Insight in stable schizophrenia: Relations with psychopathology and cognition

Comprehensive Psychiatry

Volumn 54, Issue 5, 2013, Pages 484-492

  Mingrone, Cinzia ^a   Rocca, Paola ^a   Castagna, Filomena ^a   Montemagni, Cristiana ^a   Sigaudo, Monica ^a   Scalese, Mara ^a   Rocca, Giuseppe ^a   Bogetto, Filippo ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AWARENESS; CLINICAL FEATURE; COGNITION; CROSS-SECTIONAL STUDY; FACTORIAL ANALYSIS; FEMALE; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; MEMORY; NEGATIVE SYNDROME; NEUROPSYCHOLOGICAL TEST; OUTPATIENT; PILOT STUDY; POSITIVE SYNDROME; PSYCHOLOGICAL RATING SCALE; SCHIZOPHRENIA;

ADULT; AWARENESS; COGNITION; CROSS-SECTIONAL STUDIES; EXECUTIVE FUNCTION; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PROBLEM SOLVING; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84879098533     PISSN: 0010440X     EISSN: 15328384     Source Type: Journal    
DOI: 10.1016/j.comppsych.2012.12.014     Document Type: Article

References (87)

1. C. Greenberger, and M.R. Serper Examination of clinical and cognitive insight in acute schizophrenia patients J Nerv Ment Dis 198 2010 465 469
2. X.F. Amador, and J.M. Gorman Psychopathologic domains and insight in schizophrenia Psychiatr Clin North Am 21 1998 27 42
3. A. Medalia, and R.W. Lim Self-awareness of cognitive functioning in schizophrenia Schizophr Res 71 2004 331 338
4. K.L. Subotnik, K.H. Nuechterlein, V. Irzhevsky, C.M. Kitchen, S.M. Woo, and J. Mintz Is unawareness of psychotic disorder a neurocognitive or psychological defensiveness problem? Schizophr Res 75 2005 147 157
5. L.C. Monteiro, V.A. Silva, and M.R. Louzã Insight, cognitive dysfunction and symptomatology in schizophrenia Eur Arch Psychiatry Clin Neurosci 258 2008 402 405
6. X.F. Amador, M. Flaum, N.C. Andreasen, D.H. Strauss, S.A. Yale, and S.C. Clark Awareness of illness in schizophrenia and schizoaffective and mood disorders Arch Gen Psychiatry 51 1994 826 836
7. R.C. Schwartz, B.N. Cohen, and A. Grubaugh Does insight affect long-term impatient treatment outcome in chronic schizophrenia? Compr Psychiatry 38 1997 283 288
8. G. Bartkó, I. Herczeg, and G. Zádor Clinical symptomatology and drug compliance in schizophrenic patients Acta Psychiatr Scand 77 1988 74 76
9. P.F. Buckley, D.A. Wirshing, P. Bhushan, J.M. Pierre, S.A. Resnick, and W.C. Wirshing Lack of insight in schizophrenia: impact on treatment adherence CNS Drugs 21 2007 129 141
10. R. Kemp, and A. David Psychological predictors of insight and compliance in psychotic patients Br J Psychiatry 169 1997 444 450
11. T.E. Smith, J.W. Hull, M. Goodman, A. Hedayat-Harris, D.F. Willson, and L.M. Israel The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder J Nerv Ment Dis 187 1999 102 108
12. M. Olfson, S.C. Marcus, J. Wilk, and J.C. West Awareness of illness and nonadherence to antipsychotic medications among persons with schizophrenia Psychiatr Serv 57 2006 205 211
13. A. David, J. van Os, P. Jones, I. Harvey, A. Foerster, and T. Fahy Insight and psychotic illness. Cross-sectional and longitudinal associations Br J Psychiatry 167 1995 621 628
14. P.H. Lysaker, M.D. Bell, G.J. Bryson, and E. Kaplan Insight and interpersonal function in schizophrenia J Nerv Ment Dis 186 1998 432 436
15. J.M. Pyne, D. Bean, and G. Sullivan Characteristics of patients with schizophrenia who do not believe they are mentally ill J Nerv Ment Dis 189 2001 146 153
16. P. Lysaker, and M. Bell Work rehabilitation and improvements in insight in schizophrenia J Nerv Ment Dis 183 1995 103 106
17. A.R. Mintz, K.S. Dobson, and D.M. Romney Insight in schizophrenia: a meta-analysis Schizophr Res 61 2003 75 88
18. B.J. Cuffel, J. Alford, E.P. Fischer, and R.R. Owen Awareness of illness in schizophrenia and outpatient treatment adherence J Nerv Ment Dis 184 1996 653 659
19. C.W.M. Matton, M. De Hert, and J. Peuskens Ziekte-inzicht bij patienten met schizofrenie Tijdschr Psychiatr 46 2004 589 599
