo administration on some fundamental enzymes of pentose phosphate pathway and energy metabolites of alloxanised rats
    • Abdel-Rahim EA, EI-Saadany SS, Abo-Eytta AM, Wasif MM. The effect of sammo administration on some fundamental enzymes of pentose phosphate pathway and energy metabolites of alloxanised rats. Nahrung 1992;36:8-14.
    • (1992) Nahrung , vol.36 , pp. 8-14
    • Abdel-Rahim, E.A.1    Ei-Saadany, S.S.2    Abo-Eytta, A.M.3    Wasif, M.M.4
  • 2
    • 0014028106 scopus 로고
    • Dietary and hormonal regulation of enzymes of fructose metabolism in rat liver
    • Adelman RA, Spoiler PD, Weinhouse S. Dietary and hormonal regulation of enzymes of fructose metabolism in rat liver. J Biol Chem 1966;241:5467.
    • (1966) J Biol Chem , vol.241 , pp. 5467
    • Adelman, R.A.1    Spoiler, P.D.2    Weinhouse, S.3
  • 3
    • 0026650744 scopus 로고
    • Effects of insulin and dexamethasone on lipoprotein lipase in human adipose tissue
    • Appel B, Fried SK. Effects of insulin and dexamethasone on lipoprotein lipase in human adipose tissue. Am J Physiol 1992; 262:695-9.
    • (1992) Am J Physiol , vol.262 , pp. 695-699
    • Appel, B.1    Fried, S.K.2
  • 5
    • 34249071640 scopus 로고    scopus 로고
    • Medicinal plants with potential antidiabetic activity. A review of ten years of herbal medicine research (1990-2000)
    • Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A. Medicinal plants with potential antidiabetic activity. A review of ten years of herbal medicine research (1990-2000). Int J Diabetes Metab 2006;14:1-25.
    • (2006) Int J Diabetes Metab , vol.14 , pp. 1-25
    • Bnouham, M.1    Ziyyat, A.2    Mekhfi, H.3    Tahri, A.4    Legssyer, A.5
  • 6
    • 7144228388 scopus 로고
    • The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individuals of various ages
    • Brandstrup N, Kirk JE, Bruni C. The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individuals of various ages. J Gerontol 1957;12:166-71.
    • (1957) J Gerontol , vol.12 , pp. 166-171
    • Brandstrup, N.1    Kirk, J.E.2    Bruni, C.3
  • 7
    • 33846081029 scopus 로고    scopus 로고
    • The effect of the sulfonylurea glyburide on glutathione-S-transferase and glucose-6-phosphate dehydrogenase in streptozotocin-induced diabetic rat liver
    • Bugdayci G, Altan N, Sancak B, Bukan N, Kosova F. The effect of the sulfonylurea glyburide on glutathione-S-transferase and glucose-6-phosphate dehydrogenase in streptozotocin-induced diabetic rat liver. Acta Diabetol 2006;43:131-4.
    • (2006) Acta Diabetol , vol.43 , pp. 131-134
    • Bugdayci, G.1    Altan, N.2    Sancak, B.3    Bukan, N.4    Kosova, F.5
  • 9
    • 33745471487 scopus 로고    scopus 로고
    • FXR: A target for cholestatic syndrome?
    • Cai SY, Boyer JL. FXR: A target for cholestatic syndrome? Expert Opin Ther Targets 2006;10:409-21.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 409-421
    • Cai, S.Y.1    Boyer, J.L.2
  • 10
    • 78651047985 scopus 로고
    • The determination of glycogen in liver and muscle by use of anthrone reagent
    • Carroll NV, Longely RW, Roe JH. The determination of glycogen in liver and muscle by use of anthrone reagent. J Biol Chem 1956;220:583-93.
    • (1956) J Biol Chem , vol.220 , pp. 583-593
    • Carroll, N.V.1    Longely, R.W.2    Roe, J.H.3
  • 11
    • 0042433118 scopus 로고    scopus 로고
    • Cardioprotective activity of synthetic guggulsterone (E and Z-isomers) in isoproternol induced myocardial ischemia in rats: A comparative study
    • Chander R, Rizvi F, Khanna AK, Pratap R. Cardioprotective activity of synthetic guggulsterone (E and Z-isomers) in isoproternol induced myocardial ischemia in rats: A comparative study. Indian J Clin Biochem 2003;18:71-9.
