Efficacy and tolerability of oral iron therapy in inflammatory bowel disease: A prospective, comparative trial

Alimentary Pharmacology and Therapeutics

Volumn 22, Issue 11-12, 2005, Pages 1097-1105

  De Silva, A D ^a   Tsironi, E ^a   Feakins, R M ^b   Rampton, D S ^a,c  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b BARTS HEALTH NHS TRUST   (United Kingdom)

^c ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; REACTIVE OXYGEN METABOLITE;

ADOLESCENT; ADULT; AGED; ANOREXIA; ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG TOLERABILITY; ENTERITIS; FEMALE; HISTOLOGY; HUMAN; IRON DEFICIENCY ANEMIA; IRON THERAPY; MAJOR CLINICAL STUDY; MALE; NAUSEA AND VOMITING; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RECURRENT DISEASE; SCORING SYSTEM; SIGMOIDOSCOPY; SYMPTOMATOLOGY; TREATMENT OUTCOME; ULCERATIVE COLITIS;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA, IRON-DEFICIENCY; CLINICAL PROTOCOLS; FEMALE; FERRITINS; HUMANS; INFLAMMATORY BOWEL DISEASES; IRON; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REACTIVE OXYGEN SPECIES;

EID: 28844433694     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2005.02700.x     Document Type: Article

References (35)

1. Gasche C, Lomer MC, Cavill I, et al. Iron, anaemia, and inflammatory bowel diseases. Gut 2004; 53: 1190-7.
2. Hodges P, Gee M, Grace M, et al. Vitamin and iron intake in patients with Crohn's disease. J Am Diet Assoc 1984; 84: 52-8.
3. Oldenburg B, Koningsberger JC, Berge Henegouwen GP, et al. Iron and inflammatory bowel disease. Aliment Pharmacol Ther 2001; 15: 429-38.
4. Gasche C, Reinisch W, Lochs H, et al. Anemia in Crohn's disease. Importance of inadequate erythropoietin production and iron deficiency. Dig Dis Sci 1994; 39: 1930-4.
5. de Silva AD, Mylonaki M, Rampton DS. Oral iron therapy in inflammatory bowel disease: usage, tolerance, and efficacy. Inflamm Bowel Dis 2003; 9: 316-20.
6. Gasche C. Anemia in IBD: the overlooked villain. Inflamm Bowel Dis 2000; 6: 142-50.
7. Kerr DNS, Davidson S. Gastrointestinal intolerance to iron. Lancet 1958; ii: 489-92.
8. Aghdassi E, Carrier J, Cullen J, et al. Effect of iron supplementation on oxidative stress and intestinal inflammation in rats with acute colitis. Dig Dis Sci 2001; 46: 1088-94.
9. Carrier J, Aghdassi E, Platt I, et al. Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis. Aliment Pharmacol Ther 2001; 15: 1989-99.
10. Carrier J, Aghdassi E, Cullen J, et al. Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis. J Nutr 2002; 132: 3146-50.
11. Oldenburg B, Berge Henegouwen GP, Rennick D, et al. Iron supplementation affects the production of pro-inflammatory cytokines in IL-10 deficient mice. Eur J Clin Invest 2000; 30: 505-10.
12. Seril DN, Liao J, Ho KL, et al. Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice. Dig Dis Sci 2002; 47: 1266-78.
13. Reifen R, Matas Z, Zeidel L, et al. Iron supplementation may aggravate inflammatory status of colitis in a rat model. Dig Dis Sci 2000; 45: 394-7.
14. Kawai M, Sumimoto S, Kasajima Y, et al. A case of ulcerative colitis induced by oral ferrous sulfate. Acta Paediatr Jpn 1992; 34: 476-8.
15. Erichsen K, Hausken T, Ulvik RJ, et al Ferrous fumarate deteriorated plasma antioxidant status in patients with Crohn's disease. Scand J Gastroenterol 2003; 38: 543-8.
16. Grisham MB, Granger DN. Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites. Dig Dis Sci 1988; 33 (Suppl. 3): 6S-15S.
17. Babbs CF. Oxygen radicals in ulcerative colitis. Free Radic Biol Med 1992; 13: 169-81.
18. Grisham MB. Oxidants and free radicals in inflammatory bowel disease. Lancet 1994; 344: 859-61.
19. Simmonds NJ, Rampton DS. Inflammatory bowel disease - a radical view. Gut 1993; 34: 865-8.
20. Schreiber S, Howaldt S, Schnoor M, et al. Recombinant erythropoietin for the treatment of anemia in inflammatory bowel disease. N Engl J Med 1996; 334: 619-23.
21. Kotisaari S, Romppanen J, Penttila I, et al. The Advia 120 red blood cells and reticulocyte indices are useful in diagnosis of iron-deficiency anemia. Eur J Haematol 2002; 68: 150-6.
22. Walmsley RS, Ayres RC, Pounder RE, et al. A Simple Clinical Colitis Activity Index. Gut 1998; 43: 29-32.
23. Jowett SL, Seal CJ, Phillips E, et al. Defining relapse of ulcerative colitis using a symptom-based activity index. Scand J Gastroenterol 2003; 38: 164-71.
24. Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet 1980; 1: 514.
25. Guyatt G, Mitchell A, Irvine EJ, et al. A new measure of health status for clinical trials in inflammatory bowel disease. Gastroenterology 1989; 96: 804-10.
26. Baron JH, Connell AM, Lennard-Jones JE. Variation between observers in describing mucosal appearances in proctocolitis. Br Med J 1964; 5375: 89-92.
27. Saverymuttu SH, Camilleri M, Rees H, et al. Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and fecal indium 111-granulocyte excretion. Gastroenterology 1986; 90 (5 Pt 1): 1121-8.
28. Muller T, Davies EV, Campbell AK. Pholasin chemiluminescence detects mostly superoxide anion released from activated human neutrophils. J Biolumin Chemilumin 1989; 3: 105-13.
29. Reichl S, Vocks A, Petkovic M, et al. The photoprotein pholasin as a luminescence substrate for detection of superoxide anion radicals and myeloperoxidase activity in stimulated neutrophils. Free Radic Res 2001; 35: 723-33.
30. Bland M. Clinical measurement - repeatability and precision in measurement. In: Bland, M, ed. An Introduction to Medical Statistics, 3rd edn. Oxford, UK: Oxford University Press, 1991: 276-8.
31. Simmonds NJ, Allen RE, Stevens TR, et al. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease. Gastroenterology 1992; 103: 186-96.
32. Carter MJ, Lobo AJ, Travis SP. Guidelines for the management of inflammatory bowel disease in adults. Gut 2004; 53 (Suppl. 5): V1-16.
33. Munkholm P, Langholz E, Davidsen M, et al. Disease activity courses in a regional cohort of Crohn's disease patients. Scand J Gastroenterol 1995; 30: 699-706.
34. Dincol K, Aksoy M. On the platelet levels in chronic iron deficiency anemia. Acta Haematol 1969; 41: 135-43.
35. Kanfer EJ, Nicol BA. Haemoglobin concentration and erythrocyte sedimentation rate in primary care patients. J R Soc Med 1997; 90: 16-8.