20. M.S. Ritsner, and H. Blumenkrantz Predicting domain-specific insight of schizophrenia patients from symptomatology, multiple neurocognitive functions, and personality related traits Psychiatry Res 149 2007 59 69
21. R. Macpherson, B. Jerrom, and A. Hughes Relationship between insight, educational background and cognition in schizophrenia Br J Psychiatry 168 1996 718 722
22. R.W. Goldberg, L.D. Green-Paden, A.F. Lehman, and J.M. Gold Correlates of insight in serious mental illness J Nerv Ment Dis 189 2001 137 145
23. M.U. Shad, S. Muddasani, K. Prasad, J.A. Sweeney, and M.S. Keshavan Insight and prefrontal cortex in first-episode schizophrenia Neuroimage 22 2004 1315 1320
24. A.E. Simon, G.E. Berger, V. Giacomini, F. Ferrero, and S. Mohr Insight, symptoms and executive functions in schizophrenia Cogn Neuropsychiatry 11 2006 437 451
25. M.A. De Hert, V. Simon, D. Vidovic, T. Franic, M. Wampers, and J. Peuskens Evaluation of the association between insight and symptoms in a large sample of patients with schizophrenia Eur Psychiatry 24 2009 507 512
26. E. Stefanopoulou, A.R. Lafuente, J.A. Saez Fonseca, and A. Huxley Insight, global functioning and psychopathology amongst in-patient clients with schizophrenia Psychiatr Q 80 2009 155 165
27. A.R. Mintz, J. Addington, and D. Addington Insight in early psychosis: a 1-year follow-up Schizophr Res 67 2004 213 217
28. S. Sevy, K. Nathanson, H. Visweswaraiah, and X. Amador The relationship between insight and symptoms in schizophrenia Compr Psychiatry 45 2004 16 19
29. M.S. Keshavan, J. Rabinowitz, G. DeSmedt, P.D. Harvey, and N. Schooler Correlates of insight in first episode psychosis Schizophr Res 70 2004 187 194
30. M.J. Cuesta, V. Peralta, and A. Zarzuela Reappraising insight in psychosis. Multi-scale longitudinal study Br J Psychiatry 177 2000 233 240
31. C.H. Kim, K. Jayathilake, and H.Y. Meltzer Hopelessness, neurocognitive function, and insight in schizophrenia: relationship to suicidal behavior Schizophr Res 60 2003 71 80
32. O. Moore, E. Cassidy, A. Carr, and E. O'Callaghan Unawareness of illness and its relationship with depression and self-deception in schizophrenia Eur Psychiatry 14 1999 264 269
33. T.E. Smith, J.W. Hull, L.M. Israel, and D.F. Willson Insight, symptoms, and neurocognition in schizophrenia and schizoaffective disorder Schizophr Bull 26 2000 193 200
34. L. Buchy, I.J. Torres, P.F. Liddle, and T.S. Woodward Symptomatic determinants of insight in schizophrenia spectrum disorders Compr Psychiatry 50 2009 578 583
35. F.B. Dickerson, J.J. Boronow, N. Ringel, and F. Parente Lack of insight among outpatients with schizophrenia Psychiatr Serv 48 1997 195 199
36. B. Saravanan, K.S. Jacob, S. Johnson, M. Prince, D. Bhugra, and A.S. David Assessing insight in schizophrenia: east meets west Br J Psychiatry 190 2007 243 247
37. R.W. Heinrichs, and K.K. Zakzanis Neurocognitive deficit in schizophrenia: a quantitative review of the evidence Neuropsychology 12 1998 426 445
38. R.J. Drake, and S.W. Lewis Insight and neurocognition in schizophrenia Schizophr Res 62 2003 165 173
39. P. Lysaker, and M. Bell Insight and cognitive impairment in schizophrenia. Performance on repeated administrations of the Wisconsin Card Sorting Test J Nerv Ment Dis 182 1994 656 660
40. P.H. Lysaker, M.D. Bell, G. Bryson, and E. Kaplan Neurocognitive function and insight in schizophrenia: support for an association with impairments in executive function but not with impairments in global function Acta Psychiatr Scand 97 1998 297 301
41. J.P. McEvoy, M. Hartman, D. Gottlieb, S. Godwin, L.J. Apperson, and W. Wilson Common sense, insight, and neuropsychological test performance in schizophrenia patients Schizophr Bull 22 1996 635 641
42. S.L. Rossell, J. Coakes, J. Shapleske, P.W. Woodruff, and A.S. David Insight: its relationship with cognitive function, brain volume and symptoms in schizophrenia Psychol Med 33 2003 111 119
