메뉴 건너뛰기




Volumn 183, Issue 1, 2013, Pages 119-128

CDP-choline reduces severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis

Author keywords

Apoptosis; CDP choline; Inflammation; Necrotizing enterocolitis; Neonatal rat

Indexed keywords

CASPASE 3; CITICOLINE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MEMBRANE PHOSPHOLIPID; MYELOPEROXIDASE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

EID: 84879113583     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2012.11.032     Document Type: Article
Times cited : (24)

References (62)
  • 2
    • 43049153342 scopus 로고    scopus 로고
    • What next in necrotizing enterocolitis?
    • M. Yurdakök What next in necrotizing enterocolitis? Turk J Pediatr 50 2008 1
    • (2008) Turk J Pediatr , vol.50 , pp. 1
    • Yurdakök, M.1
  • 3
    • 40749157840 scopus 로고    scopus 로고
    • Probiotics: Role in pathophysiology and prevention in necrotizing enterocolitis
    • C.R. Martin, and W.A. Walker Probiotics: role in pathophysiology and prevention in necrotizing enterocolitis Semin Perinatol 32 2008 127
    • (2008) Semin Perinatol , vol.32 , pp. 127
    • Martin, C.R.1    Walker, W.A.2
  • 4
    • 33745835469 scopus 로고    scopus 로고
    • Intestinal immune defenses and the inflammatory response in necrotizing enterocolitis
    • C.R. Martin, and W.A. Walker Intestinal immune defenses and the inflammatory response in necrotizing enterocolitis Semin Fetal Neonatal Med 11 2006 369
    • (2006) Semin Fetal Neonatal Med , vol.11 , pp. 369
    • Martin, C.R.1    Walker, W.A.2
  • 5
    • 40749097167 scopus 로고    scopus 로고
    • The importance of pro-inflammatory signaling in neonatal NEC
    • B.L. Frost, T. Jilling, and M.S. Caplan The importance of pro-inflammatory signaling in neonatal NEC Semin Perinatol 32 2008 100
    • (2008) Semin Perinatol , vol.32 , pp. 100
    • Frost, B.L.1    Jilling, T.2    Caplan, M.S.3
  • 6
    • 62549102451 scopus 로고    scopus 로고
    • Hyperbaric oxygen therapy reduces the severity of necrotizing enterocolitis in a neonatal rat model
    • A. Güven, G. Gundogdu, and B. Uysal Hyperbaric oxygen therapy reduces the severity of necrotizing enterocolitis in a neonatal rat model J Pediatr Surg 44 2009 534
    • (2009) J Pediatr Surg , vol.44 , pp. 534
    • Güven, A.1    Gundogdu, G.2    Uysal, B.3
  • 7
    • 0036080614 scopus 로고    scopus 로고
    • Reactive species mechanisms of cellular hypoxia-reoxygenation injury
    • C. Li, and R.M. Jackson Reactive species mechanisms of cellular hypoxia-reoxygenation injury Am J Physiol Cell Physiol 282 2002 C227
    • (2002) Am J Physiol Cell Physiol , vol.282 , pp. 227
    • Li, C.1    Jackson, R.M.2
  • 8
    • 79957673012 scopus 로고    scopus 로고
    • Citicholine: Pharmacological and clinical review, 2010 update
    • J.J. Secades Citicholine: pharmacological and clinical review, 2010 update Rev Neurol 52 2011 S1
    • (2011) Rev Neurol , vol.52 , pp. 1
    • Secades, J.J.1
  • 9
    • 77957886834 scopus 로고    scopus 로고
    • Phosphatidylcholine (lecithin) and the mucus layer: Evidence of therapeutic efficacy in ulcerative colitis
    • W. Stremmel, A. Hanemann, and R. Ehehalt Phosphatidylcholine (lecithin) and the mucus layer: evidence of therapeutic efficacy in ulcerative colitis Dig Dis 28 2010 490
    • (2010) Dig Dis , vol.28 , pp. 490
    • Stremmel, W.1    Hanemann, A.2    Ehehalt, R.3
  • 10
    • 33751079106 scopus 로고    scopus 로고
    • Intestinal barrier failure during experimental necrotizing enterocolitis: Protective effect of EGF treatment
    • J.A. Clark, S.M. Doelle, and M.D. Halpern Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment Am J Physiol Gastrointest Liver Physiol 291 2006 938
