Effect of normalization of fasting glucose by intensified insulin therapy and influence of eNOS polymorphisms on the incidence of restenosis after peripheral angioplasty in patients with type 2 diabetes: A randomized, open-label clinical trial

Acta Diabetologica

Volumn 50, Issue 3, 2013, Pages 373-382

  Piatti, Pier Marco ^a   Marone, Enrico ^a   Mantero, Manuela ^b   Setola, Emanuela ^a   Galluccio, Elena ^a   Lucotti, Pietro ^a   Shehaj, Ermal ^a   Villa, Valentina ^a   Perticone, Francesca ^a   Venturini, Massimo ^a   Palini, Alessio ^a   Airoldi, Flavio ^b   Faglia, Ezio ^b   Del Maschio, Alessandro ^a   Colombo, Antonio ^a   Chiesa, Roberto ^a   Bosi, Emanuele ^a   Monti, Lucilla D ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b IRCCS MULTIMEDICA   (Italy)

Author keywords

Amputation; Critical limb ischemia; Endothelial progenitor cells; eNOS polymorphism; Intensified insulin therapy; Restenosis; Type 2 diabetes

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN GLARGINE; INSULIN GLULISINE; ORAL ANTIDIABETIC AGENT; VASCULOTROPIN RECEPTOR 2;

AGED; ANGIOPLASTY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICAL LIMB ISCHEMIA; DEATH; DRUG EFFICACY; DRUG SAFETY; ENDOTHELIAL PROGENITOR CELL; FEMALE; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INCIDENCE; INSULIN TREATMENT; INTENSIFIED INSULIN THERAPY; LIMB AMPUTATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RESTENOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; EXTREMITIES; FASTING; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INCIDENCE; INSULIN; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; PERIPHERAL ARTERIAL DISEASE; POLYMORPHISM, GENETIC; TREATMENT OUTCOME;

EID: 84879247286     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-012-0426-x     Document Type: Article

References (45)

