Gastroprotective mechanisms of the chloroform and ethyl acetate phases of Praxelis clematidea (Griseb.) R.M.King & H.Robinson (Asteraceae)

Journal of Natural Medicines

Volumn 67, Issue 3, 2013, Pages 480-491

  Falcão, Heloina De Sousa ^a   Maia, Gabriela Lemos De Azevedo ^a   Bonamin, Flávia ^c   Kushima, Hélio ^c   Moraes, Thiago Mello ^c   Hiruma Lima, Clélia Akiko ^c   Takayama, Christiane ^b   Ferreira, Anderson Luiz ^b   Souza Brito, Alba Regina Monteiro ^b   Agra, Maria De Fátima ^a   Barbosa Filho, José Maria ^a   Batista, Leônia Maria ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Asteraceae; Cytoprotection; Gastric ulcer; Gastroprotective activity; Praxelis clematidea

Indexed keywords

7,4' DIMETHYLAPIGENIN; ACETIC ACID ETHYL ESTER; APIGENIN; CHLOROFORM; CIMETIDINE; CIRSIMARITIN; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; GENKWANIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LANSOPRAZOLE; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PRAXELIS CLEMATIDEA EXTRACT; PROSTAGLANDIN E2; SUPEROXIDE DISMUTASE; TETRAMETHYLSCUTELLAREIN; THIOL GROUP; TRIMETHYLAPIGENIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASTERACEAE; CELL INFILTRATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; POLYMORPHONUCLEAR CELL; PRAXELIS CLEMATIDEA; SINGLE DRUG DOSE; STOMACH MUCUS; STOMACH PROTECTION; STOMACH SECRETION; STOMACH ULCER;

ACETATES; ANIMALS; ANTI-ULCER AGENTS; ASTERACEAE; BIOLOGICAL MARKERS; CHLOROFORM; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ETHANOL; GASTRIC MUCOSA; MALE; MICE; MUCUS; PHYTOTHERAPY; PIROXICAM; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SOLVENTS; STOMACH ULCER;

EID: 84879241660     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-012-0705-4     Document Type: Article

References (62)