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291 , pp. 938
    • Clark, J.A.1    Doelle, S.M.2    Halpern, M.D.3
  • 11
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipides
    • E.P. Kennedy, and S.B. Weiss The function of cytidine coenzymes in the biosynthesis of phospholipides J Biol Chem 222 1956 193
    • (1956) J Biol Chem , vol.222 , pp. 193
    • Kennedy, E.P.1    Weiss, S.B.2
  • 12
    • 35449003300 scopus 로고    scopus 로고
    • Cardiovascular effects of CDP-choline and its metabolites: Involvement of peripheral autonomic nervous system
    • M. Cansev, M.S. Yilmaz, and Y.O. Ilcol Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system Eur J Pharmacol 577 2007 129
    • (2007) Eur J Pharmacol , vol.577 , pp. 129
    • Cansev, M.1    Yilmaz, M.S.2    Ilcol, Y.O.3
  • 13
    • 0034308088 scopus 로고    scopus 로고
    • Effect of oral CDP-choline on plasma choline and uridine levels in humans
    • R.J. Wurtman, M. Regan, and I. Ulus Effect of oral CDP-choline on plasma choline and uridine levels in humans Biochem Pharmacol 60 2000 989
    • (2000) Biochem Pharmacol , vol.60 , pp. 989
    • Wurtman, R.J.1    Regan, M.2    Ulus, I.3
  • 14
    • 33747886010 scopus 로고    scopus 로고
    • Uridine and cytidine in the brain: Their transport and utilization
    • M. Cansev Uridine and cytidine in the brain: their transport and utilization Brain Res Rev 52 2006 389
    • (2006) Brain Res Rev , vol.52 , pp. 389
    • Cansev, M.1
  • 16
    • 0029115402 scopus 로고
    • Evidence that 5' cytidinediphosphocholine can affect brain phospholipid composition by increasing choline and cytidine plasma levels
    • I. López-Coviella, J. Agut, and V. Savci Evidence that 5' cytidinediphosphocholine can affect brain phospholipid composition by increasing choline and cytidine plasma levels J Neurochem 65 1995 889
    • (1995) J Neurochem , vol.65 , pp. 889
    • López-Coviella, I.1    Agut, J.2    Savci, V.3
  • 17
    • 13844264515 scopus 로고    scopus 로고
    • Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders
    • R.M. Adibhatla, and J.F. Hatcher Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders Neurochem Res 30 2005 15
    • (2005) Neurochem Res , vol.30 , pp. 15
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 19
    • 58149295859 scopus 로고    scopus 로고
    • Assessment of a neonatal rat model of necrotizing enterocolitis
    • A. Zani, L. Cordischi, and M. Cananzi Assessment of a neonatal rat model of necrotizing enterocolitis Eur J Pediatr Surg 18 2008 423
    • (2008) Eur J Pediatr Surg , vol.18 , pp. 423
    • Zani, A.1    Cordischi, L.2    Cananzi, M.3
  • 20
    • 0028020174 scopus 로고
    • Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis
    • M.S. Caplan, E. Hedlund, and L. Adler Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis Pediatr Pathol 14 1994 1017
    • (1994) Pediatr Pathol , vol.14 , pp. 1017
    • Caplan, M.S.1    Hedlund, E.2    Adler, L.3
  • 21
    • 1642447868 scopus 로고    scopus 로고
    • Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis
    • T. Jilling, J. Lu, and M. Jackson Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis Pediatr Res 55 2004 622
    • (2004) Pediatr Res , vol.55 , pp. 622
    • Jilling, T.1    Lu, J.2    Jackson, M.3
  • 22
    • 3042560333 scopus 로고    scopus 로고
    • Ventilation strategy affects cytokine release after mesenteric ischemia-reperfusion in rats
    • L. Bouadma, F. Schortgen, and J.D. Ricard Ventilation strategy affects cytokine release after mesenteric ischemia-reperfusion in rats Crit Care Med 32 2004 1563
    • (2004) Crit Care Med , vol.32 , pp. 1563
    • Bouadma, L.1    Schortgen, F.2    Ricard, J.D.3
  • 23
