Characterization of the atherosclerotic carotid bifurcation using MRI, finite element modeling, and histology

Annals of Biomedical Engineering

Volumn 32, Issue 7, 2004, Pages 932-946

  Kaazempur Mofrad, M R ^a,b   Isasi, A G ^a   Younis, H F ^a   Chan, R C ^b   Hinton, D P ^b   Sukhova, G ^b   LaMuraglia, G M ^b   Lee, R T ^b   Kamm, R D ^a,c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NONE   (United States)

Author keywords

Atherosclerosis; Carotid 3D geometry; Excised plaque composition; FEM; Low oscillatory shear stress; MRI

Indexed keywords

BIFURCATION (MATHEMATICS); BOUNDARY CONDITIONS; COMPOSITION; DATA ACQUISITION; DISEASES; FINITE ELEMENT METHOD; FLUID DYNAMICS; HISTOLOGY; LIGHT VELOCITY; MAGNETIC RESONANCE IMAGING; STRESSES; ULTRASONICS;

ATHEROSCLEROSIS; CAROTID 3D GEOMETRY; EXCISED PLAQUE COMPOSITION; LOW/OSCILLATORY SHEAR STRESS;

BIOMEDICAL ENGINEERING;

AGED; ARTICLE; BIOLOGICAL MODEL; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAROTID ARTERY; CAROTID ARTERY DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SIMULATION; FINITE ELEMENT ANALYSIS; HUMAN; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PULSATILE FLOW; SHEAR STRENGTH; THREE DIMENSIONAL IMAGING;

AGED; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAROTID ARTERIES; CAROTID ARTERY DISEASES; COMPUTER SIMULATION; FINITE ELEMENT ANALYSIS; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; MODELS, CARDIOVASCULAR; PULSATILE FLOW; SHEAR STRENGTH;

EID: 3843084986     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:ABME.0000032456.16097.e0     Document Type: Article

References (41)