43. V. Simon, M. De Hert, M. Wampers, J. Peuskens, and R. van Winkel The relation between neurocognitive dysfunction and impaired insight in patients with schizophrenia Eur Psychiatry 24 2009 239 243
44. S.H. Mutsatsa, E.M. Joyce, S.B. Hutton, and T.R. Barnes Relationship between insight, cognitive function, social function and symptomatology in schizophrenia: the West London First Episode Study Eur Arch Psychiatry Clin Neurosci 256 2006 356 363
45. A.A. Collins, G.J. Remington, K. Coulter, and K. Birkett Insight, neurocognitive function and symptom clusters in chronic schizophrenia Schizophr Res 27 1997 37 44
46. A. Aleman, E.H. de Haan, and R.S. Kahn Insight and neurocognitive function in schizophrenia J Neuropsychiatry Clin Neurosci 14 2002 241 242
47. A. Carroll, S. Fattah, Z. Clyde, I. Coffey, D.G. Owens, and E.C. Johnstone Correlates of insight and insight change in schizophrenia Schizophr Res 35 1999 247 253
48. M.U. Shad, C.A. Tamminga, M. Cullum, G.L. Haas, and M.S. Keshavan Insight and frontal cortical function in schizophrenia: a review Schizophr Res 86 2006 54 70
49. A.P. Association Diagnostic and statistical manual of mental disorders, fourth edition, text revision (DSM-IV-TR) 2000 American Psychiatric Press Washington, DC
50. M. First, M. Gibbon, R. Spitzer, J. Williams, and L. Benjamin Structured clinical interview for DSM-IV disorders (SCID) 1997 American Psychiatric Press Washington, DC
51. S. Kay, A. Fiszbein, and L. Opler The Positive and Negative Syndrome Scale (PANSS) for schizophrenia Schizophr Bull 13 1987 261 276
52. S.D. Amador XF The scale to assess unawereness of mental disorder 1990 Columbia University and New York Psychiatric Institute New York
53. J. Stroop Studies of interference in serial verbal reactions J Exp Psychol 18 1935 643 662
54. R. Reitan Validity of the trail making test as an indication of organic brain damage Percept Mot Skills 8 1958 271 276
55. H. RK Wisconsin Card Sorting Test manual Chelune GJ TJea, 1993 Psychological Assessment Resources, Inc. Odessa (Fla)
56. D.C.K.J. Delis, E. Kaplan, and B.A. Ober California verbal learning test (CVLT) 1987 Manual. Psychological Corporation San Antonio (Tex)
57. T.M. Lincoln, E. Lüllmann, and W. Rief Correlates and long-term consequences of poor insight in patients with schizophrenia. A systematic review Schizophr Bull 33 2007 1324 1342
58. S. Tirupati, R. Padmavati, R. Thara, and R.G. McCreadie Insight and psychopathology in never-treated schizophrenia Compr Psychiatry 48 2007 264 268
59. E. Aguglia, M. De Vanna, M.L. Onor, and D. Ferrara Insight in persons with schizophrenia: effects of switching from conventional neuroleptics to atypical antipsychotics Prog Neuropsychopharmacol Biol Psychiatry 26 2002 1229 1233
60. T.T. Raij, T.J. Riekki, and R. Hari Association of poor insight in schizophrenia with structure and function of cortical midline structures and frontopolar cortex Schizophr Res 139 1-3 2012 27 32
61. G. Roberts Delusional belief systems and meaning in life: a preferred reality? Br J Psychiatry Suppl 1991 19 28
62. H.M. Lyon, S. Kaney, and R.P. Bentall The defensive function of persecutory delusions. Evidence from attribution tasks Br J Psychiatry 164 1994 637 646
63. R.P. Bentall, R. Corcoran, R. Howard, N. Blackwood, and P. Kinderman Persecutory delusions: a review and theoretical integration Clin Psychol Rev 21 2001 1143 1192
64. R. Goldbeck Denial in physical illness J Psychosom Res 43 1997 575 593
65. M.A. Erickson, and P.H. Lysaker Self-esteem and insight as predictors of symptom change in schizophrenia: a longitudinal study Clin Schizophr Relat Psychoses 6 2 2012 69 75
66. D. Danki, N. Dilbaz, I.T. Okay, and S. Telci Insight in schizophrenia: relationship to family history, and positive and negative symptoms Turk Psikiyatri Derg 18 2007 129 136
67. R.A. Kemp, and T.J. Lambert Insight in schizophrenia and its relationship to psychopathology Schizophr Res 18 1995 21 28
