Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-ser422 tau in the Alzheimer's disease brain

Brain Pathology

Volumn 23, Issue 4, 2013, Pages 378-389

  Lund, Harald ^a,b   Cowburn, Richard F ^a   Gustafsson, Elin ^a   Strömberg, Kia ^a,b   Svensson, Anne ^a   Dahllund, Leif ^a   Malinowsky, David ^a   Sunnemark, Dan ^a,b  

^a ASTRAZENECA R AND D   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Alzheimer's disease; neurofibrillary tangles; tau phosphorylation; tau tubulin kinase 1

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; TAU PROTEIN; TAU TUBULIN KINASE 1; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MALE; NEUROFIBRILLARY TANGLE; NEUROPIL THREAD; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; DENDRITES; FEMALE; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MALE; NEUROFIBRILLARY TANGLES; NEURONS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SERINE; TAU PROTEINS; TRANSFECTION;

EID: 84879198442     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12001     Document Type: Article

References (25)

1. Alonso AC, Zaidi T, Grundke-Iqbal I, Iqbal K, (1994) Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci U S A 91: 5562-5566.
2. Augustinack JC, Schneider A, Mandelkow EM, Hyman BT, (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol (Berl) 103: 26-35.
3. Binder LI, Frankfurter A, Rebhun LI, (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101: 1371-1378.
4. Brunden KR, Ballatore C, Crowe A, Smith AB, 3rd, Lee VM, Trojanowski JQ, (2010) Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Exp Neurol 223: 304-310.
5. de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT, (2010) Caspase activation precedes and leads to tangles. Nature 464: 1201-1204.
6. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI, (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83: 4913-4917.
7. Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH, (1998) New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J Neurochem 71: 2465-2476.
8. Hanger DP, Seereeram A, Noble W, (2009) Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease. Expert Rev Neurother 9: 1647-1666.
9. Hasegawa M, Jakes R, Crowther RA, Lee VM, Ihara Y, Goedert M, (1996) Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein. FEBS Lett 384: 25-30.
10. Houlden H, Johnson J, Gardner-Thorpe C, Lashley T, Hernandez D, Worth P, et al (2007) Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nat Genet 39: 1434-1436.
11. Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I, (2009) Mechanisms of tau-induced neurodegeneration. Acta Neuropathol (Berl) 118: 53-69.
12. Lebouvier T, Scales TM, Williamson R, Noble W, Duyckaerts C, Hanger DP, et al (2009) The microtubule-associated protein tau is also phosphorylated on tyrosine. J Alzheimers Dis 18: 1-9.
13. Li X, Kumar Y, Zempel H, Mandelkow EM, Biernat J, Mandelkow E, (2011) Novel diffusion barrier for axonal retention of tau in neurons and its failure in neurodegeneration. EMBO J 30: 4825-4837.
14. Reynolds CH, Nebreda AR, Gibb GM, Utton MA, Anderton BH, (1997) Reactivating kinase/p38 phosphorylates tau protein in vitro. J Neurochem 69: 191-198.
15. Reynolds CH, Utton MA, Gibb GM, Yates A, Anderton BH, (1997) Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein. J Neurochem 68: 1736-1744.
16. Sato S, Cerny RL, Buescher JL, Ikezu T, (2006) Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem 98: 1573-1584.
17. Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, et al (2008) Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J Neurosci 28: 14511-14521.
18. Sergeant N, Bretteville A, Hamdane M, Caillet-Boudin ML, Grognet P, Bombois S, et al (2008) Biochemistry of tau in Alzheimer's disease and related neurological disorders. Expert Rev Proteomics 5: 207-224.
19. Takahashi M, Tomizawa K, Sato K, Ohtake A, Omori A, (1995) A novel tau-tubulin kinase from bovine brain. FEBS Lett 372: 59-64.
20. Tomizawa K, Omori A, Ohtake A, Sato K, Takahashi M, (2001) Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau. FEBS Lett 492: 221-227.
21. Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, et al (2012) Targeting Phospho-Ser422 by active tau immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach. Curr Alzheimer Res 9: 397-405.
22. Vázquez-Higuera JL, Martinez-Garcia A, Sanchez-Juan P, Rodriguez-Rodriguez E, Mateo I, Pozueta A, et al (2011) Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort. Neurobiol Aging 32: 550 e5-550 e9.
23. Vega IE, Cui L, Propst JA, Hutton ML, Lee G, Yen SH, (2005) Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates. Brain Res Mol Brain Res 138: 135-144.
24. Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T, (2010) Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB J 24: 2904-2915.
25. Yu NN, Yu JT, Xiao JT, Zhang HW, Lu RC, Jiang H, et al (2011) Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese. Neurosci Lett 491: 83-86.