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Volumn 11, Issue 1, 2013, Pages

The differential role of androgens in early human sex development

Author keywords

Androgen insensitivity; Androgen receptor; Androgens; Disorders of sex development; Genetics; Sex development

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; ANDROGEN RECEPTOR; HEAT SHOCK PROTEIN; SEX HORMONE; TESTOSTERONE 17BETA DEHYDROGENASE; TRANSCRIPTION FACTOR;

EID: 84879213254     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-11-152     Document Type: Review
Times cited : (64)

References (41)
  • 1
    • 45149093155 scopus 로고    scopus 로고
    • Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer
    • 10.1038/nature06944, 18454134
    • Sekido R, Lovell-Badge R. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature 2008, 453:930-934. 10.1038/nature06944, 18454134.
    • (2008) Nature , vol.453 , pp. 930-934
    • Sekido, R.1    Lovell-Badge, R.2
  • 2
    • 84856215229 scopus 로고    scopus 로고
    • The end of gonad-centric sex determination in mammals
    • 10.1016/j.tig.2011.10.004, 3268825, 22078126
    • Arnold AP. The end of gonad-centric sex determination in mammals. Trends Genet 2012, 28:55-61. 10.1016/j.tig.2011.10.004, 3268825, 22078126.
    • (2012) Trends Genet , vol.28 , pp. 55-61
    • Arnold, A.P.1
  • 3
    • 70350223635 scopus 로고    scopus 로고
    • Gonad morphogenesis in vertebrates: divergent means to a convergent end
    • 10.1146/annurev.cellbio.042308.13350, 19807280
    • DeFalco T, Capel B. Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annu Rev Cell Dev Biol 2009, 25:457-482. 10.1146/annurev.cellbio.042308.13350, 19807280.
    • (2009) Annu Rev Cell Dev Biol , vol.25 , pp. 457-482
    • DeFalco, T.1    Capel, B.2
  • 4
    • 84871231849 scopus 로고    scopus 로고
    • Gene mutations associated with anomalies of human gonad formation
    • 10.1159/000342188, 23037587
    • Bashamboo A, McElreavey K. Gene mutations associated with anomalies of human gonad formation. Sex Dev 2013, 7:126-146. 10.1159/000342188, 23037587.
    • (2013) Sex Dev , vol.7 , pp. 126-146
    • Bashamboo, A.1    McElreavey, K.2
  • 7
    • 41849107583 scopus 로고    scopus 로고
    • Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    • 10.1172/JCI34241, 2267017, 18340380
    • Welsh M, Saunders PT, Fisken M, Scott HM, Hutchison GR, Smith LB, Sharpe RM. Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest 2008, 118:1479-1490. 10.1172/JCI34241, 2267017, 18340380.
    • (2008) J Clin Invest , vol.118 , pp. 1479-1490
    • Welsh, M.1    Saunders, P.T.2    Fisken, M.3    Scott, H.M.4    Hutchison, G.R.5    Smith, L.B.6    Sharpe, R.M.7
  • 8
    • 84875416683 scopus 로고    scopus 로고
    • Clinical and molecular aspects of androgen insensitivity
    • Hiort O. Clinical and molecular aspects of androgen insensitivity. Endocr Dev 2013, 24:33-40.
    • (2013) Endocr Dev , vol.24 , pp. 33-40
    • Hiort, O.1
  • 9
    • 77956622556 scopus 로고    scopus 로고
    • 46, XY disorders of sex development-the undermasculinised male with disorders of androgen action
    • 10.1016/j.beem.2009.11.002, 20541151
    • Werner R, Grötsch H, Hiort O. 46, XY disorders of sex development-the undermasculinised male with disorders of androgen action. Best Pract Res Clin Endocrinol Metab 2010, 24:263-277. 10.1016/j.beem.2009.11.002, 20541151.