1. Ness J, Aronow WS, Ahn C (2000) Risk factors for symptomatic peripheral arterial disease in older persons in an academic hospital-based geriatrics practice. J Am Geriatr Soc 48:312-314
2. Soder HK, Manninen HJ, Jaakkola P et al (2000) Prospective trial of infrapopliteal artery balloon angioplasty for critical limb ischemia: angiographic and clinical results. J Vasc Interv Radiol 11:1021-1031
3. Dorros G, Jaff MR, Dorros AM, Mathiak LM, He T (2001) Tibioperoneal (outflow lesion) angioplasty can be used as primary treatment in 235 patients with critical limb ischemia: 5 years follow-up. Circulation 104:2057-2062
4. Aronow WS (2005) Management of peripheral arterial disease. Cardiol Rev 13:61-68
5. Boyko EJ (1996) Increased mortality associated with diabetic foot ulcer. Diabetes Med 13:967-972
6. Sarwar N, Gao P, Seshasai SR et al (2010) Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative metaanalysis of 102 prospective studies. Lancet 375:2215-2222
7. Seshasai SR, Kaptoge S, Thompson A et al (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364:829-841
8. Uchmanowicz I, Loboz-Grudzien K, Jankowska-Polanska B, Sokalski L (2011) Influence of diabetes on health-related quality of life results in patients with acute coronary syndrome treated with coronary angioplasty. Acta Diabetol. Mar 27 [Epub ahead of print]. PubMed PMID: 21442428
9. Gui MH, Li X, Lu ZQ, Gao X. (2012) Fasting plasma glucose correlates with angiographic coronary artery disease prevalence and severity in Chinese patients without known diabetes. Acta Diabetol. Jun 10 [Epub ahead of print]. PubMed PMID: 22684266
10. Lazzeri C, Valente S, Chiostri M et al (2011) The prognostic role of in-hospital peak glycemia in stemi patients with and withoutdiabetes. Acta Diabetol. Oct 19 [Epub ahead of print]. PubMed PMID:22008949
11. Lazzeri C, Valente S, Chiostri M, et al (2011) The glucose dysmetabolism in the acute phase of non-diabetic ST-elevation myocardial infarction: from insulin resistance to hyperglycemia. Acta Diabetol. Oct 9. [Epub ahead of print] PubMed PMID: 21984048
12. Monti LD, Barlassina C, Citterio L et al (2003) Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome. Diabetes 52:1270-1275
13. Galluccio E, Piatti PM, Citterio L et al (2008) Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis. Am J Physiol Endocrinol Metab 294:E978-E986
14. Aicher A, Heeschen C, Mildner-Rihm C et al (2003) Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 9:1370-1376
15. Yu J, deMuinck ED, Zhuang Z, Drinane M et al (2005) Endothelial nitric oxide synthase is critical for ischemic remodelling, mural cell recruitment, and blood flow reserve. Proc Natl Acad Sci USA 102:10999-11004
16. Murohara T, Asahara T, Silver M et al (1998) Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest 101:2567-2578
17. Hamed S, Benjamin B, Abassi Z, Aharon A, Deeb Daoud D, Roguinand A (2010) Hyperglycemia and Oxidized-LDL exert a deleterious effect on endothelial progenitor cell migration in type 2 diabetes mellitus. Thromb Res 126:166-174
18. Avogaro A, Albiero M, Menegazzo L, de Kreutzenberg SV, Fadini GP (2011) Endothelial dysfunction in diabetes. The role of reparatory mechanisms. Diabetes Care 34(Suppl. 2):S285-S290
19. Chen M-C, Sheu J-J, Wang P-W et al (2009) Complications impaired endothelial progenitor cell function in Type 2 diabetic patients with or without critical leg ischemia: implication for impaired neovascularization in diabetes. Diabetes Med 26:134-141
20. Fadini GP, Miorin M, Facco M et al (2005) Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 45:1449-1457
21. Grollman J, Levin DC, Bettmann MA, et al (2000) Recurrent symptoms following lower extremity angioplasty: claudication and threatened limb. American College of Radiology. ACR Appropriateness Criteria. Radiology 215(Suppl.):95-99
22. Isner JM, Rosenfield K (1993) Redefining the treatment of peripheral artery disease: role of percutaneous revascularization. Circulation 88:1534-1557
23. Corpus RA (2004) Optimal glycemic control is associated with a lower rate of target vessel revascularization in treated type II diabetic patients undergoing elective percutaneous coronary intervention. J Am Coll Cardiol 43:8-14
24. Briguori C, Condorelli G, Airoldi F et al (2005) Impact of microvascular complications on outcome after coronary stent implantations in patients with diabetes. J Am Coll Cardiol 45:464-466
25. Briguori C, Condorelli G, Airoldi F, Mikhail GW, Ricciardelli B, Colombo A (2004) Impact of glycaemic and lipid control on outcome after percutaneous coronary interventions in diabetic patients. Heart 90:1481-1482
26. Exner M, Schillinger M, Minar E et al (2004) Interleukin-6 promoter genotype and restenosis after femoropopliteal balloon angioplasty: initial observations. Radiology 231:839-844
27. Mlekusch W, Exner M, Schillinger et al (2004) E-selectin and restenosis after femoropopliteal angioplasty: prognostic impact of the Ser128Arg genotype and plasma levels. Thromb Haemost 91:171-179
28. Mongiardo A, Curcio A, Spaccarotella C, Parise S, Indolfi C (2004) Molecular mechanisms of restenosis after percutaneous peripheral angioplasty and approach to endovascular therapy. Curr Drug Targets Cardiovasc Hematol Disord 4:275-287
29. Abizaid A (2001) Clinical and economic impact of diabetes mellitus on percutaneous and surgical treatment of multivessel coronary disease patients: insights from the arterial revascularization therapy study (ARTS) trial. Circulation 104:533-538
30. Romiti M, Albers M, Brochado-Neto FC, Durazzo AE, Pereira CA (2008) Meta-analysis of infrapopliteal angioplasty for chronic critical limb ischemia. J Vasc Surg 47:975-981
31. Kosiborod M, Rathore SS, Inzucchi SE et al (2005) Admission glucose and mortality in elderly patients hospitalized with acute myocardial infarction. Circulation 111:3078-3086
32. ACCORD Study Group (2008) Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358:2545-2559
33. Gerstein HC, Miller ME, Genuth S et al (2011) ACCORD Study Group. Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med 364:818-828
34. Song W, Ergul A (2006) Type-2 diabetes induced changes in vascular extracellular matrix gene expression: relation to vessel size. Cardiovasc Diabetol 5:3
35. Harris AK, Hutchinson JR, Sachidanandam K et al (2005) Type 2 diabetes causes remodelling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis: role of endothelin-1. Diabetes 54:2638-2644
36. Kawasumi M, Tanaka Y, Uchino H et al (2006) Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes. Endocrine J 53:45-50
37. Fadini GP, de Kreutzenberg SV, Mariano V et al (2011) Optimized glycaemic control achieved with add-on basal insulin therapy improves indexes of endothelial damage and regeneration in type 2 diabetic patients with macroangiopathy: a randomized crossover trial comparing detemir versus glargine. Diabetes Obes Metab 13:718-725
38. Chen YH, Lin SJ, Lin FY et al (2007) High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 56:1559-1568
39. Krankel N, Adams V, Linke A et al (2005) Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells. Arterioscler Thromb Vasc Biol 25:698-703
40. Quyyumi AA (2004) Circulating endothelial progenitor cells as novel biological determinants of vascular function and risk. Can J Cardiol 20:44B-48B
41. Landmesser U, Engberding N, Bahlmann FH, Schaefer et al (2004) Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase. Circulation 110:1933-1939
42. Tepper OM, Galiano RD, Capla JM et al (2002) Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106:2781-2786
43. Ceriello A, Ihnat MA, Thorpe JE (2009) The "metabolic memory": is more than just tight glucose control necessary to prevent diabetic complications? J Clin Endocrinol Metab 94:410-415
44. Boussageon R, Saadatian-Elahi M, Lafont S et al (2011) Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ 343:1-12
45. Phung OJ, Scholle JM, Talwar M, Coleman CI (2010) Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. JAMA 303:1410-1418