Effects of short-term and long-term pretreatment of Schisandra lignans on regulating hepatic and intestinal CYP3A in rats

Drug Metabolism and Disposition

Volumn 37, Issue 12, 2009, Pages 2399-2407

  Lai, Li ^a,b   Hao, Haiping ^a   Wang, Qiong ^a   Zheng, Chaonao ^a   Zhou, Fang ^a   Liu, Yitong ^a   Wang, Yuxin ^a   Yu, Guo ^a   Kang, An ^a   Peng, Ying ^a   Wang, Guangji ^a   Chen, Xijing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Natl Safety Assess Chin Med   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; DEOXYSCHIZANDRIN; GAMMA SCHIZANDRIN; GOMISIN; INTESTINE ENZYME; LIGNAN DERIVATIVE; LIVER ENZYME; MIDAZOLAM; SCHISANDRA CHINENSIS EXTRACT; SCHIZANDROL A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG HYDROXYLATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBSTRATE; HERB DRUG INTERACTION; IC 50; LONG TERM CARE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHORT COURSE THERAPY; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOTRANSFORMATION; CYTOCHROME P-450 CYP3A; DRUG ADMINISTRATION SCHEDULE; ENZYME INDUCTION; ENZYME INHIBITORS; HALF-LIFE; HERB-DRUG INTERACTIONS; HYDROXYLATION; INJECTIONS, INTRAVENOUS; INTESTINES; LIGNANS; LIVER; MALE; METABOLIC CLEARANCE RATE; MICROSOMES; MIDAZOLAM; RATS; RATS, SPRAGUE-DAWLEY; SCHISANDRA;

RATTUS; SCHISANDRA;

EID: 71049138996     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027433     Document Type: Article

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