    • (2010) Best Pract Res Clin Endocrinol Metab , vol.24 , pp. 263-277
    • Werner, R.1    Grötsch, H.2    Hiort, O.3
  • 10
    • 33645232353 scopus 로고    scopus 로고
    • Puberty in subjects with complete androgen insensitivity syndrome
    • 10.1159/000091592, 16491011
    • Papadimitriou DT, Linglart A, Morel Y, Chaussain JL. Puberty in subjects with complete androgen insensitivity syndrome. Horm Res 2006, 65:126-131. 10.1159/000091592, 16491011.
    • (2006) Horm Res , vol.65 , pp. 126-131
    • Papadimitriou, D.T.1    Linglart, A.2    Morel, Y.3    Chaussain, J.L.4
  • 12
    • 84874107780 scopus 로고    scopus 로고
    • Androgen synthesis in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    • Kamrath C, Hartmann MF, Wudy SA. Androgen synthesis in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm Metab Res 2013, 45:86-91.
    • (2013) Horm Metab Res , vol.45 , pp. 86-91
    • Kamrath, C.1    Hartmann, M.F.2    Wudy, S.A.3
  • 13
    • 84856642544 scopus 로고    scopus 로고
    • Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation Erratum in
    • Flück CE, Meyer-Böni M, Pandey AV, Kempná P, Miller WL, Schoenle EJ, Biason-Lauber A. Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation Erratum in. Am J Hum Genet 2011, 89:347.
    • (2011) Am J Hum Genet , vol.89 , pp. 347
    • Flück, C.E.1    Meyer-Böni, M.2    Pandey, A.V.3    Kempná, P.4    Miller, W.L.5    Schoenle, E.J.6    Biason-Lauber, A.7
  • 14
    • 84858064955 scopus 로고    scopus 로고
    • Increased activation of the alternative "backdoor" pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis
    • 10.1210/jc.2011-1997, 22170725
    • Kamrath C, Hochberg Z, Hartmann MF, Remer T, Wudy SA. Increased activation of the alternative "backdoor" pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis. J Clin Endocrinol Metab 2012, 97:E367-E375. 10.1210/jc.2011-1997, 22170725.
    • (2012) J Clin Endocrinol Metab , vol.97
    • Kamrath, C.1    Hochberg, Z.2    Hartmann, M.F.3    Remer, T.4    Wudy, S.A.5
  • 15
    • 84876073490 scopus 로고    scopus 로고
    • Of marsupials and men: "backdoor" dihydrotestosterone synthesis in male sexual differentiation
    • 10.1016/j.mce.2013.01.017, 23376007
    • Biason-Lauber A, Miller WL, Pandey AV, Flück CE. Of marsupials and men: "backdoor" dihydrotestosterone synthesis in male sexual differentiation. Mol Cell Endocrinol 2013, 371:124-132. 10.1016/j.mce.2013.01.017, 23376007.
    • (2013) Mol Cell Endocrinol , vol.371 , pp. 124-132
    • Biason-Lauber, A.1    Miller, W.L.2    Pandey, A.V.3    Flück, C.E.4
  • 16
    • 79955467642 scopus 로고    scopus 로고
    • Sexual differentiation of human behavior: effects of prenatal and pubertal organizational hormones
    • 10.1016/j.yfrne.2011.03.001, 21397624
    • Berenbaum SA, Beltz AM. Sexual differentiation of human behavior: effects of prenatal and pubertal organizational hormones. Front Neuroendocrinol 2011, 32:183-200. 10.1016/j.yfrne.2011.03.001, 21397624.
    • (2011) Front Neuroendocrinol , vol.32 , pp. 183-200
    • Berenbaum, S.A.1    Beltz, A.M.2
  • 18
    • 33847641062 scopus 로고    scopus 로고
    • Gender role behavior in children with XY karyotype and disorders of sex development
    • 10.1016/j.yhbeh.2007.01.001, 17306800
    • Jurgensen M, Hiort O, Holterhus PM, Thyen U. Gender role behavior in children with XY karyotype and disorders of sex development. Horm Behav 2007, 51:443-453. 10.1016/j.yhbeh.2007.01.001, 17306800.
