Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats

Journal of Physiology and Biochemistry

Volumn 68, Issue 4, 2012, Pages 573-582

  Ramesh, B ^a   Saralakumari, D ^b  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b SRI KRISHNADEVARAYA UNIVERSITY   (India)

Author keywords

Antioxidant; Commiphora mukul; High fructose diet; Hyperinsulinemia; Hypertriglyceridemia; Insulin resistance

Indexed keywords

ANTIOXIDANT; CATALASE; ETHANOLIC EXTRACT OF COMMIPHORA MUKUL; FRUCTOSE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; INSULIN; LIPID; PLANT EXTRACT; RESIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; COMMIPHORA; CONTROLLED STUDY; DIABETES MELLITUS; DIETARY INTAKE; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PLASMA; RAT; TREATMENT DURATION; WEIGHT GAIN;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; COMMIPHORA; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ETHANOL; FRUCTOSE; HYPERINSULINISM; HYPERTRIGLYCERIDEMIA; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LIPIDS; LIVER; MALE; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT GUMS; RATS; SOLVENTS; WEIGHT GAIN;

COMMIPHORA WIGHTII; RATTUS; RATTUS NORVEGICUS;

EID: 84871321673     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-012-0175-x     Document Type: Article

References (57)

1. Alarcon FJ, Aguilar R, Roman Romas Perez Gutierrez G, Aguilar Contreras A, Contrears Weber CC, Flores Saenz JL et al (1998) Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethanopharmacol 61:101-110
2. Anhauser M (2003) Pharmacists seek the solution of a shaman. Drug Discov Today 8:868-869
3. Beers RF, Sizer JW (1952) Spectrophotometric method for measuring breakdown of hydrogen peroxide catalase. J Biol Chem 195:133-140
4. Benhamou PY, Moriscot C, Richard MJ, Beatrix O, Badet L, Pattou F, Kerr-Conte J, Chroboczed J, Lemarchand P, Halimi S et al (1998) Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets. Diabetologia 41:1093-1100
5. Ceriello A, Giugliano D, Quatraro A, Donzella C, Dipalo G, Lefebvre PJ et al (1991) Vitamin E reduction of protein glycosylation in diabetes: new prospect for prevention of diabetic complications. Diabetes Care 14:68-72
6. Condell RA, Tappel AL (1983) Evidence for suitability of glutathione peroxidase as a protective enzyme: studies of oxidative damage restoration and proteolysis. Arch Biochem Biophys 223:407-416
7. De Champlain J, Wu R, Girouard H, Karas M, El Midaoui A, Laplante MA, Wu L et al (2004) Oxidative stress in hypertension. Clin Exp Hypertens 26:593-601
8. Domingues C, Ruiz E, Gussinye M, Carrascosa A et al (1998) Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diabetes Care 21:1736-1742
9. Duncan DB (1955) Multiple range and multiple tests. Biometrics 42:1-42
10. Ellman GL (1959) Tissue sulphydryl. Arch Biochem Biophys 82:70-77
11. Eriksson JW (2007) Metabolic stress in insulin's target cells leads to ROS accumulation - a hypothetical common pathway causing insulin resistance. FEBS Lett 581:3734-3742
12. Evans JL, Goldfine ID, Maddux BA, Grodsky GM et al (2003) Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52:1-8
13. Evans JL, Youngren J, Goldfine ID et al (2004) Effective treatments for insulin resistance trims the fat and douses the fire. Trends Endocrinal Metab 15:425-431
14. Flohe L (1971) Glutathione peroxidation in vitamin E deficient rat liver homogenate. Arch Biochem Biophys 97:51-58
15. George LK, Mary RL (2004) Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol 122:333-338
16. Ginsberg HN (2000) Insulin resistance and cardiovascular disease. J Clin Invest 106:453-458
17. Grundy SM (1999) Hypertriglyceridaemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 83:F25-F29?
18. Habig WH, Pabst MJ, Jakoby WB et al (1974) Glutathione- S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139
19. Hallfrisch J (1990) Metabolic effects of dietary fructose. FASEB 4:2625-2660
20. Hu X, Sato J, Oshida Y, Yu M, Bajotto G, Sato Y et al (2003) Effect of Gosha-jinkigan (Chinese herbal medicine: Niuchesenqiwan) on insulin resistance in streptozotocin induced diabetic rats. Diabetes Res Clin Pract 59:103-111
21. Hwang H, Ho B, Hoffman B, Reaven GM et al (1987) Fructose induced insulin resistance and hypertension in rats. Hypertens 10:512-516
22. Joyeux-Faure M, Rossini E, Ribuot C, Faur P et al (2006) Fructose-fed rat hearts are protected against ischemia-reperfusion injury. Exp Biol Med 231:456-462
23. Karuna R, Saralakumari D (2011) Prevention effect of Catharanthus roseus (Linn) against high-fructose dietinduced insulin resistance and oxidative stress in male Wistar rats. J DM 1(3):63-70
24. Kasim-Karakas SE, Vriend H, Almario R, Chow LC, Goodman MN et al (1996) Effect of dietary carbohydrates on glucose and lipid metabolism in golden Syrian hamsters. J Lab Clin Med 128:208-213
25. Kruszynska YT, Olefsky JM (1996) Cellular and molecular mechanisms of non insulin dependent diabetes mellitus. J Invest Med 44:413-428
26. Lee MK, Miles DP, Khoursheed M, Gao KM, Moossa AR, Olefsky MJ et al (1994) Metabolic effects of troglitazone on fructose induced insulin resistance in the rat. Diabetes 43:35-1439
27. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A, Ahn BW, Shaltier S, Stadtman ER et al (1990) Determination of carbonyl content in oxidatively modified proteins. Method Enzymol 186:464-478
28. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ et al (1951) Protein measurement with the Folin's-phenol reagent. J Biol Chem 193:265-275
29. Moore MC, Cherrington AD, Mann SL, Davis SN et al (2000) Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J Clin Endocrinol Metab 85:4515-4519
30. Nagarajan M, Waszkuc TW, Sun J et al (2001) Simultaneous determination of E- and Z-guggulsterones in dietary supplements containing Commiphora mukul extract (guggulipid) by liquid chromatography. JAOAC Int 84:24-28
31. Nityanand S, Kapoor NK (1973) Cholesterol lowering activity of the various fractions of the guggul. Indian J Exp Biol 11:395-3987
32. Pickavance LC, Tadayyon M, Widdowson PS, Buckingham RE, Wilding JP et al (1999) Therapeutic index for rosiglitazone in dietary obese rats. Seperation of efficacy and haemodiluation. Br J Pharmacol 128:1570-1576
33. Pinto RE, Bartley W (1969) The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates. J Biochem 12:109-115
34. Ram Singh B, Niaz MA, Ghosh S et al (1994) Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 8(4):659-664
35. Ramesh B, Karuna R, Sreenivasa Reddy S, Ramesh Babu K, Ramatholisamma P, Appa Rao CH, Saralakumari D et al (2011) Antihyperglycemic and antioxidant activities of alcoholic extract of Commiphora mukul gum resin in STZ induced diabetic rats. J Pathophysiol 18:255-261
36. Reaven MG, Twersk J, Chang H et al (1991) Abnormalities of carbohydrate and lipid metabolism in Dahl rats. Hypertens 18:630-635
37. Reddy SS, Karuna R, Baskar R, Saralakumari D et al (2008) Prevention of insulin resistance by ingesting aqueous extract of Ocimum sanctum to fructose-fed rats. Horm Metab Res 40:44-49
38. Reddy SS, Ramatholisamma P, Karuna R, Saralakumari D et al (2009) Preventive effect of Tinospora Cordiafolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. Food Chem Toxicol 47:2224-2229
39. Rizkalla SW, Boillot J, Tricottet V et al (1993) Effects of chronic dietary fructose with and without copper supplementation on glycemic control, adiposity, insulin binding to adipocytes and glomerular basement membrane thickness in normal rats. Br J Nutr 70:199-209
40. Rohner-Jeanrenaud F, Jeanrenaud B (1996) Obesity, leptin, and the brain. N Engl J Med 334:324-325 (editorial)
41. Rosen P, Ohly P, Gleichmann H et al (1997) Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose fed rats. J Hypertens 15:31-38
42. Rotsruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG et al (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:588-590
43. Sakai M, Oimoni M, Kasuga M et al (2002) Experimental studies on the role of fructose in the development of diabetic complications. Kobe J Med Sci 48:125-136
44. Sambandam N, Lim F, Cam CM, Rodrigues B et al (1997) Cardiac heparin-releasable lipoprotein lipase activity in fructose-hypertensive rats: effect of coronary vasodilatation. J Cardiovas Pharmacol 30:110-117
45. Sandrine D, Eleni P, Richard M, Caroline A, Theophile D, Jean-Paul C, Gerard C, Jacqueline A et al (2005) Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rats. Atherosclerosis 179:43-49
46. Simons LA (2002) Additive effect of plant sterol-ester margarine and cerivastatin in lowering low density lipoprotein cholesterol in primary hypercholesterolemia. Am J Cardiol 90:737-740
47. Soforowo A (1983) Medicinal plants and traditional medicine in Africa. Wiley, New York
48. Soon YY, Tan BKH (2002) Evaluation of the hypoglycemic and antioxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Med J 43:77-85
49. Steiner G (1994) Hyperinsulinaemia and hypertriglyceridaemia. J Intern Med 736(Suppl):23-26
50. Stringer MD, Goroj PG, Freeman A, Kokkar VV et al (1989) Lipid peroxides and atherosclerosis. Br Med J 298:281-284
51. Szekanecz Z, Koch AE, Kunkel SL, Strieter RM et al (1998) Cytokines in rheumatoid arthritis. Potential targets for pharmacological intervention. Drugs Aging 12:377-390
52. Thorburn AW, Storlien LH, Jenkins AB, Khouri S, Kraegen EW et al (1989) Fructose induced in vivo insulin resistance and elevated plasma triglyceride levels in rats. Am J Clin Nutr 49:1155-1163
53. Thresher JS, Podolin DA, Wei Y, Mazzeo RS, Pagliassotti MJ et al (2000) Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance. Am J physiol Regul Integr Comp Physiol 279R:334-340
54. Urizar NL, Moore D (2003) Gugulipid: natural cholesterollowering agent. Annu Rev Nutr 23:303-313
55. Utley HG, Bernheim F, Hochstein P et al (1967) Effect of sulfhydryl reagents on peroxidation in microsomes. Arch Biochem Biophys 118:29-32
56. Xu B, Moritz JT, Epstein PN et al (1999) Overexpression of catalase provides partial protection to transgenic mouse β- cells. Free Radic Biol Med 27:830-837
57. Yalow RS, Berson SA (1961) Immunoassay of plasma insulin in man. Diabetes 10:339-348