    • 0023952554 scopus 로고
    • A simple method for clinical assay of superoxide dismutase
    • Y. Sun, L.W. Oberley, and Y. Li A simple method for clinical assay of superoxide dismutase Clin Chem 34 1988 497
    • (1988) Clin Chem , vol.34 , pp. 497
    • Sun, Y.1    Oberley, L.W.2    Li, Y.3
  • 24
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • D.E. Paglia, and W.N. Valentine Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase J Lab Clin Med 70 1967 158
    • (1967) J Lab Clin Med , vol.70 , pp. 158
    • Paglia, D.E.1    Valentine, W.N.2
  • 25
    • 0025142672 scopus 로고
    • Malondialdehyde determination as index of lipid peroxidation
    • H.H. Draper, and M. Hadley Malondialdehyde determination as index of lipid peroxidation Methods Enzymol 186 1990 421
    • (1990) Methods Enzymol , vol.186 , pp. 421
    • Draper, H.H.1    Hadley, M.2
  • 26
    • 79251556899 scopus 로고    scopus 로고
    • The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats
    • D.N. Tihan, Y. Erbil, and R. Seven The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats Ulus Travma Acil Cerrahi Derg 17 2011 1
    • (2011) Ulus Travma Acil Cerrahi Derg , vol.17 , pp. 1
    • Tihan, D.N.1    Erbil, Y.2    Seven, R.3
  • 27
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • J. Folch, M. Lees, and G.H. Sloane-Stanley A simple method for the isolation and purification of total lipids from animal tissues J Biol Chem 226 1957 497
    • (1957) J Biol Chem , vol.226 , pp. 497
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 28
    • 79951604923 scopus 로고    scopus 로고
    • New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond
    • A. Afrazi, C.P. Sodhi, and W. Richardson New insights into the pathogenesis and treatment of necrotizing enterocolitis: toll-like receptors and beyond Pediatr Res 69 2011 183
    • (2011) Pediatr Res , vol.69 , pp. 183
    • Afrazi, A.1    Sodhi, C.P.2    Richardson, W.3
  • 29
    • 78751625682 scopus 로고    scopus 로고
    • Necrotizing enterocolitis
    • J. Neu, and W.A. Walker Necrotizing enterocolitis N Engl J Med 364 2011 255
    • (2011) N Engl J Med , vol.364 , pp. 255
    • Neu, J.1    Walker, W.A.2
  • 30
    • 34748823012 scopus 로고    scopus 로고
    • New therapies and preventive approaches for necrotizing enterocolitis: Report of a research planning workshop
    • G.D. Grave, S.A. Nelson, and W.A. Walker New therapies and preventive approaches for necrotizing enterocolitis: report of a research planning workshop Pediatr Res 62 2007 510
    • (2007) Pediatr Res , vol.62 , pp. 510
    • Grave, G.D.1    Nelson, S.A.2    Walker, W.A.3
  • 32
    • 0023753531 scopus 로고
    • The mucus barrier. Its role in gastroduodenal mucosal protection
    • A. Allen, A.J. Leonard, and L.A. Sellers The mucus barrier. Its role in gastroduodenal mucosal protection J Clin Gastroenterol 10 1988 S93
    • (1988) J Clin Gastroenterol , vol.10 , pp. 93
    • Allen, A.1    Leonard, A.J.2    Sellers, L.A.3
  • 33
    • 70350329474 scopus 로고    scopus 로고
    • Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: A clue to pathogenesis
    • A. Braun, I. Treede, and D. Gotthardt Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis Inflamm Bowel Dis 15 2009 1705
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1705
    • Braun, A.1    Treede, I.2    Gotthardt, D.3
  • 34
    • 0028915433 scopus 로고
    • The hydrophobic barrier properties of gastrointestinal mucus
    • L.M. Lichtenberger The hydrophobic barrier properties of gastrointestinal mucus Ann Rev Physiol 57 1995 565
    • (1995) Ann Rev Physiol , vol.57 , pp. 565
    • Lichtenberger, L.M.1
  • 35
    • 34848879554 scopus 로고    scopus 로고
    • Anti-inflammatory effects of phosphatidylcholine
