A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines

Biochemistry

Volumn 52, Issue 24, 2013, Pages 4274-4283

  Giessen, Tobias W ^a   Von Tesmar, Alexander M ^a   Marahiel, Mohamed A ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 ,5-DIKETOPIPERAZINES; BIOINFORMATIC ANALYSIS; BIOSYNTHETIC PATHWAY; CHEMOENZYMATIC APPROACHES; FUNCTIONAL DIVERSITY; NEW CHEMICAL ENTITIES; S ADENOSYL L METHIONINES; SUBSTRATE SPECIFICITY;

ALKYLATION; BIOINFORMATICS; ENZYMES; GENES;

AMINO ACIDS;

2,5 PIPERAZINEDIONE; BACTERIAL PROTEIN; CYCLODIPEPTIDE SYNTHASE; FUNGAL PROTEIN; KANAMYCIN; LEUCINE; METHIONINE; METHYLTRANSFERASE; PHENYLALANINE; PIPERAZINEDIONE; RECOMBINANT PROTEIN; SPECTINOMYCIN; SYNTHETASE; TRANSFER RNA; TYROSINE; UNCLASSIFIED DRUG;

ACTINOSYNNEMA MIRUM; AMINO ACID ANALYSIS; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BIOLOGICAL ACTIVITY; CORYNEBACTERIUM; CORYNEBACTERIUM JEIKEIUM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; FERMENTATION; GENE CLUSTER; IN VITRO STUDY; MICROCOCCUS LUTEUS; NEMATOSTELLA VECTENSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; STRUCTURE ACTIVITY RELATION;

ACTINOMYCETALES; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; DIKETOPIPERAZINES; METHYLATION; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHYLOGENY; RECOMBINANT PROTEINS; RNA, TRANSFER; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, NUCLEIC ACID; SOLVENTS; SUBSTRATE SPECIFICITY; TIME FACTORS; TRYPTOPHAN;

ACTINOSYNNEMA MIRUM; BACTERIA (MICROORGANISMS); PROKARYOTA;

EID: 84879211194     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4004827     Document Type: Article

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