SLC26 Chloride/Base Exchangers in the Kidney in Health and Disease

Seminars in Nephrology

Volumn 26, Issue 5, 2006, Pages 375-385

  Soleimani, Manoocher ^a   Xu, Jie ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

bicarbonate secretion; chloride absorption; chloride bicarbonate exchange; kidney stone; NaCl absorption

Indexed keywords

ANTIPORTER; BICARBONATE; CHLORIDE; DIASTROPHIC DYSPLASIA SULFATE TRANSPORTER; ISOPROTEIN; OXALIC ACID; PENDRIN; SLC26A11 PROTEIN; SLC26A6 PROTEIN; SLC26A7 PROTEIN; SLC26A8 PROTEIN; SOLUTE LINKED CARRIER 26; SULFATE ANION TRANSPORTER 1; UNCLASSIFIED DRUG; VASOPRESSIN;

ACID BASE BALANCE; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VOLUME; CELL TRANSPORT; CHLORIDE TRANSPORT; GENE EXPRESSION; GENETIC CONSERVATION; HUMAN; KIDNEY CELL; KIDNEY FUNCTION; KIDNEY INTERSTITIUM; KIDNEY MEDULLA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOLARITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; TISSUE DISTRIBUTION; URINARY EXCRETION; WATER LOADING;

ANIMALS; ANION TRANSPORT PROTEINS; ANTIPORTERS; CHLORIDES; HUMANS; KIDNEY; MEMBRANE TRANSPORT PROTEINS; PROTEIN ISOFORMS;

EID: 33750319842     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2006.07.005     Document Type: Article

References (64)