    • I. Treede, A. Braun, and R. Sparla Anti-inflammatory effects of phosphatidylcholine J Biol Chem 282 2007 27155
    • (2007) J Biol Chem , vol.282 , pp. 27155
    • Treede, I.1    Braun, A.2    Sparla, R.3
  • 36
    • 33644785216 scopus 로고    scopus 로고
    • Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux
    • G. Eros, J. Kaszaki, and M. Czobel Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux World J Gastroenterol 12 2006 271
    • (2006) World J Gastroenterol , vol.12 , pp. 271
    • Eros, G.1    Kaszaki, J.2    Czobel, M.3
  • 37
    • 0036205481 scopus 로고    scopus 로고
    • Polyunsaturated phosphatidylcholine lowers collagen deposition in a rat model of corrosive esophageal burn
    • S. Demirbilek, G. Aydin, and S. Yucesan Polyunsaturated phosphatidylcholine lowers collagen deposition in a rat model of corrosive esophageal burn Eur J Pediatr Surg 12 2002 8
    • (2002) Eur J Pediatr Surg , vol.12 , pp. 8
    • Demirbilek, S.1    Aydin, G.2    Yucesan, S.3
  • 38
    • 77954660811 scopus 로고    scopus 로고
    • Phosphatidylcholine as a constituent in the colonic mucosal barrier - Physiological and clinical relevance
    • R. Ehehalt, A. Braun, and M. Karner Phosphatidylcholine as a constituent in the colonic mucosal barrier - physiological and clinical relevance Biochim Biophys Acta 1801 2010 983
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 983
    • Ehehalt, R.1    Braun, A.2    Karner, M.3
  • 39
    • 21044457089 scopus 로고    scopus 로고
    • Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis
    • W. Stremmel, U. Merle, and A. Zahn Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis Gut 54 2005 966
    • (2005) Gut , vol.54 , pp. 966
    • Stremmel, W.1    Merle, U.2    Zahn, A.3
  • 40
    • 38449107095 scopus 로고    scopus 로고
    • Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: A randomized trial
    • W. Stremmel, R. Ehehalt, and F. Autschbach Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial Ann Intern Med 147 2007 603
    • (2007) Ann Intern Med , vol.147 , pp. 603
    • Stremmel, W.1    Ehehalt, R.2    Autschbach, F.3
  • 41
    • 0032875134 scopus 로고    scopus 로고
    • Innate mechanisms of epithelial host defense: Spotlight on intestine
    • G. Hecht Innate mechanisms of epithelial host defense: spotlight on intestine Am J Physiol 277 1999 C351
    • (1999) Am J Physiol , vol.277 , pp. 351
    • Hecht, G.1
  • 42
    • 33745177351 scopus 로고    scopus 로고
    • Regulation of mucin expression: Mechanistic aspects and implications for cancer and inflammatory diseases
    • M. Andrianifahanana, N. Moniaux, and S.K. Batra Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory diseases Biochim Biophys Acta 1765 2006 189
    • (2006) Biochim Biophys Acta , vol.1765 , pp. 189
    • Andrianifahanana, M.1    Moniaux, N.2    Batra, S.K.3
  • 43
    • 80053192711 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: A potential role in neonatal necrotizing enterocolitis
    • S.J. McElroy, L.S. Prince, and J.H. Weitkamp Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis Am J Physiol Gastrointest Liver Physiol 301 2011 G656
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. 656
    • McElroy, S.J.1    Prince, L.S.2    Weitkamp, J.H.3
  • 44
    • 77953380853 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and apoptosis signal-regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy, and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis
    • N. Baregamian, J. Song, and C.E. Bailey Tumor necrosis factor-alpha and apoptosis signal-regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy, and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis Oxid Med Cell Longev 2 2009 297
