The HIV-1 protease inhibitor indinavir impairs insulin signalling in HepG2 hepatoma cells

Diabetologia

Volumn 43, Issue 9, 2000, Pages 1145-1148

  Schutt, M ^a   Meier, M ^a   Meyer, M ^a   Klein, J ^a   Aries, S P ^a   Klein, H H ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Diabetes mellitus; HIV protease inhibitors; Insulin resistance; Insulin signalling; Lipodystrophy syndrome

Indexed keywords

INDINAVIR; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; IODINE 125; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEINASE INHIBITOR;

ARTICLE; CELL COUNT; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG INDUCED DISEASE; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; INSULIN BINDING; INSULIN RESISTANCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOLUBILIZATION; WESTERN BLOTTING;

CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; INSULIN; KINETICS; LIVER NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0033816123     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051505     Document Type: Article

References (10)

1. Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients
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3. Cultured hepatoma cells as a model system for studying insulin processing and biologic responsiveness
4. Insulin rapidly induces nuclear translocation of PI3-kinase in HepG2 cells
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6. Glucosamin infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
7. Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans
8. Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance
9. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
10. Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signalling