    • (2003) Indian J Clin Biochem , vol.18 , pp. 71-79
    • Chander, R.1    Rizvi, F.2    Khanna, A.K.3    Pratap, R.4
  • 12
    • 33745249579 scopus 로고
    • Simplified determination of the lipid components of blood serum
    • Connerty HV, Briggs AR, Eaton EH Jr. Simplified determination of the lipid components of blood serum. Clin Chem 1961;7: 7-53.
    • (1961) Clin Chem , vol.7 , pp. 7-53
    • Connerty, H.V.1    Briggs, A.R.2    Eaton Jr., E.H.3
  • 13
    • 79952026819 scopus 로고    scopus 로고
    • Antidiabetic activity of Pilocarpus microphyllus extract on streptozotocin-induced diabetic mice
    • Devi R, Singh V, Kumar AC. Antidiabetic activity of Pilocarpus microphyllus extract on streptozotocin-induced diabetic mice. Int J Pharm Sci Rev Res 2010;5:87-92.
    • (2010) Int J Pharm Sci Rev Res , vol.5 , pp. 87-92
    • Devi, R.1    Singh, V.2    Kumar, A.C.3
  • 14
    • 23044477294 scopus 로고    scopus 로고
    • The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter
    • Ding X, Staudinger JL. The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter. J Pharmacol Exp Ther 2005;314:120-7.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 120-127
    • Ding, X.1    Staudinger, J.L.2
  • 15
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and ecreted via lipoproteins in patients with non alcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and ecreted via lipoproteins in patients with non alcoholic fatty liver disease. J Clin Invest 2005;115: 1343-51.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 16
    • 0000130569 scopus 로고
    • Multiple range and multiple tests
    • Duncan DB. Multiple range and multiple tests. Biometrics 1955;42:1-42.
    • (1955) Biometrics , vol.42 , pp. 1-42
    • Duncan, D.B.1
  • 17
    • 0002322351 scopus 로고
    • The calorimetric micro determination of long-chain fatty acids
    • Duncombe WG. The calorimetric micro determination of long-chain fatty acids. Biochem J 1963;88:7-10.
    • (1963) Biochem J , vol.88 , pp. 7-10
    • Duncombe, W.G.1
  • 18
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane, S.G.H.3
  • 20
    • 50549176790 scopus 로고
    • Incorporation of malonyl Co-A into fatty acids by liver in starvation and alloxan diabetes
    • Gibson DM, Hubbard DD. Incorporation of malonyl Co-A into fatty acids by liver in starvation and alloxan diabetes. Biochem Biophys Res Commun 1960;3:531-5.
    • (1960) Biochem Biophys Res Commun , vol.3 , pp. 531-535
    • Gibson, D.M.1    Hubbard, D.D.2
  • 21
    • 33746207753 scopus 로고    scopus 로고
    • Type 1 diabetes, pathogenesis and prevention
    • Gillespie KM. Type 1 diabetes, pathogenesis and prevention. CMAJ 2006;175: 165-70.
    • (2006) CMAJ , vol.175 , pp. 165-170
    • Gillespie, K.M.1
  • 23
    • 17644384821 scopus 로고    scopus 로고
    • Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimetal animals
    • Gupta RK, Kesari AN, Murthy PS, Chandra R, Tandon V, Watal G. Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimetal animals. J Ethnopharmacol 2005;99:75-81.
    • (2005) J Ethnopharmacol , vol.99 , pp. 75-81
    • Gupta, R.K.1    Kesari, A.N.2    Murthy, P.S.3    Chandra, R.4    Tandon, V.5    Watal, G.6
  • 24
    • 31544446372 scopus 로고    scopus 로고
    • Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kB ligand and by tumor cells by suppressing nuclear factor-kB activation
    • Ichikawa H, Aggarwal BB. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kB ligand and by tumor cells by suppressing nuclear factor-kB activation. Clin Cancer Res 2006; 12:662-668.