    • (2007) Horm Behav , vol.51 , pp. 443-453
    • Jurgensen, M.1    Hiort, O.2    Holterhus, P.M.3    Thyen, U.4
  • 19
    • 49649119709 scopus 로고    scopus 로고
    • Comparison of bone mineral density and body proportions between women with complete androgen insensitivity syndrome and women with gonadal dysgenesis
    • 10.1530/EJE-08-0166, 18463105
    • Han TS, Goswami D, Trikudanathan S, Creighton SM, Conway GS. Comparison of bone mineral density and body proportions between women with complete androgen insensitivity syndrome and women with gonadal dysgenesis. Eur J Endocrinol 2008, 159:179-185. 10.1530/EJE-08-0166, 18463105.
    • (2008) Eur J Endocrinol , vol.159 , pp. 179-185
    • Han, T.S.1    Goswami, D.2    Trikudanathan, S.3    Creighton, S.M.4    Conway, G.S.5
  • 21
    • 79955468400 scopus 로고    scopus 로고
    • The genetics of sex differences in brain and behavior
    • 10.1016/j.yfrne.2010.10.001, 3030621, 20951723
    • Ngun TC, Ghahramani N, Sánchez FJ, Bocklandt S, Vilain E. The genetics of sex differences in brain and behavior. Front Neuroendocrinol 2011, 32:227-246. 10.1016/j.yfrne.2010.10.001, 3030621, 20951723.
    • (2011) Front Neuroendocrinol , vol.32 , pp. 227-246
    • Ngun, T.C.1    Ghahramani, N.2    Sánchez, F.J.3    Bocklandt, S.4    Vilain, E.5
  • 22
    • 61449263583 scopus 로고    scopus 로고
    • Evo-devo of child growth II: human life history and transition between its phases
    • Hochberg Z. Evo-devo of child growth II: human life history and transition between its phases. Eur J Endocrinol 2009, 160:135-141.
    • (2009) Eur J Endocrinol , vol.160 , pp. 135-141
    • Hochberg, Z.1
  • 23
    • 0036430945 scopus 로고    scopus 로고
    • Androgens and puberty
    • 10.1053/beem.2002.0178, 11987896
    • Hiort O. Androgens and puberty. Best Pract Res Clin Endocrinol Metab 2002, 16:31-41. 10.1053/beem.2002.0178, 11987896.
    • (2002) Best Pract Res Clin Endocrinol Metab , vol.16 , pp. 31-41
    • Hiort, O.1
  • 24
    • 0026782628 scopus 로고
    • Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene
    • 10.1016/0303-7207(92)90004-P, 1334007
    • Deslypere JP, Young M, Wilson JD, McPhaul MJ. Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene. Mol Cell Endocrinol 1992, 88:15-22. 10.1016/0303-7207(92)90004-P, 1334007.
    • (1992) Mol Cell Endocrinol , vol.88 , pp. 15-22
    • Deslypere, J.P.1    Young, M.2    Wilson, J.D.3    McPhaul, M.J.4
  • 25
    • 0036878979 scopus 로고    scopus 로고
    • Anabolic steroids, testosterone-precursors and virilizing androgens induce distinct activation profiles of androgen responsive promoter constructs
    • 10.1016/S0960-0760(02)00220-0, 12589933
    • Holterhus PM, Piefke S, Hiort O. Anabolic steroids, testosterone-precursors and virilizing androgens induce distinct activation profiles of androgen responsive promoter constructs. J Steroid Biochem Molec Biol 2002, 82:269-275. 10.1016/S0960-0760(02)00220-0, 12589933.
    • (2002) J Steroid Biochem Molec Biol , vol.82 , pp. 269-275
    • Holterhus, P.M.1    Piefke, S.2    Hiort, O.3
  • 26
    • 0033859462 scopus 로고    scopus 로고
    • Influence of androgens and age on androgen receptor and 5α-reductase II transcription
    • 10.1530/eje.0.1430217, 10913941
    • Hellwinkel OJC, Müller A, Struve D, Hiort O. Influence of androgens and age on androgen receptor and 5α-reductase II transcription. Eur J Endocrinol 2000, 143:217-225. 10.1530/eje.0.1430217, 10913941.
