MMPs-responsive release of DNA from electrospun nanofibrous matrix for local gene therapy: In vitro and in vivo evaluation

Journal of Controlled Release

Volumn 145, Issue 3, 2010, Pages 264-271

  Kim, Hye Sung ^a   Yoo, Hyuk Sang ^a  

^a Kangwon National University   (South Korea)

Author keywords

Diabetic; Gene therapy; In vivo; Matrix metalloprotease; Nanofiber; Transfection

Indexed keywords

AMINE GROUPS; ANIMAL EXPERIMENTS; ANIMAL STUDIES; CHARGE RATIO; CONTROL RELEASE; CONTROLLED RELEASE; DIABETIC ULCERS; ELECTROSPUNS; ELECTROSTATIC COMPLEXES; FUNCTIONALIZED; GEL-RETARDATION ASSAY; GENE DELIVERY SYSTEMS; HIGH CONCENTRATION; IN-VITRO; IN-VIVO; MATRIX; MATRIX METALLOPROTEASE; NAKED DNA; NANOFIBROUS MATRIX; PEPTIDE LINKAGES; POLYETHYLENEIMINE; RELEASE FRACTION; RELEASE PROFILES; TRANSFECTION EFFICIENCY;

ANIMALS; BLOCK COPOLYMERS; GELS; GENE THERAPY; GENE TRANSFER; NANOFIBERS; NUCLEIC ACIDS; ORGANIC POLYMERS; PEPTIDES; X RAY PHOTOELECTRON SPECTROSCOPY;

DNA;

COPOLYMER; DNA; GELATINASE A; MATRIX METALLOPROTEINASE; NANOFIBER; POLYETHYLENEIMINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NANOFABRICATION; NONHUMAN; PRIORITY JOURNAL; SKIN ULCER; X RAY PHOTOELECTRON SPECTROSCOPY; 3T3 CELL LINE; ANIMAL; CHEMISTRY; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; SURFACE PROPERTY; WOUND HEALING;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DNA; GENE THERAPY; MATRIX METALLOPROTEINASES; MICE; NANOFIBERS; NIH 3T3 CELLS; POLYETHYLENEIMINE; SURFACE PROPERTIES; TRANSFECTION; WOUND HEALING; GENETIC THERAPY;

EID: 77954314510     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.03.006     Document Type: Article

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