Neutrophil Elastase Inhibitor, Sivelestat, Attenuates Acute Lung Injury After Cardiopulmonary Bypass in the Rabbit Endotoxemia Model

Annals of Thoracic Surgery

Volumn 83, Issue 1, 2007, Pages 153-160

  Wakayama, Fuminori ^a   Fukuda, Ikuo ^a   Suzuki, Yasuyuki ^a   Kondo, Norihiro ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 8; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; SIVELESTAT;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD GAS; BLOOD SAMPLING; CARDIOPULMONARY BYPASS; CONTINUOUS INFUSION; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HISTOPATHOLOGY; INFECTION; LUNG LAVAGE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SHOCK;

ANIMALS; CARDIOPULMONARY BYPASS; GLYCINE; INTERLEUKIN-8; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDES; NEUTROPHILS; PEROXIDASE; RABBITS; RESPIRATORY DISTRESS SYNDROME, ADULT; SULFONAMIDES;

EID: 33845503899     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2006.08.023     Document Type: Article

References (24)

1. Baue A.E. Cardiopulmonary bypass for cardiac surgery: an inflammatory event: can it be modulated?. In: Baue A.E., Faist E., and Fry D.E. (Eds). Multiple organ failure: pathophysiology, prevention, and therapy (2000), Springer-Verlag, New York 82-85
2. Nakao S., Matsumoto S., Yamada A., et al. Studies on the in vitro, ex vivo and in vitro pharmacological profile of a neutrophil elastase inhibitor, ONO-5046Na. Kiso To Rinsho 31 (1997) 3347-3356
3. Yamazaki T., Ooshima H., Usui A., Watanabe T., and Yasuura K. Protective effects of ONO-5046Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury. Ann Thorac Surg 68 (1999) 2141-2146
4. Ishikawa N., Oda M., Kawaguchi M., Tsunezuka Y., and Watanabe G. The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury. Transpl Int 16 (2003) 341-346
5. Kotake Y., Yamamoto M., Matsumoto M., Morisaki H., and Takeda J. Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits. Shock 23 (2005) 156-160
6. Matsuzaki K., Hiramatsu Y., Homma S., Sato S., Shigeta O., and Sakakibara Y. Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation. Ann Thorac Surg 80 (2005) 611-617
7. Yoshimura K., Nakagawa S., Koyama S., Kobayashi T., and Homma T. Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit. J Appl Physiol 76 (1994) 91-96
8. Nakamura M., Fujishima S., Sawafuji M., et al. Importance of interleukin-8 in the development of reexpansion lung injury in rabbits. Am J Respir Crit Care Med 161 (2000) 1030-1036
9. Messent M., Sullivan K., Keogh B.F., Morgan C.J., and Evans T.W. Adult respiratory distress syndrome following cardiopulmonary bypass: incidence and prediction. Anaesthesia 47 (1992) 267-268
10. Christenson J.T., Aeberhard J.M., Badel P., et al. Adult respiratory distress syndrome after cardiac surgery. Cardiovasc Surg 4 (1996) 15-21
11. Kaul T.K., Fields B.L., Riggins L.S., Wyatt D.A., Jones C.R., and Nagle D. Adult respiratory distress syndrome following cardiopulmonary bypass: incidence, prophylaxis and management. J Cardiovasc Surg 39 (1998) 777-781
12. Milot J., Perron J., Lacasse Y., Letourneau L., Cartier P.C., and Maltais F. Incidence and predictors of ARDS after cardiac surgery. Chest 119 (2001) 884-888
13. Garber B.G., Hebert P.C., Yelle J.D., Hodder R.V., and McGowan J. Adult respiratory distress syndrome: a systemic overview of incidence and risk factors. Crit Care Med 24 (1996) 687-695
14. Bennett-Guerrero E., Ayuso L., Hamilton-Davies C., White W.D., Barclay G.R., and Smith P.K. Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery. JAMA 277 (1997) 646-650
15. Kinoshita M., Ono S., and Mochizuki H. Neutrophil mediate acute lung injury in rabbits: role of neutrophil elastase. Eur Surg Res 32 (2000) 337-346
16. Picone A.L., Lutz C.J., Finck C., et al. Multiple sequential insults cause post-pump syndrome. Ann Thorac Surg 67 (1999) 978-985
17. Devaney J.M., Greene C.M., Taggart C.C., Carroll T.P., O'Neill S.J., and McElvane N.G. Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4. FEBS Lett 544 (2003) 129-132
18. Stefanova I., Corcoran M.L., Horak E.M., Wahl L.M., Bolen J.B., and Horak I.D. Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn. J Biol Chem 268 (1993) 20725-20728
19. Vandivier R.W., Fadok V.A., Hoffman P.R., et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 109 (2002) 661-670
20. Efstathiou A., Vlachveis M., Tsonis G., Asteri T., Psarakis A., and Fessatidis I.T. Does leukodepletion during elective cardiac surgery really influence the overall clinical outcome?. J Cardiovasc Surg 44 (2003) 197-204
21. Chen Y.F., Tsai W.C., Lin C.C., et al. Effect of leukocyte depletion on endothelial cell activation and transendothelial migration of leukocytes during cardiopulmonary bypass. Ann Thorac Surg 78 (2004) 634-643
22. Rubens F.D., Nathan H., Labow R., et al. Effects of methylprednisolone and a biocompatible copolymer circuit on blood activation during cardiopulmonary bypass. Ann Thorac Surg 79 (2005) 655-665
23. Kawabata K., Hagio T., Matsumoto S., et al. Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters. Am J Respir Crit Care Med 161 (2000) 2013-2018
24. Zeiher B.G., Artigas A., Vincent J.L., et al. Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med 32 (2004) 1695-1702