Experimental production of peptic ulcer, gastric damage and cancer models and their use in pathophysiological studies and pharmacological treatment - Polish achievements

Journal of Physiology and Pharmacology

Volumn 54, Issue SUPPL. 3, 2003, Pages 99-126

  Brzozowski, Tomasz ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Growth factors; Helicobacter pylori; Nitric oxide; Non steroidal antiinflammatory drugs; Peptic ulcers; Prostaglandins

Indexed keywords

ACETYLSALICYLIC ACID; BILE SALT; CANCER GROWTH FACTOR; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; EPIDERMAL GROWTH FACTOR; HISTAMINE H2 RECEPTOR ANTAGONIST; LEUKOTRIENE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROTON PUMP INHIBITOR; THROMBOXANE;

ARTICLE; CANCER MODEL; CELL PROTECTION; CLINICAL TRIAL; DRUG RESEARCH; DUODENUM ULCER; EXPERIMENTAL ANIMAL; EXPERIMENTATION; GASTROINTESTINAL MUCOSA; HELICOBACTER INFECTION; HUMAN; NONHUMAN; PEPTIC ULCER; STOMACH ACID SECRETION; STOMACH INJURY; STOMACH ULCER; STRESS; UPPER GASTROINTESTINAL TRACT;

ANIMALS; DISEASE MODELS, ANIMAL; GASTRIC MUCOSA; GASTROINTESTINAL AGENTS; GASTROINTESTINAL NEOPLASMS; HISTORY, 18TH CENTURY; HISTORY, 20TH CENTURY; HUMANS; PEPTIC ULCER; POLAND;

EID: 1842580968     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (76)

