Prognostic Significance of HIF-1α Expression in Hepatocellular Carcinoma: A Meta-Analysis

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Zheng, Su Su ^a   Chen, Xiao Hong ^a   Yin, Xin ^a   Zhang, Bo Heng ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ARTICLE; CANCER PROGNOSIS; DISEASE FREE SURVIVAL; HUMAN; LIVER CELL CARCINOMA; LIVER METASTASIS; LYMPH NODE METASTASIS; OVERALL SURVIVAL; TUMOR GROWTH; TUMOR INVASION; VASCULAR INVASION;

CARCINOMA, HEPATOCELLULAR; DISEASE-FREE SURVIVAL; GENE EXPRESSION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84879057163     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065753     Document Type: Article

References (22)

1. Fan ST, Lo CM, Liu CL, Lam CM, Yuen WK, et al. (1999) Hepatectomy for hepatocellular carcinoma: toward zero hospital deaths. Ann Surg 229: 322-330.
2. Tung-Ping Poon R, Fan ST, Wong J, (2000) Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg 232: 10-24.
3. Filmus J, Capurro M, (2004) Glypican-3 and alphafetoprotein as diagnostic tests for hepatocellular carcinoma. Mol Diagn 8: 207-212.
4. Harris AL, (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47.
5. Kimura S, Kitadai Y, Tanaka S, Kuwai T, Hihara J, et al. (2004) Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma. Eur J Cancer 40: 1904-1912.
6. Lu XG, Xing CG, Feng YZ, Chen J, Deng C, (2006) Clinical significance of immunohistochemical expression of hypoxia-inducible factor-1alpha as a prognostic marker in rectal adenocarcinoma. Clin Colorectal Cancer 5: 350-353.
7. Dong ZZ, Yao DF, Li SS, Li YM, Tai BJ, et al. (2010) [Expression characteristics of hypoxia inducible factor-1a and its clinical values in hepatocellular carcinoma]. Zhonghua Gan Zang Bing Za Zhi 18: 506-510.
8. Liu L, Zhu XD, Wang WQ, Shen Y, Qin Y, et al. (2010) Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin Cancer Res 16: 2740-2750.
9. Huang GW, Yang LY, Lu WQ, (2005) Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival. World J Gastroenterol 11: 1705-1708.
10. Xia L, Mo P, Huang W, Zhang L, Wang Y, et al. (2012) The TNF-alpha/ROS/HIF-1-induced upregulation of FoxMI expression promotes HCC proliferation and resistance to apoptosis. Carcinogenesis 33: 2250-2259.
11. Wada H, Nagano H, Yamamoto H, Yang Y, Kondo M, et al. (2006) Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha. Liver Int 26: 414-423.
12. Dai CX, Gao Q, Qiu SJ, Ju MJ, Cai MY, et al. (2009) Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery. BMC Cancer 9: 418.
13. Xiang ZL, Zeng ZC, Fan J, Tang ZY, He J, et al. (2012) The expression of HIF-1alpha in primary hepatocellular carcinoma and its correlation with radiotherapy response and clinical outcome. Mol Biol Rep 39: 2021-2029.
14. Xie H, Song J, Liu K, Ji H, Shen H, et al. (2008) The expression of hypoxia-inducible factor-1alpha in hepatitis B virus-related hepatocellular carcinoma: correlation with patients' prognosis and hepatitis B virus X protein. Dig Dis Sci 53: 3225-3233.
15. Zhang CH, Xu GL, Jia WD, Ge YS, Li JS, et al. (2012) Prognostic significance of osteopontin in hepatocellular carcinoma: a meta-analysis. Int J Cancer 130: 2685-2692.
16. Parmar MK, Torri V, Stewart L, (1998) Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 17: 2815-2834.
17. Mao C, Chung VC, He BF, Luo RC, Tang JL, (2012) Association between ATM 5557G>A polymorphism and breast cancer risk: a meta-analysis. Mol Biol Rep 39: 1113-1118.
18. DerSimonian R, Laird N, (1986) Meta-analysis in clinical trials. Control Clin Trials 7: 177-188.
19. Mantel N, Haenszel W, (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748.
20. Egger M, Davey Smith G, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
21. Bertout JA, Patel SA, Simon MC, (2008) The impact of O2 availability on human cancer. Nat Rev Cancer 8: 967-975.
22. Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, et al. (2003) Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 38: 200-207.