    • (2006) Clin Cancer Res , vol.12 , pp. 662-668
    • Ichikawa, H.1    Aggarwal, B.B.2
  • 25
    • 0031973526 scopus 로고    scopus 로고
    • Glutathione and glucose-6phosphate dehydrogenase deficiency can increase protein glycosylation
    • Jain SK. Glutathione and glucose-6phosphate dehydrogenase deficiency can increase protein glycosylation. Free Radical Biol Med 1998;24:197-201.
    • (1998) Free Radical Biol Med , vol.24 , pp. 197-201
    • Jain, S.K.1
  • 26
    • 54949093947 scopus 로고    scopus 로고
    • Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats
    • Kaleem M, Medha P, Ahmed QA, Asif M, Bano B. Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J 2008;49: 800-804.
    • (2008) Singapore Med J , vol.49 , pp. 800-804
    • Kaleem, M.1    Medha, P.2    Ahmed, Q.A.3    Asif, M.4    Bano, B.5
  • 27
    • 77955133247 scopus 로고    scopus 로고
    • Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats
    • Karuna R, Bellamkonda R, Singareddy SR, Desireddy S. Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats. Pharmacognosy Res 2010;2:195-201.
    • (2010) Pharmacognosy Res , vol.2 , pp. 195-201
    • Karuna, R.1    Bellamkonda, R.2    Singareddy, S.R.3    Desireddy, S.4
  • 29
    • 49449118557 scopus 로고    scopus 로고
    • Trichosanthes cucumerina Linn. improves glucose tolerance and tissue glycogen in non insulin dependent diabetes mellitus induced rats
    • Kirana H, Srinivasan BP. Trichosanthes cucumerina Linn. improves glucose tolerance and tissue glycogen in non insulin dependent diabetes mellitus induced rats. Indian J Pharmacol 2008;40:103-106.
    • (2008) Indian J Pharmacol , vol.40 , pp. 103-106
    • Kirana, H.1    Srinivasan, B.P.2
  • 30
    • 33845978046 scopus 로고    scopus 로고
    • Lipid lowering effect of S-methyl cysteine sulfoxide from Allium cepa Linn in high cholesterol diet fed rats
    • Kumari K, Augusti KT. Lipid lowering effect of S-methyl cysteine sulfoxide from Allium cepa Linn in high cholesterol diet fed rats. J Ethnopharmacol 2007;367-371.
    • (2007) J Ethnopharmacol , pp. 367-371
    • Kumari, K.1    Augusti, K.T.2
  • 31
  • 33
    • 33646021903 scopus 로고    scopus 로고
    • Glucose-6-phosphate dehydrogenase activity and ADPH/ NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat
    • Díaz-Flores M, Ibáñez-Hernández MA, Galván RE, Gutiérrez M, Durán-Reyes G, Medina-Navarro R et al. Glucose-6-phosphate dehydrogenase activity and ADPH/ NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat. Life Sci 2006;78:2601-2607.
    • (2006) Life Sci , vol.78 , pp. 2601-2607
    • Díaz-Flores, M.1    Ibáñez-Hernández, M.A.2    Galván, R.E.3    Gutiérrez, M.4    Durán-Reyes, G.5    Medina-Navarro, R.6
  • 34
    • 21044440450 scopus 로고    scopus 로고
    • Changes in some liver enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides) or commercial diosgenin
    • McAnuff MA, Omoruyi FO, Morrison EY, Asemota HN. Changes in some liver enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides) or commercial diosgenin. West Indian Med J 2005;54:97-101.
    • (2005) West Indian Med J , vol.54 , pp. 97-101
    • McAnuff, M.A.1    Omoruyi, F.O.2    Morrison, E.Y.3    Asemota, H.N.4
  • 35
    • 0036906508 scopus 로고    scopus 로고
    • Lipoprotein lipase: Genetics, lipid uptake, and regulation
    • Merkel M, Eckel RH, Goldberg IJ. Lipoprotein lipase: genetics, lipid uptake, and regulation. J Lipid Res 2002;43:1997-2006.
    • (2002) J Lipid Res , vol.43 , pp. 1997-2006
    • Merkel, M.1    Eckel, R.H.2    Goldberg, I.J.3
  • 36
    • 84858140887 scopus 로고    scopus 로고
    • Efficacy of naringin on hepatic enzymes of carbohydrate metabolism in streptozotocin-nicotinamide induced type 2 diabetic rats
    • Pari L, Suman S. Efficacy of naringin on hepatic enzymes of carbohydrate metabolism in streptozotocin-nicotinamide induced type 2 diabetic rats. Int J Pharm Biol Arch 2010;1:280-6.