68. K. Osatuke, J. Ciesla, J.W. Kasckow, S. Zisook, and S. Mohamed Insight in schizophrenia: a review of etiological models and supporting research Compr Psychiatry 49 2008 70 77
69. W.S. Fenton, C.R. Blyler, and R.K. Heinssen Determinants of medication compliance in schizophrenia: empirical and clinical findings Schizophr Bull 23 1997 637 651
70. Y.C. Kao, and Y.P. Liu Compliance and schizophrenia: the predictive potential of insight into illness, symptoms, and side effects Compr Psychiatry 51 2010 557 565
71. E.M. Beck, M. Cavelti, S. Kvrgic, B. Kleim, and R. Vauth Are we addressing the 'right stuff' to enhance adherence in schizophrenia? Understanding the role of insight and attitudes towards medication Schizophr Res 132 1 2011 42 49
72. M. Startup Insight and cognitive deficits in schizophrenia: evidence for a curvilinear relationship Psychol Med 26 1996 1277 1281
73. S. Raffard, S. Bayard, M.C. Gely-Nargeot, D. Capdevielle, M. Maggi, and E. Barbotte Insight and executive functioning in schizophrenia: a multidimensional approach Psychiatry Res 167 2009 239 250
74. A. Aleman, N. Agrawal, K.D. Morgan, and A.S. David Insight in psychosis and neuropsychological function: meta-analysis Br J Psychiatry 189 2006 204 212
75. D.A. Young, R. Davila, and H. Scher Unawareness of illness and neuropsychological performance in chronic schizophrenia Schizophr Res 10 1993 117 124
76. M.A. Cooke, E.R. Peters, E. Kuipers, and V. Kumari Disease, deficit or denial? Models of poor insight in psychosis Acta Psychiatr Scand 112 2005 4 17
77. R. Ayesa-Arriola, J.M. Rodríguez-Sánchez, C. Morelli, J.M. Pelayo-Terán, R. Pérez-Iglesias, and I. Mata Insight dimensions in first-episode psychosis patients: clinical, cognitive, pre-morbid and sociodemographic correlates Early Interv Psychiatry 5 2011 140 149
78. A. Medalia, and J. Thysen A comparison of insight into clinical symptoms versus insight into neuro-cognitive symptoms in schizophrenia Schizophr Res 118 2010 134 139
79. D. Turkington, D. Kingdon, T. Turner Group IiSR Effectiveness of a brief cognitive-behavioural therapy intervention in the treatment of schizophrenia Br J Psychiatry 180 2002 523 527
80. S. Rathod, D. Kingdon, P. Smith, and D. Turkington Insight into schizophrenia: the effects of cognitive behavioural therapy on the components of insight and association with sociodemographics - data on a previously published randomised controlled trial Schizophr Res 74 2005 211 219
81. E. Granholm, L. Auslander, J. Gottlieb, J. McQuaid, and F. McClure Therapeutic factors contributing to change in cognitive-behavioral group therapy for older persons with schizophrenia J Contemp Psychother 36 2006 31 41
82. S. Raffard, S. Bayard, D. Capdevielle, F. Garcia, J.P. Boulenger, and M.C. Gely-Nargeot Lack of insight in schizophrenia: a review. Part I: theoretical concept, clinical aspects and Amador's model Encéphale 34 6 2008 597 605
83. D. Perivoliotis, P.M. Grant, E.R. Peters, R. Ison, E. Kuipers, and A.T. Beck Cognitive insight predicts favorable outcome in cognitive behavioral therapy for psychosis Psychosis 2 2010 23 33
84. M.D. Orfei, F. Piras, E. Macci, C. Caltagirone, and G. Spalletta The neuroanatomical correlates of cognitive insight in schizophrenia Soc Cogn Affect Neurosci 9 2012 1 6
85. G. Nicolò, G. Dimaggio, R. Popolo, A. Carcione, M. Procacci, and J. Hamm Associations of metacognition with symptoms, insight, and neurocognition in clinically stable outpatients with schizophrenia J Nerv Ment Dis 200 7 2012 644 647
86. H. Tastet, H. Verdoux, V. Bergua, J.M. Destaillats, and A. Prouteau Cognitive insight in schizophrenia: the missing link between insight and neurocognitive complaint? J Nerv Ment Dis 200 10 2012 908 910
87. P.H. Lysaker, G. Dimaggio, K.D. Buck, S.S. Callaway, G. Salvatore, and A. Carcione Poor insight in schizophrenia: links between different forms of metacognition with awareness of symptoms, treatment need, and consequences of illness Compr Psychiatry 52 3 2011 253 260