    • (2000) Eur J Endocrinol , vol.143 , pp. 217-225
    • Hellwinkel, O.J.C.1    Müller, A.2    Struve, D.3    Hiort, O.4
  • 27
    • 0034739783 scopus 로고    scopus 로고
    • Transkription of androgen receptor and 5α-reductase II in genital skin fibroblasts from patients with androgen insensitivity syndrome
    • 10.1016/S0960-0760(00)00174-6, 11282274
    • Hellwinkel OJC, Bassler J, Hiort O. Transkription of androgen receptor and 5α-reductase II in genital skin fibroblasts from patients with androgen insensitivity syndrome. J Steroid Biochem Molec Biol 2000, 75:213-218. 10.1016/S0960-0760(00)00174-6, 11282274.
    • (2000) J Steroid Biochem Molec Biol , vol.75 , pp. 213-218
    • Hellwinkel, O.J.C.1    Bassler, J.2    Hiort, O.3
  • 28
    • 21344470386 scopus 로고    scopus 로고
    • Isoenzyme type 1 of 5α-reductase is abundantly transcribed in normal human genital skin fibroblasts and may play an important role in masculinization of 5α-reductase type 2 deficient males
    • 10.1530/eje.1.01927, 15941927
    • Thiele S, Hoppe U, Holterhus PM, Hiort O. Isoenzyme type 1 of 5α-reductase is abundantly transcribed in normal human genital skin fibroblasts and may play an important role in masculinization of 5α-reductase type 2 deficient males. Eur J Endocrinol 2005, 152:875-880. 10.1530/eje.1.01927, 15941927.
    • (2005) Eur J Endocrinol , vol.152 , pp. 875-880
    • Thiele, S.1    Hoppe, U.2    Holterhus, P.M.3    Hiort, O.4
  • 29
    • 33746740095 scopus 로고    scopus 로고
    • Tissue-specific transcription profiles of sex steroid biosynthesis enzymes and the androgen receptor
    • 10.1007/s00109-006-0049-1, 16572348
    • Hoppe U, Holterhus PM, Wünsch L, Jocham D, Drechsler T, Thiele S, Marschke C, Hiort O. Tissue-specific transcription profiles of sex steroid biosynthesis enzymes and the androgen receptor. J Mol Med 2006, 84:651-659. 10.1007/s00109-006-0049-1, 16572348.
    • (2006) J Mol Med , vol.84 , pp. 651-659
    • Hoppe, U.1    Holterhus, P.M.2    Wünsch, L.3    Jocham, D.4    Drechsler, T.5    Thiele, S.6    Marschke, C.7    Hiort, O.8
  • 30
    • 34547764773 scopus 로고    scopus 로고
    • Altered transcription profiles of key-enzymes of androgen biosynthesis in genital skin fibroblasts from patients with 46, XY disorders of sex development
    • 10.1159/000104773, 18391534
    • Hoppe U, Wünsch L, Holterhus PM, Jocham D, Richter-Unruh A, Hiort O. Altered transcription profiles of key-enzymes of androgen biosynthesis in genital skin fibroblasts from patients with 46, XY disorders of sex development. Sex Dev 2007, 1:230-237. 10.1159/000104773, 18391534.
    • (2007) Sex Dev , vol.1 , pp. 230-237
    • Hoppe, U.1    Wünsch, L.2    Holterhus, P.M.3    Jocham, D.4    Richter-Unruh, A.5    Hiort, O.6
  • 32
    • 0027283705 scopus 로고
    • Nuclear import of the human androgen receptor
    • 1134432, 8352744
    • Jenster G, Trapman J, Brinkmann AO. Nuclear import of the human androgen receptor. Biochem J 1993, 293:761-768. 1134432, 8352744.