1. Milani S, Calabro A (2001) Role of growth factors and their receptors in gastric ulcer healing. Microsc Res Tech 53:360-371
2. Bandyopadhyay D, Biswas K, Bhattacharyya M, Reiter RJ, Banerjee RK (2001) Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin. Curr Mol Med 1:501-513
3. Chan FKL, Leung WK (2002) Peptic-ulcer disease. Lancet 360:933-941
4. Brozozowski T (2003) Experimental production of peptic ulcer, gastric damage and cancer models and their use in pathophysiological studies and pharmacological treatment - Polish achievements. J Physiol Pharmacol 54:99-126
5. Yuan Y, Padol IT, Hunt RH (2006) Peptic ulcer disease today. Nat Clin Pract Gastroenterol Hepatol 3:80-89
6. Lipof T, Shapiro D, Kozol RA (2006) Surgical perspectives in peptic ulcer disease and gastritis. World J Gastroenterol 12:3248-3252
7. Alper JA (1993) Ulcers as an infectious disease. Science 260:159-160
8. Sandes ARR, Di Blasi G (2000) Biodiversidade e diversidade química e genética. Biotecnologia Cienc Desenvolv 13:28-32
9. Sousa FO (2007) Asteraceae no Parque Estadual da Ilha do Cardoso, Cananéia, SP. Thesis to Instituto de Botânica da Secretaria do Meio Ambiente, São Paulo
10. Pollock S, Holland A, Smith W (2004) New alien weed for Queensland Praxelis. Queensland Herbarium Alert Sheet, Environmental Protection Agency
11. Wang ZH, Christie P, Chen QB, Liu XX, Xie LL, Bai CJ, Li XL (2006) Allelopathic potential and chemical constituents of volatile oil from Praxelis clematidea. Allelopathy J 18:225-235
12. Corlett RT, Shaw JC (1995) Praxelis clematidea: yesterday South America, today Hong Kong, tomorrow the world? Mem Hong Kong Nat Hist Soc 20:235-236
13. Noumi E, Dibakto TW (2000) Medicinal plants used for peptic ulcer in the Bangangte region, Western Cameroon. Fitoterapia 71:406-412
14. Bohlmann F, Wegner P, Jakupovic J, King RM (1984) Structure and synthesis of the methyl ester of N-(acetoxy)jasmonoylphenylalanine from Praxelis clematidea. Tetrahedron 40:2537-2540
15. Maia GLA, Falcão-Silva VS, Aquino PGV, Araújo-Júnior JX, Tavares JF, Silva MS, Rodrigues LC, Siqueira-Júnior JP, Barbosa-Filho JM (2011) Flavonoids from Praxelis clematidea R.M. King and H. Robinson modulate bacterial drug resistance. Molecules 16:4828-4835
16. Almeida JRGS, Silva MS, Cunha EVL, Athayde-Filho PF, Diniz MFFM, Silva MG, Takemura OS, Barbosa-Filho JM (2006) Chemical constituents and analgesic activity of Conocliniopsis prasiifolia. Pharm Biol 44:76-78
17. Agrawal PK (1989) Carbon-13 NMR of flavonoids. Elsevier, New York
18. Middleton EJ, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673-751
19. Morimoto Y, Shimohara K, Oshima S, Sukamoto T (1991) Effects of the new antiulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terpenone and cimetidine. Jpn J Pharmacol 57:495-505
20. Szelenyi I, Thiemer K (1978) Distention ulcer as a model for testing of drugs for ulcerogenic side effects. Arch Toxicol 41:99-105
21. Puscas I, Puscas C, Coltau M, Pasça R, Torres J, Márquez M, Herrero E, Fillat O, Ortiz JA (1997) Comparative study of the safety and efficacy of ebrotidine versus ranitidine and placebo in the prevention of piroxicam-induced gastroduodenal lesions. Arzneimittelforschung 47:568-572
22. Senay SE, Levine RJ (1967) Synergism between cold and restraint for rapid production of stress ulcer in rats. Proc Soc Exp Biol Med 124:1221-1223
23. Ueda S, Yoshikawa T, Takahashi S, Ichikawa H, Yasuda M, Oyamada H, Tanigawa T, Sugino S, Kondo M (1989) Role of free radicals and lipid peroxidation in gastric mucosal injury induced by ischemia-reperfusion in rats. Scand J Gastroenterol 162:55-58
24. Anderson M (1985) Determination of glutathione disulfide in biological samples. Methods Enzymmol 113:548-555
25. Winterbourn CC, Hawkins RE, Brian M, Carrel RW (1995) The stimulation of red cell superoxide dismutase activity. J Lab Clin Med 85:337-341
26. Yoshikawa T, Naito Y, Kishi A, Tomii T, Kaneko T, Iinuma S, Ichikawa H, Yasuda M, Takahashi S, Kondo M (1993) Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut 34:732-737
27. Carlberg I, Mannervik B (1985) Glutathione reductase. Methods Enzymol 113:484-490
28. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358
29. Krawisz JE, Sharon P, Stenson WF (1984) Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in the rat and hamster model. Gastroenterology 87:1344-1350
30. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H (1945) A simple method for the uniform production of gastric ulceration in rat. Gastroenterology 5:43-61
31. Corne SJ, Morriessay SM, Woods RJ (1974) A method for the quantitative estimation of gastric barrier mucus. J Physiol 242:116-117
32. Curtis GH, Macnaughton WK, Gall DG, Wallace JL (1995) Intraluminal pH modulates gastric prostaglandin synthesis. Can J Physiol Pharmacol 73:130-134
