Cornin induces angiogenesis through PI3K-Akt-eNOS-VEGF signaling pathway

Food and Chemical Toxicology

Volumn 58, Issue , 2013, Pages 340-346

  Kang, Zechun ^a   Jiang, Wanglin ^a   Luan, Haiyun ^a   Zhao, Feng ^a   Zhang, Shuping ^a  

^a BINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Cornin; ENOS; HBMEC; VEGF

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECEPTOR BLOCKING AGENT; SFLT 1; SU 1498; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VERBENALIN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; BRAIN CELL; CAPILLARY; CELL ASSAY; CELL CULTURE; CELL HYPOXIA; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MICROVASCULAR ENDOTHELIAL CELL; NEUROPROTECTION; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

ANGIOGENESIS; CORNIN; ENOS; HBMEC; VEGF;

APOPTOSIS; CASPASE 3; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; ENDOTHELIUM, VASCULAR; HUMANS; IRIDOID GLYCOSIDES; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84879283666     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.05.017     Document Type: Article

References (24)

1. Arai K., Jin G., Navaratna D., Lo E.H. Brain angiogenesis: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009, 276:4644-4652.
2. Beck H., Plate K.H. Angiogenesis after cerebral ischemia. Acta Neuropathol. 2009, 117:481-496.
3. Cardone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E., Frisch S., Reed J.C. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282:1318-1321.
4. Carmeliet P., Ferreira V., Breier G., Pollefeyt S., Kieckens L., Gertsenstein M. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996, 380:435-439.
5. Carmeliet P., Lampugnani M.G., Moons L., Breviario F., Compernolle V., Bono F. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 1999, 98:147-157.
6. Chen J., Cui X., Zacharek A., Jiang H., Roberts C., Zhang C., Lu M., Kapke A., Feldkamp C.S., Chopp M. Niaspan increases angiogenesis and improves functional recovery after stroke. Ann. Neurol. 2007, 62:49-58.
7. DeBusk L.M., Hallahan D.E., Lin P.C. Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway. Exp. Cell Res. 2004, 298:167-177.
8. Esser S., Lampugnani M.G., Corada M., Dejana E., Risau W. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J. Cell Sci. 1998, 111(Pt 13):1853-1865.
9. Faraci F.M., Heistad D.D. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol. Rev. 1998, 78:53-97.
10. Ferrara N., Carver-Moore K., Chen H., Dowd M., Lu L., O'Shea K.S. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996, 380:439-442.
11. Francis S.C., Raizada M.K., Mangi A.A., Melo L.G., Dzau V.J., Vale P.R., Isner J.M., Losordo D.W., Chao J., Katovich M.J., Berecek K.H. Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb?. Physiol. Genom. 2001, 21:79-94.
12. Gory-Fauré S., Prandini M.H., Pointu H., Roullot V., Pignot-Paintrand I., Vernet M., Huber P. Role of vascular endothelial-cadherin in vascular morphogenesis. Development 1999, 126:2093-2102.
13. Jiang W.L., Zhang S.P., Zhu H.B., Hou J., Tian J.W. Cornin ameliorates cerebral infarction in rats by antioxidant action and stabilization of mitochondrial function. Phytother. Res. 2010, 24:547-552.
14. Lo E.H. Degeneration and repair in central nervous system disease. Nat. Med. 2010, 16:1205-1209.
15. Muñoz-Chápuli R., Quesada A.R., Angel Medina M. Angiogenesis and signal transduction in endothelial cells. Cell Mol. Life Sci. 2004, 61:2224-2243.
16. Murohara T., Asahara T., Silver M., Bauters C., Masuda H., Kalka C., Kearney M., Chen D., Symes J.F., Fishman M.C., Huang P.L., Isner J.M. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J. Clin. Invest. 1998, 101:2567-2578.
17. Ohab J.J., Fleming S., Blesch A., Carmichael S.T. A neurovascular niche for neurogenesis after stroke. J. Neurosci. 2006, 26:13007-130016.
18. Radisavljevic Z., Avraham H., Avraham S. Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric oxide pathway and modulates migration of brain microvascular endothelial cells. J. Biol. Chem. 2000, 275:20770-20774.
19. Simão F., Pagnussat A.S., Seo J.H., Navaratna D., Leung W., Lok J., Guo S., Waeber C., Salbego C.G., Lo E.H. Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases. J. Cereb. Blood Flow Metab. 2012, 32:884-895.
20. + cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J. Clin. Invest. 2004, 114:330-338.
21. Vareed S.K., Schutzki R.E., Nair M.G. Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory compounds in Cornus kousa fruits. Phytomedicine 2007, 14:706-709.
22. Xiong Y., Mahmood A., Chopp M. Angiogenesis, neurogenesis and brain recovery of function following injury. Curr. Opin. Invest. Drugs 2010, 11:298-308.
23. Yang S., Toy K., Ingle G., Zlot C., Williams P.M., Fuh G., Li B., de Vos A., Gerritsen M.E. Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors. Arteriosc. Throm. Vasc. Biol. 2002, 22:1797-1803.
24. Zhang R., Wang L., Zhang L., Chen J., Zhu Z., Zhang Z., Chopp M. Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat. Circ. Res. 2003, 92:308-313.