    • (2010) Int J Pharm Biol Arch , vol.1 , pp. 280-286
    • Pari, L.1    Suman, S.2
  • 37
    • 0034284524 scopus 로고    scopus 로고
    • Effects of Averrhoa bilimli leaf extract on blood glucose and lipids in streptozotocin diabetic rats
    • Pushparaj P, Tan CH, Tan BKH. Effects of Averrhoa bilimli leaf extract on blood glucose and lipids in streptozotocin diabetic rats. J Ethnopharmacol 2000;72:69-76.
    • (2000) J Ethnopharmacol , vol.72 , pp. 69-76
    • Pushparaj, P.1    Tan, C.H.2    Tan, B.K.H.3
  • 38
    • 33846242568 scopus 로고    scopus 로고
    • Antihyperglycaemic effect of umbelliferone in STZdiabetic rats
    • Ramesh B, Pugalendi KV. Antihyperglycaemic effect of umbelliferone in STZdiabetic rats. J Med Food 2006;9:562-6.
    • (2006) J Med Food , vol.9 , pp. 562-566
    • Ramesh, B.1    Pugalendi, K.V.2
  • 39
    • 79960995779 scopus 로고    scopus 로고
    • Antihyperglycemic and antioxidant activities of alcoholic extract of Commiphroa mukul in strptozotocin induced diabetic rats
    • Ramesh B, Karuna R, Sreenivasa Reddy S, Ramesh Babu K, Ramatholisamma P, Appa Rao Ch, Saralakumari D. Antihyperglycemic and antioxidant activities of alcoholic extract of Commiphroa mukul in strptozotocin induced diabetic rats. Pathophysiology 2011;18:255-61.
    • (2011) Pathophysiology , vol.18 , pp. 255-261
    • Ramesh, B.1    Karuna, R.2    Sreenivasa, R.S.3    Ramesh, B.K.4    Ramatholisamma, P.5    Appa, R.C.6    Saralakumari, D.7
  • 40
    • 84871321673 scopus 로고    scopus 로고
    • Antidiabetic and antioxidant property of Ethanolic extract of Commiphora mukul gum resin on fructose induced insulin resistant rats
    • Ramesh B, Saralakumari D. Antidiabetic and antioxidant property of Ethanolic extract of Commiphora mukul gum resin on fructose induced insulin resistant rats. J Physiol Biochem 2012;68:573-82.
    • (2012) J Physiol Biochem , vol.68 , pp. 573-582
    • Ramesh, B.1    Saralakumari, D.2
  • 41
    • 0035990605 scopus 로고    scopus 로고
    • Antihyperglycemic effects of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism
    • Rathi SS, Grover JK, Vats V. Antihyperglycemic effects of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytotherapy Res 2002;16:236-43.
    • (2002) Phytotherapy Res , vol.16 , pp. 236-243
    • Rathi, S.S.1    Grover, J.K.2    Vats, V.3
  • 42
    • 0023339943 scopus 로고
    • The NADPH-producing pathways (pentose phosphate and malic enzyme) are regulated by the NADPH consumption in rat mammary gland
    • Revilla E, Fabregat I, Santa María C, Machado A. The NADPH-producing pathways (pentose phosphate and malic enzyme) are regulated by the NADPH consumption in rat mammary gland. Biochem Int 1987;14: 957-62.
    • (1987) Biochem Int , vol.14 , pp. 957-962
    • Revilla, E.1    Fabregat, I.2    Santa, M.C.3    Machado, A.4
  • 43
    • 0031021410 scopus 로고    scopus 로고
    • Effect of methadone addiction on glucose metabolism in rats
    • Sadava D, Alonso D, Hong H, Barrett PD. Effect of methadone addiction on glucose metabolism in rats. General Pharmacol 1997;28:27-9.
