The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion

Journal of Molecular Medicine

Volumn 91, Issue 5, 2013, Pages 561-572

  Amlal, Hassane ^a,b,c   Xu, Jie ^a,b,c   Barone, Sharon ^a,b,c   Zahedi, Kamyar ^a,b,c   Soleimani, Manoocher ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

High salt intake; Hypertension; Kidney medullary collecting duct; Renal chloride excretion; SLC26 isoforms

Indexed keywords

CHLORIDE; CHLORIDE CHANNEL; SLC2619 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CELLULAR DISTRIBUTION; CHLORIDE URINE LEVEL; CONTROLLED STUDY; ELECTROLYTE EXCRETION; GENE DELETION; MOUSE; NONHUMAN; URINARY EXCRETION; URINE VOLUME; WATER DEPRIVATION;

ANIMALS; ANTIPORTERS; ARTERIAL PRESSURE; BODY WEIGHT; CATIONS, MONOVALENT; CHLORIDES; DRINKING; EATING; GENE EXPRESSION REGULATION; HUMANS; HYPERTENSION; ION TRANSPORT; KIDNEY TUBULES, COLLECTING; MICE; MICE, KNOCKOUT; SODIUM; SODIUM CHLORIDE, DIETARY; WATER;

EID: 84879091299     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0973-1     Document Type: Article

References (41)

