Does microcalcification increase the risk of rupture?

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Volumn 227, Issue 5, 2013, Pages 588-599

  Cilla, Myriam ^a,b   Monterde, David ^a   Pena, Estefania ^a,b   Martinez, Miguel A ^a,b  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

Coronary disease; Hyperelastic material; Microcalcifications; Parametric finite element analysis; Vulnerable plaque

Indexed keywords

CORONARY DISEASE; HYPERELASTIC MATERIALS; MICROCALCIFICATIONS; PARAMETRIC FINITE ELEMENTS; VULNERABLE PLAQUES;

FINITE ELEMENT METHOD; STRESS CONCENTRATION; THERMOELECTRICITY; BLOOD VESSELS; STRAIN;

BLOOD VESSELS; FINITE ELEMENT METHOD;

ANIMAL; AUDIOVISUAL EQUIPMENT; BIOLOGICAL MODEL; CALCINOSIS; COMPLICATION; COMPUTER SIMULATION; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; HUMAN; MECHANICAL STRESS; PATHOLOGY; PATHOPHYSIOLOGY; RISK ASSESSMENT; RUPTURE, SPONTANEOUS; SHEAR STRENGTH; TENSILE STRENGTH; YOUNG MODULUS;

ANIMALS; CALCINOSIS; COMPUTER SIMULATION; CORONARY ARTERY DISEASE; CORONARY VESSELS; ELASTIC MODULUS; HUMANS; MODELS, ANATOMIC; MODELS, CARDIOVASCULAR; RISK ASSESSMENT; RUPTURE, SPONTANEOUS; SHEAR STRENGTH; STRESS, MECHANICAL; TENSILE STRENGTH;

EID: 84879236284     PISSN: 09544119     EISSN: 20413033     Source Type: Journal    
DOI: 10.1177/0954411913479530     Document Type: Conference Paper

References (57)

1. Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke statistics -2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009; 119: 21-181.
2. Hanke H, Lenz C and Finking G. The discovery of the pathophysiological aspects of atherosclerosis -a review. Acta Chir Belg 2001; 101: 162-169.
3. Ohayon J, Finet G, Treyve F, et al. A three dimensional finite element analysis of stress distribution in a coronary atherosclerotic plaque: in-vivo prediction of plaque rupture location. Biomech Appl Comput Assist Surg 2005; 17: 225-241.
4. Versluis A, Bank AJ and Douglas WH. Fatigue and plaque rupture in myocardial infarction. J Biomech 2006; 39: 339-347.
5. Virmani R, Kolodgie FD, Burke AP, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000; 20: 1262-1275.
6. Krishna Kumar R and Balakrishnan KR. Influence of lumen shape and vessel geometry on plaque stresses: possible role in the increased vulnerability of a remodelled vessel and the shoulder of a plaque. Heart 2005; 91: 1459-1465.
7. Cilla M, Pen a E and Martinez MA. 3D computational parametric analysis of eccentric atheroma plaque: influence of axial residual stresses. Biomech Model Mechanobiol 2012; 11(7): 1001-1013.
8. Roijers RB, Dutta RK, Cleutjens JPM, et al. Early calcifications in human coronary arteries as determined with a proton microprobe. Anal Chem 2008; 80: 55-61.
9. Van der Giessen AG, Gijsen FJH, Wentzel JJ, et al. Small coronary calcifications are not detectable by 64-slice contrast enhanced computed tomography. Int J Cardiovasc Imaging 2011; 27(1): 143-152.
10. Friedrich GJ, Moes NY, Muhlberger VA, et al. Detection of intralesional calcium by intracoronary ultrasound depends on the histologic pattern. Am Heart J 1994; 128: 435-441.
11. Lee RT, Schoen FJ, Loree HM, et al. Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Arterioscler Thromb Vasc Biol 1996; 16(8): 1070-1073.
12. Kaazempur-Mofrad MR, Isasi AG, Younis HF, et al. Characterization of the atherosclerotic carotid bifurcation using MRI, finite element modeling, and histology. Ann Biomed Eng 2004; 32(7): 932-946.
13. Vengrenyuk Y, Carlier S, Xanthos S, et al. A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci USA 2006; 103: 14678-14683.
14. Cheng G, Loree H, Kamm R, et al. Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. Circulation 1993; 87: 1179-1187.
15. Huang H, Virmani R, Younis H, et al. The impact of calcification on the biomechanical stability of atherosclerotic plaques. Circulation 2001; 103: 1051-1056.
16. Wong K, Thavornpattanapong P, Cheung S, et al. Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model. BMC Cardiovasc Disord 2012; 12(1): 7.
17. Bluestein D, Alemu Y, Avrahami I, et al. Influence of microcalcifications on vulnerable plaque mechanics using FSI modelling. J Biomech 2008; 41: 1111-1118.
18. Wenk JF, Papadopoulos P and Zohdi TI. Numerical modeling of stress in stenotic arteries with microcalcifications: a micromechanical approximation. ASME J Biomech Eng 2010; 132(9): 091011.
19. Wenk JF. Numerical modeling of stress in stenotic arteries with microcalcifications: a parameter sensitivity study. ASME J Biomech Eng 2011; 133: 014503.
20. Maldonado N, Kelly-Arnold A, Vengrenyuk Y, et al. A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture. Am J Physiol Heart Circ Physiol 2012; 303(5): H619-H628.
21. Finet G, Ohayon J and Rioufol G. Biomechanical interaction between cap thickness, lipid core composition and blood pressure in vulnerable coronary plaque: impact on stability or instability. Coron Artery Dis 2004; 15: 13-20.
22. Lee R. Atherosclerotic lesion mechanics versus biology. Zeitschrift fur Kardiologie 2000; 89: 80-84.
23. Ohayon J, Finet G, Gharib AM, et al. Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture. Am J Physiol Heart Circ Physiol 2008; 295: H717-H727.
24. Cilla M, Martinez J, Pen a E, et al. Machine learning techniques as a helpful tool towards determination of plaque vulnerability. IEEE Trans Biomed Eng 2012; 9(4): 1155-1161.
25. Williamson SD, Lam Y, Younis HF, et al. On the sensitivity of wall stresses in diseased arteries to variable material properties. ASME J Biomech Eng 2003; 125: 147-155.
26. Li Z, Howarth S, Tang T, et al. Does calcium deposition play a role in the stability of atheroma Location may be the key. Cerebrovasc Dis 2007; 24: 452-459.
27. Tang D, Yang C, Zheng J, et al. Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models. ASME J Biomech Eng 2005; 127: 1185-1194.
28. Sobol IM. Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates. Math Comput Simulat 2001; 55: 271-280.
