Electrospun chitosan microspheres for complete encapsulation of anionic proteins: Controlling particle size and encapsulation efficiency

AAPS PharmSciTech

Volumn 14, Issue 2, 2013, Pages 794-801

  Choi, Ji Suk ^a   Kim, Younghee ^a   Kang, Jihyun ^a   Jeong, Seo Young ^b   Yoo, Hyuk Sang ^a  

^a Kangwon National University   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

chitosan; electrospinning; encapsulation; microspheres; protein

Indexed keywords

CHITOSAN; CHITOSAN ACETATE; FLUORESCEIN ISOTHIOCYANATE; MICROSPHERE; PROTEIN; SODIUM CARBONATE;

ARTICLE; CONFOCAL LASER MICROSCOPY; CONFOCAL MICROSCOPY; DRUG RELEASE; ELECTRIC POTENTIAL; ELECTROSPINNING; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; FLOW RATE; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MICROENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL; PRODUCTIVITY; PROTEIN SECRETION; REVERSED PHASE LIQUID CHROMATOGRAPHY; SCANNING ELECTRON MICROSCOPY; STATIC ELECTRICITY; SURFACE TENSION;

ACETIC ACID; ANIONS; CARBONATES; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DESICCATION; DRUG CARRIERS; FREEZING; KINETICS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; PROTEIN CONFORMATION; SERUM ALBUMIN, BOVINE; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY;

EID: 84879125334     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-9965-x     Document Type: Article

References (47)