1. Schwartz GJ, Barasch J, Al-Awqati Q (1985) Plasticity of functional epithelial polarity. Nature 318(6044):368-371
2. Schuster VL (1993) Function and regulation of collecting duct intercalated cells. Annu Rev Physiol 55:267-288
3. +-ATPases: regulation and role in pathophysiological states. Am J Physiol Renal Physiol 276:F799-F811
4. Gamba G (2005) Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension. Am J Physiol Renal Physiol 288(2):F245-F252
5. Ishibashi K, Hara S, Kondo S (2009) Aquaporin water channels in mammals. Clin Exp Nephrol 13(2):107-117
6. Soundararajan R, Pearce D, Hughey RP, Kleyman TR (2010) Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem 285(40):30363-30369
7. Greenlee MM, Lynch IJ, Gumz ML, Cain BD, Wingo CS (2010) The renal H,K-ATPases. Curr Opin Nephrol Hypertens 19(5):478-482
8. - exchanger in the kidney cortex. Am J Physiol Renal Physiol 280:F356-F364
9. Royaux IE, Wall SM, Karniski LP, Everett LA, Suzuki K, Knepper MA, Green ED (2001) Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A 98:4221-4226
10. Verlander JW, Hassell KA, Royaux IE, Glapion DM, Wang ME, Everett LA, Green ED, Wall SM (2003) Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension. Hypertension 179:356-362
11. Amlal H, Petrovic S, Xu J, Wang Z, Sun X, Barone S, Soleimani M (2010) Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct. Am J Physiol Cell Physiol 299(1):C33-C41
12. - conductance in mouse renal inner medullary collecting duct cells. Am J Physiol Renal Physiol 286:F682-F692
13. - secretion in a mouse renal inner medullary collecting duct cell line. J Physiol 523(Pt 2):325-338
14. Wallace DP, Christensen M, Reif G, Belibi F, Thrasher B, Herrell D, Grantham JJ (2002) Electrolyte and fluid secretion by cultured human inner medullary collecting duct cells. Am J Physiol Renal Physiol 283(6):F1337-F1350
15. Lohi H, Kujala M, Kerkela E, Saarialho-Kere U, Kestila M, Kere J (2000) Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. Genomics 70:102-112
16. Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (2002) Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem 277:14246-14254
17. Romero MF, Chang MH, Plata C, Zandi-Nejad K, Mercado A, Broumand V, Sussman CR, Mount DB (2006) Physiology of electrogenic SLC26 paralogues. Novartis Found Symp 273:126-138
18. - exchangers in kidney and gastrointestinal tract. Novartis Found Symp 273:91-102
19. Soleimani M, Xu J (2006) SLC26 chloride/base exchangers in the kidney in health and disease. Semin Nephrol 26:375-385
20. Alper SL, Stewart AK, Chernova MN, Zolotarev AS, Clark JS, Vandorpe DH (2006) Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides. Novartis Found Symp 273:107-119
21. Schweinfest CW, Spyropoulos DD, Henderson KW, Kim JH, Chapman JM, Barone S, Worrell RT, Wang Z, Soleimani M (2006) Slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. J Biol Chem 281:37962-37971
22. - exchanger in the small intestine. Am J Physiol 282:G573-G579
23. Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, Lorenz JN, Seidler U, Aronson PS, Soleimani M (2005) Renal and intestine transport defects in Slc26a6-null mice. Am J Physiol Cell Physiol 288:C957-C965
24. Xu J, Song P, Nakamura S, Miller M, Barone S, Alper SL, Riederer B, Bonhagen J, Arend LJ, Amlal H et al (2009) Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem 284(43):29470-29479
25. 4+. Am J Physiol Cell Physiol 289:C493-C505
26. Xu J, Song P, Miller ML, Borgese F, Barone S, Riederer B, Wang Z, Alper SL, Forte JG, Shull GE et al (2008) Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc Natl Acad Sci U S A 105(46):17955-17960
27. - channel regulated by intracellular pH. J Biol Chem 280:6463-6470
28. - channel regulated by the WNK kinases. J Physiol 584:333-345
29. + transporter. J Membr Biol 228(3):125-140
30. Xu J, Barone S, Li H, Holiday S, Zahedi K, Soleimani M (2011) Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney. Kidney Int 80(9):926-937
31. Van Huyen JP, Bens M, Teulon J, Vandewalle A (2001) Vasopressin- stimulated chloride transport in transimmortalized mouse cell lines derived from the distal convoluted tubule and cortical and inner medullary collecting ducts. Nephrol Dial Transplant 16(2):238-245
32. Kose H, Boese SH, Glanville M, Gray MA, Brown CD, Simmons NL (2000) Bradykinin regulation of salt transport across mouse inner medullary collecting duct epithelium involves activation of a Ca(2+)-dependent Cl(-) conductance. Br J Pharmacol 131(8):1689-1699
33. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG (2009) Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest 119(6):1647-1658
34. Bartolo RC, Donald JA (2008) The effect of water deprivation on the tonicity responsive enhancer binding protein (TonEBP) and TonEBP-regulated genes in the kidney of the Spinifex hopping mouse, Notomys alexis. J Exp Biol 211(Pt 6):852-859
35. Stein CS, Yancey PH, Martins I, Sigmund RD, Stokes JB, Davidson BL (2010) Osmoregulation of ceroid neuronal lipofuscinosis type 3 in the renal medulla. Am J Physiol Cell Physiol 298(6):C1388-C1400
36. Rajagopal M, Pao AC (2010) Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells. Hypertension 55(5):1123-1128
37. Wallace DP, Rome LA, Sullivan LP, Grantham JJ (2001) cAMP-dependent fluid secretion in rat inner medullary collecting ducts. Am J Physiol Renal Physiol 280(6):F1019-F1029
38. Kizer NL, Vandorpe D, Lewis B, Bunting B, Russell J, Stanton BA (1995) Vasopressin and cAMP stimulate electrogenic chloride secretion in an IMCD cell line. Am J Physiol 268(5 Pt 2):F854-F861
39. Bertrand CA, Zhang R, Pilewski JM, Frizzell RA (2009) SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia. J Gen Physiol 133(4):421-438
40. Singh AK, Amlal H, Haas PJ, Dringenberg U, Fussell S, Barone SL, Engelhardt R, Zuo J, Seidler U, Soleimani M (2008) Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int 74:438-447
41. Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U et al (2009) Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem 284:5056-5066