1. Aronson P.S. The renal proximal tubule: A model for diversity of anion exchangers and stilbene-sensitive anion transporters. Annu Rev Physiol 51 (1989) 419-441
2. Aronson P.S., and Giebisch G. Mechanisms of chloride transport in the proximal tubule. Am J Physiol 273 (1997) F179-F192
3. Soleimani M. Molecular physiology of the renal chloride-formate exchanger. Curr Opin Nephrol Hypertens 10 (2001) 677-683
4. Alper S.L. Molecular physiology of SLC4 anion exchangers. Exp Physiol 91 (2006) 153-161
5. Mount D.B., and Romero M.F. The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch 447 (2004) 710-721
6. Soleimani M., and Burnham C.E. Na+:HCO(3-) cotransporters (NBC): Cloning and characterization. J Membr Biol 183 (2001) 71-84
7. Alper S.L. Genetic diseases of acid-base transporters. Annu Rev Physiol 64 (2002) 899-923
8. Romero M.F., Fulton C.M., and Boron W.F. The SLC4 family of HCO 3-transporters. Pflugers Arch 447 (2004) 495-509
9. Pushkin A., and Kurtz I. SLC4 base (HCO3-, CO3 2-) transporters: Classification, function, structure, genetic diseases, and knockout models. Am J Physiol 290 (2006) F580-F599
10. - transporter superfamily is an apical anion exchanger of β-intercalated cells in the kidney. J Biol Chem 276 (2001) 8180-8189
11. Ko S.B., Luo X., Hager H., et al. AE4 is a DIDS-sensitive Cl-/HCO3 exchanger in the basolateral membrane of the renal CCD and the SMG duct. Am J Physiol 283 (2002) C1206-C1218
12. Xu J., Barone S., Petrovic S., et al. Identification of an apical Cl-/HCO3- exchanger in gastric surface mucous and duodenal villus cells. Am J Physiol 285 (2003) G1225-G1234
13. Bissig M., Hagenbuch B., Stieger B., et al. Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. J Biol Chem 269 (1994) 3017-3021
14. Hastabacka J., de la Chapelle A., Mahtani M.M., et al. The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping. Cell 78 (1994) 1073-1087
15. Schweinfest C.W., Henderson K.W., Suster S., et al. Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas. Proc Natl Acad Sci U S A 90 (1993) 4166-4170
16. Hoglund P., Haila S., Socha J., et al. Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhea. Nat Genet 14 (1996) 316-319
17. Melvin J.E., Park K., Richardson L., et al. Mouse down-regulated in adenoma (DRA) is an intestinal Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na(+)/H(+) exchanger. J Biol Chem 274 (1999) 22855-22861
18. Everett L.A., Glaser B., Beck J.C., et al. Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet 17 (1997) 411-422
19. Soleimani M., Greeley T., Petrovic S., et al. Pendrin: An apical Cl-/OH-/HCO3- exchanger in the kidney cortex. Am J Physiol 280 (2001) F356-F364
20. Zheng J., Shen W., He D.Z., et al. Prestin is the motor protein of cochlear outer hair cells. Nature 405 (2000) 149-155
21. Lohi H., Kujala M., Kerkela E., et al. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. Genomics 70 (2000) 102-112
22. Lohi H., Kujala M., Makela S., et al. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem 277 (2002) 14246-14254
23. Knauf F., Yang C.L., Thomson R.B., et al. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A 98 (2001) 9425-9430
24. Vincourt J.B., Jullien D., Kossida S., et al. Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. Genomics 79 (2002) 249-256
25. Wang Z., Petrovic S., Mann E., et al. Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine. Am J Physiol 282 (2002) G573-G579
26. Vincourt J.B., Jullien D., Amalric F., et al. Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules. FASEB J 17 (2003) 890-892
27. Ko S.B., Zeng W., Dorwart M.R., et al. Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol 6 (2004) 343-350
28. Petrovic S., Ju X., Barone S., et al. Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells. Am J Physiol 284 (2003) G1093-G1103
29. Petrovic S., Barone S., Xu J., et al. SLC26A7: A basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct. Am J Physiol 286 (2004) F161-F169
30. Xie Q., Welch R., Mercado A., et al. Molecular characterization of the murine Slc26a6 anion exchanger: Functional comparison with Slc26a1. Am J Physiol 283 (2002) F826-F838
31. Karniski L.P., Lotscher M., Fucentese M., et al. Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney. Am J Physiol 275 (1998) F79-F87
32. Karniski L.P. Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene: Correlation between sulfate transport activity and chondrodysplasia phenotype. Hum Mol Genet 10 (2001) 1485-1490
33. Scott D.A., Wang R., Kreman T.M., et al. The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet 21 (1999) 440-443
34. Gillam M.P., Sidhaye A.R., Lee E.J., et al. Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux. J Biol Chem 279 (2004) 13004-13010
35. Everett L.A., Belyantseva I.A., Noben-Trauth K., et al. Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome. Hum Mol Genet 10 (2001) 153-161
36. Reardon W., and Trembath R.C. Pendred syndrome. J Med Genet 33 (1996) 1037-1040
37. Everett L.A., and Green E.D. A family of mammalian anion transporters and their involvement in human genetic diseases. Hum Mol Genet 8 (1999) 1883-1891
38. Kopp P. Pendred's syndrome and genetic defects in thyroid hormone synthesis. Rev Endocr Metab Disord 1 (2000) 109-121
39. Royaux I.E., Wall S.M., Karniski L.P., et al. Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A 98 (2001) 4221-4226
40. Wall S.M., Hassell K.A., Royaux I.E., et al. Localization of pendrin in mouse kidney. Am J Physiol 284 (2003) F229-F241
41. Wagner C.A., Finberg K.E., Stehberger P.A., et al. Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status. Kidney Int 62 (2001) 2109-2117
42. Petrovic S., Wang Z., Ma L., et al. Regulation of the apical Cl-/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis. Am J Physiol 284 (2003) F103-F112
43. Verlander J.W., Hassell K.A., Royaux I.E., et al. Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: Role of pendrin in mineralocorticoid-induced hypertension. Hypertension 42 (2003) 356-362
44. Wall S.M., Kim Y.H., Stanley L., et al. NaCl restriction upregulates renal Slc26a4 through subcellular redistribution: Role in Cl- conservation. Hypertension 44 (2004) 982-987
45. Brown C.D., Dunk C.R., and Turnberg L.A. Cl-HCO3 exchange and anion conductance in rat duodenal apical membrane vesicles. Am J Physiol 257 (1989) G661-G667
46. Isenberg J.I., Ljungstrom M., Safsten B., et al. Proximal duodenal enterocyte transport: Evidence for Na(+)-H+ and Cl(-)-HCO3-exchange and NaHCO3 cotransport. Am J Physiol 265 (1993) G677-G685
47. Petrovic S., Ma L., Wang Z., et al. Identification of an apical Cl-/HCO-3 exchanger in rat kidney proximal tubule. Am J Physiol 285 (2003) C608-C617
48. Wang Z., Wang T., Petrovic S., et al. Renal and intestinal transport defects in Slc26a6-null mice. Am J Physiol 288 (2005) C957-C965
49. - exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells. Am J Physiol 283 (2002) G1207-G1216
50. Freel R.W., Hatch M., Green M., et al. Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice. Am J Physiol 290 (2006) G719-G728
51. Jiang Z., Asplin J.R., Evan A.P., et al. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet 38 (2006) 474-478
52. Chernova M.N., Jiang L., Friedman D.J., et al. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: Differences in anion selectivity, regulation, and electrogenicity. J Biol Chem 280 (2005) 8564-8580
53. Shcheynikov N., Wang Y., Park M., et al. Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol 127 (2006) 511-524
54. Kim K.H., Shcheynikov N., Wang Y., et al. SLC26A7 is a Cl- channel regulated by intracellular pH. J Biol Chem 280 (2005) 6463-6470
55. Schuster V.L. Function and regulation of collecting duct intercalated cells. Annu Rev Physiol 55 (1993) 267-288
56. Weiner I.D., Wingo C.S., and Hamm L.L. Regulation of intracellular pH in two cell populations of inner stripe of rabbit outer medullary collecting duct. Am J Physiol 265 (1993) F406-F415
57. Verlander J.W., Madsen K.M., Low P.S., et al. Immunocytochemical localization of band 3 protein in the rat collecting duct. Am J Physiol 255 (1988) F115-F125
58. Schuster V.L., Fejes-Toth G., Naray-Fejes-Toth A., et al. Colocalization of H(+)-ATPase and band 3 anion exchanger in rabbit collecting duct intercalated cells. Am J Physiol 260 (1991) F506-F517
59. Stehberger P.A., Stuart-Tilley A.K., Scmukler B.E., et al. Impaired distal renal acidification in a mouse model for distal renal tubular acidosis lacking AE1 (band 3) Cl-/HCO3- exchanger Slc41a. J Am Soc Nephrol 15 (2004) 70A (abstr)
60. Barone S., Amlal H., Xu J., et al. Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct. J Am Soc Nephrol 15 (2004) 2002-2011
61. Xu J., Worrell R.T., Li H.C., et al. Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. J Am Soc Nephrol 17 (2006) 956-967
62. Petrovic S., Amlal H., Sun X., et al. Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rat. Am J Physiol 290 (2006) F1194-F1201
63. Dudas P.L., Mentone S., Greineder C.F., et al. Immunolocalization of anion transporter Slc26a7 in mouse kidney. Am J Physiol 290 (2006) F937-F945
64. Toure A., Morin L., Pineau C., et al. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhoGTPase signaling. J Biol Chem 276 (2001) 20309-20315