Indinavir and nelfinavir inhibit proximal insulin receptor signaling and salicylate abrogates inhibition: Potential role of the NFkappa B pathway

Journal of Cellular Biochemistry

Volumn 114, Issue 8, 2013, Pages 1729-1737

  Ismail, Wan Iryani W ^a,b   King, Judy A ^a,c   Anwar, Khawar ^a   Pillay, Tahir S ^a,c,d,e  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

HIV PROTEASE INHIBITORS; INSULIN RESISTANCE; SALICYLATE

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDINAVIR; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; MITOGEN ACTIVATED PROTEIN KINASE; NELFINAVIR; PLECKSTRIN; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; SALICYLIC ACID; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; INTRACELLULAR SIGNALING; NONHUMAN; PRIORITY JOURNAL;

3T3-L1 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTI-INFECTIVE AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; NELFINAVIR; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SALICYLIC ACID; SIGNAL TRANSDUCTION;

CRICETULUS GRISEUS;

EID: 84879173246     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24513     Document Type: Article

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