    • (2009) Oxid Med Cell Longev , vol.2 , pp. 297
    • Baregamian, N.1    Song, J.2    Bailey, C.E.3
  • 45
    • 33846817498 scopus 로고    scopus 로고
    • Physiology and immunology of the cholinergic antiinflammatory pathway
    • K.J. Tracey Physiology and immunology of the cholinergic antiinflammatory pathway J Clin Invest 117 2007 289
    • (2007) J Clin Invest , vol.117 , pp. 289
    • Tracey, K.J.1
  • 46
    • 36749061943 scopus 로고    scopus 로고
    • Presence of a marked nonneuronal cholinergic system n human colon: Study of normal colon and colon in ulcerative colitis
    • M. Jönnson, O. Norrgard, and S. Forsgren Presence of a marked nonneuronal cholinergic system n human colon: study of normal colon and colon in ulcerative colitis Inflamm Bowel Dis 13 2007 1347
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1347
    • Jönnson, M.1    Norrgard, O.2    Forsgren, S.3
  • 47
    • 0035798703 scopus 로고    scopus 로고
    • Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor jB
    • M.Q. Holmes-McNary, A.S. Baldwin Jr., and S.H. Zeisel Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor jB J Biol Chem 276 2001 41197
    • (2001) J Biol Chem , vol.276 , pp. 41197
    • Holmes-Mcnary, M.Q.1    Baldwin, Jr.A.S.2    Zeisel, S.H.3
  • 48
    • 24644514247 scopus 로고    scopus 로고
    • Endotoxin alters serum-free choline and phospholipid-bound choline-concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs
    • Y.O. Ilcol, Z. YIlmaz, and I.H. Ulus Endotoxin alters serum-free choline and phospholipid-bound choline-concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs Shock 24 2005 288
    • (2005) Shock , vol.24 , pp. 288
    • Ilcol, Y.O.1    Yilmaz, Z.2    Ulus, I.H.3
  • 49
    • 84859139732 scopus 로고    scopus 로고
    • Lipid based therapy for ulcerative colitis- modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation
    • H. Schneider, A. Braun, and J. Füllekrug Lipid based therapy for ulcerative colitis- modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation Int J Mol Sci 11 2010 4149
    • (2010) Int J Mol Sci , vol.11 , pp. 4149
    • Schneider, H.1    Braun, A.2    Füllekrug, J.3
  • 50
    • 68249135240 scopus 로고    scopus 로고
    • TNF-α-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells
    • I. Treede, A. Braun, and P. Jeliaskova TNF-α-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells BMC Gastroenterol 9 2009 53
    • (2009) BMC Gastroenterol , vol.9 , pp. 53
    • Treede, I.1    Braun, A.2    Jeliaskova, P.3
  • 51
    • 0024212465 scopus 로고
    • SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis
    • M.J. Miller, H. McNeill, and K.M. Mullane SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis Am J Physiol 255 1988 556
    • (1988) Am J Physiol , vol.255 , pp. 556
    • Miller, M.J.1    McNeill, H.2    Mullane, K.M.3
  • 52
    • 0024323487 scopus 로고
    • Developmental biology of oxidant-producing enzymes and antioxidants in the piglet intestine
    • K.D. Crissinger, M.B. Grisham, and D.N. Granger Developmental biology of oxidant-producing enzymes and antioxidants in the piglet intestine Pediatr Res 25 1989 612
    • (1989) Pediatr Res , vol.25 , pp. 612
    • Crissinger, K.D.1    Grisham, M.B.2    Granger, D.N.3
  • 53
    • 55949116151 scopus 로고    scopus 로고
    • Oral phosphatidylcholine pretreatment decreases ischemia-reperfusion- induced methane generation and the inflammatory response in the small intestine
    • M. Ghyczy, C. Torday, and J. Kaszaki Oral phosphatidylcholine pretreatment decreases ischemia-reperfusion-induced methane generation and the inflammatory response in the small intestine Shock 30 2008 596