    • (1993) Biochem J , vol.293 , pp. 761-768
    • Jenster, G.1    Trapman, J.2    Brinkmann, A.O.3
  • 34
    • 34547731515 scopus 로고    scopus 로고
    • Nuclear receptor coregulators and human disease
    • 10.1210/er.2007-0012, 17609497
    • Lonard DM, Lanz RB, O'Malley BW. Nuclear receptor coregulators and human disease. Endocr Rev 2007, 28:575-587. 10.1210/er.2007-0012, 17609497.
    • (2007) Endocr Rev , vol.28 , pp. 575-587
    • Lonard, D.M.1    Lanz, R.B.2    O'Malley, B.W.3
  • 35
    • 34548252291 scopus 로고    scopus 로고
    • Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation
    • 10.1016/j.molcel.2007.08.012, 17803935
    • Lonard DM, O'Malley BW. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell 2007, 27:691-700. 10.1016/j.molcel.2007.08.012, 17803935.
    • (2007) Mol Cell , vol.27 , pp. 691-700
    • Lonard, D.M.1    O'Malley, B.W.2
  • 36
    • 33750457376 scopus 로고    scopus 로고
    • Cell-line and tissue specific signatures of androgen receptor coregulator transcription
    • 10.1007/s00109-006-0081-1, 16932916
    • Bebermeier JH, Brooks J, DePrimo S, Werner R, Deppe U, Demeter J, Hiort O, Holterhus PM. Cell-line and tissue specific signatures of androgen receptor coregulator transcription. J Mol Med 2006, 84:919-931. 10.1007/s00109-006-0081-1, 16932916.
    • (2006) J Mol Med , vol.84 , pp. 919-931
    • Bebermeier, J.H.1    Brooks, J.2    DePrimo, S.3    Werner, R.4    Deppe, U.5    Demeter, J.6    Hiort, O.7    Holterhus, P.M.8
  • 37
    • 0038576864 scopus 로고    scopus 로고
    • Differential gene expression patterns in genital fibroblasts of normal and 46, XY-females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor
    • 10.1186/gb-2003-4-6-r37, 193616, 12801411
    • Holterhus PM, Hiort O, Demeter J, Brown PO, Brooks JD. Differential gene expression patterns in genital fibroblasts of normal and 46, XY-females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor. Genome Biol 2003, 4:R37. 10.1186/gb-2003-4-6-r37, 193616, 12801411.
    • (2003) Genome Biol , vol.4
    • Holterhus, P.M.1    Hiort, O.2    Demeter, J.3    Brown, P.O.4    Brooks, J.D.5
  • 39
    • 67349256338 scopus 로고    scopus 로고
    • Apolipoprotein D (APOD) is a putative biomarker of androgen receptor function in androgen insensitivity syndrome
    • 10.1007/s00109-009-0462-3, 19330472
    • Appari M, Werner R, Wünsch L, Cario G, Demeter J, Hiort O, Riepe F, Brooks JD, Holterhus PM. Apolipoprotein D (APOD) is a putative biomarker of androgen receptor function in androgen insensitivity syndrome. J Mol Med 2009, 87:623-632. 10.1007/s00109-009-0462-3, 19330472.
    • (2009) J Mol Med , vol.87 , pp. 623-632
    • Appari, M.1    Werner, R.2    Wünsch, L.3    Cario, G.4    Demeter, J.5    Hiort, O.6    Riepe, F.7    Brooks, J.D.8    Holterhus, P.M.9
  • 40
    • 67949117229 scopus 로고    scopus 로고
    • Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes
    • 10.1186/1471-2164-10-292, 2713997, 19570224
    • Holterhus PM, Bebermeier JH, Werner R, Demeter J, Richter-Unruh A, Cario G, Appari M, Siebert R, Riepe F, Brooks JD, Hiort O. Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes. BMC Genomics 2009, 10:292. 10.1186/1471-2164-10-292, 2713997, 19570224.
    • (2009) BMC Genomics , vol.10 , pp. 292
    • Holterhus, P.M.1    Bebermeier, J.H.2    Werner, R.3    Demeter, J.4    Richter-Unruh, A.5    Cario, G.6    Appari, M.7    Siebert, R.8    Riepe, F.9    Brooks, J.D.10    Hiort, O.11


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