1. Zhu G, Mallery SR, Schwendeman SP. Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide). Nat Biotechnol. 2000;18:52-7.
2. Okada H, Heya T, Igari Y, Ogawa Y, Toguchi H, Shimamoto T. One-month release injectable microspheres of leuprolide acetate inhibit steroidogenesis and genital organ growth in rats. Int J Pharm. 1989;54:231-9.
3. Jain RA, Rhodes CT, Raikar AM, Malick AW, Shah NH. Controlled release of drugs from injectable in situ formed biodegradable PLGA microspheres: effect of various formulation variables. Eur J Pharm Biopharm. 2000;50:257-62.
4. Yan C, Resau JH, Hewetson J, West M, Rill WL, Kende M. Characterization and morphological analysis of protein-loaded poly (lactide-co-glycolide) microparticles prepared by water-in-oil-in-water emulsion technique. J Control Release. 1994;32:231-41.
5. Lemoine D, Wauters F, Bouchend'homme S, Preat V. Preparation and characterization of alginate microspheres containing a model antigen. Int J Pharm. 1998;176:9-19.
6. Prottey C, Ferguson TFM. The effect of surfactants upon rat peritoneal mast cells in vitro. Food Cosmet Toxicol. 1976;14:425-30.
7. Ernst R, Arditti J. Biological effects of surfactants. IV. Effects of non-ionics and amphoterics on hela cells. Toxicology. 1980;15:233-42.
8. Baimark Y. Preparation of organic solvent/surfactant-free microspheres of methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) by a melt dispersion method. Asian J Appl Sci. 2009;2:341-7.
9. Li JK, Wang N, Wu XS. Gelatin nanoencapsulation of protein/peptide drugs using an emulsifier-free emulsion method. J Microencapsul. 1998;15:163-72.
10. Sebti T, Amighi K. Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation. Eur J Pharm Biopharm. 2006;63:51-8.
11. DL-lactide-co-glycolide) microspheres prepared by a spray drying technique: influence of g-irradiation on radical formation and polymer degradation. J Control Release. 1999;59:23-32.
12. Sashiwa H, Aiba S. Chemically modified chitin and chitosan as biomaterials. Prog Polym Sci. 2004;29:887-908.
13. Dutta PK, Dutta J, Tripathi VS. Chitin and chitosan: chemistry, properties and applications. J Sci Ind Res. 2004;63:20-31.
14. Wang YC, Lin MC, Wang DM, Hsieh HJ. Fabrication of a novel porous PGA-chitosan hybrid matrix for tissue engineering. Biomaterials. 2003;24:1047-57.
15. Kast CE, Frick W, Losert U, Schnurch AB. Chitosan-thioglycolic acid conjugate: a new scaffold material for tissue engineering. Int J Pharm. 2003;256:183-9.
16. Pillai CKS, Paul W, Sharma CP. Chitin and chitosan polymers: chemistry, solubility and fiber formation. Prog Polym Sci. 2009;34:641-78.
17. Mi FL, Sung HW, Shyu SS. Release of indomethacin from a novel chitosan microsphere prepared by a naturally occurring crosslinker: examination of crosslinking and polycation-anionic drug interaction. J Appl Polym Sci. 2001;81:1700-11.
18. Wang LY, Gu YH, Zhou QZ, Ma GH, Wan YH, Su ZG. Preparation and characterization of uniform-sized chitosan microspheres containing insulin by membrane emulsification and a two-step solidification process. Colloids Surf B Biointerfaces. 2006;50:126-35.
19. He P, Davis SS, Illum L. Chitosan microspheres prepared by spray drying. Int J Pharm. 1999;187:53-65.
20. Muzzarelli C, Stanic V, Gobbi L, Tosi G, Muzzarelli RAA. Spray-drying of solutions containing chitosan together with polyuronans and characterization of the microspheres. Carbohydr Polym. 2004;57:73-82.
21. Desai KG, Park HJ. Effect of manufacturing parameters on the characteristics of vitamin C encapsulated tripolyphosphate-chitosan microspheres prepared by spray-drying. J Microencapsul. 2006;23:91-103.
22. Buttafoco L, Kolkman NG, Engbers-Buijtenhuijs P, Poot AA, Dijkstra PJ, Vermes I, et al. Electrospinning of collagen and elastin for tissue engineering application. Biomaterials. 2006;25:724-34.
23. Lee S, Obendorf SK. Use of electrospun nanofiber web for protective textile materials as barriers to liquid penetration. Text Res. 2007;77:696-702.
24. Yoshimoto H, Shin YM, Terai H, Vacanti JP. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials. 2003;24:2077-82.
25. DL-lactide) fibers with paracetanol inoculation. Macromolecules. 2006;7:1623-9.
26. Choi JS, Leong KW, Yoo HS. In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials. 2008;29:587-96.
27. Choi JS, Yoo HS. Nano-inspired fibrous matrix with bi-phasic release of proteins. J Nanosci Nanotechnol. 2010;10:3038-45.
28. Cho YI, Choi JS, Jeong SY, Yoo HS. Nerve growth factor (NGF)-conjugated electrospun nanostructures with topographical cues for neuronal differentiation of mesenchymal stem cells. Acta Biomater. 2010;6:4725-33.
29. Sanders EH, Kioefkorn R, Bowlin GL, Simpson DG, Wnek GE. Two-phase electrospinning from a single electrified jet: microencapsulation of aqueous reservoirs in poly(ethylene-co-vinyl acetate) fibers. Macromolecules. 2003;36:3803-5.
30. Kim SE, Park JH, Cho YW, Chung H, Jeong SY, Lee EB, et al. Porous chitosan scaffold containing microspheres loaded with transforming growth factor- β1: Implications for cartilage tissue engineering. J Control Release. 2003;91:365-74.
31. Schiffman JD, Stulga LA, Schauer CL. Chitin and chitosan: transformations due to the electrospinning process. Polym Eng Sci. 2009;49:1918-28.
32. Sangsanoh P, Supaphol P. Stability improvement of electrospun chitosan nanofibrous membranes in neutral or basic aqueous solutions. Biomacromolecules. 2006;7:2710-4.
33. Thompson CJ, Chase GG, Yarin AL, Reneker DH. Effect of parameters on nanofiber diameter determined from electrospinning model. Polymer. 2007;48:6913-22.
34. Lee HW, Karin MR, Ji HM, Choi JH, Ghim HD, Park SM, et al. Electrospinning fabrication and characterization of poly(vinyl alcohol)/montmorillonite nanofiber mats. J Appl Polym Sci. 2009;113:1860-7.
35. Geng X, Kwon OH, Jang J. Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials. 2005;26:5427-32.
36. Katti DS, Robinson KW, Ko FK, Laurencin CT. Bioresornanle nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. Biomed Mater Res B Appl Biomater. 2004;70:286-96.
37. Son B, Yeom BY, Song SH, Lee CS, Hwang TS. Antibacterial electrospun chitosan/poly(vinyl alcohol) nanofibers containing silver nitrate and titanium dioxide. J Appl Polym Sci. 2008;111:2892-9.
38. Ohsawa O, Lee KH, Kim BS, Lee S, Kim IS. Preparation and characterization of polyketone (PK) fibrous membrane via electrospinning. Polymer. 2010;51:2007-12.
39. Choi JS, Yoo HS. Eletrospun nanofibers surface-modified with fluorescent proteins. J Bioact Compat Polym. 2007;22:508-24.
40. Kim HS, Yoo HS. MMPs-responsive release of DNA from electrospun nanofibrous matrix for local gene therapy: in vitro and in vivo evaluation. J Control Release. 2010;145:264-71.
41. Mo XM, Xu CY, Kotaki M, Ramakrishna S. Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation. Biomaterials. 2004;25:1883-90.
42. Ding B, Kim HY, Lee SC, Lee DR, Choi KJ. Preparation and characterization of nanoscaled poly(vinyl alcohol) fibers via electrospinning. Fiber Polym. 2002;3:73-9.
43. Carrasquillo KG, Stanley AM, Aponte-Carro JC, Jesus PD, Costantino HR, Bosques CJ, et al. Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein. J Control Release. 2001;76:199-208.
44. Crotts G, Park TG. Preparation of porous and nonporous biodegradable polymeric hollow microspheres. J Control Release. 1995;35:91-105.
45. Calvo P, Remuflan-Lopez C, Vila-Jato JL, Alouso MJ. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res. 1997;14:1431-6.
46. Yu CY, Yin BC, Zhang W, Cheng SX, Zhang XZ, Zhuo RX. Conposite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH-sensitive drug release property. Colloids Surf B Biointerfaces. 2009;68:245-9.
47. Nold MJ, Wesdemiotis C, Yalcin T, Harrison AG. Amide bond dissociation in protonated peptides. Structures of the N-terminal ionic and neutral fragments. Int J Mass Spectrom Ion Process. 1997;164:137-53.