Neutrophil elastase inhibitor sivelestat attenuates perioperative inflammatory response in pediatric heart surgery with cardiopulmonary bypass: A prospective randomized study

International Heart Journal

Volumn 54, Issue 3, 2013, Pages 149-153

  Inoue, Nobuyuki ^a   Oka, Norihiko ^a   Kitamura, Tadashi ^a   Shibata, Ko ^a   Itatani, Keiichi ^a   Tomoyasu, Takahiro ^a   Miyaji, Kagami ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Systemic inflammatory response syndrome

Indexed keywords

C REACTIVE PROTEIN; ELASTASE; INTERLEUKIN 6; INTERLEUKIN 8; POLYMORPHONUCLEAR ELASTASE; SIVELESTAT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BODY WEIGHT; CARDIOPULMONARY BYPASS; CHILD; CHILD HEALTH CARE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONGENITAL HEART DISEASE; CONTINUOUS INFUSION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; ELECTIVE SURGERY; ENZYME BLOOD LEVEL; FEMALE; HEART SURGERY; HUMAN; INFANT; MALE; NEUTROPHIL COUNT; PEDIATRIC SURGERY; PERIOPERATIVE PERIOD; POSTOPERATIVE CARE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; DOUBLE-BLIND METHOD; FEMALE; GLYCINE; HUMANS; INFANT; INFLAMMATION; MALE; NEUTROPHILS; PROSPECTIVE STUDIES; PROTEINASE INHIBITORY PROTEINS, SECRETORY; SULFONAMIDES; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TREATMENT OUTCOME;

EID: 84879040191     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.54.149     Document Type: Article

References (25)

1. Butler J, Rocker GM, Westaby S. Inflammatory response to cardio-pulmonary bypass. Ann Thorac Surg 1993; 55: 552-559. (Review)
2. Gessler P, Pfenninger J, Pfammatter JP, Carrel T, Baenziger O, Dahinden C. Plasma levels of interleukin-8 and expression of in-terleukin-8 receptors on circulating neutrophils and monocytes after cardiopulmonary bypass in children. J Thorac Cardiovasc Surg 2003; 126: 718-725.
3. Chew MS, Brandslund I, Brix-Christensen V, et al. Tissue injury and the inflammatory response to pediatric cardiac surgery with cardiopulmonary bypass: a descriptive study. Anesthesiology 2001; 94: 745-753.
4. Yamazaki T, Ooshima H, Usui A, Watanabe T, Yasuura K. Protective effects of ONO-5046*Na, a specifc neutrophil elastase inhibitor, on postperfusion lung injury. Ann Thorac Surg 1999; 68: 2141-2146.
5. Ryugo M, Sawa Y, Takano H, et al. Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: fndings of a double-blind randomized study. Surg Today 2006; 36: 321-326.
6. Fujii M, Miyagi Y, Bessho R, Nitta T, Ochi M, Shimizu K. Effect of a neutrophil elastase inhibitor on acute lung injury after cardio-pulmonary bypass. Interact Cardiovasc Thorac Surg 2010; 10: 859-862.
7. Matsuzaki K, Hiramatsu Y, Homma S, Sato S, Shigeta O, Sakaki-bara Y. Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation. Ann Thorac Surg 2005; 80: 611-617.
8. Akamoto S, Okano K, Sano T, et al. Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the infam-matory mediators associated with major surgery. Surg Today 2007; 37: 359-365.
9. Miyaji K, Miyamoto T, Kohira S, et al. Miniaturized cardiopulmo-nary bypass system in neonates and small infants. Interact Cardio-vasc Thorac Surg 2008; 7: 75-78.
10. Miyaji K, Kohira S, Miyamoto T, et al. Pediatric cardiac surgery without homologous blood transfusion, using a miniaturized bypass system in infants with lower body weight. J Thorac Cardio-vasc Surg 2007; 134: 284-289.
11. Jenkins KJ, Gauvreau K, Newburger JW, Spray TL, Moller JH, Iezzoni LI. Consensus-based method for risk adjustment for surgery for congenital heart disease. J Thorac Cardiovasc Surg 2002; 123: 110-118. (Review)
12. Finn A, Naik S, Klein N, Levinsky RJ, Strobel S, Elliott M. Inter-leukin-8 release and neutrophil degranulation after pediatric cardio-pulmonary bypass. J Thorac Cardiovasc Surg 1993; 105: 234-241.
13. Brix-Christensen V. The systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children. Acta Anaesthesiol Scand 2001; 45: 671-679. (Review)
14. Carvalho M V, Maluf MA, Catani R, et al. Cytokines and pediatric open heart surgery with cardiopulmonary bypass. Cardiol Young 2001; 11: 36-43.
15. Gessler P, Schmitt B, Prètre R, Latal B. Inflammatory response and neurodevelopmental outcome after open-heart surgery in children. Pediatr Cardiol 2009; 30: 301-305.
16. Tárnok A, Hambsch J, Emmrich F, et al. Complement activation, cytokines, and adhesion molecules in children undergoing cardiac surgery with or without cardiopulmonary bypass. Pediatr Cardiol 1999; 20: 113-125.
17. Gessler P, Pfenninger J, Pfammatter JP, Carrel T, Baenziger O, Dahinden C. Plasma levels of interleukin-8 and expression of in-terleukin-8 receptors on circulating neutrophils and monocytes after cardiopulmonary bypass in children. J Thorac Cardiovasc Surg 2003; 126: 718-725.
18. Ueyama K, Nishimura K, Nishina T, Nakamura T, Ikeda T, Kome-da M. PMEA coating of pump circuit and oxygenator may attenuate the early systemic inflammatory response in cardiopulmonary bypass surgery. ASAIO J 2004; 50: 369-372.
19. Fromes Y, Gaillard D, Ponzio O, et al. Reduction of the infamma-tory response following coronary bypass grafting with total minimal extracorporeal circulation. Eur J Cardiothorac Surg 2002; 22: 527-533.
20. Ohata T, Mitsuno M, Yamamura M, et al. Minimal cardiopulmo-nary bypass attenuates neutrophil activation and cytokine release in coronary artery bypass grafting. J Artif Organs 2007; 10: 92-5.
21. Miyaji K, Miyamoto T, Kohira S, et al. Miniaturized cardiopulmo-nary bypass system in neonates and small infants. Interact Cardio-vasc Thorac Surg 2008; 7: 75-78.
22. Makino H, Kunisaki C, Kosaka T, Akiyama H, Morita S, Endo I. Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer. Br J Surg 2011; 98: 975-982.
23. Nishiyama J, Matsuda M, Ando S, Hirasawa M, Suzuki T, Maku-uchi H. The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer. Surg Today 2012; 42: 659-665.
24. Wakayama F, Fukuda I, Suzuki Y, Kondo N. Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopul-monary bypass in the rabbit endotoxemia model. Ann Thorac Surg 2007; 83: 153-160.
25. Abe T, Usui A, Oshima H, Akita T, Ueda Y. A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery. Interact Cardiovasc Thorac Surg 2009; 9: 236-240.