1. Dupuytren G. Lecons Orales de Clinique Chirurgicale. Brussels, 1836.
2. Curling TB. On the Acute Ulceration of the Duodenum in Cases of Burn. London 1841.
3. Hartman FW. Curling's ulcer in experimental burn. Ann Surgery 1945; 121: 54-58.
4. Biesiadecki A. O wrzodach ostrych dwunastnicy. Przeglad Lekarski 1869; 31: 247-249.
5. Billroth TH. Offenes Schreiben an Herren Dr. L. Wittelshoer. Feuilleton. Wiener Med Wochensch 1881; 6: 164-166.
6. Rydygier L. Die erste Magenresection beim Magengeschwur. Berliner Klinische Wochenschrift 1882; 3: 4-6.
7. Moynihan B. The diagnosis and treatment of duodenal ulcer. Proc Royal Soc Med 1909; 3: 1909-1910.
8. Latarjet MA. Resection des nerfs l'estomac. Technique operatoire. Resultats cliniques. Bull Acad Med 1992; 5: 681-683.
9. Dragstedt LR, Oberhelman HA, Smith CA. Experimental hyperfunction of the gastric antrum with ulcer formation. Ann Surg 1951; 134: 332-335.
10. Edkins J.S. The chemical mechanism of gastric secretion. J Physiol 1906; 34: 133-144.
11. Schwarz K. Uber penetrierende Magen- and Jejunalgeschwure, 1910.
12. 2 receptors. Nature 1972; 236: 385-390.
13. Popielski L. Uber das peripherische reflectorische Centrum der Magendrusen. Zentralblatt fur Physiologie 1902; 16: 121-123.
14. Buchner F, Siebert P, Mollay PJ. Lieber experimental erzeugte akute peptische Geschwure des Rattenvormagens. Beitr. zur pathol Anat. und zur allgem. Pathol 1928; 81: 391-425.
15. Hay LJ, Varco RL, Code CF, Wangensteen OF. Experimental production of gastric and duodenal ulcers in laboratory animals by intramuscular injection of histamine in beeswax. Surg Gyn Obst 1942; 74: 70-182.
16. Conrad V, Kowalewski K, van Geertruyden J. Contribution a l'etude de l'achlorhydrie vraie. Action de doses croissantes d'histamine sur la secretion gastrique de malades proteges par l'antistine. Acta Gastro-Enter Belg 1949; 12: 545-570.
17. Kowalewski K. Importance of dosage of stimulant in histamine test of gastric function. D.V.A. Treatment Service Bullet 1953; 8: 325-327.
18. Kowalewski K, Bain GO. Prevention of post-histaminic gastric ulcers in guinea pigs by posterior pituitary extract. Acta Gastro-Enter Belg 1954; 17: 539-551.
19. Kay AW. Effect of large doses of histamine on gastric secretion of HCl; augmented histamine test. Br Med J 1953; 2: 77-80.
20. Kowalewski K. Vascular factor in the etiology of post-histaminic gastric ulcer in guinea pig. Protective action of synthetic vasopressin analoque octapressin. Arch Int Pharmacol Ther 1967; 170:66-73.
21. Mann FC, Williamson CS. The experimental production of peptic ulcer. Ann Surg 1973; 77: 409-411.
22. Kaulbersz J, Oginski A, Bilski R, Bugajski J. Wplyw wagotomii na powstawanie doświadczalnych wrzodów trawiennych u szczurów. Acta Physiol Pol 1956; 7: 3-6.
23. Bilski J, Radecki T, Kaulbersz J. Doswiadczalne wrzody trawienne u szczurów w obnizonym cisnieniu atmosferycznym. Acta Physiol Pol 1960; 11: 661-665.
24. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1945; 5: 45-48.
25. Radecki T. Powstawanie doswiadczalnych wrzodów trawiennych u szczurów w zaleznosci od retencji soku zoladkowego i poprzedniego glodzenia. Acta Physiol Pol 1956; 7: 7-11.
26. Konturek S, Radecki T, Kaulbersz J. Doswiadczalne wrzody trawienne u szczurów pozbawionych przysadki. Acta Physiol Pol 1957; 3: 383-386.
27. Konturek S, Kaulbersz J. Effect of urogastrone from adrenalectomized dogs on gastric secretion. Gastroenterology 1963; 44: 801-805.
28. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 1979; 77: 433-440.
29. Konturek SJ, Piastucki I, Brzozowski T et al. Role of prostaglandins in the formation of aspirin induced gastric ulcers. Gastroenterology 1981; 80: 4-9.
30. Robert A, Nezamis IE, Lancaster C, Davies IP, Field SO, Hanchar AJ. Mild irritant prevent gastric necrosis through adaptive cytoprotection mediated by prostaglandins. Am J Physiol 1983; 245: 113-116.
31. Konturek SJ, Brzozowski T, Piastucki I, Dembinski A, Dembinska-Kiec A. Role of locally generated prostaglandin in adaptive gastric cytoprotection. Dig Dis Sci 1982; 27: 967.
32. 2 in gastric mucosa and its role in the prevention of ulcers induced by acetyl salicylic acid in cats. Digestion 1981; 21: 205-213.
33. 2, colloidal bismuth and sucralfate in rats. Digestion 1987; 38: 102-113.
34. Cho CH, Ko IK, Tang XL. The differential mechanism of mild irritants on adaptative cytoprotection. Eur J Gastroenterol Hepatol 1994; 9 (Suppl 1): 24-27.
35. Hawkey CJ, Kemp RT, Walt RP, Bhaskar NK, Davies J, Filipowicz B. Evidence that adaptive cytoprotection in rats is not mediated by prostaglandins. Gastroenterology 1988; 94: 948-953.
36. Whittle BJR, Lopez-Bolmonte J, Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 1990; 99: 607-611.
37. Konturek SJ, Brzozowski T, Bielanski W, Schally AV. Role of endogenous gastrin in gastroprotection. Eur J Pharmacol 1995; 278: 203-212.
38. Brzozowski T, Konturek PCh, Pajdo R, Duda A, Pierzchalski P, Bielanski W. Leptin in gastroprotection induced by cholecystokinin or by a meal. Role of vagal and sensory nerves and nitric oxide. Eur J Pharmacol 1999; 374: 263-276.
39. Konturek SJ, Brzozowski T, Majka J, Pytko-Polonczyk J, Stachura J. Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers. Eur J Pharmacol 1993; 239: 215-217.
40. Takagi K, Okabe S, Saziki R. A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Jpn J Pharmacol 1970; 19: 418-421.
41. Okabe S, Pfeiffer CJ, Roth JLR. A method for experimental penetrating gastric and duodenal ulcers in rats. Am J Dig Dis 1971; 16: 277-284.
42. Konturek SJ, Brzozowski T, Majka J, Dembinski A, Slomiany A, Slomiany BL. Transforming growth factor and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992; 27: 649-655.