    • (1997) General Pharmacol , vol.28 , pp. 27-29
    • Sadava, D.1    Alonso, D.2    Hong, H.3    Barrett, P.D.4
  • 44
    • 0030009271 scopus 로고    scopus 로고
    • Hypoglycemic and hypolipidaemic effects of Cinnamomum tomala nees leaves
    • Sharma SR, Dwivedi SK, Swarup D. Hypoglycemic and hypolipidaemic effects of Cinnamomum tomala nees leaves. Ind J Exp Biol 1996;34:372-4.
    • (1996) Ind J Exp Biol , vol.34 , pp. 372-374
    • Sharma, S.R.1    Dwivedi, S.K.2    Swarup, D.3
  • 45
    • 69549118305 scopus 로고    scopus 로고
    • Effects of guggulsterone isolated from Commiphora mukul in high at diet induced diabetic rats
    • Sharma B, Salunki R, Srivastava S, Majumder C, Roy. Effects of guggulsterone isolated from Commiphora mukul in high at diet induced diabetic rats. Food Chem Toxicol 2009;47:2631-9.
    • (2009) Food Chem Toxicol , vol.47 , pp. 2631-2639
    • Sharma, B.1    Salunki, R.2    Srivastava, S.3    Roy, M.C.4
  • 46
    • 0020478566 scopus 로고
    • Lipoprotein lipasecatalyzed hydrolysis of p-nitrophenyl butyrate. Interfacial activation by phospholipid vesicles
    • Shirai K, Jackson RL. Lipoprotein lipasecatalyzed hydrolysis of p-nitrophenyl butyrate. Interfacial activation by phospholipid vesicles. J Biol Chem 1982;257:1253-8.
    • (1982) J Biol Chem , vol.257 , pp. 1253-1258
    • Shirai, K.1    Jackson, R.L.2
  • 47
    • 70949087937 scopus 로고    scopus 로고
    • Biochemical and hematological studies for the protective effect of oyster mushroom Pleurotus ostreatus) against glycerol-induced acute renal failure in rats
    • Sirag HM. Biochemical and hematological studies for the protective effect of oyster mushroom Pleurotus ostreatus) against glycerol-induced acute renal failure in rats. J Biol Sci 2009;9:746-52.
    • (2009) J Biol Sci , vol.9 , pp. 746-752
    • Sirag, H.M.1
  • 48
    • 70350361188 scopus 로고    scopus 로고
    • Beneficiary effect of Tinospora cordifolia against high-fructose diet induced abnormalities in carbohydrate and lipid metabolism in Wistar rats
    • Sreenivasa Reddy, Ramatholisamma P, Ramesh B, Baskar R, Saralakumari D. Beneficiary effect of Tinospora cordifolia against high-fructose diet induced abnormalities in carbohydrate and lipid metabolism in Wistar rats. Horm Metab Res 2009;41: 741-6.
    • (2009) Horm Metab Res , vol.41 , pp. 741-746
    • Reddy, S.1    Ramatholisamma, P.2    Ramesh, B.3    Baskar, R.4    Saralakumari, D.5
  • 49
    • 77956995387 scopus 로고
    • Polysaccharide phosphorylase, liver
    • Sutherland EW. Polysaccharide phosphorylase, liver. Meth Enzymol 1955:2;215-8.
    • (1955) Meth Enzymol , vol.2 , pp. 215-218
    • Sutherland, E.W.1
  • 50
    • 16244416215 scopus 로고    scopus 로고
    • Antidiabetic activity of the semipurified fractions of Averrhoa bilimbi in high fat diet fed-streptozotocin induced diabetic rats
    • Tan BK, Tan CH, Pushparaj PN. Antidiabetic activity of the semipurified fractions of Averrhoa bilimbi in high fat diet fed-streptozotocin induced diabetic rats. Life Sci 2005;76:2827-39.
    • (2005) Life Sci , vol.76 , pp. 2827-2839
    • Tan, B.K.1    Tan, C.H.2    Pushparaj, P.N.3
  • 54
    • 0032511090 scopus 로고    scopus 로고
    • Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase
    • Wagle A, Jivraj S, Garlock GL, Stapleton SR. Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase. J Biol Chem 1998; 273:14968-74.
    • (1998) J Biol Chem , vol.273 , pp. 14968-14974
    • Wagle, A.1    Jivraj, S.2    Garlock, G.L.3    Stapleton, S.R.4


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