1. AHA. 1998 Heart and Stroke Statistical Update. Dallas, TX: American Heart Association, 1997.
2. Berger, S. A., and L. D. Jou. Flows in stenotic vessels. Ann. Rev. Fluid Mech. 32:347-384, 2000.
3. Bonnet, A. Characterization of global minimizers for Mumford-Shah functional image segmentation. Comptes Rendus de l'Academie des Sciences, Serie l-Mathematique 321:1121-1126, 1995.
4. Chan, R. C., J. Kaufhold, R. Lees, and W. Karl. Ultrasound analysis of vascular structure and deformation. In: SPIE, Aerosense 2000, edited by H. H. Pien. Orlando, FL: Battlefield Biomedical Technologies II, 2000, pp. 24-28.
5. Davies, P. F. Endothelial cells, hemodynamic forces, and the localization of atherosclerosis. In: Endothelial Cells. Boca Raton, FL: CRC Press, 1988.
6. Davies, P. F., and S. C. Tripathi. Mechanical-stress mechanisms and the cell - An endothelial paradigm. Circ. Res. 72:239-245, 1993.
7. Delfino, A., N. Stergiopulos, J. E. Moore, Jr., and J. J. Meister. Residual strain effects on the stress field in a thick wall finite element model of the human carotid bifurcation. J. Biomech. 30:777-786, 1997.
8. Deng, X. Y., P. W. Stroman, and R. Guidoin. Theoretical modeling of the release rate of low-density lipoproteins and their breakdown products at arterial stenoses. Clin. Invest. Med. 19:83-91, 1996.
9. Dirksen, M. T., A. C. van der Wal, F. M. van den Berg, C. M. van der Loos, and A. E. Becker. Distribution of inflammatory cells in atherosclerotic plaques relates to the direction of flow. Circulation 98:2000-2003, 1998.
10. Edelman, R. R., D. Chien, and D. Kim. Fast selective black blood MR imaging. Radiology 181:655-660, 1991.
11. Ethier, C. R. Computational modeling of mass transfer and links to atherosclerosis. Ann. Biomed. Eng. 30:461-471, 2002.
12. Falk, E. Progressive atherogenesis: Why do plaques rupture. Circulation 86:111-30-111-42, 1992.
13. Gonzales, R. S., and T. M. Wick. Hemodynamic modulation of monocytic cell adherence to vascular endothelium. Ann. Biomed. Eng. 24:382-393, 1996.
14. He, X., D. N. Ku, and J. E. Moore, Jr. Simple calculation of the velocity profiles for pulsatile flow in a blood vessel using Mathematica [published erratum appears in Ann. Biomed. Eng. 21(5):557-558, 1993]. Ann. Biomed. Eng. 21:45-49, 1993.
15. Kaazempur-Mofrad, M., and C. Ethier. Mass transport in a Realistic Human Right Coronary Artery Model. Ann. Biomed. Eng. 29:121-127, 2001.
16. Kaazempur-Mofrad, M. R., M. Bathe, H. Karcher, H. Younis, H. Seong, E. Shim, R. Chan, D. Hinton, M. Powers, L. Griffith, and R. Kamm. Role of simulation in understanding biological systems. Comput. Struct. 81:715-726, 2003.
17. Kaazempur-Mofrad, M. R., H. F. Younis, S. Patel, A. G. Isasi, C. Chung, R. C. Chan, D. P. Hinton, R. T. Lee, and R. D. Kamm. Cyclic strain in human carotid bifurcation and its potential correlation to atherogenesis: Idealized and anatomically-realistic models. J. Eng. Math. 47:299-314, 2003.
18. Klein, A. K., F. Lee, and A. A. Amini. Quantitative coronary angiography with deformable spline models. IEEE Trans. Med. Imaging 16:468-482, 1997.
19. Ku, D. Blood flow in arteries. Ann. Rev. Fluid Mech. 32:346-384, 1997.
20. Ku, D. N., D. P. Giddens, C. K. Zarins, and S. Glagov. Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis 5:293-302, 1985.
21. Lee, R. T., F. J. Schoen, H. M. Loree, M. W. Lark, and P. Libby. Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture. Arteriosder. Thromb. Vasc. Biol. 16:1070-1073, 1996.
22. Libby, P., Y. J. Geng, M. Aikawa, U. Schoenbeck, F. Mach, S. K. Clinton, G. K. Sukhova, and R. T. Lee. Macrophages and atherosclerotic plaque stability. Curr. Opin. Lipidol. 7:330-335, 1996.
23. Malek, A. M., S. L. Alper, and S. Izumo. Hemoclynamic shear stress and its role in atherosclerosis. JAMA 282:2035-2042., 1999.
24. Milner, J. S., J. A. Moore, B. K. Rutt, and D. A. Steinman. Hemodynamics of human carotid artery bifurcations: Computational studies with models reconstructed from magnetic resonance imaging of normal subjects. J. Vasc. Surg. 28:143-156, 1998.
25. Mohan, S., N. Mohan, and E. A. Sprague. Differential activation of NF-kappa B in human aortic endothelial cells conditioned to specific flow environments. Am. J. Physiol. 273:C572-C578, 1997.
26. Moore J. A., B. Rutt, S. J. Karlik, K. Yin, and C. R. Ethier. Computational blood flow modeling based on in vivo measurements. Ann. Biomed. Eng. 27:627-640, 1999.
27. Perktold, K., and G. Rappitsch. Computer simulation of local blood flow and vessel mechanics in a compliant carotid artery bifurcation model. J. Biomech. 28:845-856, 1995.
28. Perktold, K., M. Resch, and H. Florian. Pulsatile non-Newtonian flow characteristics in a three-dimensional human carotid bifurcation model. J. Biomech. Eng. 113:464-475, 1991.
29. Rosner, R. A. Regression and Correlation Methods. Boston, MA: PWS Publishers, 1986.
30. Simonetti, O. P., J. P. Finn, R. D. White, G. Laub, and D. A. Henry. "Black blood" T2-weighted inversion-recovery MR imaging of the heart. Radiology 199:49-57, 1996.
31. Steinman, D. A., J. B. Thomas, H. M. Ladak, J. S. Milner, B. K. Rutt, and J. D. Spence. Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI. Magn. Reson. Med. 47:149-159, 2002.
32. Stroud, J. S. Numerical Simulations of Blood Flow in Stenotic Vessels, PhD dissertation, University of California at Berkeley, Berkeley, 2000.
33. Sukhova, G. K., U. Schonbeck, E. Rabkin, F. J. Schoen, A. R. Poole, R. C. Billinghurst, and P. Libby. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation 19:2503-2509, 1999.
34. Sumpio, B. E. Hemodynamic forces and the biology of the endothelium - Signal transduction pathways in endothelial-cells subjected to physical forces in vitro. J. Vase. Surg. 13:744-746, 1991.
35. Tarbell, J. Mass transport in arteries and the localization of atheroslerosis. Ann. Rev. Biomed. Eng. 5:79-118, 2003.
36. Thoumine, O., R. M. Nerem, and P. R. Girard. Changes in organization and composition of the extracellular-matrix, underlying cultured endothelial-cells exposed to laminar steady shear-stress. Lab. Invest. 73:565-576, 1995.
37. Tsao, P. S., R. Buitrago, J. R. Chan, and J. P. Cooke. Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1. Circulation 94:1682-1689, 1996.
38. Tsao, P. S., N. P. Lewis, S. Alpert, and J. P. Cooke. Exposure to shear stress alters endothelial adhesiveness. Role of nitric oxide. Circulation 92:3513-3519, 1995.
39. Williamson, S. D., Y. Lam, H. F. Younis, S. Patel, M. R. Kaazempur-Mofrad, and R. D. Kamm. On the sensitivity of wall stresses in diseased arteries to variable material properties. J. Biomech. Eng 125:147-155, 2003.
40. Zhao, S. Z., X. Y. Xu, M. W. Collins, A. V. Stanton, A. D. Hughes, and S. A. Thom. Flow in carotid bifurcations: Effect of the superior thyroid artery. Med. Eng. Phys. 21:207-214, 1999.
41. Zwiebel, W. J. Peripheral vascular system. Ultrasound Med. Biol. 26:S92-S96, 2000.