Optimized glycaemic control achieved with add-on basal insulin therapy improves indexes of endothelial damage and regeneration in type 2 diabetic patients with macroangiopathy: A randomized crossover trial comparing detemir versus glargine

Diabetes, Obesity and Metabolism

Volumn 13, Issue 8, 2011, Pages 718-725

  Fadini, G P ^a   de Kreutzenberg, S V ^a   Mariano, V ^a   Boscaro, E ^a   Bertolini, F ^b   Mancuso, P ^b   Quarna, J ^b   Marescotti, M ^a   Agostini, C ^a   Tiengo, A ^a   Avogaro, A ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

Bone marrow; Cardiovascular disease; Diabetes complications; Insulin analogues; Stem cells

Indexed keywords

ACETYLSALICYLIC ACID; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HEMOGLOBIN A1C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN DETEMIR; INSULIN GLARGINE; INTERCELLULAR ADHESION MOLECULE 1; METFORMIN; VASCULAR CELL ADHESION MOLECULE 1;

ADD ON THERAPY; ADULT; AGED; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE ASSOCIATION; DRUG EFFECT; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM LESION; FEMALE; FLUID RETENTION; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN TREATMENT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; VASCULAR DISEASE; WEIGHT GAIN;

EID: 79959476110     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2011.01396.x     Document Type: Article

References (28)

1. Boos CJ, Lip GY, Blann AD. Circulating endothelial cells in cardiovascular disease. J Am Coll Cardiol 2006; 48: 1538-1547.
2. He T, Smith LA, Harrington S et al. Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries. Stroke 2004; 35: 2378-2384.
3. Fadini GP, Avogaro A. Cell-based methods for ex vivo evaluation of human endothelial biology. Cardiovasc Res 2010; 87: 12-21.
4. McClung JA, Naseer N, Saleem M et al. Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independently of HbA(1)c. Diabetologia 2005; 48: 345-350.
5. Fadini GP, Avogaro A. Potential manipulation of endothelial progenitor cells in diabetes and its complications. Diabetes Obes Metab 2010; 12: 570-583.
6. Fadini GP, Boscaro E, Albiero M et al. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes mellitus. Possible role of stromal derived factor-1α. Diabetes Care 2010; 33: 1607-1609.
7. Humpert PM, Neuwirth R, Battista MJ et al. SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes. Diabetes Care 2005; 28: 934-936.
8. Humpert PM, Djuric Z, Zeuge U et al. Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor-dependent signaling. Mol Med 2008; 14: 301-308.
9. Muniyappa R, Montagnani M, Koh KK, Quon MJ. Cardiovascular actions of insulin. Endocr Rev 2007; 28: 463-491.
10. Petrelli A, Maestroni A, Fadini GP et al. Improved function of circulating angiogenic cells is evident in type 1 diabetic islet-transplanted patients. Am J Transplant 2010; 10: 2690-2700.
11. Pozzilli P, Leslie RD, Chan J et al. The A1C and ABCD of glycaemia management in type 2 diabetes: a physician's personalized approach. Diabetes Metab Res Rev 2010; 26: 239-244.
12. Wright RJ, Newby DE, Stirling D et al. Effects of acute insulin-induced hypoglycemia on indices of inflammation: putative mechanism for aggravating vascular disease in diabetes. Diabetes Care 2010; 33: 1591-1597.
13. Gogitidze JN, Hedrington MS, Briscoe VJ et al. Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals. Diabetes Care 2010; 33: 1529-1535.
14. Wilson PW, Bozeman SR, Burton TM et al. Prediction of first events of coronary heart disease and stroke with consideration of adiposity. Circulation 2008; 118: 124-130.
15. Powell TM, Paul JD, Hill JM et al. Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2005; 25: 296-301.
16. Hermansen K, Davies M, Derezinski T et al. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care 2006; 29: 1269-1274.
17. Fleiss JL. The Design and Analysis of Clinical Experiments. New York: John Wiley & Sons, 1999.
18. Roberts LJ, Morrow JD. Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med 2000; 28: 505-513.
19. Aljada A, Friedman J, Ghanim H et al. Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects. Metabolism 2006; 55: 1177-1185.
20. Gimbrone MA Jr, Nagel T, Topper JN. Biomechanical activation: an emerging paradigm in endothelial adhesion biology. J Clin Invest 1997; 100: S61-65.
21. Fadini GP, Maruyama S, Ozaki T et al. Circulating progenitor cell count for cardiovascular risk stratification. A pooled analysis. PLoS ONE 2010; 5: e11488.
22. Fadini GP, Sartore S, Agostini C, Avogaro A. Significance of endothelial progenitor cells in subjects with diabetes. Diabetes Care 2007; 30: 1305-1313.
23. Aljada A, Saadeh R, Assian E, Ghanim H, Dandona P. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab 2000; 85: 2572-2575.
24. Dandona P, Aljada A, Mohanty P et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 2001; 86: 3257-3265.
25. Fadini GP, Boscaro E, de Kreutzenberg S et al. Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes. Diabetes Care 2010; 33: 1097-1102.
26. Oikawa A, Siragusa M, Quaini F et al. Diabetes mellitus induces bone marrow microangiopathy. Arterioscler Thromb Vasc Biol 2010; 30: 498-508.
27. Gerstein HC, Miller ME, Byington RP et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008; 358: 2545-2559.
28. Fadini GP, Rigato M, Tiengo A, Avogaro A. Characteristics and mortality of type 2 diabetic patients hospitalized for severe iatrogenic hypoglycemia. Diabetes Res Clin Pract 2009; 84: 267-272.