29. Davies MJ. Stability and instability: two faces of coronary atherosclerosis: the Paul Dudley White lecture 1995. Circulation 1996; 94: 2013-2020.
30. Ohayon J, Teppaz P, Finet G, et al. In-vivo prediction of human coronary plaque rupture location using intravascular and finite element method. Coron Artery Dis 2001; 12: 655-663.
31. Fujii K, Carlier SG, Mintz GS, et al. Association of plaque characterization by intravascular ultrasound virtual histology and arterial remodeling. Am J Cardiol 2005; 96: 1476-1483.
32. Roy CS. The elastic properties of the arterial wall. J Physiol 1881; 3(2): 125-159.
33. Patel DJ and Fry DL. The elastic symmetry of arterial segments in dogs. Circ Res 1969; 24(1): 1-8.
34. Cox RH. Passive mechanics and connective tissue composition of canine arteries. Am J Physiol 1978; 234(5): 533-541.
35. Holzapfel GA, Gasser CT, Sommer G, et al. Determination of the layer-specific mechanical properties of human coronary arteries with non-atherosclerotic intimal thickening, and related constitutive modelling. Am J Physiol Heart Circ Physiol 2005; 289: H2048-H2058.
36. Carew TE, Vaishnav RN and Patel DJ. Compressibility of the arterial wall. Circ Res 1968; 23: 61-86.
37. Chuong CJ and Fung YC. Compressibility and constitutive equation of arterial wall in radial compression experiments. J Biomech 1984; 17(1): 35-40.
38. Gasser TC, Ogden RW and Holzapfel GA. Hyperelastic modelling of arterial layers with distributed collagen fibre orientations. J R Soc Interface 2006; 3: 15-35.
39. Spencer AJM. Theory of invariants. In: Continuum physics. AC Eringen (Ed) New York: Academic Press, 1971, pp.239-253.
40. Marquardt DW. An algorithm for least-squares estimation of nonlinear parameters. SIAM J Appl Math 1963; 11: 431-441.
41. Loree HM, Grodzinsky AJ, Park SY, et al. Static circumferential tangential modulus of human atherosclerotic tissue. J Biomech 1994; 27: 195-204.
42. Lendon CL, Davies MJ, Born GVR, et al. Atherosclerotic plaque caps are locally weakened when macrophages density is increased. Atherosclerosis 1991; 87: 87-90.
43. Lee RT, Loree HM and Fishbein MC. High stress regions in saphenous vein bypass graft atherosclerotic lesions. J Am Coll Cardiol 1994; 24(7): 1639-1644.
44. Beattie D, Xu C, Vito R, et al. Mechanical analysis of heterogeneous, atherosclerotic human aorta. ASME J Biomech Eng 1998; 120: 602-607.
45. Holzapfel GA, Stadler M and Schulze-Bauer CAJ. A layer specific three-dimensional model for the simulation of balloon angioplasty using magnetic resonance imaging and mechanical testing. Ann Biomed Eng 2002; 30: 753-767.
46. Holzapfel GA, Sommer G and Regitnig P. Anisotropic mechanical properties of tissue components in human atherosclerotic plaques. ASME J Biomech Eng 2004; 126: 657-665.
47. Kiousis DE, Rubinigg SF, Auer M, et al. A methodology to analyze changes in lipid core and calcification onto fibrous cap vulnerability: the human atherosclerotic carotid bifurcation as an illustratory example. ASME J Biomech Eng 2009; 131(12): 121002.
48. Arroyo LH and Lee RT. Mechanisms of plaque rupture: mechanical and biologic interactions. Cardiovasc Res 1999; 41: 369-375.
49. Briley-Saebo KC, Mulder WJM, Mani V, et al. Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes. J Magn Reson Imaging 2007; 26: 460-479.
50. Armentano R, Megnien JL, Simon A, et al. Effects of hypertension on viscoelasticity of carotid and femoral arteries in humans. Hypertension 1995; 26: 48-54.
51. Pena E, Alastrue V, Laborda A, et al. A constitutive formulation of vascular tissue mechanics including viscoelasticity and softening behaviour. J Biomech 2010; 43: 984-989.
52. Saito GE and Werff TJ. The importance of viscoelasticity in arterial blood flow models. J Biomech 1975; 8(3-4): 237-245.
53. Alastrue V, Pen a E, Martinez MA, et al. Assessing the use of the ''opening angle method'' to enforce residual stresses in patient-specific arteries. Ann Biomed Eng 2007; 35: 1821-1837.
54. Ohayon J, Dubreuil O, Tracqui P, et al. Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: potential impact for evaluating the risk of plaque rupture. Am J Physiol Heart Circ Physiol 2007; 293: H1987-H1996.
55. Kock SA, Nygaard JV, Eldrup N, et al. Mechanical stresses in carotid plaques using MRI-based fluid-structure interaction models. J Biomech 2008; 41: 1651-1658.
56. Himburg HA, Grzybowski DM, Hazel AL, et al. Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability. Am J Physiol Heart Circ Physiol 2004; 286: H1916-H1922.
57. Raggi P, Callister TQ, Cooil B, et al. Identification of patients at increased risk of first unheralded acute myocardial infarction by electron-beam computed tomography. Circulation 2000; 101: 850-855.