    • (2008) Shock , vol.30 , pp. 596
    • Ghyczy, M.1    Torday, C.2    Kaszaki, J.3
  • 54
    • 47549099175 scopus 로고    scopus 로고
    • Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: Involvement of the peripheral autonomic nervous system
    • M. Cansev, Y.O. Ilcol, and M.S. Yilmaz Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system Eur J Pharmacol 589 2008 315
    • (2008) Eur J Pharmacol , vol.589 , pp. 315
    • Cansev, M.1    Ilcol, Y.O.2    Yilmaz, M.S.3
  • 55
    • 38049072149 scopus 로고    scopus 로고
    • Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: Muscarinic and nicotinic acetylcholine receptors are both involved in their actions
    • Y.O. Ilcol, M. Cansev, and M.S. Yilmaz Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions Neurosci Lett 431 2008 71
    • (2008) Neurosci Lett , vol.431 , pp. 71
    • Ilcol, Y.O.1    Cansev, M.2    Yilmaz, M.S.3
  • 56
    • 1342269932 scopus 로고    scopus 로고
    • Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
    • H. Guo, D. Liu, and H. Gelbard Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron 41 2004 563
    • (2004) Neuron , vol.41 , pp. 563
    • Guo, H.1    Liu, D.2    Gelbard, H.3
  • 57
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis
    • D.E. Joyce, L. Gelbert, and A. Ciaccia Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis J Biol Chem 276 2001 11199
    • (2001) J Biol Chem , vol.276 , pp. 11199
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3
  • 58
    • 77649216557 scopus 로고    scopus 로고
    • Activated protein C reduces intestinal injury in an experimental model of necrotizing enterocolitis
    • A. Kumral, D.C. YesilIrmak, and K. Tugyan Activated protein C reduces intestinal injury in an experimental model of necrotizing enterocolitis J Ped Surg 45 2010 483
    • (2010) J Ped Surg , vol.45 , pp. 483
    • Kumral, A.1    Yesilirmak, D.C.2    Tugyan, K.3
  • 59
    • 52949121779 scopus 로고    scopus 로고
    • CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia
    • M. Fiedorowicz, D. Makarewicz, and K.I. Stanczak-Brozek CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia Acta Neurobiol Exp 68 2008 389
    • (2008) Acta Neurobiol Exp , vol.68 , pp. 389
    • Fiedorowicz, M.1    Makarewicz, D.2    Stanczak-Brozek, K.I.3
  • 60
    • 10744221070 scopus 로고    scopus 로고
    • Vascular changes play a role in the pathogenesis of necrotizing enterocolitis in asphyxiated newborn pigs
    • B. Gellén, J. Kovács, and L. Németh Vascular changes play a role in the pathogenesis of necrotizing enterocolitis in asphyxiated newborn pigs Pediatr Surg Int 19 2003 380
    • (2003) Pediatr Surg Int , vol.19 , pp. 380
    • Gellén, B.1    Kovács, J.2    Németh, L.3
  • 61
    • 33745197344 scopus 로고    scopus 로고
    • Cytidine 5'-diphosphocholine restores blood flow of superior mesenteric and renal arteries and prolongs survival time in haemorrhaged anaesthetized rats
    • M.S. YIlmaz, M. YalcIn, and V. SavcI Cytidine 5'-diphosphocholine restores blood flow of superior mesenteric and renal arteries and prolongs survival time in haemorrhaged anaesthetized rats Clin Exp Pharmacol Physiol 33 2006 415
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 415
    • Yilmaz, M.S.1    Yalcin, M.2    Savci, V.3
  • 62
    • 0037720339 scopus 로고    scopus 로고
    • Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: Effect is mediated by central cholinergic activation
    • V. Savci, G. Goktalay, and M. Cansev Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation Eur J Pharmacol 468 2003 129
    • (2003) Eur J Pharmacol , vol.468 , pp. 129
    • Savci, V.1    Goktalay, G.2    Cansev, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.