33. Sikiric P, Seiwerth S, Grabarevi E, Ruman R, Petek M, Jagi V, Turkovi B, Rotkvimie I, Mie S, Zorii I, Konjevoda P, Perovi D, Jurina L, Eparovi J, Hanevaki M, Artukovi B, Bratuli M, Tiljar M, Gjurain M, Mikli P, Stani-Rokotov D, Slobodnjak Z, Jelovac N, Marovi A (1997) The influence of a novel pentadecapeptide, BPC 157, on NG-nitro-l-arginine methylester and l-arginine effect on stomach mucosa integrity and blood pressure. Eur J Pharmacol 332:23-33
34. Matsuda H, Li Y, Yoshikawa M (1999) Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol 373:63-70
35. Hirschowitz BI, Keeling D, Lewin M, Okabe S, Parsons M, Sewing K, Wallmark B, Sachs G (1995) Pharmacological aspects of acid secretion. Dig Dis Sci 40:3s-23s
36. Dembieska-Kiec A, Pallapies D, Simmet T, Peskar BM, Peskar BA (1991) Effect of carbenoxolone on the biological activity of nitric oxide: relation to gastroprotection. Br J Pharmacol 104:811-816
37. Elisabetsky E (1991) Sociopolitical, economical and ethical issues in medicinal plant research. J Ethnopharmacol 32:235-239
38. Szabo S, Trier JS, Frankel P (1981) Sulfhydryl compounds may mediate gastric cytoprotection. Science 214:200-202
39. Hirokawa M, Miura S, Yoshida H, Kurose I, Shigematsu T, Hokari R, Higuchi H, Watanabe N, Yokoyama Y, Kimura H, Kato S, Ishii H (1998) Oxidative stress and mitochondrial damage precedes gastric mucosal cell death induced by ethanol administration. Alcohol Clin Exp Res 22:111S-114S
40. Kvietys PR, Twohig B, Danzell J, Specian RD (1990) Ethanol-induced injury to the rat gastric mucosa. Role of neutrophils and xanthine oxidase-derived radicals. Gastroenterology 98:909-920
41. Oates PJ, Hakkinen JP (1988) Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology 94:10-21
42. Konturek SJ, Konturek PC, Brzozowski T (2005) Prostaglandins and ulcer healing. J Physiol Pharmacol 56:5-31
43. Dhabhar FS (2009) Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology. Neuroimmunomodulation 16:300-317
44. Dugan LL, Choi DW (1994) Excitotoxicity, free radicals, and cell membrane changes. Ann Neurol 35:S17-S21
45. Paller MS (1994) The cell biology of reperfusion injury in the kidney. J Invest Med 42:632-639
46. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress-induced câncer. Chem Biol Interact 160:1-40
47. Mojzis J, Hvisčová K, Germanová D, Bukovičová D, Mirossay L (2001) Protective effect of quercetin on ischemia/reperfusion induced gastric mucosal injury in rats. Physiol Res 50:501-506
48. Schroeter H, Boyd C, Spencer JPE, Williams RJ, Cadenas E, Rice-Evans C (2002) MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide. Neurobiology 23:861-880
49. Maia GLA, Oliveira AMF, Silva Filho RN, Costa VCO, Tavares JF, Assis TS, Barbosa Filho JM (2010) Teor de fenólicos totais e capacidade antioxidante do extrato, das fases e de flavonóides de Praxelis clematidea - XXI Simpósio de Plantas Medicinais do Brasil, João Pessoa, Brazil
50. Deoda RS, Kumar D, Bhujbal SS (2011) Gastroprotective effect of Rubia cordifolia Linn. on aspirin plus pylorus-ligated ulcer. Evid Based Complement Alternat Med 2011:541-624
51. Flemstrom G, Isenberg JI (2001) Gastroduodenal mucosal alkaline secretion and mucosal protection. News Physiol Sci 16:23-28
52. Grisham MB, Von Ritter C, Smith BF, Lamont JT, Granger DN (1987) Interaction between oxygen radicals and gastric mucin. Am J Physiol 253:G93-G96
53. Forstner G (1995) Signal transduction, packaging and secretion of mucins. Annu Rev Physiol 57:585-605
54. Avila JR, Lastra CADL, Martín MJ, Motilva V, Luque I, Delgado D, Esteban J, Herrerias J (1996) Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflamm Res 45:83-88
55. Motilva V, López A, Martin MJ, La Casa C, Alacón De La Lastra C (1996) Cytoprotective activity of cisapride on experimental gastric mucosal lesions induced by ethanol. Role of endogenous prostaglandins. Prostaglandins 52:63-74
56. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P (1993) Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA 90:7240-7244
57. Kortezova NI, Shikova LI, Milusheva EA, Itzev DE (2004) Muscarinic modulation of nitrergic neurotransmission in guinea-pig gastric fundus. Neurogastroenterol Motil 16:155-165
58. Aly ATMM (1995) The role of nitric oxide and sulfhydryls in gastric mucosal protection induced by sodium cromoglycate in rats. J Pharm Pharmacol 47:739-743
59. Szelenyi I, Brune K (1988) Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 33:865-871
60. Rastogi L, Patnaik GK, Dikshit M (1998) Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats. Pharmacol Res 38:125-132
61. Brzozowski T, Konturek PC, Konturek SJ, Brzozowska I, Pawlik T (2005) Role of prostaglandins in gastroprotection and gastric adaptation. J Physiol Pharmacol 56:33-55
62. Matsui H, Shimokawa O, Kaneko T, Nagano Y, Rai K, Hyodo I (2011) The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine. J Clin Biochem Nutr 48:107-111