43. Brzozowski T, Konturek PC, Konturek SJ et al. Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. Microsc Res Tech 2001; 53: 343-353.
44. Brzozowski T, Konturek P Ch, Konturek SJ et al. Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves. Reg Pept 1999; 82: 19-33.
45. Brzozowski T, Konturek PC, Konturek SJ et al. Central leptin and cholecystokinin in gastroprotection against ethanol-induced damage. Digestion 2000; 62: 126-131.
46. Kargman S, Charleson S, Cartwright M et al. Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey and human gastrointestinal tracts. Gastroenterology 1996; 111: 445-454.
47. Eberhart CE, Dubois RN. Eicosanoids and the gastrointestinal tract. Gastroenterology 1995; 109: 258-301.
48. Brzozowski T, Konturek PCh, Konturek SJ et al. Role of prostaglandin-generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion induced gastric lesions. Eur J Pharmacol 1999; 385: 47-61.
49. Konturek PC, Brzozowski T, Konturek SJ, Ernst H, Drozdowicz D, Pajdo R. Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Scand J Gastroenterol 1997; 32: 6-15.
50. Kishimoto Y, Wada K, Nakamoto K et al. Quantitative analysis of cyclooxygenase-2 gene expression on acute gastric injury induced by ischemia-reperfusion in rats. Life Sci 1998; 60: 127-133.
51. Gretzer B, Ehrlich K, Maricic N, Lambrecht N, Respondek M, Peskar BM. Selective cyclooxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach. Br J Pharmacol 1998; 123: 927-935.
52. Konturek PK, Brzozowski T, Konturek SJ, Dembinski A. Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress-induced gastric lesions. Gastroenterology 1990; 99: 1607-1615.
53. Mizuno H, Sakamoto Ch, Matsuda K et al. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specifi antagonist delays healing in mice. Gastroenterology 1997; 12: 387-397.
54. Schmassmann A, Peskar BM, Stettler C et al. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastrointestinal ulcer models in rats. Br J Pharmacol 1997; 123: 795-804.
55. Konturek SJ, Brzozowski T, Stachura J, Dembiński A, Majka J. Role of gastric blood flow, neutrophil infiltration, and mucosal cell proliferation in gastric adaptation to aspirin in the rat. Gut 1994, 35, 1189-1196.
56. Brzozowski T, Konturek PC, Konturek SJ, Ernst H, Stachura J, Hahn EG. Gastric adaptation to injury by repeated doses of aspirin strengthens mucosal defense against subsequent exposure to various strong irritants in rats. Gut 1995, 37, 749-757.
57. Takagi K, Okabe S. The effects of drugs on the production and recovery process of the stress ulcer. Jpn. J Pharmacol 1968; 18: 9-11.
58. Vane JR, Botting RM. New insights into the mode of action of anti-inflammatory drugs. Inflammation 1995; 44: 1-10.
59. Wallace JL, Reuter B, Cicala C, McKnight W, Grishman M, Cirino G. A diclofenac derivative without ulcerogenic properties. Eur J Pharmacol 1994; 257: 249-255.
60. Elliott SN, McKnight W, Cirino G, Wallace JL. A nitric oxide-releasing non steroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 1995; 109: 524-530.
61. Takeuchi K, Suzuki K, Yammamoto H, Araki H, Mizoguchi H, Ukawa H. Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses. J Physiol Pharmacol 1998; 49: 501-505.
62. Brzozowski T, Drozdowicz D, Szlachcic A, Pytko-Polonczyk J, Majka J. Role of nitric oxide and prostaglandins in gastroprotection induced by capsaicin and papaverine. Digestion 1993; 54: 24-31.
63. Brzozowski T, Konturek SJ, Śliwowski Z, Pytko-Polonczyk J, Szlachcic A, Drozdowicz D. Role of capsaicin-sensitive sensory nerves in gastroprotection against acid-independent and acid-dependent ulcerogens. Digestion 1996, 57: 424-428.
64. Brzozowski T, Konturek PC, Konturek SJ et al. Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs. Dig Liver Dis 2000, 32: 583-594.
65. Fiorucci S, Antonelli E, Santucci L et al. Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats. Gastroenterology 1999; 116: 1089-1106.
66. Parratt J.R. Protection of the heart by ischemic preconditioning: mechanism and possibilities for pharmacological exploitation. TiPS 1994; 15: 19-21.
67. Murry CE, Jenning RB, Reimer KA. Preconditioning with ischemia: a delay in lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124.
68. Pajdo R, Brzozowski T, Konturek PC et al. Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves. Eur J Pharmacol 2001; 427: 263-276.
69. Konturek PCh, Konturek SJ, Konturek JW. Gastric secretion and the pathogenesis of peptic ulcer in the Helicobacter pylori infection. J Physiol Pharmacol 1996; 47: 5-12.
70. Jaworski W. Podrȩcznik chorób żoła̧dka. Wydawnictwo Dzieł Lekarskich Polskich 1893; 32.
71. Blaser MJ. Hypothesis on the pathogenesis and natural history of Helicobacter pylori - induced inflammation. Gastroenterology 1992; 102: 720-727.
72. Crabtree JE, Figura N, Taylor JD, Bungnoli M, Armellini D, Tompkins DS. Expression of 120 kilodalton protein and cytotoxicity in Helicobacter pylori. J Clin Pathol 1992; 45: 733-734.
73. Konturek PCh, Brzozowski T, Konturek SJ et al. Mouse model of Helicobacter pylori infection: studies on gastric function and ulcer healing. Aliment Pharm Ther 1999; 13: 333-346.
74. Brzozowski T, Konturek PC, Konturek SJ et al. Water extracts of Helicobacter pylori delay healing of chronic gastric ulcers in rats: Role of cytokines and gastrin-somatostatin link. Digestion 1999; 60: 22-33.
75. Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 1998; 115: 642-648.
76. Konturek PC, Brzozowski T, Konturek SJ et al. Functional and morphological aspects of Helicobacter pylori-induced gastric cancer in Mongolian gerbils. Eur J Gastroentcrol Hepatol 2003; 15: 745-754.